NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

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One Health: potential synergy between infectious and toxic agents. The case of COVID-19 by Jorge Herkovits

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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

“…These molecules inhibiting the aldose reductase, the key enzyme of the polyol pathway, can be developed as therapeutic agents to manage diabetic complications. However, we recommend in vitro and in vivo studies to confirm our findings.…”
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Interferon-free therapy of chronic hepatitis C: replacement of medications or new treatment paradigm? by S. N. Batskikh

“…A critical estimation of interferon-free modes of antiviral therapy (AVT) of chronic hepatitis C (CHC) according to the analysis of clinical studies.Key points. …”
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Physiological impact of Trichoderma viride agents on the quality and production of melon that is grown on soils continuously cropped to melon by Jingyi Liu, Hua Lian, Jingwei Dou, Jingjing Li, Guangliang Zhu, Jiatong Wang, Guangshu Ma, Mei Li

“…The results showed that different amounts of T. viride agents could improve physiological and biochemical indices of melon leaves during the fruiting stage; the treatment of 6.4 × 105 CFU/g was the most effective; chlorophyll content, nitrate nitrogen content, sucrose content, reducing sugar content, free proline content, nitrate reductase (NR) activity, peroxidase (POD) activity, and superoxide dismutase (SOD) activity of melon leaves increased at 30 days after melon pollination. …”
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Assessment of the essential oil extracted from Citrus aurantifolia leaves using solvent-free microwave extraction technique by G.M. Masud Rana, Md. Jasim Uddin, Jaytirmoy Barmon, Bijoy Chandra Ghos, Tahmina Akter Chowdhury, Amit Kumar Dey, Bijoy Maitra, Ismat Moin Tamanna, AHM Mahbubur Rahman, Barun Kanti Saha, Mst. Sarmina Yeasmin

“…Essential oil (EO) extracted from Bangladeshi C. aurantifolia leaves was evaluated for its potential to act as a bioactive, antioxidant, and antibacterial agent. EO was obtained from C. aurantifolia leaves using solvent-free microwave extraction (SFME). …”
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Opioid-free versus opioid-based anesthesia in laparoscopic sleeve gastrectomy: a single-center, randomized, controlled trial by Hanane Barakat, Linda Gholmieh, Jessy Abou Nader, Vanda Yazbeck Karam, Obey Albaini, Mohamad El Helou, Rony Al Nawwar

“…This study aims to investigate the efficacy of opioid-free anesthesia (OFA) compared to traditional opioid-based anesthesia (OBA) in patients undergoing laparoscopic sleeve gastrectomy. …”
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Antibacterial mechanism of Lactiplantibacillus plantarum SHY96 cell-free supernatant against Listeria monocytogenes revealed by metabolomics and potential application on chicken br... by Ming Liang, Hongwei Wang, Zhaoquan Zhou, Yechuan Huang, Huayi Suo

“…The cell-free supernatant of Lactiplantibacillus plantarum (LCFS) is considered a potential natural antimicrobial agent due to its outstanding antimicrobial activity. …”
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UNHEARD/HEARD VOICES IN EXODUS 1-17 AND SOME THOUGHTS ON POVERTY IN SOUTH AFRICA by J.S. Van der Walt

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Jesus talks to the Samaritan woman by P. Rule

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African theological education and its curriculum responsiveness towards African Union’s Agenda 2063. by M. Naidoo

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PANDEMIC OASIS: POPULAR RELIGIOSITIES AS WOMEN’S LIFE-GIVING COMMUNITAS by K.F. Chan

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5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects by Liangliang Hu, Ting Meng, Davies Marabada, Zhichao Jin, Qing Huang, Shijie Wei, Zhizhong Wang

“…5-Fluorouracil (5-FU) serves as a first-line therapeutic agent for colorectal cancer, however, its utility is limited by a short half-life and significant cytotoxicity. …”
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Anti-constitutional activities and cover organisations of national-socialist movement in Klaipėda region in 1935-1937 by Mindaugas Valiukevičius

“…A broad agent network had been established - informants and cooperatives had been recruited in „larger Lithuania" and its state institutions. …”
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Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment by Chengyang Zhu, Zun Fan, Zhijie Cheng, Jun Yin, Lei Qin, Xin Zhao

“…Therefore, the combined advantages of microneedles-based patch system and MPNs-based nanotherapeutic agent are explored for the first time, and our proposed Cu-Cur-NMs represent a multifunctional and promising device for CSTDs repair.…”
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A novel chitosan microsphere as food processing enzyme immobilization carrier and its application in nucleotide production by Xiao-Yan Yin, Rui-Fan Yang, Zhong-Hua Yang

“…The activity recovery yield reach to 75 %. Compared to the free NP1, the stability of NP1@CSMs-GA was significantly enhanced. …”
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Reducing the effective dose of doxycycline using chitosan silver nanocomposite as a carriers on gram positive and gram-negative bacteria by Elham M. Mostafa, Y. Badr, M. M. Hashem, K. Abo-EL-Sooud, Amna H. Faid

“…This combined therapeutic agent restored the susceptibility of doxy and showed an antibacterial activity against tested bacteria. …”
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Efficacy and safety of new protease inhibitor faldaprevir in treatment of hepatitis C by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…Significant progress was achieved in development of new modes of antiviral treatment of patients with the 1st HCV genotype due to introduction of the third agent possessing direct antiviral action. Faldaprevir (BI-201335) is NS3/4A protease inhibitor with long-term half-life period that allows once per day dosing. …”
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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

“…The primary endpoint is progression-free survival at 6 months. Secondary objectives include assessment of overall survival, response rate, safety and quality of life measures. …”
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Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy by Diana Peixoto, João M. Ravasco, Barbara Blanco-Fernandez, Francisco Veiga, Angel Concheiro, João Conde, Ana Cláudia Paiva-Santos, Carmen Alvarez-Lorenzo

“…The findings reported here indicate that VD3S-PEG micelles may have a promising role in PDAC therapy, since VD3 could act not only as a hydrophobic core of the micelles but also as a therapeutic agent that provides synergetic therapeutic effects with the encapsulated PTX.…”
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