<i>Mycobacterium Ulcerans</i> Ulcer: Current Trends in Antimicrobial Management and Reconstructive Surgical Strategies by Bryan Lim, Omar Shadid, Jennifer Novo, Yi Mon, Ishith Seth, Gianluca Marcaccini, Roberto Cuomo, Daniel P. O’Brien, Warren M. Rozen

“…Its toxin, mycolactone, drives tissue destruction, and the infection is transmitted via environmental reservoirs or vectors. Disease patterns vary globally, and an improved understanding of their pathogenesis may enhance current antimicrobial and surgical treatments. …”
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Identification and Characterization of the OCT4 Upstream Regulatory Region in Sus scrofa by Seung-Hun Kim, Kwang-Hwan Choi, Dong-Kyung Lee, Mingyun Lee, Jae Yeon Hwang, Chang-Kyu Lee

“…However, the OCT4 promoter and four regulatory regions, including distal and proximal enhancer elements, had high similarity. Next, a functional analysis of the porcine OCT4 promoter region was conducted. …”
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Repetitive transcranial magnetic stimulation ameliorates chronic pain behavior and modulates the brain transcriptome in a mouse model of chronic constriction injury by Tianying Li, Guanwen Lin, Tao Zhang, Yani Guo, Yongjin He, Jing Luan, Jin Wang, Dan Lyu, Yiqi Weng, Xin Jin

“…Transcriptomic analysis revealed that CCI induced dysregulation of 66 genes, while rTMS partially normalized gene expression patterns. Functional enrichment analysis indicated significant involvement of pathways related to inflammatory responses, transporter activity, and ion channel regulation. …”
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The Trehalose-6-Phosphate Synthase and Trehalose-6-Phosphate Phosphatase in Cocoa (Theobroma cacao L.): Genome-Wide Identification and Expression Analysis by Quy Phuong Nguyen, Phi Bang Cao, Ngoc Thi Bich Chu, Lan Thi Mai Tran, Man Thi Le, Hang Thi Luong, Quynh Thi Ngoc Le, Gioi Huy Dong, Ha Duc Chu

“…Based on publicly available datasets, expression profiling demonstrated differential expression patterns of TcTPP and TcTPS genes during embryo development and under biotic stress conditions, such as pathogen infection by Phytophthora megakarya. …”
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Gait-Based AI Models for Detecting Sarcopenia and Cognitive Decline Using Sensor Fusion by Rocío Aznar-Gimeno, Jose Luis Perez-Lasierra, Pablo Pérez-Lázaro, Irene Bosque-López, Marina Azpíroz-Puente, Pilar Salvo-Ibáñez, Martin Morita-Hernandez, Ana Caren Hernández-Ruiz, Antonio Gómez-Bernal, María de la Vega Rodrigalvarez-Chamarro, José-Víctor Alfaro-Santafé, Rafael del Hoyo-Alonso, Javier Alfaro-Santafé

“…<b>Methods</b>: A cross-sectional case-control study was conducted involving 42 individuals aged 60 years or older. …”
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Transcriptome analysis reveals the candidate genes associated with skin color variation in Luciobarbus capito by Longwu Geng, Xinchi Shang, Haijun Wei, Guangxiang Tong, Wei Xu, Youyi Kuang

“…Among the DEGs, six genes (ywhae, c3, cdk4, mt-atp6, rhoa, and tuba1) were associated with melanin synthesis and transport, functioning through the PI3K/Akt and cAMP signaling pathways. …”
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Wogonin inhibits the proliferation of prolactinoma through the PI3K/AKT signaling pathway by Zhiyong Du, Zhiyong Du, Zhiyong Du, Zhiyong Du, Cuiping Sun, Cuiping Sun, Cuiping Sun, Cuiping Sun, Jiawei Wu, Jiawei Wu, Hongwei Gao, Hongwei Gao, Hongwei Gao, Hongwei Gao, Jialong Wu, Jialong Wu, Jialong Wu, Jialong Wu, You Zhou, You Zhou, You Zhou, You Zhou, Xuechao Wu, Xuechao Wu, Liping Shen, Liping Shen, Qing Wang, Qing Wang, Qing Wang, Qing Wang

“…Functional and pathway enrichment analyses were executed utilizing Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) methodologies. …”
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The m6A modification of LINC01133 suppresses ER+ breast cancer progression by modulating IGF2BP2 protein stability via a ubiquitination-dependent mechanism by Mai-dong Li, Mai-dong Li, Ben-jie Shan, Lei Wang, Shuang Gao, Li Hao, Hai-yang Yu, Yue-yin Pan, Yue-yin Pan

“…Functionally, LINC01133 inhibited migration and invasion in vitro and metastasis in vivo of ER+ breast cancer cells. …”
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Effectiveness and cost-effectiveness of a structured integrated post-pulmonary embolism follow-up care model (Attend-PE): a rationale and protocol for a multicentre clinical pre-po... by Thomas Kümler, Søren Paaske Johnsen, Anette Arbjerg Højen, Erik Lerkevang Grove, Frederikus A Klok, Bettina Wulff Risør, Stavros Konstantinides, Jan Brink Valentin, Nanna Rolving, Stine Foged Lindegaard

“…Introduction Patients with pulmonary embolism (PE) experience impaired functional ability and reduced quality of life long after discharge from the hospital. …”
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Age-Related Changes in Action Observation EEG Response and Its Effect on BCI Performance by Fukang Zeng, Xingyu Wen, Hongmei Tang, Guiyu Hu, Wensheng Hou, Xin Zhang

“…We employed task discriminant component analysis (TDCA) to decode observed actions and performed comprehensive analyses of prefrontal EEG responses, i.e. approximate entropy (ApEn), sample entropy (SamEn), and rhythm power ratios (RPR), and the whole-brain functional network. Regression analyses were subsequently conducted to analyze the effects on the classification accuracy. …”
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SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma by Shanshan Wang, Weicheng Wu, Zhen Shi, Mei Bin, Fengwei Zhang, Long Cai, Kaiqing Lin, Zhihui Li

“…To investigate the biological functions of SMYD2, we conducted a series of functional assays in vitro and in vivo. …”
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CLU, FOS, and CXCL8 as diagnostic biomarkers for heart failure progression post-acute myocardial infarction: an integrated RNA-Seq and multi-machine learning study by Jingjing Wei, Peng Yu, Peng Yu, Yucai Hu, Lijie Qiao, Lijie Qiao, Bin Li, Bin Li, Haitao Li, Shiyang Xie, Zhengwei Dong, Aolong Wang, Yilin Zhang, Xinlu Wang, Yongxia Wang, Mingjun Zhu

“…Functional enrichment analysis was used to explore the biological roles of DEGs. …”
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Raman spectroscopy and bioinformatics-based identification of key genes and pathways capable of distinguishing between diffuse large B cell lymphoma and chronic lymphocytic leukemi... by Haoyue Liang, Haoyue Liang, Zhijie Cao, Zhijie Cao, Yansong Ren, Yansong Ren, Yihan Li, Yihan Li, Haoyu Wang, Haoyu Wang, Fanfan Sun, Fanfan Sun, Mei Xue, Guoqing Zhu, Guoqing Zhu, Yuan Zhou, Yuan Zhou

“…In this study, bioinformatics analyses of these two NHL subtypes were conducted, identifying key patterns of gene expression and then experimentally validating the results. …”
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Integrated multi-omics analysis identifies TPX2 as a potential prognostic and immunological biomarker in hepatocellular carcinoma by Hui Peng, Yong-peng Wei, Xin-bo Liu, Yu Wang, Jian-yong Yuan

“…Methods: We conducted an integrated multi-omics analysis using transcriptomic (TCGA, GTEx, GEO), proteomic (CPTAC), and pharmacogenomic (GDSC, PRISM, CTRP) datasets to assess TPX2 expression patterns in HCC. …”
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Challenges and opportunities for data integration to improve estimation of migratory connectivity by Jeffrey A. Hostetler, Emily B. Cohen, Christen M. Bossu, Amy L. Scarpignato, Kristen Ruegg, Andrea Contina, Clark S. Rushing, Michael T. Hallworth

“…Integration of the diverse measures of migratory movements can help elucidate migratory connectivity patterns with methodology that accounts for differences in sampling design, directionality, effort, precision and bias inherent to each data type. …”
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Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism by Lauren Wagner, Megan Banchik, Tawny Tsang, Nana J. Okada, Rebecca Altshuler, Nicole McDonald, Susan Y. Bookheimer, Shafali S. Jeste, Shulamite Green, Mirella Dapretto

“…Methods In this study, we used functional magnetic resonance imaging (fMRI) to examine differences in language processing in 9-month-old infants at high (HL) and typical (TL) familial likelihood for ASD. …”
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DHCR24 overexpression is involved in lipid metabolic reprogramming to drive cervical cancer malignant progression and is associated with immune microenvironment by Lin Cheng, Yuance Xu, Zhuo Li, Danting Sun, Yan Xu, Junqi He, Yulong Chen, Qin Yao

“…A prognostic nomogram incorporating tumor stage and DHCR24 expression levels was developed to predict clinical outcomes in patients. Functional studies using SiHa cell lines were conducted to elucidate the oncogenic properties of DHCR24. …”
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An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure by Cristina Manuela Drăgoi, Anca Zanfirescu, Ion-Bogdan Dumitrescu, Anca Ungurianu, Denisa Marilena Margină, Alina-Crenguţa Nicolae

“…Tryptophan, an essential amino acid, serves as a vital structural element in proteins and a precursor for bioactive compounds like serotonin and melatonin, which impact various physiological functions. Methods: Experimental studies have been conducted to reveal the interaction mechanisms of these endogenous indole derivatives with calf thymus DNA (ct-DNA). …”
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Genomic features, antimicrobial resistance and pathogenicity assessment of Escherichia coli serotype O177:H51 strain JS01 isolated from a diseased chicken by Lunbin Xia, Guanglei Wang, Naidong Chen, Deliang Qiao, Jianwen Cao, Shaoshuai Bi

“…Further analyses were conducted to characterize its antimicrobial resistance (AMR) phenotype and pathogenicity. …”
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Sorghum-peanut intercropping under salt stress mediates rhizosphere microbial community shaping in sorghum by affecting soil sugar metabolism pathways by Xia Shao, Chunmei Yang, Yuxuan Chen, Chang Liu, Chunjuan Liu, Xiaolong Shi, Yufei Zhou

“…These correlations indicate that sorghum intercropped with peanuts can promote the enrichment of microbial taxa under salt stress, thereby enhancing soil metabolic functions and stress tolerance by optimizing the rhizosphere microbial community. …”
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