An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primatesResearch in context by Beryl B. Cummings, Page R. Bouchard, Mark N. Milton, Peter F. Moesta, Vyas Ramanan, John W. Trauger, Eleftheria Maratos-Flier, Andrei Voznesensky, Igor Splawski, Amitabh V. Nimonkar, Keith DiPetrillo, Daniel LaSala, Meihui Pan, Meghan M. Flaherty, Francois Huet, Sukhdeep K. Sahambi, Jijun Dong, Deborah Knee, Regis Cebe, Thomas Huber, Joshua Lehrer-Graiwer, Rebecca A. Juliano, Ethan J. Weiss

“…Human ANGPTL4 loss-of-function (LoF) is associated with reduced plasma triglyceride (TG), remnant cholesterol (RC), and apolipoprotein B (ApoB) levels, and lower risk of type 2 diabetes and ASCVD, without observable safety concerns. …”
Get full text

Self-assembled hybrid hydrogel microspheres create a bone marrow-mimicking niche for bone regeneration by Zhi He, Peilun Hu, Zifan Li, Kaige Mao, Jingchuan Zheng, Chun-Yi Yang, Yuyang Luo, Jia Yang, Zheng Cao, Jingsong Lu, Xiaobin Luo, Sengpav Tong, Zhijun He, Kunkoo Kim, Yaosai Liu, Xiaodan Sun, Lingyun Zhao, Yongwei Pan, Yongping Cao, Yu Wang, Xiumei Wang

“…Drawing inspiration from the regenerative properties of BM, we developed self-assembled hybrid microspheres to replicate its function and address these challenges through a tissue engineering approach. …”
Get full text

Cell-Type-Specific Heat-Induced Changes in the Proteomes of Pollen Mother Cells and Microspores Provide New Insights into Tomato Pollen Production Under Elevated Temperature by Priya Thapa, Jun Guo, Kajol Pradhan, Dibya Thapa, Sudhakar Madhavarapu, Jing Zou, Jesse Potts, Hui Li, Joshua O’Hair, Chen Wang, Suping Zhou, Yong Yang, Tara Fish, Theodore W. Thannhauser

“…Background: Tomatoes are self-pollinating plants, and successful fruit set depends on the production of functional pollen within the same flower. Our previous studies have shown that the ‘Black Vernissage’ tomato variety exhibits greater resilience to heat stress in terms of pollen productivity compared to the ‘Micro-Tom’ variety. …”
Get full text

3D-printed porous tantalum for acetabular reconstruction in complex primary arthroplasty and revision of hip by Zonghan Wang, Zonghan Wang, Zonghan Wang, Ze Wang, Ze Wang, Ze Wang, Lingchuan Gu, Lingchuan Gu, Lingchuan Gu, Ying Zhang, Ying Zhang, Ying Zhang, Tiao Su, Tiao Su, Tiao Su, Jiangming Luo, Jiangming Luo, Jiangming Luo, Chengjun Huang, Chengjun Huang, Chengjun Huang, Xiaoyuan Gong, Xiaoyuan Gong, Xiaoyuan Gong, Yang Peng, Yang Peng, Yang Peng, Guangxing Chen, Guangxing Chen, Guangxing Chen

“…For individuals whose hip abnormalities stem from congenital issues, injuries, or previous operations, this procedure can encounter considerable obstacles, including complex bone defects, soft tissue deficiencies, and an increased risk of infections, which may result in poor alignment, joint instability, and higher need for revisions. …”
Get full text

A Telephone-based Physiotherapy Intervention for Patients with Osteoarthritis of the Knee by Adesola C Odole, Oluwatobi D. Ojo

“…<p>This study assessed the effects of a 6-week telephone based intervention on the pain intensity and physical function of patients with knee osteoarthritis (OA), and compared the results to physiotherapy conducted in the clinic. …”
Get full text

The changing face of the Arctic: four decades of greening and implications for tundra ecosystems by Gerald V. Frost, Uma S. Bhatt, Matthew J. Macander, Logan T. Berner, Donald A. Walker, Martha K. Raynolds, Rúna Í. Magnússon, Annett Bartsch, Jarle W. Bjerke, Jarle W. Bjerke, Howard E. Epstein, Bruce C. Forbes, Scott J. Goetz, Elizabeth E. Hoy, Elizabeth E. Hoy, Stein R. Karlsen, Timo Kumpula, Trevor C. Lantz, Mark J. Lara, Efrén López-Blanco, Paul M. Montesano, Paul M. Montesano, Christopher S. R. Neigh, Ingmar Nitze, Kathleen M. Orndahl, Taejin Park, Taejin Park, Gareth K. Phoenix, Adrian V. Rocha, Brendan M. Rogers, Gabriela Schaepman-Strub, Hans Tømmervik, Mariana Verdonen, Mariana Verdonen, Alexandra Veremeeva, Anna-Maria Virkkala, Christine F. Waigl

“…Nonetheless, long-term increases in NDVI—commonly known as “the greening of the Arctic”—remain prominent across large areas in all available long-term spaceborne datasets and align with long-term shifts in vegetation structure documented in disparate Arctic regions. …”
Get full text

Use of ICT to Confront COVID-19 by Yousry Saber El Gamal

“…<p style="text-align: justify;" align="center"><span style="text-align: justify;">The impact of COVID-19 outbreak has now become of grave concern for virtually every country in the world, and forced a majority of countries into partial or complete lockdowns. …”
Get full text

Use of gonadotropin-releasing hormone agonists in transgender and gender diverse youth: a systematic review by Gianluca Tornese, Gianluca Tornese, Raffaella Di Mase, Jessica Munarin, Silvia Ciancia, Fabiana Santamaria, Daniela Fava, Daniela Fava, Egidio Candela, Egidio Candela, Donatella Capalbo, Carla Ungaro, Nicola Improda, Pierluigi Diana, Patrizia Matarazzo, Laura Guazzarotti, Tommaso Toschetti, Vanessa Sambati, Gianluca Tamaro, Giulia Bresciani, Maria Rosaria Licenziati, Maria Elisabeth Street, Maria Elisabeth Street, Tommaso Aversa, Maurizio Delvecchio, Maria Felicia Faienza, Lorenzo Iughetti, Lorenzo Iughetti, Valeria Calcaterra, Valeria Calcaterra, Luisa de Sanctis, Mariacarolina Salerno, Roberto Franceschi, Roberto Franceschi

“…This pause in pubertal progression provides time to explore gender identity or facilitates alignment with affirmed gender in those with an established identity. …”
Get full text

Preliminary Study on Natural Infection of Shellfish with Movement Disorder Nodavirus (MDNV) by Ping LI, Jitao XIA, Changming BAI, Ruidong XU, Tingting XU, Shuang LIU, Liang YAO, Xingtong YU, Qingli ZHANG

“…Shellfish is an important source of high-quality protein for human beings and simultaneously plays an important ecological service function in the marine ecosystem. Shellfish aquaculture in China mainly focuses on marine shellfish, accounting for the highest proportion of the total marine aquaculture output in China. …”
Get full text

SCIENCE TEACHERS’ ICT USE FREQUENCY AND THE BARRIERS THEY WERE EXPOSED by Fatma TAŞKIN EKİCİ, Seçil DEMİRHAN, İzzet KARA, Erhan EKİCİ

“…Öğretmenlerin BİT ‘i dönemde birçok defa kullandıkları ve derslerinde teknoloji kullanımı konusunda karşılaştıkları engelleri çok önemli görmedikleri belirlenmiştir.</p><p align="center"><strong>Extended Abstracts</strong><strong></strong></p><p><strong>Introduction</strong></p><p>Developments in ICTs effect construct and function of educational initiatives and institutions and in the same time, change the expectations of several sectors (e.g. economy, industry and communication) from educational institutions. …”
Get full text

The actuator farm model for large eddy simulation (LES) of wind-farm-induced atmospheric gravity waves and farm–farm interaction by S. Stipa, A. Ajay, J. Brinkerhoff

“…Turbine force is distributed to the surrounding cells using a new projection function characterized by an axisymmetric spatial support in the rotor plane and Gaussian decay in the streamwise direction. …”
Get full text

Tertiary lymphoid structure-related score as a predictor for survival prognosis and immunotherapy response in head and neck squamous cell carcinoma by Fan Wu, Fan Wu, Haotian Cao, Haotian Cao, Siqi Ren, Siqi Ren, Jiaying Wu, Jiaying Wu, Xin Liu, Xin Liu, Qunxing Li, Qiuping Xu, Qiuping Xu, Jiali Chen, Jiali Chen, Ruixin Wang, Ruixin Wang, Suling Chen, Suling Chen, Shijia Kuang, Shijia Kuang, Binbin Xia, Yanyan Li, Yanyan Li, Liansheng Wang, Jintao Li, Bowen Li, Bowen Li, Jinsong Li, Jinsong Li, Tianjun Lan, Tianjun Lan

“…Additionally, we identify a specific subtype of T cells that might elucidate the mechanism of TLS function in anti-tumor activities. This T cell subtype holds the potential to be a prognostic marker and a target for adoptive cell therapy (ACT) in the future.…”
Get full text

LH Gene Cloning, Sequence Feature Analysis and Prokaryotic Expression in Conger myriaster by Yan CHEN, Bao SHI, Chenggang WANG, Wanjun BO, Kewen YAN, Meijun TAO, Xinyu ZHAO, Xiaodong MA

“…Through the signal peptide analysis and transmembrane domain analysis of LH protein, the first 1–22 amino acids function as signal peptides without containing any transmembrane domain. …”
Get full text

Constitutive model of metal rubber material considering plastic accumulation behavior by FENG Zhipeng, YANG Fang, FU Hailong, AI Shigang, WANG Yue, YUAN Liangyang

“…Metal rubber, as a novel functional material characterized by its unique three-dimensional reticulated porous structure, has demonstrated significant application value in aerospace engine mounts, aircraft landing gear buffer systems, satellite vibration damping devices, and precision vibration isolation systems for intelligent equipment, owing to its exceptional energy dissipation capacity, remarkable temperature resistance, and excellent environmental adaptability. …”
Get full text

從工具示能性與關係行動主體之觀點 探討偏鄉教育系統賦能策略之研究 Investigating the Construction of Empowerment Action Models in Remote Educational Systems Through the Lenses of Tool Affordance and Relational Age... by 陳佩英 Peiying Chen, 洪琴雯 Chin-Wen Hung

“…However, users’ behaviors can also exceed the original intentions of tool designers; that is, the flexible use of tools depends on users’ cognition of tool properties, the use of the tool’s own prompts, and the judgment of problems or environments to modify the use or function of the tool to achieve goals (Hammond, 2010). …”
Get full text

Clinical Sports Medicine by Joost T, Engel T, Risch L, Mayer F, Cassel M, 2

“…Problem Statement: In athletes with spondylolisthesis, segmental instability and impaired spinopelvic alignment are considered as clinically relevant. Functional MRI in supine and upright position enables a load-dependent acquisition, but neither the reposition effect nor the difference in the extent of inter-position-related differences has been investigated for their reliability. …”
Get full text

Handheld imageless robotic total knee arthroplasty improves accuracy and early clinical outcomes when compared with navigation by Joshua Yeuk-Shun Tran, Abbie Yan-Tung Tang, Cham-Kit Wong, Gloria Yan-Ting Lam, Tsz-Lung Choi, Rex Wang-Fung Mak, Jonathan Patrick Ng, Kevin Ki-Wai Ho, Michael Tim-Yun Ong, Patrick Shu-Hang Yung

“…Compared to ABN, RATKA provides a unique advantage by achieving greater accuracy in planned alignment, which may translate into improved functional recovery. …”
Get full text

Unraveling the Interfacial Carrier Behavior in PtSe2–MoSe2 Heterostructures: Insights from Combined Pump‐Probe Spectroscopy and Scanning Tunneling Microscopy by Weili Zhang, Hu Chen, Jiangbo Peng, Xiaoguang Pan, Hangxin Bai, Fangli Jing, Hailong Qiu, Zhanggui Hu, Yicheng Wu, Hongjun Liu

Get full text

Coordinated representations for naturalistic memory encoding and retrieval in hippocampal neural subspaces by Dasom Kwon, Jungwoo Kim, Seng Bum Michael Yoo, Won Mok Shim

“…Finally, the identified functional subspaces reflect the intrinsic functional organization of the hippocampus. …”
Get full text

Spatial resources in pre-service teachers’ instructional practices in VR tandems: co-constructing shared spaces and embodied spatial scaffolding by Milica Lazovic

“…The linguistic, perceptual, epistemological, and technical asymmetries within this setting necessitate scaffolding the co-participant through the virtual environment, guiding them in spatial exploration, orienting them to usability cues, leveraging spatial resources to support interactive and learning processes, developing embodied practices, and fostering mutual alignment. The analysis focuses on pre-service teachers’ use of spatial resources and their practices of embodied spatial scaffolding to support learning in three key areas: instructing on app functionality, developing new embodied action patterns, and fostering a functional understanding of virtual objects. …”
Get full text