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    Evaluation of the Development, Implementation, Maintenance, and Impact of 3 Digital Surveillance Tools Deployed in Malawi During the COVID-19 Pandemic: Protocol for a Modified Delp... by Alanna Denny, Isaach Ndemera, Kingston Chirwa, Joseph Tsung Shu Wu, Griphin Baxter Chirambo, Simeon Yosefe, Ben Chilima, Matthew Kagoli, Hsin-yi Lee, Kwong Leung Joseph Yu, John O'Donoghue

    Published 2024-12-01
    “…ResultsThe ability of a country to collate, diagnose, monitor, and analyze data forms the cornerstone of an efficient surveillance system, allowing countries to plan and implement appropriate control actions. …”
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    After action review of the response to an outbreak of Lassa fever in Sierra Leone, 2019: Best practices and lessons learnt. by Charles Njuguna, Mohamed Vandi, Evans Liyosi, Jane Githuku, James Sylvester Squire, Ian Njeru, Ian Rufus, Victoria Katawera, Wilson Gachari, Robert Musoke, Claudette Amuzu, Mukeh Fahnbulleh, Joseph Bunting-Graden, Janet Kayita, James Bunn, Ambrose Talisuna, Zabulon Yoti

    Published 2022-10-01
    “…A standardized template was used to report on the key findings on what happened, what was supposed to happen, what went well and lessons learnt.<h4>Results</h4>This was a hospital associated outbreak that likely occurred due to a breach in infection prevention and control (IPC) practices resulting in three health workers being infected during a surgical operation. …”
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    La gestion de l’eau à Bibracte (Saône-et-Loire), avant et après la Conquête romaine by Laetitia Borau

    Published 2020-12-01
    “…Water was evacuated from the basin via a square hole cut in the bottom of the basin, sealed by a sluice gate operated vertically from the outside and connected to a system of pipes built from wooden boards. …”
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    Chemometrically assisted optimization and validation of the HPLC method for the analysis of alectinib and its related impurity with measurement uncertainty evaluation and whiteness... by Serkan Levent, Abeer Elriş, Hazal Avcı, Saniye Özcan, Nafiz Öncü Can

    Published 2025-05-01
    “…The stationary phase was an Ascentis® Express 90 Å C8 (10 cm × 4.6 mm, 2.7 µm) HPLC column; the separation was obtained using a gradient system with a mobile phase consisting of acetonitrile and ammonium acetate buffer, and the responses were recorded from the PDA detector at a wavelength of 269 nm. …”
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    Diagnostic value of serum levels of interleukin-9,interleukin-18 and interleukin-32 in patients with multiple myeloma by Zhuang Ni-la, Zhan Wen-li, Mo Tai-jin, Li Xiao-gan, Zeng Xiang-xing, Wang Qiu-xiang

    Published 2021-01-01
    “…Objective To explore the serum expressions of interleukin-9(IL-9),interleukin-18(IL-18)and interleukin-32(IL-32)in patients with multiple myeloma(MM)and examine their values in predicting renal injury.Methods Seventy-eight MM patients from January 2015 to December 2019 were divided into phase I(n=15),phase II(n=26)and phase III(n=37)according to the International Staging System.Based upon renal function, they were divided into renal injury group(n=28)and renal non-injury group(n=50).Another 50 normal subjects in the same period were selected as control group.The serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-microglobulin(β<sub>2</sub>-MG)were detected in each group.Receiver operating characteristic(ROC)curve was utilized for examining the values of serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG in the diagnosis of renal injury.Pearson’s correlation analysis was utilized for examining the correlation between serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG.Results The serum levels of IL-9[(63.15±18.36)ng/L vs(22.78±7.15)ng/L],IL-18[(580.64±70.35)ng/L vs(174.30±26.82)ng/L],IL-32[(817.62±112.36)ng/L vs(260.85±34.70)ng/L]and β<sub>2</sub>-MG](6.50±2.52)mg/L vs(1.66±0.58)mg/L]were significantly higher in MM group than those in control group(P<0.001).With the advancing of ISS stage, the serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG spiked in MM patients(P<0.001).The serum levels of IL-9[(91.26±19.42)ng/L vs(45.30±14.20)ng/L],IL-18[(812.46±95.2)ng/L vs(407.28±53.60)ng/L],IL-32[(1130.85±154.70)ng/L vs(604.20±71.38) ng/L]and β<sub>2</sub>-MG[(10.18±4.75)mg/L vs(3.15±1.06) mg/L]were significantly higher in renal injury group than those in renal non-injury group(P<0.001).ROC curve analysis revealed that the area under the curve(0.963,95%CI:0.905-0.997)of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG combined diagnosis of renal injury in MM was the largest and its sensitivity and specificity were 98.6% and 81.2%.Correlation analysis showed that serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG were positively correlated in MM patients(P<0.001).Conclusion The serum levels of IL-9,IL-18 and IL-32 are significantly elevated in MM patients.Correlated with disease stage and renal injury, combine detection of β<sub>2</sub>-MG has an excellent value in the diagnosis of renal injury in MM patients.…”
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