Comprehensive bioinformatics analysis of MEX3 family genes in hepatocellular carcinoma by Xuezhong Zhang, Peng Sun, Tingting Chu, Yuling Feng, Xuebin Zhang

“…This study aims to systematically analyze the expression patterns, prognostic significance, and immune-related functions of MEX3A, MEX3B, MEX3C, and MEX3D in HCC using comprehensive bioinformatics approaches. …”
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Transcriptomic analysis of mammary gland tissues in lactating and non-lactating dairy goats reveals miRNA-mediated regulation of lactation, involution, and remodeling by Yanan Peng, Xinhua Duan, Linfan Zhang, Yiyi Guo, Jinlin Cao, Weiping Ao, Rong Xuan

“…Differential expression analysis, miRNA clustering, Gene Ontology (GO) annotation, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed to predict the functions of target genes. A miRNA-mRNA regulatory network associated with mammary gland development was constructed, and functional validation experiments were conducted to confirm key regulatory relationships.ResultsA total of 1,120 miRNAs were identified, including 408 known and 712 newly predicted miRNAs. …”
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Temporal Transcriptome Analysis Reveals Core Pathways and Orphan Gene <i>EARLY FLOWERING 1</i> Regulating Floral Transition in Chinese Cabbage by Hong Lang, Yuting Zhang, Shouhe Zhao, Kexin Li, Xiaonan Li, Mingliang Jiang

“…Temporal transcriptome profiling was conducted across three developmental stages: pre-bolting (PBS), bolting (BS), and flowering stages (FS), to investigate the underlying molecular mechanisms. …”
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Comprehensive Analysis of Multi-Omics Data on RNA Polymerase as an Adverse Factor in Head and Neck Squamous Cell Carcinoma by Gu YJ, Zhang J, Liu YJ, Zhang Q, Geng QF

“…In vitro and in vivo experiments were conducted to validate the functional role of the YY1-POLR2C axis in cancer proliferation and immune modulation.Results: POLRs were found to be aberrantly expressed in cancers and associated with genomic alterations. …”
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Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers by Gautam Kundu, Selvakumar Elangovan

“…<b>Methods</b>: In this study, we conducted a further examination of the transcriptomic expression profile of SPP1 (Osteopontin) during the progression of cancer in four human tissues, breast, prostate, renal and skin, in order to understand the circumstances conducive to its activation and dysregulation, the biological pathways and other mechanisms involved as well as differences in its splicing patterns influencing its expression and functionality. …”
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Identification of hub genes in myocardial infarction by bioinformatics and machine learning: insights into inflammation and immune regulation by Juan Yang, Xiang Li, Li Ma, Jun Zhang

“…These genes were then subjected to functional enrichment analysis, including Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and Gene Set Enrichment Analysis (GSEA). …”
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Epigenetic regulation of TNNT1 in gastrointestinal cancers prognostic implications and clinical significance by Jin Xie, Xin-Yang Qu, Rui-Min Wu, Jie Liu, Fan Cheng, Yu Zhang, Xu-Sheng Liu

“…The impact of TNNT1 expression on patient prognosis was evaluated through Cox regression analyses. Furthermore, functional enrichment analysis was conducted to explore the biological pathways involved, alongside promoter methylation and mutation analyses, to elucidate its regulatory mechanisms. …”
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Single-cell RNA sequencing technology was employed to construct a risk prediction model for genes associated with pyroptosis and ferroptosis in lung adenocarcinoma by Longfei Ji, Binyu Wang, Danfei Shi, Weiyun Shen, Xinmin Li, Yong Li

“…Method This study integrated single-cell RNA sequencing (scRNA seq), bulk transcriptome data, and clinical information to comprehensively analyze the expression patterns and functional roles of pyroptosis related genes (PRGs) in LUAD. …”
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Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis by Liansha Tang, Wenbo He, Handan Hu, Jiyan Liu, Zhike Li

“…Circulating plasma proteins, dynamically accessible and functionally linked to immunity, may predict and offer novel targets for irAEs. …”
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Analysis of the structural changes in domestic consumption of FUEL and energetic resources of Moscow by L. G. Moiseykina, E. S. Darda

“…The fuel and energy complex of Moscow is one of the largest in Russia. A feature of its functioning is the concentrated consumption of gas, fuel, electricity, heat energy and other energy resources. …”
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Exploration of biomarkers associated with histone lactylation modification in spinal cord injury by Yisong Sun, Jie Gao, Juehua Jing

“…Inter-cluster comparisons were conducted to examine Hallmark pathways, HLA genes, and immune functions. …”
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Expressing the Author's Position in the English-Language Network Film Review by I. V. Kononova, T. A. Klepikova, E. A. Klenova

“…The authors proceed from the position that the methods of subject verbalization are determined by functional characteristics of discourse. The relevance of the study is due to the interest of modern linguistics in the study of the subject factor in “personal” types of discourse. …”
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Placental whole transcriptome expression profile in patients with early-onset, late-onset preeclampsia and gestational diabetes mellitus by Zhuo Chen, Li Yang, Li Geng, Xinwen Zhang, Mingyu Du, Yonghu Sun, Lin Zhao, Bing Bai, Xiaohong Li

“…The results revealed dysregulation of key pathways in early-onset-PE (OE-PE), including Wnt signaling, PI3K-Akt signaling, MAPK signaling, FoxO signaling, and TNF signaling, along with downregulation of genes related to Ca2 + conduction and hormone pathways. In late-onset-PE (LO-PE) and GDM, abnormalities were observed in immune pathways including chemokine signaling pathway and IL-17 signaling pathway, with differing immune cell infiltration patterns. …”
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Age modulates, religious coping mediates: the role of attitude to self in cancer patients’ quality of life by Maria-Chidi C. Onyedibe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Barbara L. Andersen, Uzoamaka F. Ugwoke, Lawrence Ejike Ugwu, Lawrence Ejike Ugwu

“…Mediation and moderation analyses were conducted using SPSS (Version 29) and SmartPLS (Version 4).ResultsNegative generalization (β = −0.25, p &lt; 0.001) and self-criticism (β = −0.19, p &lt; 0.001) reduced physical well-being, while high standards positively influenced emotional well-being (β = 0.27, p &lt; 0.001) but negatively impacted functional well-being (β = −0.13, p &lt; 0.01). …”
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Unraveling the laser decal transfer-based printing of ZnO ceramic towards FEP-ZnO-based Piezo-Tribo hybrid nanogenerators by Arpit Kumar Singh, Anshu Sahu, Palani Iyamperumal Anand

“…The selectively transferred nanoparticles in various patterns are further grown using a hydrothermal technique. …”
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Exploration of RNA-binding proteins identified RPS27 as a potential regulator associated with Kaposi’s sarcoma development by Jingzhan Zhang, Peng Wang, Tingting Li, Dong Luo, Yuanyuan Qu, Yuan Ding, Xiaojing Kang

“…Cellular experiments were conducted for dysregulated RPS27 to explore its functions. …”
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Genome-wide and transcriptome analysis of PdWRKY transcription factors in date palm (Phoenix dactylifera) revealing insights into heat and drought stress tolerance by Ibrahim Khan, Lubna, Saqib Bilal, Ashraf M. M. Abdelbacki, Sang-Mo Kang, Ahmed AL-Harrasi, Sajjad Asaf, In-Jung Lee

“…Looking at the extensive importance of WRKY transcription factors (TFs) in plant growth, development and defense responses to various biotic and abiotic stresses, we conducted a study to identify and functionally annotate the WRKY TFs of P. dactylifera, with a particular focus on their involvement in drought and heat stress. …”
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Identification of Critical Signature in Post‐Traumatic Stress Disorder Using Bioinformatics Analysis and in Vitro Analyses by Lifen Liu, Yang Liu, Rui Li, Yue Teng, Shuyang Zhao, Jinhong Chen, Changjiang Li, Xinyu Hu, Lin Sun

“…Weighted gene co‐expression network analysis (WGCNA) was employed to examine gene correlation patterns. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed for functional annotation and enrichment analysis, respectively. …”
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NSUN6 expression correlates with prognosis and immune infiltration in human cancers based on pan-cancer analysis by Jie Gao, Yao Xu, Chan Tian, Qiuhong Zhang, Ming Zhang, Hu Shan, Jie Shi, Zongjuan Ming, Shuanying Yang, Xia Yang

“…To further understand NSUN6’s role, a detailed Gene Set Enrichment Analysis (GSEA) was conducted, revealing its enrichment patterns in various carcinoma subtypes and hinting at its involvement in tumor growth. …”
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Characterization of lactylation modification subtypes and the promoting role of CCL20 in hepatocellular carcinoma progression by Li-Hong Wu, Liu Yang, Xiang-Xu Wang, Shuang Bai, Xi Yan, Jing Wei, Jun Wang, Fei Tian

“…The CIBERSORT algorithm was utilized to analyze immune cell infiltration. Functional validation of the lactylation-related gene CCL20 in HCC was conducted through in vitro experiments using HCC cell lines.ResultsWe identified three distinct lactylation modification patterns, with higher lactylation modification levels correlating with worse prognosis in HCC. …”
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