Targeting Cancer with Paris’ Arrow: An Updated Perspective on Targeting Wnt Receptor Frizzled 7 by Kieran Hodson, Hector M. Arredondo, William E. Humphrey, Dustin J. Flanagan, Elizabeth Vincan, Karl Willert, Helen B. Pearson, Toby J. Phesse

“…Additionally, we present new figures generated by our group using the publicly available Pan-Cancer Atlas RNAseq datasets, highlighting FZD7 expression patterns in patient samples. This integrated approach aims to provide updated insights into the function of FZD7 during cancer and its growing status as an attractive target for therapy. …”
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Assessment of the attractiveness of a region for coffee production: the case of Karo Regency by Syahbudin Hasibuan, Zulkarnain Lubis, Sri Ariani Safitri, Zahraturrahmi Zahraturrahmi, Marizha Nurcahyani

“…Polyculture planting patterns can diversify farmers’ income while improving the supply chain, creating a fairer distribution of profits, and supporting Karo as a leading coffee centre in North Sumatra.…”
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Transcriptome-wide identification and systematic analysis of the Retrotransposon genes and their roles in ginsenoside biosynthesis in Panax ginseng by Chaofan Wang, Ruicen Liu, Dinghui Wang, Li Li, Yue Jiang, Yanfang Wang, Kangyu Wang, Mingzhu Zhao, Yi Wang, Meiping Zhang

“…Results 1,301 Retrotransposon genes were identified in ginseng transcriptome using bioinformatics methods, and a systematic analysis was conducted on their gene structures, phylogenetic relationships, and expression patterns. …”
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Deep Learning–Based Chronic Obstructive Pulmonary Disease Exacerbation Prediction Using Flow-Volume and Volume-Time Curve Imaging: Retrospective Cohort Study by Eun-Tae Jeon, Heemoon Park, Jung-Kyu Lee, Eun Young Heo, Chang Hoon Lee, Deog Kyeom Kim, Dong Hyun Kim, Hyun Woo Lee

“…Acute exacerbations (AE) of COPD (AE-COPD) are key determinants of disease progression; yet, existing predictive models relying mainly on spirometric measurements, such as forced expiratory volume in 1 second, reflect only a fraction of the physiological information embedded in respiratory function tests. Recent advances in artificial intelligence (AI) have enabled more sophisticated analyses of full spirometric curves, including flow-volume loops and volume-time curves, facilitating the identification of complex patterns associated with increased exacerbation risk. …”
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Multi‐omics profiling identifies TNFRSF18 as a novel marker of exhausted CD8⁺ T cells and reveals tumour‐immune dynamics in colorectal cancer by Tengfei Jia, Yingxi Guo, Xin meng Cheng, Zeyang Zhou, Xiaojiang Xu, Hebin Liu, Xiaodong Yang

“…T cell exhaustion markers, immune clonality, gene expression profiles, and the spatial distribution of both tumour cells and immune cells were systematically profiled. Functional enrichment and intercellular communication analyses were conducted. …”
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Effect of traditional Chinese medicine combined with conventional Western medicine for patients with severe/very severe chronic obstructive pulmonary disease: a multi-center, rando... by Jiansheng Li, Yang Xie, Minghang Wang, Suyun Li, Xuefeng Yu, Nianzhi Zhang, Zhengang Zhu, Wei Zhang, Jihong Feng, Zikai Sun, Lin Lin, Zhijia Sun, Hailong Zhang, Xueqing Yu

“…This study aimed to evaluate the clinical efficacy of comprehensive therapy based on TCM patterns for patients with stable, severe to very severe COPD. …”
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Status and trends in transcranial magnetic stimulation research: a bibliometric analysis by Qi Deng, Fei Xing, Dan Li, Dan Li, Maomao Huang, Maomao Huang, Zhangyu Xv, Yue Yang, Lei Li, Jiayi Zhu, Rongnan Shi, Guoya Meng, Qin Wang, Jianxiong Wang, Jianxiong Wang, Jianxiong Wang

“…BackgroundTranscranial magnetic stimulation (TMS), as a rapidly advancing non-invasive brain stimulation technique, has demonstrated reliable therapeutic efficacy and significant potential in brain function assessment and research. However, comprehensive bibliometric analyses of the overall TMS field remain limited. …”
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DualDyConvNet: Dual-Stream Dynamic Convolution Network via Parameter-Efficient Fine-Tuning for Predicting Motor Prognosis in Subacute Stroke by Yunjeong Jang, Joohye Jeong, Yun Kwan Kim, Da-Hye Kim, Wanjoo Park, Laehyun Kim, Yun-Hee Kim, Minji Lee

“…The proposed framework holds significant potential in facilitating early rehabilitation planning by predicting motor function prognosis in stroke patients. Furthermore, it can contribute to enhancing the quality of life by providing patients with prognostication.…”
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Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…LASSO regression analysis was conducted to identify prognostic genes and construct an SLC-related prognostic signature. …”
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Control Indicators for Typical Persistent Organic Pollutants in Lake Sediments by LUO Xi, XIE Xiao-jing, XU Cheng-jian, ZHANG Lu, YAN Dan, TANG Qiang

“…Combined with the co-distribution patterns of heavy metal pollution, the response relationship between pollutant concentrations and lake functions was established. …”
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Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models by Colleen S. Curran, Xizhong Cui, Yan Li, Tom Gamble, Junfeng Sun, Samuel Minkove, Alicia A. Livinski, Peter Q. Eichacker, Parizad Torabi-Parizi

“…Abstract Disruption of nicotinamide adenine dinucleotide (NAD) biosynthesis and function during infection may impair host defenses and aggravate inflammatory and oxidative organ injury. …”
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An anoikis-related signature predicts prognosis and immunotherapy response in gastrointestinal cancers by Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng

“…A correlation analysis between the Anoscore, the tumor microenvironment and drug sensitivity was conducted in GI cancers. The expression and function of some candidate genes were validated in vitro.ResultsIn terms of prognostic ARGs, two anoikis-related patterns, ARG clusters A and B, were identified. …”
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Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation by Dídac Llop, Pere Rehues, Silvia Paredes, Montse Guardiola, Josefa Girona, Roser Rosales, Yaiza Esteban, Lluís Masana, Daiana Ibarretxe, Joan-Carles Vallvé, Josep Ribalta

“…We aimed to investigate the relationship between circulating apoCIII levels and subclinical inflammation markers across different cohorts with distinctive inflammatory patterns: patients with metabolic disorders (MDs), patients with rheumatoid arthritis (RA), and controls. …”
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Age-Onset-Related Particularities of Pediatric MS—Understanding the Spectrum: A Tertiary Center Experience by Alice Denisa Dică, Dana Craiu, Florentina Ionela Linca, Magdalena Budișteanu, Catrinel Iliescu, Carmen Sandu, Cristina Pomeran, Diana Bârcă, Niculina Butoianu, Carmen Burloiu, Ioana Minciu, Ina Ofelia Focșa, Dana Surlică, Oana Tarța-Arsene, Cristina Cazacu, Andreea Badea, Alexandru Stefan Niculae, Daniela Adriana Ion

“…Patients were grouped by age at onset and assessed for clinical presentation, number and timing of relapses, EDSS scores, imaging findings, and treatment patterns. Results: Early-onset MS was associated with atypical symptoms, delayed diagnosis, more frequent relapses, and multifocal brainstem and cerebellar involvement. …”
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Population prevalence and correlates of prolonged and shortened QTc intervals in a nationwide survey of adults in China: a report from Chinese arrhythmia epidemiology cross-section... by Li-Guo Tan, Li-Guo Tan, Jing-Xuan Liu, Fei Guo, Jing Lin, Ran Xiong, Hao Fu, Hao-Ming You, Liu He, Shi-Jun Xia, Xin Du, Jian-Zeng Dong

“…This study aimed to elucidate the distribution of the QT interval (QTc) patterns in Chinese adults and the risk factors associated with a prolonged QTc interval and shortened QTc interval.MethodsThis study was based on data from the Chinese Arrhythmia Epidemiology Cross-Sectional Study conducted in seven provinces of China between 2014 and 2016. …”
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Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury by Lingyan Li, Xingjie Wu, Qianqian Guo, Yu'e Wang, Zhiyong He, Guangqiong Zhang, Shaobo Liu, Liping Shu, Babu Gajendran, Ying Chen, Xiangchun Shen, Ling Tao

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Using five exposure metrics to explore the association between ambient PM2.5 and the hospital admissions for COPD in Tianshui city, China by Deshun Li, Jiyuan Dong, Xiaoju Liu, Juan Shu, Lisha Zhu, Hairong Bao

“…Stratified analyses were conducted to examine the effect modifications of gender, age, and season. …”
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Transcriptomic profiling and bioinformatic insights into myocardial injury following aneurysmal subarachnoid hemorrhage by Zuoli Wu, Zuoli Wu, Wenbo He, Weihao Ye, Shang Xu, Shengwei Wei, Baozi Huang, Pingping Li, Yanyan Tang, Chao Qin, Ying Liu, Ziming Ye

“…While RNA plays a critical role in pathophysiological processes, its expression patterns and functions in myocardial injury after aSAH (aSAH-MI) remain poorly understood.ObjectiveTo construct the RNA expression profile of aSAH-MI patients, explore their biological functions, and establish a gene expression regulatory network for aSAH-MI. …”
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Regreening Practices and Effectiveness Evaluation for Rocky Slope Drawdown Zones in Pumped Storage Power Station Reservoirs by YANG Zhi-chao, MA Xiao-xiao, CHANG Shi-ju, TANG Yu-shuang, ZHAO Rui-yi, WAN Dan, ZHANG Qian-zhu

“…[Methods] To address the severely impaired ecological function of the drawdown zone, this study conducted systematic analysis of habitat characteristics, including hydrological patterns, bank characteristics, non-point source pollution, and plant communities. …”
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Study on the mechanical traits, failure mechanisms, energy responses, and influencing factors of columnar jointed basalts under direct and indirect tensile conditions by Dan Liang, Dan Liang, Dan Liang, Haiqing Yang, Haiqing Yang, Zekang Ping, Zekang Ping, Yongyi Wang, Yongyi Wang, Kanglei Song, Kanglei Song, Chiwei Chen, Chiwei Chen, Hao Li, Hao Li, Xingyue Li, Xingyue Li, Lixin Peng, Lixin Peng, Anhua Ju, Anhua Ju

“…In this study, by merging mesoscopic damage mechanics, the probabilistic strength principle, and continuum mechanics, the visuals of columnar jointed basalts (CJBs) featuring various joint arrangement patterns are converted into inhomogeneous numerical models utilizing the digital visual analysis based on the digital image correlation (DIC)-enhanced rock failure process analysis (RFPA). …”
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