<i>Mycobacterium Ulcerans</i> Ulcer: Current Trends in Antimicrobial Management and Reconstructive Surgical Strategies by Bryan Lim, Omar Shadid, Jennifer Novo, Yi Mon, Ishith Seth, Gianluca Marcaccini, Roberto Cuomo, Daniel P. O’Brien, Warren M. Rozen

“…Its toxin, mycolactone, drives tissue destruction, and the infection is transmitted via environmental reservoirs or vectors. Disease patterns vary globally, and an improved understanding of their pathogenesis may enhance current antimicrobial and surgical treatments. …”
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Identification and Characterization of the OCT4 Upstream Regulatory Region in Sus scrofa by Seung-Hun Kim, Kwang-Hwan Choi, Dong-Kyung Lee, Mingyun Lee, Jae Yeon Hwang, Chang-Kyu Lee

“…However, the OCT4 promoter and four regulatory regions, including distal and proximal enhancer elements, had high similarity. Next, a functional analysis of the porcine OCT4 promoter region was conducted. …”
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Repetitive transcranial magnetic stimulation ameliorates chronic pain behavior and modulates the brain transcriptome in a mouse model of chronic constriction injury by Tianying Li, Guanwen Lin, Tao Zhang, Yani Guo, Yongjin He, Jing Luan, Jin Wang, Dan Lyu, Yiqi Weng, Xin Jin

“…Transcriptomic analysis revealed that CCI induced dysregulation of 66 genes, while rTMS partially normalized gene expression patterns. Functional enrichment analysis indicated significant involvement of pathways related to inflammatory responses, transporter activity, and ion channel regulation. …”
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Roaming the Seas—Assessing Marine Invertebrate Biodiversity Along Salinity Gradients With Zooplankton and eDNA Metabarcoding by Alica Ohnesorge, Uwe John, Lucie Kuczynski, Stefan Neuhaus, Kingsly Chuo Beng, Bernd Krock, Silke Laakmann

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Evaluation of Rural Housing Structural Transformations Based on the Rural Livelihood; Case Study : Riab Village in Khorasan Razavi Province by Abasalt Askari Rabori, Shahab Abbaszadeh, Ali Asghar Abroon

“…The villages of the country have not been functioning with their full capacity for several years due to various reasons. …”
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Identifying Psychosocial, Self-Management, and Health Profiles Among Women With Chronic Pain Who Have Experienced Intimate Partner Violence and Those Who Have Not: Protocol for a 2... by Ainara Nardi-Rodríguez, Sónia Bernardes, María Ángeles Pastor-Mira, Sofía López-Roig, Lidia Pamies-Aubalat, Andrés Sánchez-Prada, Victoria A Ferrer-Pérez, Ignacio Rodríguez-Rodríguez, Purificación Heras-González

“…ResultsAs of May 2025, we had contacted relevant associations to present the project and begin recruiting voluntary participants. We have conducted the pilot study to assure the adequacy of the questionnaire and usability or technical functionality of the web-based platform. …”
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Genome-wide identification of cyclic nucleotide-gated channel gene family in Solanum tuberosum and silencing of StCNGC2 provides resistance to Pectobacterium carotovorum by Kaile Sun, Kaile Sun, Shuai Liu, Huipo Mao, Qianqian Zha, Han Liu, Shunshan Shen, Evert Jacobsen, Richard G. F. Visser, Yuling Bai, Chengwei Li, Zhiqi Jia, Zhiqi Jia, Geng Meng, Geng Meng, Yawen Shen

“…Expression patterns were examined in different tissues and under stress conditions. …”
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Integrated multi-omics analysis identifies TPX2 as a potential prognostic and immunological biomarker in hepatocellular carcinoma by Hui Peng, Yong-peng Wei, Xin-bo Liu, Yu Wang, Jian-yong Yuan

“…Methods: We conducted an integrated multi-omics analysis using transcriptomic (TCGA, GTEx, GEO), proteomic (CPTAC), and pharmacogenomic (GDSC, PRISM, CTRP) datasets to assess TPX2 expression patterns in HCC. …”
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Challenges and opportunities for data integration to improve estimation of migratory connectivity by Jeffrey A. Hostetler, Emily B. Cohen, Christen M. Bossu, Amy L. Scarpignato, Kristen Ruegg, Andrea Contina, Clark S. Rushing, Michael T. Hallworth

“…Integration of the diverse measures of migratory movements can help elucidate migratory connectivity patterns with methodology that accounts for differences in sampling design, directionality, effort, precision and bias inherent to each data type. …”
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Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism by Lauren Wagner, Megan Banchik, Tawny Tsang, Nana J. Okada, Rebecca Altshuler, Nicole McDonald, Susan Y. Bookheimer, Shafali S. Jeste, Shulamite Green, Mirella Dapretto

“…Importantly, we also demonstrate that HL infants show distinctly atypical patterns of lateralization for speech processing, particularly during native speech processing, suggesting a failure to left-lateralize. …”
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DHCR24 overexpression is involved in lipid metabolic reprogramming to drive cervical cancer malignant progression and is associated with immune microenvironment by Lin Cheng, Yuance Xu, Zhuo Li, Danting Sun, Yan Xu, Junqi He, Yulong Chen, Qin Yao

“…A prognostic nomogram incorporating tumor stage and DHCR24 expression levels was developed to predict clinical outcomes in patients. Functional studies using SiHa cell lines were conducted to elucidate the oncogenic properties of DHCR24. …”
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An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure by Cristina Manuela Drăgoi, Anca Zanfirescu, Ion-Bogdan Dumitrescu, Anca Ungurianu, Denisa Marilena Margină, Alina-Crenguţa Nicolae

“…Tryptophan, an essential amino acid, serves as a vital structural element in proteins and a precursor for bioactive compounds like serotonin and melatonin, which impact various physiological functions. Methods: Experimental studies have been conducted to reveal the interaction mechanisms of these endogenous indole derivatives with calf thymus DNA (ct-DNA). …”
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Genomic features, antimicrobial resistance and pathogenicity assessment of Escherichia coli serotype O177:H51 strain JS01 isolated from a diseased chicken by Lunbin Xia, Guanglei Wang, Naidong Chen, Deliang Qiao, Jianwen Cao, Shaoshuai Bi

“…The findings of this study provide valuable insights into the serotype distribution, antibiotic resistance patterns, and virulence characteristics of APEC isolates from diseased chickens in China. …”
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Sorghum-peanut intercropping under salt stress mediates rhizosphere microbial community shaping in sorghum by affecting soil sugar metabolism pathways by Xia Shao, Chunmei Yang, Yuxuan Chen, Chang Liu, Chunjuan Liu, Xiaolong Shi, Yufei Zhou

“…Metabolome analyses revealed significant differences in microbial community structure across diverse soil conditions and cropping patterns. At phylum level, Proteobacteria, Gemmatimonadetes, and Verrucomicrobia predominated, with their relative abundance experiencing substantial changes under salt stress. …”
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Expression characteristics, molecular mechanisms, and clinical significance of DICER1 in breast cancer by Xi Zhang, Long Yu, Cuizhi Geng

“…Weighted gene co-expression network analysis (WGCNA) was used to identify gene modules associated with the breast cancer phenotype, and gene set enrichment analysis (GSEA) was performed to explore their biological functions. Cellular experiments were conducted to verify the effects of DICER1 on the proliferation, migration, and invasion of breast cancer cells. …”
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Health-related quality of life, physical and mental capacity at one year follow up of COVID-19 ICU patients: A prospective cohort study by Anders Ersson, Henrik Överengen Reuterborg, Anestis Divanoglou, Richard Levi, Lotti Orwelius

“…Overall, our findings show similarities with previously reported recovery patterns after intensive care. However, the COVID-19 cohort displayed a more profound reduction in HRQoL paralleled with severe fatigue and respiratory limitations. …”
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Examining the effects of femoral anteversion and passive hip rotation on ACL injury and knee biomechanics: a systematic review and meta‐analysis by Jennifer A. Hogg, Justin P. Waxman, Sandra J. Shultz

“…Well‐designed studies using reliable methods are needed to investigate biomechanical patterns associated with more extreme ROM values within each sex, and their prospective associations with ACL injury. …”
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Multi-omics network toxicology reveals the role of benzo[a]pyrene in ovarian cancer: Integrating gut microbiota dynamics and Mendelian randomization by Jinfa Huang, Qian Yang, Lingling Zeng, Kaixian Deng

“…Protein-protein interaction networks and functional enrichment analyses were conducted utilizing Cytoscape, while molecular docking (CB-Dock 2) confirmed a strong binding affinity between BaP and core targets (e.g., HSP90AA1: −11.7; AHR: −10.0). …”
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Biomarker Investigation Using Multiple Brain Measures from MRI Through Explainable Artificial Intelligence in Alzheimer’s Disease Classification by Davide Coluzzi, Valentina Bordin, Massimo W. Rivolta, Igor Fortel, Liang Zhan, Alex Leow, Giuseppe Baselli

“…Then, differences in explainability patterns between the two models were assessed to explore the insights offered by each piece of data (i.e., MRI vs. connectivity). …”
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Effects of DCM Leaf Extract of Gnidia glauca (Fresen) on Locomotor Activity, Anxiety, and Exploration-Like Behaviors in High-Fat Diet-Induced Obese Rats by Wycliffe Makori Arika, Cromwell Mwiti Kibiti, Joan Murugi Njagi, Mathew Piero Ngugi

“…Obesity is the main component of metabolic syndromes involving distinct etiologies that target different underlying behavioral and physiological functions within the brain structures and neuronal circuits. …”
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