Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers by Weiping Ji, Ye Fang, Liwei Chen, Yitong Zheng, Yifei Pei, Changqiu Mei, Meng Zhou

“…The role of N6-methyladenosine (m6A) modification in regulating immune cell function has been recognized, but its impact on TEX dynamics across cancer types and clinical outcomes remains unclear. …”
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Multi-omic analyses reveal PTPN6’s impact on tumor immunity across various cancers by Yuchen Zhong, Weiyuan Zhang, Chaojing Zheng, Hongyu Wu, Jun Luo, Ziming Yuan, Hao Zhang, Chunlin Wang, Haiyang Feng, Meng Wang, Qian Zhang, Haixing Ju, Guiyu Wang

“…We analyzed PTPN6 expression data from open access databases using various statistical techniques, including survival analysis, genetic heterogeneity analysis, immune profiling, single-cell analysis, drug sensitivity analysis, and protein interaction analysis. We also conducted in vitro experiments utilizing colorectal cancer cell lines to validate PTPN6’s functional role. …”
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Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation by Victòria Ayala, Laia Fontdevila, Santiago Rico-Rios, Mònica Povedano, Pol Andrés-Benito, Pascual Torres, José C. E. Serrano, Reinald Pamplona, Manuel Portero-Otin

“…Of note, different studies do not agree on common patterns of microbiota being linked to ALS, supporting the need for further, more extensive studies. …”
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Multi-element Accurate Analysis of Sulfide Minerals by Low-temperature Ablation LA-ICP-MS by Huilai LI, Fan LI, Dingwen ZHANG, Wei GUO, Lanlan JIN, Shenghong HU

“…Similarly, particle size distribution at −30℃ also presented a bimodal pattern, which was consistent with previous studies. …”
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Kinesin-related genes stratified the prognosis and immune responses of clear cell renal cell carcinoma by Wenchong Zang, Luqi Ge, Xiaoping Hu, Tong Xu, Zhentao Zhang, Yiwen Zhang, Feifeng Song

“…Validation studies involving immunohistochemical staining, malignant phenotype assays, and immunofluorescence were conducted to assess the expression and function of these signature genes. …”
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Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming by Pengcheng Liu, Fuxin Huang, Peixu Lin, Jiayao Liu, Pincheng Zhou, Jie Wang, Huanhuan Sun, Fan Xing, Haiqing Ma

“…In vivo and in vitro experiments were conducted to validate how histidine treatment affects macrophage and T-cell function. …”
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Seasonal Self-Purification Process of Nutrients Entering Coastal Water from Land-Based Sources in Tieshan Bay, China: Insights from Incubation Experiments by Fang Xu, Peng Zhang, Yingxian He, Huizi Long, Jibiao Zhang, Dongliang Lu, Chaoxing Ren

“…Nutrients function as essential biological substrates for coastal phytoplankton growth and serve as pivotal indicators in marine environmental monitoring. …”
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Cardiovascular and renal comorbidities among saudi patients with type 2 diabetes: A cross-sectional observational study. by Syed Irfan Karim, Kamran Sattar, Tauseef Ahmad, Mustafa Kamal Memon, Abdulfattah S Alqahtani, Abdulrahman M Alsubiheen, Fahad Abdulaziz Alrashed

“…<h4>Objective</h4>This study aims to investigate the prevalence and patterns of cardiovascular and renal complications among patients with T2DM in the Saudi population and elucidate the extent of these comorbidities and their potential risk factors.…”
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Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring by Snezana Milosavljevic, Maria V. Piroli, Emma J. Sandago, Gerardo G. Piroli, Holland H. Smith, Sarah Beggiato, Norma Frizzell, Ana Pocivavsek

“…Behavioral assessments were conducted on wild-type offspring from two parental groups: (i) WT-Control from WT-Control parents, (ii) wild-type Kmo (WT-Kmo +/+) from Kmo heterozygous parents (HET-Kmo +/–). …”
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A study of morpho-phonological processes in the Zanjani dialect of Azerbaijani Turkish based on optimality theory by farnaz ebadi, Mohammad Reza Oroji, Sakine Jafari, Mehri Talkhabi

“…The interviews were conducted in a friendly environment to minimize the influence of hypercorrection. …”
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Inter and intrasentential code switching among late bilinguals by Barzan Jaafar Ali

“…PhD thesis Chan, B. and Hock-Shing. (2015) A diachronic-function approach to explaining grammatical patterns in code-switching: Postmodification in Cantonese English noun phrase. …”
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Next-generation sequencing in early-stage multiple primary lung cancer: The prognostic significance of genomic accumulation status and BCL2L11del by Mu-Ting Wang, Chen-Hui Ni, Yan-Qi Lu, Wei Zheng, Shu-Liang Zhang, Mao-Hui Chen, Bin Zheng, Chun Chen

“…Objective: This study aimed to define the genomic features of tumors and to delineate the potential mutational pattern underlying the prognosis of patients using large-panel next-generation sequencing (NGS) assays. …”
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Analysis of the Causal Model of the Effective Criteria on the Development of Creative Tourism in Iran by Ahmad hajarian

“…Conclusion This research was conducted with the aim of evaluating the causal pattern of criteria affecting creative tourism. …”
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Filling knowledge gaps: A methodological approach for the rapid investigation of species with restricted populations by André Cesar Furlaneto Sampaio, Pablo Melo Hoffmann, Elivelton Marcos Gurski, Ollyver Rech Bizarro, Santiago José Elías Velazco, Marcos Bergmann Carlucci, Marília Borgo, Mayara Monteiro Ferreira, Alessandro Camargo Angelo, Christopher Thomas Blum

“…In the third phase, we analyzed spatial patterns using Morisita’s Index and Ripley’s K function. …”
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Automatic detection of lucky bamboo nodes based on Improved YOLOv7 by Jing Zhang, Jing Zhang, Jing Zhang, Ruoling Deng, Ruoling Deng, Ruoling Deng, Chengzhi Cai, Erpeng Zou, Haitao Liu, Haitao Liu, Mingxin Hou, Xinzhi Chen, Huamin Lin, Zhenye Wei

“…Future work will address limitations in detecting nodes obscured by mottled patterns or severe occlusions by expanding label categories during training.…”
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Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway by Shengnan Shi, Jiaming Gao, Yehao Zhang, Min Zhan, Zhanfei Tan, Peili Wang, Jianhua Fu, Jianxun Liu

“…Inflammation markers, platelet aggregation function, and CD62p levels were assessed using flow cytometry. …”
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Distribution, behavior and diet of the Asiatic black bear in human modified landscapes by Hadi Fahimi, Mahmood Soofi, Nahid Ahmadi, Ali T. Qashqaei, Hamidreza Heidari, Haaken Bungum, Bent Rech, Jonas Trepel, Matthias Waltert

“…The broad negative effects of land-use conversion for agriculture on wildlife species are well known, but few studies have evaluated how different land-use types impact spatiotemporal patterns and trophic strategy of large carnivores. …”
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To operate or not to operate? The impact of surgical treatment on quality of life in women with ovarian endometriosis by Emanuela Spagnolo, Emanuela Spagnolo, David Ramiro-Cortijo, David Ramiro-Cortijo, Blanca Díaz Fuentes, María Suarez Vega, Lucía Calvillo-Fernández, Ana López, Ana López, Alicia Hernández, Alicia Hernández

“…OE- S exhibited intermediate health and quality of life patterns between control and DE groups, whereas OE- NS was more similar to DE.ConclusionPsychological well-being and social support are reduced in all endometriosis groups, but surgical treatment in women with ovarian endometriosis preserve vitality, sexual, and occupational functions. …”
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Vestibular afferent neurons develop normally in the absence of quantal/glutamatergic input by Katherine Regalado Núñez, Katherine Regalado Núñez, Daniel Bronson, Daniel Bronson, Ryan Chang, Radha Kalluri, Radha Kalluri, Radha Kalluri

“…Patch-clamp recordings showed that biophysical diversity of vestibular ganglion neurons in the Vglut3-ko mice is comparable to that found in wild-type controls, with a similar range firing patterns at both immature and juvenile ages. However, our results suggest a subtle biophysical alteration to the largest ganglion cells (putative somata of central zone afferents); those in the knockout had smaller net conductance and were more excitable than those in the wild type.DiscussionThus, unlike in the auditory nerve, glutamatergic signaling is unnecessary for producing biophysical diversity in vestibular ganglion neurons. …”
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Alteration in motor control in patients with low back pain and myotonic syndrome of lumbar osteochondrosis by V.A. Kolesnichenko, H.H. Holka, I.V. Hresko, V.V. Burlaka, V.V. Vesnin, B.P. Vvedensky, D.B. Vvedensky

“…The majority of studies associate low back pain with limitation of motor function of the spine and muscle control of the lumbar-pelvic area, however, in a number of reports such a connection was not found. …”
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