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1741
Immune intrinsic escape signature stratifies prognosis, characterizes the tumor immune microenvironment, and identifies tumorigenic PPP1R8 in glioblastoma multiforme patients
Published 2025-08-01“…TIME analysis was carried out using multiple deconvolution algorithms. Additionally, functional assays including CCK8, cell cycle, and apoptosis assays were conducted on PPP1R8-silenced U251 cells using CRISPR/Cas9 technologyResultsThirty-six IERGs were associated with GBM outcomes, with 20 linked to poor survival and 16 to better outcomes. …”
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1742
Retinol and Hydroxyasiaticoside Synergistically Relieve Histamine-Induced Atopic Dermatitis Activity by Repressing TRPV1, L1R1, and CD130 Targets
Published 2024-11-01“…Quantitative RNA-seq analysis revealed that the gene expression patterns were similar in different concentration groups. …”
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1743
ENHANCEMENT OF SENSOR PANEL TACTILE TOUCH INTERFACE
Published 2025-03-01“…The neural network is designed to learn the patterns and characteristics of the signals, allowing it to accurately classify new, unseen signals. …”
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1744
The developmental transcriptome dynamics of current-year shoot utilized as scion in Camellia chekiangoleosa
Published 2025-05-01“…Results Analysis of temporal expression characteristics of genome-wide genes and differentially expressed genes (DEGs) revealed that genes differentially patterned between stem and apical bud were enriched in functions related to cell division and differentiation, hormone responses, and vascular or flower development. …”
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1745
Exploring potential methylation markers for ovarian cancer from cervical scraping samples
Published 2025-05-01“…Furthermore, an over-representation analysis was conducted to explore the functions associated with genes mapped from differentially methylated positions (DMPs) in comparisons between normal and tumor samples, as well as between benign and malignant samples. …”
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1746
Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach
Published 2025-05-01“…Molecular docking simulations were conducted to assess the binding affinities between PFAS compounds and selected target proteins. …”
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1747
A usability evaluation framework for a mobile application in supporting home-based rehabilitation for stroke patients: A qualitative study
Published 2025-05-01“…Conclusions Satisfaction and performance surveys and qualitative data analysis revealed that most participants described the interface design of the app as intuitive and easy to use. Although some functions presented challenges, there was still a high level of satisfaction among both groups. …”
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1748
Genome-wide identification of PP2A gene family in Camellia sinensis reveals the potential role of CsPP2A-TON2/FASS1 in abiotic stress
Published 2025-05-01“…Further, a systematic study was conducted wherein physicochemical properties, phylogeny, gene structure and gene expression were explored. …”
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1749
Study on Enzyme Activity and Metabolomics during Culture of Liquid Spawn of <i>Floccularia luteovirens</i>
Published 2024-08-01“…By comparing three different culture stages (10 days, 20 days, and 30 days), 299, 291, and 381 metabolites, respectively, showed different accumulation patterns in the comparison groups of 10d vs. 20d, 20d vs. 30d, and 10d vs. 30d. …”
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1750
Transcriptome sequencing and Mendelian randomization analysis identified biomarkers related to neutrophil extracellular traps in diabetic retinopathy
Published 2024-10-01“…Additional analysis, including nomogram construction, gene set enrichment analysis, drug prediction and molecular docking, were performed to investigate the functions and molecular mechanisms of the key genes. …”
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1751
Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus
Published 2025-06-01“…Cell-type-specific RBPs expression patterns were systematically profiled across epidermal keratinocytes, dermal endothelial cells, and T cells. …”
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1752
Comparative metagenomics highlights the habitat-related diversity in taxonomic composition and metabolic potential of deep-sea sediment microbiota
Published 2024-11-01“…Additionally, we analyzed the metabolic patterns of microbial communities in different deep-sea sediments. …”
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1753
Maize Herbivore-Induced Volatiles Enhance Xenobiotic Detoxification in Larvae of <i>Spodoptera frugiperda</i> and <i>S. litura</i>
Published 2024-12-01“…In addition, the expression of four genes encoding uridine diphosphate (UDP)-glycosyltransferases (<i>UGT33F28</i>, <i>UGT40L8</i>) and P450s (<i>CYP4d8</i>, <i>CYP4V2</i>) showed similar induction patterns in <i>S. frugiperda.</i> Cis-3-hexen-1-ol, an important component in maize HIPVs, also showed the same functions as maize HIPVs, and its exposure increased larval xenobiotic tolerance and induced the detoxification enzymes and gene expression. …”
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1754
Genomic and Transcriptomic Analysis to Explore the Biological Characteristics of <i>Cyclocybe chaxingu</i>
Published 2025-04-01“…Transcriptomic analysis revealed distinct gene expression patterns in mycelia, stipe, and cap, reflecting their functional specialization. …”
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1755
Performance exploration of multi-gene panels of alopecia areata susceptibility and drug-binding targets
Published 2025-03-01“…ObjectiveThis study aims to identify potential target genes and therapeutic drugs for alopecia areata (AA).MethodsUtilizing training and testing data, we evaluated multi-gene panels derived from commonly upregulated genes in publicly available AA patient datasets. The functions of these genes in biological processes were analyzed to identify special multi-gene panels that may play crucial roles in AA. …”
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1756
Genome-wide identification and characterization of the CCT gene family in Chinese cabbage (Brassica rapa) response to abiotic stress
Published 2025-07-01“…Results In this study, we conducted a genome-wide identification and analysis ofCCT genes in Chinese cabbage. …”
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1757
How topographic factors regulate vegetation vigor in reservoir drawdown zones with different levels of hydrological disturbances?
Published 2025-09-01“…Topography plays a fundamental role in shaping vegetation distribution, community structure, and ecosystem functioning. This influence remains significant in hydrologically complex environments, particularly in reservoir drawdown zones (RDZs). …”
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1758
Pelagic fish camouflage in shallow waters from the humboldt current system through intracellular structures and reflectance mechanisms
Published 2025-08-01“…These Scanning Electron Microscopy (SEM) images were analyzed using the 2D discrete Fourier transform to extract the spatial patterns that govern the light interaction with the guanine crystal structures. …”
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1759
Genome-wide identification and expression profile analysis of TALE superfamily genes under hormone and abiotic stress in maize (Zea may L.)
Published 2025-02-01“…These results can lay the foundation for analysis of the functions of ZmTALE genes under ABA and abiotic stresses.…”
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1760
Strength-agility and fine motor are differently associated with non-verbal intelligence in dependency to sex and age in school children: Structural equation modelling multigroup ap...
Published 2024-11-01“…While motor proficiency has been positively linked to various cognitive functions in children, its relationship with nonverbal Intelligence remains an open question. …”
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