Semantical and geometrical protein encoding toward enhanced bioactivity and thermostability by Yang Tan, Bingxin Zhou, Lirong Zheng, Guisheng Fan, Liang Hong

“…Protein engineering is a pivotal aspect of synthetic biology, involving the modification of amino acids within existing protein sequences to achieve novel or enhanced functionalities and physical properties. Accurate prediction of protein variant effects requires a thorough understanding of protein sequence, structure, and function. …”
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Spatial transcriptomic analysis of immune checkpoint blockade response in triple negative breast cancers with tertiary lymphoid structures by Richard H. Mebane, Teia Noel, Nathan Ing, Kenneth H. Gouin, III, Aagam Shah, David Zitser, Andrew Martinez, Gaorav Gupta, Sandra Demaria, Lorenzo Galluzzi, Alice Ho, Heather McArthur, Stephen L. Shiao, Simon.R.V. Knott

“…We developed a computational framework to align and analyze spatial trajectories between TLSs and tumor beds. …”
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Effectiveness of resistance training of masticatory muscles for patients with temporomandibular disorders: protocol for a systematic review by Deborah Falla, Filippo Maselli, Giacomo Asquini, Andrea Giusti, Giulia Pisacane, Giovanni Galeoto, Firas Mourad, Paolo Bizzarri, Edoardo Balli, Cecilia Bagnoli, Anna Manzari, Marco Pernici

“…Resistance training (RT) has been shown to be effective at reducing pain and improving function for different musculoskeletal conditions (eg, neck pain, low back pain); however, the effectiveness of RT for patients with TMDs remains unclear. …”
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Postoperative anterior knee pain in robot assisted total knee arthroplasty: a propensity score matching analysis by Jiajie Yan, Shuangshuang Deng, Qiuyan Chen, Ning Liu, Songwei Huan, Min Zheng, Jiamin Zhang, Yanyan Gao

“…This study aimed to evaluate the medium- and long-term effects of RA-TKA on AKP intensity, functional outcomes, and knee mobility compared to CM-TKA. …”
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Feasibility of Observing Glymphatic System Activity During Sleep Using Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) Index by Chang-Soo Yun, Chul-Ho Sohn, Jehyeong Yeon, Kun-Jin Chung, Byong-Ji Min, Chang-Ho Yun, Bong Soo Han

“…The Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) index has been proposed as a non-invasive marker of glymphatic function by measuring diffusivity along perivascular spaces; however, its sensitivity to sleep-related changes in glymphatic activity has not yet been validated. …”
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The spectrum of embodied intersubjective synchrony in empathy: from fully embodied to externally oriented engagement in Parkinson's disease by Antonia Zepeda, Alejandro Troncoso, Daniela Pizarro, Constanza Baquedano, Rodrigo Gomez, Silvia Barria, Kevin Blanco, David Martínez-Pernía, David Martínez-Pernía

“…BackgroundParkinson's disease is a prevalent neurodegenerative disorder that not only affects motor function but also impairs empathy. While the neurobiological changes underlying these deficits are known, the impact of PD on the lived experience of empathy remains poorly understood. …”
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A Reflection on the Visual Representation of Nationalism Discourse in Iran During the Qajar Period (A Case Study of Qajar Newspaper Images as Cultural Texts of the Modernization Pe... by Shadi Taki, Sedaghat Jabbari Kalkhoran, Yaghoub Azhand

“…In response to this question, the formation and function of modern nationalist thought and the process of its discursive development within the context of its related codes will first be explored. …”
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Enhancing underwater acoustic communication networks with RIS: Precise performance analysis over κ − μ shadowed fading distribution by Moloy Kumar Ghosh, Mostafa Zaman Chowdhury

“…To evaluate these impacts, the novel closed-form expressions of three essential performance metrics: outage probability (OP), average bit error rate (ABER), and average channel capacity (ACC) are derived in terms of Meijer-G function. To offer deeper insights, the asymptotic behaviors of these performance metrics are also demonstrated. …”
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Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation by Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Zen-Ichi Tanei, Shinya Tanaka, Norimasa Iwasaki

“…Case presentation A 58-year-old female with progressive right knee pain, varus alignment, and Kellgren-Lawrence grade 3 osteoarthritis underwent atelocollagen-associated ACI combined with medial opening wedge high tibial osteotomy. …”
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Evaluating the Effectiveness of InsightApp for Anxiety, Valued Action, and Psychological Resilience: Longitudinal Randomized Controlled Trial by Victoria Amo, Falk Lieder

“…Furthermore, individuals in the treatment group demonstrated a 7% higher tendency to align their actions with their values compared to the control group (t197=3.23; P=.002). …”
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Development process, principles and adaptive technologies for rock and soil layer reconstruction in open-pit coal mines by Zhenqi HU, Zixuan ZHANG, Huang SUN

“…The Critical Layer Reconstruction Principle focuses on identifying and enhancing key functional layers through ecological function analysis and optimization measures. …”
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Cloning, sequence and expression analysis of two SOC1 genes from Anthurium by MA Guangying, ZHU Kaiyuan, SHI Xiaohua, ZOU Qingcheng, LIU Huichun, ZHAN Jing, TIAN Danqing

“…Preliminary analysis of their characteristics, structure, and potential function were performed through bioinformatics software, combined with multiple sequence alignment and phylogenetic tree construction. …”
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Clinical Measures Associated With Tibial Torsion in Ambulatory Children With Cerebral Palsy and Pes Valgus by Eva Ciccodicola, PT, DPT, PCS, Oussama Abousamra, MD, Veronica Beltran, BS, Susan A. Rethlefsen, PT, DPT, Tishya A.L. Wren, PhD

“…Background: Transverse plane alignment deviations in individuals with cerebral palsy (CP) contribute to lever arm dysfunction. …”
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Tracking Lava Flow Cooling from Space: Implications for Erupted Volume Estimation and Cooling Mechanisms by Simone Aveni, Gaetana Ganci, Andrew J. L. Harris, Diego Coppola

“…Beyond volume estimation, we show that VRP_TIR cooling curves follow a consistent decay pattern that aligns with established theoretical thermal models, indicating a stable conductive regime during the cooling stage. …”
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Global transcriptome modulation by xenobiotics: the role of alternative splicing in adaptive responses to chemical exposures by Andrew J. Annalora, Jacki L. Coburn, Antony Jozic, Patrick L. Iversen, Craig B. Marcus

“…A 3D-clustergram integrating KEGG pathway analysis with differential gene expression provided distinct splicing landscapes for each xenobiotic, showing that splicing diversity does not always align with gene expression changes. Results Endpoint PCR revealed a Cyp2b2v to wild-type Cyp2b2 splicing ratio near 1:1 (100%) under most conditions, while RNA-seq showed a stable baseline closer to 40%. …”
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All‐Level Versus Alternative‐Level in Unilateral Laminoplasty: A Retrospective Comparative Study by Bin Zheng, Zhenqi Zhu, Yan Liang, Haiying Liu

“…The Japanese Orthopaedic Association (JOA) score is used for neurological function evaluation, while pain is assessed with the Visual Analog Scale (VAS). …”
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Surgical ICU Admission Criteria: A Scoping Review by Kenneth L. Abbott, MD, Philip Hong, MD, Matthew M. Ruppert, MS, Purvi P. Patel, MD, MHPE, FACS, Philip A. Efron, MD, FACS, FCCM, Natasha Keric, MD, MBA, FACS, Lewis J. Kaplan, MD, FACS, FCCP, FSIS, MCCM, Niels D. Martin, MD, FACS, FCCM, Tyler J. Loftus, MD, PhD, FACS

“…Abstracted data addressed SICU structure, function, findings, and potential future directions. …”
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Kernel Density Estimation: a novel tool for visualising training intensity distribution in biathlon by Craig A. Staunton, Craig A. Staunton, Andreas Kårström, Andreas Kårström, Hannes Kock, Hannes Kock, Marko S. Laaksonen, Glenn Björklund

“…Incorporating KDE plots into training monitoring could improve training alignment, helping reduce overtraining or undertraining risks and optimising athlete development.…”
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Deconvolving X-Ray Galaxy Cluster Spectra Using a Recurrent Inference Machine by Carter Lee Rhea, Julie Hlavacek-Larrondo, Alexandre Adam, Ralph Kraft, Ákos Bogdán, Laurence Perreault-Levasseur, Marine Prunier

“…In this article, we present a methodology to disentangle the intrinsic X-ray spectrum of galaxy clusters from the instrumental response function. Employing state-of-the-art modeling software and data mining techniques of the Chandra data archive, we construct a set of 100,000 mock Chandra spectra. …”
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Computer‐Aided High Tibial Osteotomy—A Comparative Study of Commonly Used 3D Printing Technology and Navigation Application by Elvis Chun‐Sing Chui, Kyle Ka‐Kwan Mak, Randy Hin‐Ting Ng, Ericsson Chun‐Hai Fung, Mei‐Shuen Chan, Kai Yue, Lawrence Chun‐Man Lau, Clifford Long‐Fung Chan, Edmond Wing‐Fung Yau, Wei Zhao, Xiuyun Su, Jin Zhang, Jianglong Xu, Hongxun Sang, Guoxian Pei, Louis Wing‐Hoi Cheung, Sheung‐Wai Law, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung

“…Proper execution of HTO can preserve joint function and delay or avoid the need for total knee replacement. …”
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