Single-cell transcriptomic dynamics of scallop heart reveals the heterogeneous response to heat stress by Danyang Wang, Na Liu, Xiangfu Kong, Xinghai Zhu, Yangfan Wang, Jingjie Hu, Zhenmin Bao

“…Conclusions Our study investigated the heterogeneous response of the scallop heart to high temperatures, revealing distinct response patterns between VMs and AMs. We further identified a key gene, AiPLRP2-like, which exhibits unique cellular localization patterns compared to its mammalian counterpart and may play a pivotal role in regulating cardiac thermotolerance in organisms with open circulatory systems. …”
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Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma by Jianwei Cui, Fanyi Zeng, Ming Tang, Ming Tang, Shiwu Yin, Shiwu Yin

“…Specific malignant cell subtypes strongly associated with MVI were identified, exhibiting distinctive gene expression patterns related to proliferation, invasion, and metabolic reprogramming of tumour cells. …”
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Design Optimization Approach for Residential Outdoor Environments Based on Seasonal Variations in Local Thermal Perception by Yikai Yan, Qingqin Wang, Haizhu Zhou, Yanan Song

“…Strategies such as dynamic shading arrangements for summer cooling and wind-shielding structures for winter warmth were tailored to actual usage patterns, enhancing the functionality and livability of outdoor spaces. …”
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General and Specific Problems of the Formation of Intellectual Operations in Younger Schoolchildren with Learning Difficulties by A.I. Andriashina, L.A. Tishina

“…The article presents the results of a research conducted to identify general and specific patterns of intellectual operations formations in younger schoolchildren who have writing disorders. …”
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Effects of Managerialism Reflected in Public Institutions Serving Women in Turkey by Tuğçe Uğur Güler, Derya Şaşman Kaylı

“…This study is aimed at revealing the effects of managerialism ideology on the structure and functioning of public institutions providing services for women. …”
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Recreational and tourist destination research methods by Tetiana Bozhuk

“…To study and synthesis of theoretical and methodological approaches to determining the conceptual and terminology used RTDe research methods and logical structure and system analysis (structural and geographic analysis); in identifying and clarifying the spatial patterns of differences in territorial organization used methods of space-time analysis; for comparative characteristics of individual properties RTDe and regional level – comparative method; to systematize information, determine the classification categories of types and subtypes RTDe – methods of systematization and classification; to study the history of RTDe, the origin of their individual components and varieties – historical-geographical method; in the present state of research, planning and organizational and functional structure of different types RTDe methods applied field research (conducted in 2006-2013 years.) poll (questionnaire), peer assessment, recording and evaluation of Christian sacred objects for the needs of tourism and recreation, mathematical logic and computer graphics, and other cartographic modeling. …”
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ESTONIAN WEST COAST REVIVAL IN RETROSPECT: THE BIBLE AS A TOOL FOR INTERPRETING CHANGE by Toivo PILLII

“…Secondly, scriptural language and images functioned both to justify and balance emotional phenomena which were characteristic of the Revival. …”
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Multi-User Satisfaction-Driven Bi-Level Optimization of Electric Vehicle Charging Strategies by Boyin Chen, Jiangjiao Xu, Dongdong Li

“…A bi-level optimization architecture is subsequently formulated, leveraging deep reinforcement learning (DRL) to capture user-specific demand characteristics through customized reward functions and adaptive constraint structures. Validation is conducted within a high-fidelity simulation environment featuring 90 autonomous EV charging agents operating in a metropolitan parking facility. …”
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Multidimensional analysis suggests that ZNF433 is a promising biomarker for the diagnosis and prognosis of human cancers by Lingyu Xie, Lingyu Xie, Xin Zeng, Xin Zeng, Hui Luo, Hui Luo, Bin Xie, Xuefeng Wang, Nan Wu, Junrong Zou, Junrong Zou, Junrong Zou, Guoxi Zhang, Guoxi Zhang, Guoxi Zhang, Xiaofeng Zou, Xiaofeng Zou, Xiaofeng Zou, Hui Xu, Hui Xu, Hui Xu

“…Functional enrichment and protein interaction network analyses were also performed to explore its potential involvement in cancer-related pathways.ResultsOur findings revealed that ZNF433 is significantly downregulated in most cancer types, with stage-dependent expression patterns observed in KIRC and KIRP. …”
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Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD by Pedro Mendes-Bastos, Elisavet Lazaridou, Tiago Torres, Charalampos Aggelakopoulos, Ioannis Katsantonis, Pantelis Aronis, Dimitrios Rigopoulos, Filomena Azevedo, Felicidade Santiago, Markos Papakonstantis, Paulo Varela, Vera S. G. Ribeiro, Aikaterini Kollia, Evaggelia Papadavid

“…Methods MEASURE-AD was a global, cross-sectional observational study in adolescents and adults with moderate-to-severe AD, conducted to describe disease burden, treatment patterns, and healthcare resource utilization. …”
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Genome-wide identification of cyclic nucleotide-gated channel gene family in Solanum tuberosum and silencing of StCNGC2 provides resistance to Pectobacterium carotovorum by Kaile Sun, Kaile Sun, Shuai Liu, Huipo Mao, Qianqian Zha, Han Liu, Shunshan Shen, Evert Jacobsen, Richard G. F. Visser, Yuling Bai, Chengwei Li, Zhiqi Jia, Zhiqi Jia, Geng Meng, Geng Meng, Yawen Shen

“…Expression patterns were examined in different tissues and under stress conditions. …”
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Impact of alkali-silica reaction and delayed ettringite formation-induced cracking on air permeability and water diffusivity in concrete by Joe Maalouf, Hugo Cagnon, Jérôme Verdier, Stéphane Multon, Jacques Jabbour, David Bouhjiti

“…Managing the effects of Internal Swelling Reactions (ISR), Delayed Ettringite Formation (DEF), and Alkali-Silica Reaction (ASR) on the integrity of concrete structures with containment functions, such as nuclear facilities and dams, remains a major challenge for both long-term operation and maintenance. …”
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Assessment of the hilsa breeding ground in Meghna River estuary, Bangladesh for sustainable conservation by Md Anisur Rahman, Md Mehedi Hasan Pramanik, Md Monjurul Hasan, Flura, Rumana Yasmin, Yahia Mahmud

“… Hilsa, a significant fish species in Bangladesh, undergoes migratory patterns between the sea and rivers. This study, conducted from 2018 to 2020 in four locations (Ramnewaz, Hazirhat, Janata Bazar, and Sakuchia) along the River Meghna in Monpura, aimed to assess the effectiveness and reevaluate a previously identified hilsa breeding ground. …”
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Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality by Jiansen Lu, Zhiqiang Hu, Huaji Jiang, Zebin Wen, Hongyu Li, Jian Li, Ke Zeng, Yingchao Xie, Huadan Chen, Xin-zhuan Su, Chunmei Cai, Xiao Yu

“…Methods: Here we perform single-cell RNA sequencing analyses (scRNA-seq) to dissect the dynamics of IFN-α/β responses against P. yoelii 17XL (17XL) and P. berghei ANKA (PbANKA) infections; conduct flow cytometry analysis and functional depletion to identify key cellular players induced by IFN-I; and establish mathematical models to explore the mechanisms underlying the differential IFN-I dynamics regulated by SOCS1. …”
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Impact assessment of differential chlormequat chloride exposure on soil fungal community dynamics by Qiujun Lin, Qiujun Lin, Xianxin Wu, Xianxin Wu, Lina Li, Lina Li, Tianshu Peng, Tianshu Peng, Xun Zou, Xun Zou, Guang Li, Guang Li, Jianzhong Wang, Jianzhong Wang, Chunjing Guo, Chunjing Guo

“…The significant shifts observed in key functional guilds, particularly the decline in pathogens and proliferation of saprophytes, highlight the impact of CC application on soil fungal ecological functions.…”
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Comparative analysis of spatiotemporal gait parameters in patients with distal femoral megaprosthesis and healthy subjects using an inertial measurement unit (IMU) by Nadia Jover-Jorge, Paula González-Rojo, José Vicente Amaya-Valero, Francisco Baixauli-García, Carolina de la Calva-Ceinós, Manuel Angulo-Sánchez, Javier Martínez-Gramage, Juan Francisco Lisón

“…Despite these changes, gait patterns remained within functional ranges. IMU-based gait analysis reveals significant but functional alterations in gait mechanics among patients with distal femoral megaprosthesis. …”
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Incompatibility Between Regulations and Implications: Under-Explored Impacts of Sindh’s Local Government Policies on Sukkur’s Urban Governance by Zubair Ahmed Pirzada, Nida Shafaat, Dr. Shoukat Ali Mahar

“…Inductive thematic analysis extracted recurrent patterns of authority overlaps and fiscal dependency. …”
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Deterioration of Thermal Barrier Coated Turbine Blades by Erosion by Rohan Swar, Awatef Hamed, Dongyun Shin, Nathanial Woggon, Robert Miller

“…A combined experimental and computational study was conducted to investigate the erosion of thermal barrier coated (TBC) blade surfaces by alumina particles ingestion in a single-stage turbine. …”
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Spatial Differentiation and Correlation of Ecological Stoichiometric Characteristics of Cynodon dactylon and Soil in the Water-level Fluctuation Zone of the Three Gorges Reservoir... by XU Liwen, ZHANG Yuewei, JIAN Chen, ZHANG Yuanyuan, WANG Xiaofeng

“…Investigation on the spatial distribution patterns and correlations of nutrient and stoichiometric characteristics between C. dactylon and its periradical soil is of significant importance in comprehending nutrient cycling as well as species adaptation features within the WLFZ. …”
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Morphological Characteristics of Inferior Pole Patellar Fractures and a Finite‐Element Analysis Combined With a Retrospective Clinical Study of Anchor Suture and Titanium Cable Cer... by Zhenghui Hu, Chen Sun, Hongquan Heng, Jian Li, Hainan Chen, Fuchao Chen, Peng Su, Dengfeng Wang

“…Methods (1) A retrospective analysis was conducted on 61 patients with IPPF. For each case, fracture reduction was manually simulated, with fracture lines and fragments overlaid onto a complete patella template to identify fracture patterns. (2) Finite‐element models were used to analyze the mechanical properties of anchor suture and titanium cable cerclage treatment and Kirschner‐wire tension band combined with patellar cerclage in treating IPPFs. …”
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