Comprehensive Analysis of Multi-Omics Data on RNA Polymerase as an Adverse Factor in Head and Neck Squamous Cell Carcinoma by Gu YJ, Zhang J, Liu YJ, Zhang Q, Geng QF

“…In vitro and in vivo experiments were conducted to validate the functional role of the YY1-POLR2C axis in cancer proliferation and immune modulation.Results: POLRs were found to be aberrantly expressed in cancers and associated with genomic alterations. …”
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Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers by Gautam Kundu, Selvakumar Elangovan

“…<b>Methods</b>: In this study, we conducted a further examination of the transcriptomic expression profile of SPP1 (Osteopontin) during the progression of cancer in four human tissues, breast, prostate, renal and skin, in order to understand the circumstances conducive to its activation and dysregulation, the biological pathways and other mechanisms involved as well as differences in its splicing patterns influencing its expression and functionality. …”
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Identification of hub genes in myocardial infarction by bioinformatics and machine learning: insights into inflammation and immune regulation by Juan Yang, Xiang Li, Li Ma, Jun Zhang

“…These genes were then subjected to functional enrichment analysis, including Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and Gene Set Enrichment Analysis (GSEA). …”
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Epigenetic regulation of TNNT1 in gastrointestinal cancers prognostic implications and clinical significance by Jin Xie, Xin-Yang Qu, Rui-Min Wu, Jie Liu, Fan Cheng, Yu Zhang, Xu-Sheng Liu

“…The impact of TNNT1 expression on patient prognosis was evaluated through Cox regression analyses. Furthermore, functional enrichment analysis was conducted to explore the biological pathways involved, alongside promoter methylation and mutation analyses, to elucidate its regulatory mechanisms. …”
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Single-cell RNA sequencing technology was employed to construct a risk prediction model for genes associated with pyroptosis and ferroptosis in lung adenocarcinoma by Longfei Ji, Binyu Wang, Danfei Shi, Weiyun Shen, Xinmin Li, Yong Li

“…Method This study integrated single-cell RNA sequencing (scRNA seq), bulk transcriptome data, and clinical information to comprehensively analyze the expression patterns and functional roles of pyroptosis related genes (PRGs) in LUAD. …”
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Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis by Liansha Tang, Wenbo He, Handan Hu, Jiyan Liu, Zhike Li

“…Tissue-specific gene expression patterns, CSF1, TGFβ1 in lung, TNFSF12 in the ileum may explain organ-specific irAE vulnerabilities. …”
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Analysis of the structural changes in domestic consumption of FUEL and energetic resources of Moscow by L. G. Moiseykina, E. S. Darda

“…That is why, a comprehensive analysis of the dynamics and structure of consumption of fuel and energy resources will allow not only to assess the existing patterns of distribution and trends, but also as a consequence to form a highly effective energy strategy for the megacity.…”
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Exploration of biomarkers associated with histone lactylation modification in spinal cord injury by Yisong Sun, Jie Gao, Juehua Jing

“…Inter-cluster comparisons were conducted to examine Hallmark pathways, HLA genes, and immune functions. …”
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Expressing the Author's Position in the English-Language Network Film Review by I. V. Kononova, T. A. Klepikova, E. A. Klenova

“…The methodology of describing the author's position in evaluative genres is proposed, which boils down to the following steps: identifying the leading linguistic means of self-nomination; displaying main genre-typical patterns of subject modality (modus types); describing evaluation semantics specificity and linguistic means of dominant evaluative meanings verbalization. …”
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Placental whole transcriptome expression profile in patients with early-onset, late-onset preeclampsia and gestational diabetes mellitus by Zhuo Chen, Li Yang, Li Geng, Xinwen Zhang, Mingyu Du, Yonghu Sun, Lin Zhao, Bing Bai, Xiaohong Li

“…The results revealed dysregulation of key pathways in early-onset-PE (OE-PE), including Wnt signaling, PI3K-Akt signaling, MAPK signaling, FoxO signaling, and TNF signaling, along with downregulation of genes related to Ca2 + conduction and hormone pathways. In late-onset-PE (LO-PE) and GDM, abnormalities were observed in immune pathways including chemokine signaling pathway and IL-17 signaling pathway, with differing immune cell infiltration patterns. …”
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ZmHsp18 screened from the ZmHsp20 gene family confers thermotolerance in maize by Ming Xue, Yiwen You, Luyao Zhang, Jinming Cao, Mingliang Xu, Saihua Chen

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De Novo Synthesis of Anticholinergic Hyoscyamine and Scopolamine in <i>Nicotiana benthamiana</i> Based on Elucidating Tropane Alkaloid Biosynthetic Pathway of <i>Anisodus luridus</... by Mengling Wen, Junlan Zeng, Fei Qiu, Fangyuan Zhang, Zhihua Liao

“…Its high yield of hyoscyamine makes <i>A. luridus</i> a valuable plant source for commercially producing TAs. In this study, we conduct homologous gene research across transcriptome data of different tissues together with functionally tested sequences in <i>Atropa belladonna</i> as a reference and identify 13 candidate genes for TAs biosynthesis in <i>A. luridus</i>. …”
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Design and Experimentation of a Height-Adjustable Management Platform for Pineapple Fields by Sili Zhou, Fengguang He, Ganran Deng, Ye Dai, Xilin Wang, Bin Yan, Pinlan Chen, Zehua Liu, Bin Li, Dexuan Pan

“…To address the challenges of inadequate adaptability, insufficient power, high ground clearance, and limited functionality in existing pineapple field machinery, this study proposes a height-adjustable pineapple field management platform based on previously established cultivation patterns and agronomic requirements. …”
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The impact of Alzheimer's disease on cortical complexity and its underlying biological mechanisms by Leian Chen, Xiao Zhou, Yanan Qiao, Yu Wang, Zhi Zhou, Shuhong Jia, Yu Sun, Dantao Peng

“…In addition, transcription–neuroimaging association analyses, as well as Mendelian randomization of AD and cortical thickness data, were conducted to investigate the genetic mechanisms and biological functions of AD. …”
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Clinical Phenotypes and Age-Related Differences in Presentation, Treatment, and Outcome of Heart Failure with Preserved Ejection Fraction: A Vietnamese Multicenter Research by Ngoc-Thanh-Van Nguyen, Diep Tuan Tran, Pham Le An, Sy Van Hoang, Hoai-An Nguyen, Hoa Ngoc Chau

“…While Southeast Asia reported the highest mortality and morbidity among Asian population, little is known about the Vietnamese population, including patient characteristics, prescribing pattern and mortality rate. Methods. We conducted an observational study on 477 patients diagnosed with HFpEF from seven hospitals in Southern Vietnam from January 2019 to December 2019. …”
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WFDC3 identified as a prognostic and immune biomarker in pancreatic cancer by Bohan Liu, Xuqing Shi, Tianqi Liu, Huanwen Wu, Zhiyong Liang

“…To address this, we conducted an initial investigation using comprehensive bioinformatic analyses to evaluate WFDCs expression patterns across multiple tumor types, with a focus on PAAD. …”
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Genome-wide characterization and expression analysis of the JRL gene family in response to hormones and abiotic stress in tomato (Solanum lycopersicum L.) by Hui Li, Hongling Hu, Lina Cao, Yue Zhuo, Liting Wang, Hui Ma, Ming Zhong

“…The results show that the SlJRL gene family exhibits tissue-specific expression patterns and responds to a variety of hormonal and stress conditions. …”
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Digital Storytelling for People With Cognitive Impairment Using Available Mobile Apps: Systematic Search in App Stores and Content Analysis by Di Zhu, Abdullah Al Mahmud, Wei Liu, Dahua Wang

“…The reviewed apps featured capture memory, save, reminisce, and share functions, which are critical in supporting cognitive functions and enhancing user engagement. …”
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Prevalence of poststroke fatigue and its relationship with clinical characteristics among community-dwelling stroke survivors: A cross-sectional survey by Akhila Jagadish, Manikandan Natarajan, Vasudeva Guddattu, John M. Solomon

“…Telephonic consent was obtained, and an interview was conducted to obtain the scores for fatigue, daytime sleepiness, depression, functional mobility, and disability. …”
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Bioinformatic Insights and XGBoost Identify Shared Genetics in Chronic Obstructive Pulmonary Disease and Type 2 Diabetes by Qianqian Ji, Yaxian Meng, Xiaojie Han, Chao Yi, Xiaoliang Chen, Yiqiang Zhan

“…A multifaceted bioinformatics approach, encompassing the limma R package, unified matrix analysis, and weighted gene co‐expression network analysis (WGCNA), was deployed to identify differentially expressed genes (DEGs) and hub genes. Functional enrichment and protein–protein interaction (PPI) analyses were conducted, followed by cross‐species validation in Mus musculus models. …”
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