Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets by Ansarullah, Colette Free, Jenica Christopherson, Quanhai Chen, Jie Gao, Chengyang Liu, Ali Naji, Alex Rabinovitch, Zhiguang Guo

Get full text

Two New 1,1,3,3-Tetramethylguanidinium Halochromates (C5H14N3CrO3X) (X: Cl, F): Efficient Reagents for Oxidation of Organic Substrates under Solvent-Free Conditions and Microwave I... by Kıvılcım Şendıl, H. Beytiye Özgün, Ebru Üstün

“…Two new mild oxidizing agents 1,1,3,3-tetramethylguanidinium fluorochromate (TMGFC) and 1,1,3,3-tetramethylguanidinium chlorochromate (TMGCC) were prepared in high yields by reacting tetramethylguanidine with CrO3 and related acid. …”
Get full text

PARP inhibitor‐based treatment in metastatic, castration‐resistant prostate cancer (mCRPC): A systematic review and meta‐analysis by Michela Roberto, Mattia Alberto Di Civita, Daniele Marinelli, Andrea Torchia, Nertila Cara, Giulia Maltese, Iolanda Speranza, Daniele Santini

“…Abstract Background We present a systematic review and meta‐analysis of randomized clinical trials (RCTs) with PARPi either as monotherapy or in combination with an androgen receptor‐targeted agent (ARTA) in first‐ and second‐line settings. …”
Get full text

The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future by S. E. Richardson, C. McNamara

Get full text

Application of ZnO Semiconductor Nanomaterial Ink in Packaging and Printing Design by Changjian Guo

“…The method uses zinc acetate dihydrate as raw material, ethylenediamine as a complexing agent, absolute ethanol as a solvent, and ethyl cellulose as an auxiliary agent to prepare particle-free ZnO functional ink. …”
Get full text

New Photosensitizers for Photodynamic Therapy in Gastroenterology by SG Bown, AZ Rogowska

Get full text

A Study on Deep Learning Based Parking Lot Allotment to the Vehicles by Aziza Algarni

“…Parking a vehicle in dense traffic environments often leads to excessive driving time in search of free space, which leads to congestion and environmental pollution. …”
Get full text

Outcomes of Six-Dose High-Dose Cytarabine as a Salvage Regimen for Patients with Relapsed/Refractory Acute Myeloid Leukemia by Brandi Anders, Lauren Veltri, Abraham S. Kanate, Alexandra Shillingburg, Nilay Shah, Michael Craig, Aaron Cumpston

“…Relapsed/refractory acute myeloid leukemia (RR-AML) is associated with poor prognosis and long-term disease-free survival requires allogeneic hematopoietic cell transplantation (allo-HCT). …”
Get full text

UNHEARD/HEARD VOICES IN EXODUS 1-17 AND SOME THOUGHTS ON POVERTY IN SOUTH AFRICA by J.S. Van der Walt

Get full text

Preparation and characterization of simvastatin/DMβCD complex and its pharmacokinetics in rats by Gu Fugen, Ning Jia, Fan Huimin, Wu Chunzhi, Wang Yi

“…Main pharmacokinetic parameters such as tmax, cmax were significantly different (p < 0.01) between the simvastatin complex and free drug. Bioavailability of the simvastatin complex relative to free drug was up to 167.0 %.…”
Get full text

In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from Paecilomyces hepiali by Akang Dan, Yushi Chen, Yongqi Tian, Shaoyun Wang

“…The purpose of this study was to explore the potential of the development and application of Paecilomyces hepiali, a fungus with edible and medicinal value, as a foodborne antioxidant and anti-aging agent. Its n-butanol extract (PHE) from rice cultures was selected for anti-aging experiment because of significant free radical scavenging activity in vitro. …”
Get full text

Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses by Jiayu Song, Yuan Ren, Lihua Liu, Yixin Wang, Chuandao Shi, Xiaoqing Ji, Yunlan Li, Qingshan Li

“…Di-n-butyl-di-(4-chlorobenzohydroxamato) tin(IV) (DBDCT), a new patent agent, exhibited strong antitumor activity. In some cases, its activity was close to or even higher than cisplatin, a first-line clinical metallic agent. …”
Get full text

Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases by Alireza Ebrahimi, Amirhossein Kamyab, Sahar Hosseini, Sedigheh Ebrahimi, Soheil Ashkani-Esfahani

“…This study reviews the literature to highlight this agent’s potential therapeutic effects in the mentioned neurological disorders.…”
Get full text

Patient Care and Support Measures Overcome Reluctance to Initiate New Regimen Containing Enfuvirtide by Benoit Trottier

“…Because the introduction of a new drug class can substantially enhance the efficacy of an antiretroviral regimen, supporting the patient in the introduction of enfuvirtide, a safe and efficacious agent in a new class, offers therapeutic benefits. …”
Get full text

Absential Suspension: Malebranche and Locke on Human Freedom by Julie Walsh

“…This paper treats a heretofore-unnoticed concept in the history of the philosophical discussion of human freedom, a kind of freedom that is not defined solely in terms of the causal power of the agent. Instead, the exercise of freedom essentially involves the non-occurrence of something.That being free involves the non-occurrence, that is, the absence, of an act may seem counterintuitive. …”
Get full text

Problem of contagious bovine pleuropneumonia by A. V. Piskunov, A. V. Kononov, A. V. Mischenko

“…Today, there is a huge risk of the agent introduction with animals and raw material exported from affected endemic areas of Africa to the areas free from contagious bovine pleuropneumonia (including Eurasia).…”
Get full text

Synthesis and Antioxidative Activity of Piperine Derivatives Containing Phenolic Hydroxyl by Bei Qin, Kuan Yang, Ruijun Cao

“…This study synthesized novel piperine derivatives for use as potential antioxidant agent candidates.…”
Get full text

Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…., sequence and timing of agent administration; drug selectivity; compatibility of combined therapies i.e., adoptive T cell or agents, i.e., MEK inhibitor trametinib, PD-1 and PDL-1 blockers). …”
Get full text

Jesus talks to the Samaritan woman by P. Rule

Get full text

Crohn’s Disease – The Pathogenesis of a Granulomatous Vasculitis: A Hypothesis by Andrew J Wakefield

Get full text