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Tolerogenic β2-glycoprotein I DNA vaccine and FK506 as an adjuvant attenuates experimental obstetric antiphospholipid syndrome.
Published 2018-01-01“…Blood titers of the anti-β2-GPI antibody, platelet counts, activated partial thromboplastin times (aPTTs), and the percentage of fetal loss were measured. …”
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Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degeneration
Published 2025-04-01“…These findings suggest that FK506’s neuroprotective effects may be partially mediated through GAP-43 phosphorylation, providing a potential target for therapeutic intervention in synucleinopathies.…”
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Soliton models of dislocation and acoustic emission in metallic materials
Published 2000-01-01“…A new class of nonlinear partial differential equations (NLPD equations), which may play a role in the theory of lattice vibration of the crystal with dislocation as well as in the theory of dislocations, has been obtained. …”
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Accurate solution estimates for nonlinear nonautonomous vector difference equations
Published 2004-01-01“…We also discuss applications of our main result to partial reaction-diffusion difference equations.…”
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Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis
Published 2025-07-01“…Patients were categorized into Responder and Non-Responder groups based on their response to treatment: complete/partial healing (Responder group) versus disease progression or need for additional surgery (Non-Responder group). …”
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PERFORMANCE COMPARISON OF SOME TYPES OF WAVELET TRANSFORMS FOR TOURISM DATA PATTERN APPROXIMATION
Published 2025-07-01“…Partially, the best approximation of the data on the number of foreign tourist visits was given by the Bi-orthogonal Splines wavelet type order 2.6 (bior2.6) at the 2nd decomposition level with an RMSE value of 1.1718 × 10-11 and for the data on domestic tourist visits was given by the Fejér-Korovkin wavelet type order 4-th (fk4) and the best-localized Daubechies wavelet order 7-th (bl7) at the 2nd level with an RMSE value of 1.3352 × 10-11.…”
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Computational investigation of heat transfer and fluid flow in a NEPCM-filled cavity with sinusoidal porous layer: Influence of magnetic field and exothermic reactions
Published 2025-05-01“…A corrugated porous layer with a thickness of 0.2L adheres to the left wall. The cavity is partially filled with a nano-enhanced phase change material (NEPCM) suspended porous medium. …”
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Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome
Published 2021-01-01“…As a highly effective immunosuppressant, tacrolimus（TAC,FK506）has been widely applied for primary nephrotic syndrome.However, excessive dose or underexposure of TAC remains rampant in clinical practices.Recent studies have indicated that cytochrome P450 family 3 subfamily A4（CYP3 A4）,cytochrome P450 family 3 subfamily A5（CYP3 A5）metabolic enzymes and ABC transporter play important roles in its metabolisms and transports and single nucleotide gene polymorphisms may partially explain differences in pharmacokinetic profiles among individuals.This review summarized the effects of CYP3 A4/3 A5 and ABC transporter gene polymorphisms on TAC plasma concentrations in patients with primary nephrotic syndrome.It was intended as a theoretical basis for individualized treatment of TAC in this population.…”
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Analyses of factors affecting and predicting the efficacy of tacrolimus in patients with idiopathic membranous nephropathy
Published 2022-10-01“…According to curative effect， they were divided into three groups of complete remission （CR）， partial remission （PR） and no remission （NR）. The impact of clinical characteristics on efficacy and outcome was examined.ResultsNo difference existed in average blood trough concentration of tacrolimus among three groups. …”
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Examining Behavioural Aspects of Financial Decision Making: The Working Women Perspective
Published 2022-12-01“…The study is based on primary data collected through a structured questionnaire designed on a 5-point Likert scale and was analysed through a partial least square-structural equation modelling (PLS-SEM) approach. …”
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Global solvability of a mixed problem for a singular semilinear hyperbolic 1d system
Published 2024-06-01“…Using the method of characteristics and the Banach fixed point theorem (for the Bielecki metric), in the paper it is established the existence and uniqueness of a global (continuous) solution of the mixed problem in the rectangle $\Pi=\{(x,t)\colon 0<x<l<\infty,\ 0<t<T<\infty\}$ for the first order hyperbolic system of semi-linear equations of the form $$ \dfrac{\partial u}{\partial t}+\Lambda(x,t) \dfrac{\partial u}{\partial x}=f(x,t,u,v,w), \dfrac{\partial v}{\partial x}=g(x,t,u,v,w), \dfrac{\partial w}{\partial t }=h(x,t,u,v,w), $$ for a singular with orthogonal (degenerate) and non-orthogonal to the coordinate axes characte\-ristics and with nonlinear boundary conditions, where $\Lambda(x,t)=\mathrm{diag}(\lambda_1(x,t),\ldots,\lambda_k(x,t)),$ $u=(u_1,\ldots,u_k),$ $v=(v_1,\ldots,v_m),$ $w=(w_1,\ldots,w_n),$ $f=(f_1,\ldots,f_k),$ $g=(g_1,\ldots,g_m),$ $h=(h_1,\ldots,h_n)$ and besides $\textrm{sign } \lambda_i(0,t)=\mathrm{const}\neq 0$, $\textrm{sign } \lambda_i(l,t)=\mathrm{const}\neq 0 $ $\text{for all} \ t \in [0, T] $ and for all $i \in \{1,\ldots,k\}$. …”
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Terapi Medikamentosa pada Paralisis Saraf Fasialis Akibat Fraktur Tulang Temporal
Published 2015-01-01Get full text
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A Case Study of Psoriasis Vulgaris After COVID-19 Vaccination in Saudi Arabia
Published 2025-03-01Get full text
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Complex Actions of FKBP12 on RyR1 Ion Channel Activity Consistent with Negative Co-Operativity in FKBP12 Binding to the RyR1 Tetramer
Published 2025-01-01“…The results suggest a high-affinity activation when FKBP12 binding sites on the RyR1 tetramer are partially occupied by FKBP12 and lower affinity inhibition as more RyR1 monomers become occupied. …”
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