An immune activator encapsulating PD-L1 siRNA for augmented immune checkpoint blockade immunotherapy through Zn2+ overload triggered pyroptosis by Liming Gong, Yanhong Liu, Jing Feng, Congcong Xiao, Chenfei Liu, Bohan Chen, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao, Wei Huang

“…Pyroptosis is an inflammatory form of programmed cell death mediated by Caspase-1/GSDMD pathway, which can cause immunogenic cell death (ICD) and boost the immunogenicity of tumor. …”
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‘A good decision is the one that feels right for me’: Codesign with patients to inform theoretical underpinning of a decision aid website by Kelly Kohut, Kate Morton, Karen Hurley, Lesley Turner, The CanGene‐CanVar Patient Reference Panel, Caroline Dale, Susan Eastbrook, Rochelle Gold, Kate Henwood, Sonia Patton, Reshma Punjabi, Helen White, Charlene Young, Julie Young, Elizabeth Bancroft, Lily Barnett, Sarah Cable, Gaya Connolly, Beth Coad, Andrea Forman, Helen Hanson, Grace Kavanaugh, Katherine Sahan, Katie Snape, Bethany Torr, Rosalind Way, Elizabeth Winchester, Alice Youngs, The International Lynch Decision Aid Stakeholder Panel, Diana Eccles, Claire Foster

“…There was no one ‘best fit’ theory to target support needs in a PtDA, suggesting an inductive, flexible framework approach to programme theory would be most effective. …”
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Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid ca... by Yan Liu, Matthew Zibelman, Timothy Chan, Justin Guinney, Douglas Adkins, Ezra E W Cohen, Michelle M Stein, Halla Nimeiri, Sandip P Patel, Alia D Zander, Rossin Erbe, Ailin Jin, Sayantoni Mukhopadhyay, Ben Terdich, Mario G Rosasco, Nirali Patel, Chithra Sangli, Timothy Taxter, Seung Won Hyun, Brett M Mahon, A Kate Sasser, Michelle A Ting-Lin, Kyle A Beauchamp

“…The IPS model was developed using a machine learning framework that includes tumor mutational burden (TMB) and 11 RNA-based biomarkers as features.Results IPS-High patients demonstrated significantly longer overall survival (OS) compared with IPS-Low patients (HR=0.45, 90% CI (0.40 to 0.52)). …”
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Heat stress-induced genomic instability in neural stem cells and its association with neuronal developmental deficits by Zeze Wang, Zhen Luo, Yulong Tan, Xue Luo, Xuesen Yang

“…The ''first hit'' is an acute disruption of developmental programming via a p53-p21-mediated response to DNA damage. …”
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Multidimensional comparative evaluation of first-line therapies for extensive-stage small cell lung cancer: a systematic review and network meta-analysis of clinical efficacy and s... by Ziyao Jiang, Fangrui Zhao, Butuo Li, Junyi He, Huiwen Yang, Yuhan Ji, Bing Zou, Jinming Yu, Linlin Wang

“…Therefore, this study employs a comprehensive multidimensional evaluation framework to identify optimized therapeutic combinations with enhanced efficacy and improved safety profiles in the immunotherapy era. …”
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Innovation in the blue economy and environmental sustainability in marine and fisheries strategy by S.W. Trenggono, I. Meilano, H. Latief, S.D. Diantara, W. Sakti, D.G.K. Ketaren, I.N.P. Winata, T. Yuwono, Syamdidi , F.Y. Arthatiani, K. Kasim, I.N. Radiarta

“…BACKGROUND AND OBJECTIVES: The Ministry of Marine Affairs and Fisheries of Indonesia has introduced its Blue Economy framework to promote sustainable use of marine and fishery resources while ensuring ecosystem protection. …”
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Suicidality Treatment Occurring in Paediatrics (STOP) Medication Suicidality Side Effects Scale in young people in two cohorts across Europe by David Coghill, Jatinder Singh, Federico Fiori, Paramala Santosh, Kate Lievesley, Diane Purper-Ouakil, Ulrike Schulze, Pieter J Hoekstra, Alessandro Zuddas, Ralf W Dittmann, Jan K Buitelaar, Celso Arango, Mohapradeep Mohan, Nathan Parnell, Regina Sala, Josefina Castro-Fornieles, Itziar Flamarique, Cloe Llorente

“…Objectives As part of the ‘Suicidality: Treatment Occurring in Paediatrics (STOP)’ study, we developed and performed psychometric validation of an electronic-clinical-outcome-assessment (eCOA), which included a patient-reported-outcome (ePRO), an observer-rated-outcome (eObsRO) for parents/carers and a clinician-reported-outcome (eClinRO) that allows identification and monitoring of medication-related suicidality (MRS) in adolescents.Design STOP: Prospective study: A two phase validation study to assess the impact of medication on suicidal ideations.Setting Six participating countries: Netherlands, UK, Germany, France, Spain and Italy that were part of the Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 261411.Participants Cohort 1 consisted of 41 adolescent-completions, 50 parent-completions and 56 clinician-completions. …”
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Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma by Ge Zhang, Zhenfa Zhang, Lianmin Zhang, Guangyao Zhou, Pengpeng Zhang, Dingli Wang, Shuai Jiang

“…Significantly, suppression of B4GALT2 was found to enhance CD8+ T lymphocyte populations and their functional status, thereby potentiating anti-programmed cell death protein 1 immunotherapeutic efficacy in animal studies. …”
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Pre-Implementation Assessment of a Sexual Health eClinic in Canadian Oncology Care by Taylor Incze, Dalia Peres, Steven Guirguis, Sarah E. Neil-Sztramko, Jackie Bender, Dean Elterman, Shabbir M. H. Alibhai, Antonio Finelli, Phil Vu Bach, Emily Belita, Gerald Brock, Julia Brown, Jeffrey Campbell, Trustin Domes, Andrew Feifer, Ryan Flannigan, Celestia Higano, Jesse Ory, Premal Patel, Monita Sundar, Luke Witherspoon, Andrew Matthew

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Quantitative release assessment for beta-lactamase-producing Escherichia coli of dairy origin into vegetables by Kohei Makita, Dongsheng Zhang, Ayaka Okamura, Akira Fukuda, Natsumi Tokunaga, Tetsuo Asai, Yoko Shimazaki, Masaru Usui

“…Data on the indicated diseases and antimicrobial use in dairy cattle were obtained from the agricultural insurance program in Hokkaido Prefecture between 2016 and 2019. …”
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FACTORS ASSOCIATED WITH ANXIETY AND DEPRESSION SPECTRUM DISORDERS IN BEHCHET’S DISEASE by P. S. Ovcharov, T. A. Lisitsyna, D. Yu. Veltishchev, O. F. Seravina, O. B. Kovalevskaya, S. I. Glukhova, Z. S. Alekberova, E. L. Nasonov

“…This investigation was conducted within the framework of the interdisciplinary scientific program «Stress factors and mental disorders in rheumatic diseases». …”
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A 3D Clinical Face Phenotype Space of Genetic Syndromes Using a Triplet-Based Singular Geometric Autoencoder by Soha S. Mahdi, Eduarda Caldeira, Harold Matthews, Michiel Vanneste, Nele Nauwelaers, Meng Yuan, Giorgos Bouritsas, Gareth S. Baynam, Peter Hammond, Richard Spritz, Ophir D. Klein, Michael Bronstein, Benedikt Hallgrimsson, Hilde Peeters, Peter Claes

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Empowering bioinformatics communities with Nextflow and nf-core by Björn E. Langer, Andreia Amaral, Marie-Odile Baudement, Franziska Bonath, Mathieu Charles, Praveen Krishna Chitneedi, Emily L. Clark, Paolo Di Tommaso, Sarah Djebali, Philip A. Ewels, Sonia Eynard, James A. Fellows Yates, Daniel Fischer, Evan W. Floden, Sylvain Foissac, Gisela Gabernet, Maxime U. Garcia, Gareth Gillard, Manu Kumar Gundappa, Cervin Guyomar, Christopher Hakkaart, Friederike Hanssen, Peter W. Harrison, Matthias Hörtenhuber, Cyril Kurylo, Christa Kühn, Sandrine Lagarrigue, Delphine Lallias, Daniel J. Macqueen, Edmund Miller, Júlia Mir-Pedrol, Gabriel Costa Monteiro Moreira, Sven Nahnsen, Harshil Patel, Alexander Peltzer, Frederique Pitel, Yuliaxis Ramayo-Caldas, Marcel da Câmara Ribeiro-Dantas, Dominique Rocha, Mazdak Salavati, Alexey Sokolov, Jose Espinosa-Carrasco, Cedric Notredame, the nf-core community

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Transformation in the Socio-Political Positions of the Liberation Movement of the People of Iran/JAMA (1963–1979): From Theistic Socialism to Revolution and Islamic Government by Mehdi Zamani

“…The ideology in question was theistic socialism, which emphasized moral and humanistic socialism while grounding itself in a religious identity with a monotheistic framework. Politically, JAMA sought to overthrow the monarchy and establish a democratic system characterized by justice and labor. …”
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Stem rust in Western Siberia – race composition and effective resistance genes by V. P. Shamanin, I. V. Pototskaya, S. S. Shepelev, V. E. Pozherukova, E. A. Salina, E. S. Skolotneva, D. Hodson, M. Hovmøller, M. Patpour, A. I. Morgounov

“…The third  set included spring bread wheat varieties created in the Omsk State Agrarian University within the framework of  a shuttle breeding program, with a synthetic wheat with the Ae. tauschiigenome in their pedigrees. …”
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Antimicrobial Stewardship and Infection Prevention and Control in the Veneto Region, Northeastern Italy: Governance Models, Resources, and Key Challenges Across Hospital and Commun... by Paola Anello, Stefano Vianello, Vincenzo Baldo, Enrica Frasson, Umberto Gallo, Roberta Rampazzo, Milvia Marchiori, Mara Carraro, Sara Marchiori, Marta Pigozzo, Vinicio Manfrin, Annarita Mazzariol, Paola De Ambrosis, Davide Gentili, Michele Tonon, Romina Cazzaro, Giovanna Scroccaro, Francesca Russo, Daniele Mengato

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How firearm legislation impacts firearm mortality internationally: A scoping review by Brianna Greenberg, Alexandria Bennett, Asad Naveed, Raluca Petrut, Sabrina M. Wang, Niyati Vyas, Amir Bachari, Shawn Khan, Tea Christine Sue, Nicole Dryburgh, Faris Almoli, Becky Skidmore, Nicole Shaver, Evan Chung Bui, Melissa Brouwers, David Moher, Julian Little, Julie Maggi, Najma Ahmed

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Early findings from the integration of hypertension care into differentiated service delivery models for HIV in Uganda: a mixed‐method study by John Baptist Kiggundu, Fred C. Semitala, Chelsea Faith Lipoto, Lilian Giibwa, Robert Twine, Savio Mwaka, Florence Ayebare, Christine Kiwala, Evelyn N. Magambo, Gerald Mutungi, Isaac Ssinabulya, Donna Spiegelman, James Kayima, Martin Muddu, Jeremy I. Schwartz, Anne R. Katahoire, Chris T. Longenecker

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A multi-component, community-based strategy to facilitate COVID-19 vaccine uptake among Latinx populations: From theory to practice. by Carina Marquez, Andrew D Kerkhoff, Jamie Naso, Maria G Contreras, Edgar Castellanos Diaz, Susana Rojas, James Peng, Luis Rubio, Diane Jones, Jon Jacobo, Susy Rojas, Rafael Gonzalez, Jonathan D Fuchs, Douglas Black, Salustiano Ribeiro, Jen Nossokoff, Valerie Tulier-Laiwa, Jacqueline Martinez, Gabriel Chamie, Genay Pilarowski, Joseph DeRisi, Maya Petersen, Diane V Havlir

“…We evaluated our prototype outdoor, "neighborhood" vaccination program located in a central commercial and transport hub in the Mission District in San Francisco, using the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework during a 16-week period from February 1, 2021 to May 19, 2021. …”
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Development and implementation of Phleos, a web-based tool for the data collection on Hypereosinophilic syndrome: the Italian Network on HES (INHES) study protocol by Stefania Nicola, Stefania Nicola, Marco Caminati, Marco Caminati, Richard Borrelli, Luca Lo Sardo, Federica Corradi, Iuliana Badiu, Angelo Vacca, Palma Carlucci, Amato De Paulis, Amato De Paulis, Ilaria Mormile, Marco Zurlo, Marco Zurlo, Mario Di Gioacchino, Vincenzo Patella, Vincenzo Patella, Stefano Del Giacco, Giulia Costanzo, Simone Negrini, Simone Negrini, Giovanni Rolla, Luisa Brussino

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