Transcriptomic and metabolomic analyses for the mechanism underlying anthocyanin synthesis during the growth and development of purple eggplant (Solanum melongena L) by Ting Yang, Wanping Lv, Runjie Zhuang, Shiyu Wang, Shuqi Fan, Yongxian Wen, Yongxian Wen

“…This study aimed to elucidate the dynamics of anthocyanin accumulation and identify key regulatory genes across three developmental stages of eggplant fruit peel (S1: white, S2: light purple, S3: dark purple).MethodsIntegrated metabolomic and transcriptomic analyses were conducted to investigate anthocyanin profiles and gene expression patterns during fruit development. …”
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Improved smart city security using a deep maxout network-based intrusion detection system with walrus optimization by Wahid Rajeh, Majed Aborokbah, Manimurugan S., Umar Albalawi, Ahamed Aljuhani, Osama Shibl Abdalghany Younes, Karthikeyan Periyasami

“…The DMN is configured with an architecture that includes multiple layers with maxout activation functions. These layers are capable of capturing complex patterns in the data, making the DMN particularly effective for identifying anomalies in IoT network traffic. …”
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<i>DBI</i> as a Novel Immunotherapeutic Candidate in Colorectal Cancer: Dissecting Genetic Risk and the Immune Landscape via GWAS, eQTL, and pQTL by Ting Tian, Huan Han, Jingtao Huang, Jun’e Ma, Ruoxi Ran

“…Further validation was performed using The Cancer Genome Atlas (TCGA) to assess gene expression patterns and prognostic significance. Additionally, immune infiltration analysis was conducted to characterize the tumor immune microenvironment. …”
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Study on the Wind Pressure Distribution in Complicated Spatial Structure Based on k-ε Turbulence Models by Jing Wang, Shixiong Zhou, Hui Liu, Shixing Zhao, Fei He, Lei Zhao

“…Both wind tunnel test and CFD simulations are conducted to analyze the wind pressure distribution on building surface. …”
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Identification and characterization of soybean phytochrome-interacting factors and their potential roles in abiotic stress by Dewei Mu, Zhaowei Shui, Haoyu Guo, Hengke Jiang, Yuhan Liu, Liqiu Luo, Yanpeng Zhang, Xinxin Zhang, Jiaxin Yu, Shulin Liao, Liang Yu, Chunyan Liu, Junbo Du

“…Nevertheless, research on PIFs in soybean is relatively scarce. In this study, we conducted a comprehensive analysis of the gene structure, chromosomal location, conserved motifs, phylogenetic relationships, and expression patterns of the Glycine max PIF (GmPIF) genes. …”
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Real-world safety of carboplatin in non-small cell lung cancer: a retrospective signal detection and subgroup analysis based on the FAERS database by Lei Wang, Kunpeng Yang, Kunpeng Yang, Hui Zhao, Peiyun Lv, Chenglun Cai, Zhe Wang, Bao Wang, Bao Wang, Bao Wang

“…Subgroup analyses revealed distinct patterns: males exhibited increased infection-related events, whereas females were more prone to gastrointestinal and hepatic complications. …”
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eQTL and multi-omics integration reveal PPIH as a prognostic and immunotherapeutic biomarker by Fenglin Lv, Fenglin Lv, Xinlu Zhang, Yanmei Wu, Zhipeng Li, Zhipeng Li, Xiaomen Zheng, Xiaomen Zheng, Huaxin Zhou, Huaxin Zhou, Wei Wang

“…A comprehensive series of multi-omics bioinformatics analyses was subsequently conducted to assess the gene’s expression patterns, genomic alterations, prognostic relevance, and associations with the tumor microenvironment (TME) across various cancer types. …”
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Genome-wide characterization and expression analysis of the JRL gene family in response to hormones and abiotic stress in tomato (Solanum lycopersicum L.) by Hui Li, Hongling Hu, Lina Cao, Yue Zhuo, Liting Wang, Hui Ma, Ming Zhong

“…Our results lay the foundation for further studies on the biological functions of tomato JRL genes.…”
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Multiomic analysis of the synthetic pathways of secondary metabolites in tobacco leaves at different developmental stages by Zhijun Tong, Kun Yang, Xuejun Chen, Fei Xu, Xueyi Sui, Yujie Huang, Shenyun Zhu, Enhui Shen, Sanling Wu, Longjiang Fan, Bingguang Xiao

“…Despite substantial progress, the comprehensive regulatory landscape governing secondary metabolite biosynthesis during N. tabacum leaf development remains largely unclear.MethodsTo better understand the molecular regulatory mechanisms underlying the biosynthesis of secondary metabolites, particularly flavonoids, during N. tabacum leaf development, we conducted a transcriptomic and non-targeted metabolomic sequencing and analysis at three critical developmental stages: vigorous growth stage (T1), topping stage (T2), and harvest stage (T3).ResultsBased on our transcriptomic and metabolomic data, 25 unigenes exhibiting stage-specific expression patterns that were strongly associated with flavonoid accumulation were identified. …”
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Potential influence of geomagnetic activity on blood pressure statistical fluctuations at mid-magnetic latitudes by Pengzhi He, Chen Li, Minlan Xu, Ruilong Guo, Alexander William Degeling, Timo Pitkänen, Yude Bu, Xiangyun Zheng, Yue Zhang, Xianghong Jia, Anmin Tian, Chenyao Han, Shifeng Wang, Tianlu Chen, Jiangping Fang, Shaowei Sun, Wenlong Liu, Jinbin Cao, Kimmen Quan, Zhiyuan Cong, Dedong Ma, Qiugang Zong, Suiyan Fu, Shutao Yao, Huanhu Zhang, Quanqi Shi

“…Both BP and the GMA index exhibit similar annual bimodal patterns and multiple periodicities, including 12-month and 6-month cycles, and an intermittent 3-month cycle. …”
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Genome-wide identification of fasciclin-like arabinogalactan proteins (FLAs) in melon and the role of CmFLA8 in glucose accumulation in fruit by Suying Wen, Ruijie Huang, Muyao Gao, Jiayin Li, Yixuan Zhou, Rundi Sun, Zhilong Bie, Jintao Cheng

“…The RNA-seq and qRT-PCR assays showed that CmFLA10 exhibited specific expression patterns in male flowers, while CmFLA12 was highly expressed in the root tissue. …”
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Meta-analysis of muscle transcriptome data identifies key genes influencing intramuscular fat content in pigs by Yan Wang, Jiahao Wang, Yanhui Zhao, Xihui Sheng, Xiaolong Qi, Lei Zhou, Jianfeng Liu, Chuduan Wang, Jianliang Wu, Yongchun Cao, Kai Xing

“…To identify key genes affecting IMF content, we performed a meta-analysis of the differential expression results from the 10 datasets using MetaVolcanoR. Subsequently, we conducted protein-protein interaction network analysis, Gene Ontology and Kyoto encyclopedia of genes and genomes functional enrichment analysis, and quantitative trait locus (QTL) analysis on the DEGs. …”
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Integrated Cytological, Physiological, and Comparative Transcriptome Profiling Analysis of the Male Sterility Mechanism of ‘Xinli No.7’ <i>Pear</i> (<i>Pyrus</i> sp.) by Hao Li, Xiangyü Li, Yüjia Luo, Quanhui Ma, Zhi Luo, Jiayuan Xuan, Cuiyun Wu, Fenfen Yan

“…Comparative transcriptomics identified 283 co-expressed differentially expressed genes (DEGs). Functional enrichment linked these DEGs to ROS-scavenging pathways: galactose metabolism, ascorbate and aldarate metabolism, arginine and proline metabolism, fatty acid degradation, pyruvate metabolism, and flavonoid biosynthesis. qRT-PCR validated the expression patterns of key DEGs in these pathways. …”
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Genetic Alterations in War-Related Post-Traumatic Stress Disorder: A Systematic Review by Amir Hossein Rajabi, Samaneh Zafarabadi, Kimia Jazi, Maryam Moghbel Baerz, Omid Bahrami, Gelareh Azarinoush, Pardis Habibi, Negar Azami, Shahram Paydar

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Ocean alkalinity enhancement approaches and the predictability of runaway precipitation processes: results of an experimental study to determine critical alkalinity ranges for safe... by N. Suitner, G. Faucher, C. Lim, J. Schneider, C. A. Moras, U. Riebesell, J. Hartmann

“…The experiments lasted for 20–25 <span class="inline-formula">d</span> to monitor the temporal development of carbonate chemistry parameters after alkalinity addition and the subsequent triggered carbonate precipitation process. Identified uniform patterns before and during the triggered runaway process can be described by empirical functional relationships. …”
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Arthroscopic all-inside ACL reconstruction with anterolateral tendon fixation: a prospective cohort study on restoring rotational stability in high-grade tibial shift by Haoran Gu, Aifang Niu, Jingrui Ji, Miao He, Ying Yang, Junxia Lu, Jianghong Lv, Yongdong Yi, Hui Zhou, Wuping Zhou

“…Early outcomes demonstrate promising functional recovery and objective stability at short-term follow-up, suggesting that this technique may offer biomechanical benefits for managing severe instability patterns. …”
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New biomarkers of Kawasaki disease identified by gingival crevicular fluid proteomics by Xue Fan, Ying Li, Yuehao Xu, Jianqing Lin, Xin Guo, Jinwen Liao, Mingguo Xu

“…DEPs were identified and subjected to functional enrichment analysis using KEGG and GO. Protein–protein interaction (PPI) analysis was conducted for all detected DEPs. …”
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Molecular cloning of TPM3 gene in qinchuan cattle and its effect on myoblast proliferation and differentiation by Juntao Guo, Jianfang Wang, Ke Zhang, Zhimei Yang, Bingzhi Li, Yueting Pan, Hengwei Yu, Shengchen Yu, Sayed Haidar Abbas Raza, Belete Kuraz Abebea, Linsen Zan

“…Despite its importance, limited research has been conducted to investigate the influence of TPM3 on bovine skeletal muscle development. …”
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Proteomic Analysis of Retinas in a Rat Model of High-Fat Diet-Induced Type 2 Diabetes: Implications of Interventional Targets for Nonproliferative Diabetic Retinopathy by Pang X, Bai S, Feng Z, Zhang Y, Hu B, Zhang Y

“…The expression patterns of selected differentially expressed proteins (DEPs) were validated in rat retinas via Western blotting and in aqueous humor from NPDR patients via slot blotting.Results: After the 12-w HFD and STZ injection, the rats presented typical symptoms of T2DM. …”
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Identification and evaluation of metabolic mRNAs and key miRNAs in colorectal cancer liver metastasis by Guanxuan Chen, Shiwen Wang, Meng Zhang, Wenna Shi, Ruoyu Wang, Wanqi Zhu

“…We screened the featured genes using a machine-learning technique, followed by an evaluation of their diagnostic potential for CRC liver metastasis. Additionally, we conducted a functional enrichment analysis and constructed a network of miRNA-targeted mRNAs. …”
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