Circulating microRNAs as biomarkers for ischemic heart disease: a systematic review and gene set enrichment analysis by Yasmine Alcibahy, Radwan Darwish, Ghena Abu-Sharia, Quinten Maes, Omar Elgamassy

“…Although expression patterns varied, these miRNAs were recurrently implicated in IHD-related processes. …”
Get full text

Research on the electro-magnetic-thermal–mechanical characteristics of shearer cables by Lijuan Zhao, Guocong Lin, Yadong Wang, Bo Xie, Zhongjian Bai, Meichen Zhang, Hongmei Liu, Zifeng Liu

“…The variation patterns of these characteristics were then analyzed. …”
Get full text

Early Digital Engagement Among Younger Children and the Transformation of Parenting in the Digital Age From an mHealth Perspective: Scoping Review by Nafisa Anjum, Md Mehedi Hasan, Nursat Jahan, Sheikh Iqbal Ahamed, Allison Garefino, Nazmus Sakib

“…Synthesized data were scrutinized to detect patterns, variances, and reasonable recommendations. …”
Get full text

Comparative analysis of spatiotemporal gait parameters in patients with distal femoral megaprosthesis and healthy subjects using an inertial measurement unit (IMU) by Nadia Jover-Jorge, Paula González-Rojo, José Vicente Amaya-Valero, Francisco Baixauli-García, Carolina de la Calva-Ceinós, Manuel Angulo-Sánchez, Javier Martínez-Gramage, Juan Francisco Lisón

“…Despite these changes, gait patterns remained within functional ranges. IMU-based gait analysis reveals significant but functional alterations in gait mechanics among patients with distal femoral megaprosthesis. …”
Get full text

Transcriptome analysis reveals the candidate genes associated with skin color variation in Luciobarbus capito by Longwu Geng, Xinchi Shang, Haijun Wei, Guangxiang Tong, Wei Xu, Youyi Kuang

“…Of these, 659 genes were significantly down-regulated in yellow skin, and 196 genes were significantly up-regulated in yellow skin. The patterns of expression of 12 randomly selected differentially expressed genes were confirmed by the quantitative real-time PCR analysis between two color skin. …”
Get full text

Single- and Multi-Locus GWAS Unravels Novel Genomic Regions Related to Low-Phosphate Stress in Cotton Seedlings by Xianxu Wei, Siyu Yao, Jiangnuo Di, Jiaxin Guan, Aohan Wang, Jie Yang, Luyao Zhang, Yang Liu, Mengyao Liang, Zhihao Niu, Xuan Zhang, Jiarui Xue, Mengxue Shen, Lin Li, Yao Su, Zhengwen Sun

“…Multi-locus models significantly enhanced detection sensitivity, identifying 123 SNPs undetected by single-locus approaches. Functional annotations prioritized six candidate genes near associated SNPs, including GhM_A08G1315 (remorin protein) and GhM_D06G1152 (carotenoid cleavage dioxygenase), whose LP-induced expression patterns were validated by qRT-PCR. …”
Get full text

Bibliometric and visualization analysis of temporomandibular joint osteoarthritis from 2004 to 2024 by Chi Xu, Chi Xu, Chi Xu, Chongqing Yu, Chongqing Yu, Chongqing Yu, Tao Wang, Tao Wang, Tao Wang, Xiang Gao, Xiang Gao, Xiang Gao

“…BackgroundTemporomandibular joint osteoarthritis (TMJOA) is a severe condition affecting the temporomandibular joint, impairing essential oral functions such as chewing, speaking, and swallowing. …”
Get full text

Evolutionary insights and expression dynamics of the glutathione peroxidase (GPX) gene family in water lily (Nymphaea colorata) in response to multiple abiotic stresses by Wasi Ullah Khan, Latif Ullah Khan, Noor Muhammad Khan, Wang Wenquan, Fei Chen

“…The glutathione peroxidase (GPX) family in plants contains various isoenzymes, each with distinct subcellular localizations, tissue-specific expression patterns, and responses to environmental stress. In current study, we conducted genome-wide bioinformatics analyses of the GPX gene family in Nymphaea colorata, identifying five putative NcGPX genes dispersed across five of the fourteen chromosomes. …”
Get full text

Deep-Learning-Based Land Cover Mapping in Franciacorta Wine Growing Area by Girma Tariku, Isabella Ghiglieno, Andres Sanchez Morchio, Luca Facciano, Celine Birolleau, Anna Simonetto, Ivan Serina, Gianni Gilioli

“…Land cover mapping is essential to understanding global land-use patterns and studying biodiversity composition and the functioning of eco-systems. …”
Get full text

Chromatin modifiers in endometriosis pathogenesis by K. A. Abaeva, R. T. Murtazova, I. A. Vaniev, A. V. Lazarova, A. A. Sozaeva, M. A. Gogichaeva, A. A. Pirozhnikova, K. V. Ignashev, M. S. Dadashov, D. V. Kolesnikova, A. A. Bayramova, V. E. Kucherskaya, L. D. Zulfalieva, A. M. Zaitseva

“…The regulation of chromatin structure is carried out mainly by chromatin modifiers (CMs), which stimulate generation of genomic regions with different functional structures and thus change the patterns or levels of gene expression by exerting expected biological functions and causing epigenetic changes.Aim: to consider CMs role in endometriosis pathogenesis and their regulation mechanism assessing current publications.Materials and Methods. …”
Get full text

Integrative analysis of taurine metabolism-related genes prognostic signature with immunotherapy and identification of ABCB1 and GORASP1 as key genes in nasopharyngeal carcinoma by Zhang Feng, Yuhang Yang, Wenqi Luo, Jinqing Li, Zhenlian Xie, Long Zuo, Meijiao Duan, Dongzhi Zuo, Ruwei MO, Xuejing Tang, Shijiang Yi, Xiaosong He, Fangxian Liu, Ning Ma, Feng He

“…Abstract Taurine is an amino acid with several physiological functions and has been shown to be involved in the anti-tumor of human nasopharyngeal carcinoma (NPC) cells. …”
Get full text

Comprehensive bioinformatics analysis of MEX3 family genes in hepatocellular carcinoma by Xuezhong Zhang, Peng Sun, Tingting Chu, Yuling Feng, Xuebin Zhang

“…This study aims to systematically analyze the expression patterns, prognostic significance, and immune-related functions of MEX3A, MEX3B, MEX3C, and MEX3D in HCC using comprehensive bioinformatics approaches. …”
Get full text

Sustainable Placemaking and Thermal Comfort Conditions in Urban Spaces: The Case Study of Avenida dos Aliados and Praça da Liberdade (Porto, Portugal) by Hélder Silva Lopes, Paula C. Remoaldo, Diogo Guedes Vidal, Vítor Ribeiro, Lígia Torres Silva, Javier Martín-Vide

Get full text

Identification of aging-related biomarkers for intervertebral disc degeneration in whole blood samples based on bioinformatics and machine learning by Zi-hang Li, Shi-pian Li, Shi-pian Li, Ya-hao Li, Yu-cheng Wang, Zhen-yu Tang, Kai-yang Xu, Xiao-rong Li, Zhen Tan, Jiao-yi Pan, Jin-tao Liu, Hong Jiang, Zhi-jia Ma, Yu-xiang Dai, Yu-xiang Dai, Yu-xiang Dai, Peng-fei Yu

“…To further validate these findings, we collected human blood specimens and conducted in vitro experiments. ELISA assays confirmed that CBS and FASLG are crucial biomarkers of IVDD, with distinct expression patterns in patients with moderate versus severe degeneration.DiscussionThese results highlight the diagnostic potential of AIDEGs and provide a new perspective for early intervention and treatment strategies in IVDD.…”
Get full text

Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…Cell-type-specific RBPs expression patterns were systematically profiled across epidermal keratinocytes, dermal endothelial cells, and T cells. …”
Get full text

Exploring Work Engagement and Cynicism in Industry: A Preliminary Investigation in a Central Italian Engineering Company by Luca Di Giampaolo, Teresa Galanti, Michela Cortini, Simone De Sio, Claudia Giurgola, Federica Marino, Piergiorgio Astolfi, Rossella Martelli, Daria Ziccardi, Paola Borrelli, Laura Forcella, Maria Elisa Maiolo, Luca Coppeta

“…The results emphasize the need to expand the sample and to conduct comparative analyses across different teams within the company better understand engagement patterns and inform targeted interventions. …”
Get full text

Designing a Policy Model Based on the Development of Human Capabilities of the Ministry of Education of the Kurdistan Region of Iraq by Rahman Rasul Fatah, Mojtaba Amiri, Seyed Reza Seyed Javadin, Rasool Norouzi Seyed Hosseini

“…This stage was done carefully to clearly highlight patterns, concepts, and significant differences in the data. …”
Get full text

miR-34-5p mediates 20E-induced autophagy in the fat body of Bombyx mori by targeting Atg1 by Huili Qiao, Ziqian Tong, Yuanzhuo Wang, Juanjuan Yang, Yanyan Sun, Huixuan Shi, Zhuo Liu, Jianping Duan, Dandan Li, Yunchao Kan

“…Results We constructed six small RNA libraries using Bombyx mori fat body treated with 20E. Expression and functional analyses were conducted to identify 20E-responsive miRNAs. …”
Get full text

Clinical Molecular Immunohistochemistry Mismatch Repair Mutations in Lynch Syndrome in Patients Under 50 Years: A Systematic Review by Bogdan Adrian Manta, Adrian Cosmin Ilie, Felicia Marc, Daciana Nistor, Patricia Octavia Mazilu, Claudia Borza

Get full text

STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences by Ning Lan, Xintong Li, Yifan Qiao, Siyi Zhang, Min Chen, Xiaofeng Yang, Yuliang Zou, Juan Ren, Meili Pei

“…Abstract Objectives As a central regulator of the JAK/STAT signaling pathway, STAT1 generates functionally distinct α and β protein isoforms through alternative splicing. …”
Get full text