Trends in pulmonary function in patients with Birt-Hogg-Dubé syndrome: a retrospective cohort study by Marie Moldt Holmager, Sarah Wordenskjold Stougaard, Ole Graumann, Marianne Præstegaard, Lilian Bomme Ousager, Lars Lund, Annette Schuster, Casper Falster, Jesper Rømhild Davidsen

“…The overall aim of this study was to assess clinical characteristics of patients with BHD-emphasizing on trends in pulmonary function patterns.Methods By use of data from electronic patient journals, we conducted a retrospective cohort study on clinical characteristics and pulmonary function tests (PFT) from patients with BHD, who were clinically followed-up in a Danish tertiary referral center for rare and interstitial lung diseases.Results A total of 101 patients (44 men (43.6%); mean age 48.4 years (SD ± 15.9 years)) with BHD were included. …”
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Optimizing arable land suitability evaluation using improved suitability functions in the Anning River Basin by Fang Luo, Li He, Zhongsheng Chen, Zhengwei He, Wenqian Bai, Yang Zhao, Yuxin Cen

“…Highly Suitable CAL and Highly Suitable PAL cover 93.14% and 82.97% of this region, respectively, making it a focal point for regional agricultural development. (3) The spatial distribution patterns of ALSE results based on the original function and the improved function are essentially consistent. …”
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Metabolomic Profiling and Functional Characterization of Biochar from Vine Pruning Residues for Applications in Animal Feed by Serena Reggi, Sara Frazzini, Maria Claudia Torresani, Marianna Guagliano, Cinzia Cristiani, Salvatore Roberto Pilu, Martina Ghidoli, Luciana Rossi

“…The aim of this study was to characterize the metabolomic and functional properties of an aqueous biochar extract from vine pruning waste, in order to predict its potential in vivo effects as a functional feed ingredient. …”
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Proteolysis and volatile compounds in Mediterranean buffalo milk blue cheese: Quality determinants and functional peptides by Federica Della Cerra, Giuseppina Garro, Rosaria Cozzolino, Sabrina De Pascale, Mariapia Esposito, Gianluca Picariello, Simonetta Caira, Andrea Scaloni, Francesca Marino, Francesco Addeo

“…Casein phosphopeptides displayed ripening-dependent dephosphorylation patterns, driven by fungal phosphatase activity. VOC profiling revealed 55 key compounds, mainly methyl ketones, esters, and short-chain acids, that contributed to the evolving sensory profile of the cheese.These findings highlight the complex biochemical transformations that define both the functional and sensory qualities of buffalo blue cheese. …”
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The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis by Longyao Ma, Longyao Ma, Qiuying Tao, Qiuying Tao, Jinghan Dang, Jinghan Dang, Jieping Sun, Jieping Sun, Xiaoyu Niu, Xiaoyu Niu, Mengzhe Zhang, Mengzhe Zhang, Yimeng Kang, Yimeng Kang, Weijian Wang, Weijian Wang, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang

“…Consequently, it is important to utilize relevant coordinate data for a comprehensive meta-analysis to identify the shared patterns of structural, functional, and multimodal alternations in TUD.MethodThe present study conducted a systematic retrieval of studies published on PubMed, Web of Science, and Scopus from January 1, 2010, to December 12, 2023, to identify studies on voxel-based morphometry (VBM) and resting-state functional magnetic resonance imaging (rs-fMRI) for TUD. …”
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Reference equations for pulmonary function testing in healthy Chinese children aged 4–18 years by Jinhong Wu, Hao Zhang, Yufen Wu, Qiaoling Zhang, Ming Li, Fuli Dai, Changfu Xu, Yongsheng Shi, Ning Wang, ChunMei Jia, Sha Liu, Yuehua Zhang, Zhongping Zhang, Aihong Liu, Fei Wang, Li Liu, Qiang Chen, Jinrong Wang, Yuling Han, Yuxin Song, Yong Feng, Yun Sun, Huaping Rao, Lili zhong, Quanhua Liu, Liya Wan, Zhen Long, Xiaoyan Dong, Yanli Zhang, Wenhui Jiang, Minghong Ji, Jianfeng Huang, Zhiwei Pan, Dongjun Ma, Suping Tang

“…These equations reflect contemporary growth patterns and regional diversity in China, providing an additional option for clinical use. …”
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Brain-wide mapping of acute hypoxia-induced neuronal activation in mice: A c-Fos immunofluorescence study by Xingyao Yu, Pai Pang, Tao Liu, Xiufang Jiang, Jiayi Zhang, Xiangpei Yue, Jianjun Guo, Xiang Cheng, Tong Zhao, Yongqi Zhao, Zhonghua Dai, Lingling Zhu

“…To systematically characterize hypoxia-induced brain activation patterns, we conducted whole-brain mapping of neuronal activity changes in mice exposed to acute hypobaric hypoxia versus normoxic controls using c-Fos immunofluorescence, a robust marker of neuronal activation. …”
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Evaluating traditional Chinese medicine diagnostic instruments for functional dyspepsia: A systematic review on measurement properties by Leonard TF Ho, Vincent CH Chung, Charlene HL Wong, Irene XY Wu, Kun Chan Lan, Darong Wu, Jerry WF Yeung, Nevin L Zhang, Ting Hung Leung, Justin CY Wu

“…Background: Pattern diagnosis-guided treatments in Traditional Chinese Medicine (TCM) has been recognised by the eleventh revision of the International Classification of Diseases (ICD-11). …”
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Identification and functional characterization of the RPP13 gene family in potato (Solanum tuberosum L.) for disease resistance by Baoqi Yuan, Chuang Li, Qingfeng Wang, Qi Yao, Xiaowei Guo, Yuhang Zhang, Zhongwei Wang

“…The RPP13 gene family is known to play a pivotal role in plant disease resistance responses; however, its specific functions in potato remain unclear. In this study, we conducted the first comprehensive identification and analysis of 28 RPP13 gene family members in potato, examining their gene structures, chromosomal locations, expression patterns, and functional characteristics. …”
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Species and Functional Diversity of Bird Communities in Different Habitats in Shiquan River National Wetland Park, Tibet by Yang Wei, Jingshan Wang, Yi Guo, Chen Huang, Xu Li

“…Finally, the functional dispersion (FDis) results demonstrated a pattern of grass land > marsh land > bare land > water bodies, indicating a greater number of species with similar functional traits in grass habitats. …”
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Empirical assessment of functional somatic disorder (FSD): frequency, applicability, and diagnostic refinement in a population-based sample by Abigail Smakowski, Judith Rosmalen, Bernd Löwe, Christopher Burton, Anne Toussaint

“…In response, the international research network EURONET-SOMA has proposed a diagnostic classification for persistent and troublesome symptoms entitled “functional somatic disorder (FSD)”. Focusing on symptom patterns across organ systems, the FSD approach aims to enhance diagnosis, treatment, and healthcare access for patients. …”
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Study on the relationship between topological characteristics of vegetation ecospatial network and sand fixation function in the Mongolian Plateau

“…These findings can provide insights into optimizing vegetation patterns and enhancing sand fixation function. © 2025 The Authors…”
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Autonomic correlates of osteopathic manipulative treatment on facial functional mapping: an innovative approach based on thermal imaging by Francesco Cerritelli, David Perpetuini, Jordan Keys, Arcangelo Merla, Daniela Cardone

“…The comparative analysis of thermal maps and SCA results represents a significant advancement in our understanding of the physiological mechanisms underlying OMT’s effects on autonomic functions. By elucidating specific patterns of temperature change, correlation intensity and specific clusters, this research provides valuable insights for optimizing clinical practice and refining theoretical models of manual therapy.…”
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Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings. by Albert Batalla, Sagnik Bhattacharyya, Murat Yücel, Paolo Fusar-Poli, Jose Alexandre Crippa, Santiago Nogué, Marta Torrens, Jesús Pujol, Magí Farré, Rocio Martin-Santos

“…<h4>Background</h4>The growing concern about cannabis use, the most commonly used illicit drug worldwide, has led to a significant increase in the number of human studies using neuroimaging techniques to determine the effect of cannabis on brain structure and function. We conducted a systematic review to assess the evidence of the impact of chronic cannabis use on brain structure and function in adults and adolescents.…”
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Silent but significant: Functional elucidation of a synonymous ATP7B mutation in Wilson’s disease pedigrees by Qi Zhang, Qi Zhang, Xiaoming Xie, Hairong Li, Yulei Li, Hongyao Huang, Hongyao Huang

“…Bioinformatics tools (HSF, SpliceAI and ESEfinder 3.0) were used to predict the impact of mutations on the splicing function of precursor mRNA. The in vitro minigene experiment was conducted to verify the impact of the mutation on the splicing function of the precursor mRNA.ResultsWhole-exome sequencing of the proband identified a synonymous variant c.2145C&gt;T (p. …”
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Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia by Yunyun Yuan, Ya Zhao, Lingqiang Meng, Shuyun Zheng, Hui Li, Jiabao Ren, Beibei Li, Chenyun Dou, Yan Hou, Wenjing Chen, Jing Zhang, Jing Zhang, Yulin Ding, Yulin Ding, Wenjing Shen

“…Herein we aimed to identify novel LRP6 variants in patients with non-syndromic oligodontia (NSO) and perform functional analyses of these variants.Methods:Whole-exome sequencing (WES) was conducted on probands and their first-degree relatives to identify potential pathogenic variants. …”
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The Impact of Physical Activity on Metabolic Health and Cognitive Function in Postmenopausal Women: A Cross-Sectional Study by Kinga Mruczyk, Rafał W. Wójciak, Marta Molska, Ewa Śliwicka, Tomasz Podgórski, Aleksandra Skoczek-Rubińska, Anna Borowiecka, Angelika Cisek-Woźniak

“…The analyzed dietary pattern of the studied group shows slight deviations from current nutritional recommendations. …”
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Training protocol characteristics in studies comparing functional versus traditional training: systematic review of controlled trials by Jader Alfredo Beck, Jean Marlon Machado, Amandda de Souza, Cristiano Gomes Sanchotene, Fábio Hech Dominski, Caroline Ruschel

“… Introduction: Functional training and traditional training are widely used in rehabilitation and strength training, but their methodological differences remain debated. …”
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Integrative Genomic and Functional Approaches Identify FUOM as a Key Driver and Therapeutic Target in Cervical Cancer by Wenzhi Jiao, Shanshan Liu, Jianwei Shi, Minmin Yu

“…Methods MR analysis identified eQTL‐related genes with significant causal associations with cervical cancer. Functional enrichment and Gene Set Variation Analysis (GSVA) revealed their involvement in key pathways. scRNA‐seq explored cell‐specific expression patterns and immune cell infiltration in the tumor microenvironment (TME). …”
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Physical, Cognitive, Social, and Functional Health Correlates of Major Depressive Disorder Subtypes: A Systematic Review by Jen E. McKeough, Christopher F. Sharpley, Kirstan A. Vessey, Vicki Bitsika, Rebecca J. Williams, G. Lorenzo Odierna, Ian D. Evans

“…This systematic review examined the methods used to define several MDD subtypes and their associations with physical, cognitive, social, and functional health outcomes. Methods: A systematic search of PubMed was conducted in accordance with PRISMA 2020 guidelines to identify peer-reviewed studies published in English between 2014 and 2025. …”
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