Tolerogenic β2-glycoprotein I DNA vaccine and FK506 as an adjuvant attenuates experimental obstetric antiphospholipid syndrome. by Ya-Hsuan Chao, Der-Yuan Chen, Joung-Liang Lan, Kuo-Tung Tang, Chi-Chien Lin

“…To examine the therapeutic potential of a β2-GPI DNA vaccine, we administered a vaccine mixed with FK506 as an adjuvant to a mouse model of obstetric APS. …”
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Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degeneration by Ekaterina Grebenik, Sofia Zaichick, Gabriela Caraveo

“…These findings suggest that FK506’s neuroprotective effects may be partially mediated through GAP-43 phosphorylation, providing a potential target for therapeutic intervention in synucleinopathies.…”
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Interferensi Hematokrit Tinggi Terhadap Pemeriksaan Prothrombin Time dan Activated Partial Thromboplastin Time by Hevrina Yufani, Zelly Dia Rofinda

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Effects of energy source on growth and body composition of Holstein calves fed only milk replacer or whole milk by K.S. Bartlett, F.K. McKeith, R.A. Molano, M.E. Van Amburgh, M.J. VandeHaar, G.E. Dahl, J.K. Drackley

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Accurate solution estimates for nonlinear nonautonomous vector difference equations by Rigoberto Medina, M. I. Gil'

“…The paper deals with the vector discrete dynamical system xk+1=Akxk+fk(xk). Thewell-known result by Perron states that this system is asymptotically stable if Ak≡A=const is stable and fk(x)≡f˜(x)=o(‖x‖). …”
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Soliton models of dislocation and acoustic emission in metallic materials by A. PAWEŁEK, S. PILECKI

“…At the same time the equivalence of the FK model with the string model of dislocation (S model) has been demonstrated. …”
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Global solvability of a mixed problem for a singular semilinear hyperbolic 1d system by V. M. Kyrylych, O. V. Peliushkevych

“…Using the method of characteristics and the Banach fixed point theorem (for the Bielecki metric), in the paper it is established the existence and uniqueness of a global (continuous) solution of the mixed problem in the rectangle $\Pi=\{(x,t)\colon 0<x<l<\infty,\ 0<t<T<\infty\}$ for the first order hyperbolic system of semi-linear equations of the form $$ \dfrac{\partial u}{\partial t}+\Lambda(x,t) \dfrac{\partial u}{\partial x}=f(x,t,u,v,w),  \dfrac{\partial v}{\partial x}=g(x,t,u,v,w), \dfrac{\partial w}{\partial t }=h(x,t,u,v,w), $$ for a singular with orthogonal (degenerate) and non-orthogonal to the coordinate axes characte\-ristics and with nonlinear boundary conditions, where $\Lambda(x,t)=\mathrm{diag}(\lambda_1(x,t),\ldots,\lambda_k(x,t)),$ $u=(u_1,\ldots,u_k),$ $v=(v_1,\ldots,v_m),$ $w=(w_1,\ldots,w_n),$ $f=(f_1,\ldots,f_k),$ $g=(g_1,\ldots,g_m),$ $h=(h_1,\ldots,h_n)$ and besides $\textrm{sign } \lambda_i(0,t)=\mathrm{const}\neq 0$, $\textrm{sign } \lambda_i(l,t)=\mathrm{const}\neq 0 $ $\text{for all} \ t \in [0, T] $ and  for all $i \in \{1,\ldots,k\}$.  …”
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Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis by Zhengwei Yang, Miaomiao Liu, Guihua Yang, Lijin Wen, Juan Yang, Hanqiao Li, Zhiwen Xie, Xie Fang, Shunrong Luo, Xianwen Xiao, Yuan Lin, Huping Wu

“…Abstract Purpose To identify prognostic factors and their optimal thresholds influencing the treatment outcome of low-temperature plasma ablation therapy in patients with fungal keratitis (FK). Methods The clinical information of fifty-one patients with FK treated with low-temperature plasma ablation at Xiamen Eye Center from 2018 to 2024 was retrospectively analyzed. …”
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Terapi Medikamentosa pada Paralisis Saraf Fasialis Akibat Fraktur Tulang Temporal by Jacky Munilson, Yan Edward, Dedy Rusdi

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Examining Behavioural Aspects of Financial Decision Making: The Working Women Perspective by C. Gautam, R. Wadhwa, T. V. Raman

“…The study is based on primary data collected through a structured questionnaire designed on a 5-point Likert scale and was analysed through a partial least square-structural equation modelling (PLS-SEM) approach. …”
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Analyses of factors affecting and predicting the efficacy of tacrolimus in patients with idiopathic membranous nephropathy by Zhang Cheng-ning, Duan Su-yan, Yuan Yang-gang, Zhu Jing-feng, Huang Zhi-min, Sun Bin, Zhang Bo, Mao Hui-juan, Xing Chang-ying

“…ObjectiveTo explore the factors of affecting and predicting the therapeutic efficacy of tacrolimus （FK506） in patients with idiopathic membranous nephropathy （IMN）.MethodsA total of 76 IMN patients receiving oral FK506 （0.05-0.075 mg·kg^-1·d^-1） plus prednisone （0.5 mg·kg^-1·d^-1） were recruited. …”
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Analisis Pengaruh Kepemimpinan dan Motivasi Kerja Terhadap Turnover Intention Karyawan dengan Komitmen Organisasi Sebagai variabel Mediasi di Rumah Sakit Islam Siti Rahmah by Yori Rahmadianti

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Efektivitas Pemberian Papain Getah Pepaya Terhadap Kadar Faktor Pertumbuhan Transforming Growth Factor -Β (Tgf-Β) pada Proses Penyembuhan Luka Bakar Tikus Percobaan by Gusti Revilla

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HbA1c Level in Type 2 Diabetes Mellitus Patients With and Without Obesity in An Indonesian Regional Hospital by Fritsal Tinangon, Linny Luciana, Martina Rentauli Sihombing, Harny Edward

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PERFORMANCE COMPARISON OF SOME TYPES OF WAVELET TRANSFORMS FOR TOURISM DATA PATTERN APPROXIMATION by Syamsul Bahri, Lailia Awalushaumi, Bulqis Nebulla Syechah, Satriawan Pradana

“…Partially, the best approximation of the data on the number of foreign tourist visits was given by the Bi-orthogonal Splines wavelet type order 2.6 (bior2.6) at the 2nd decomposition level with an RMSE value of 1.1718 × 10-11 and for the data on domestic tourist visits was given by the Fejér-Korovkin wavelet type order 4-th (fk4) and the best-localized Daubechies wavelet order 7-th (bl7) at the 2nd level with an RMSE value of 1.3352 × 10-11.…”
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The influence of pH and temperature on benthic chlorophyll-a: Insights from SHAP-XGBoost and random forest models by Sangar Khan, Noël P.D. Juvigny-Khenafou, Tatenda Dalu, Paul J. Milham, Yasir Hamid, Kamel Mohamed Eltohamy, Habib Ullah, Bahman Jabbarian Amiri, Hao Chen, Naicheng Wu

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Computational investigation of heat transfer and fluid flow in a NEPCM-filled cavity with sinusoidal porous layer: Influence of magnetic field and exothermic reactions by Mohammed Azeez Alomari, Ahmed M. Hassan, Hawkar Qsim Birdawod, Faris Alqurashi, Mujtaba A. Flayyih, Abdellatif M. Sadeq

“…A corrugated porous layer with a thickness of 0.2L adheres to the left wall. The cavity is partially filled with a nano-enhanced phase change material (NEPCM) suspended porous medium. …”
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Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome by Xiong Lian-lian, Yi Bin

“…As a highly effective immunosuppressant, tacrolimus（TAC,FK506）has been widely applied for primary nephrotic syndrome.However, excessive dose or underexposure of TAC remains rampant in clinical practices.Recent studies have indicated that cytochrome P450 family 3 subfamily A4（CYP3 A4）,cytochrome P450 family 3 subfamily A5（CYP3 A5）metabolic enzymes and ABC transporter play important roles in its metabolisms and transports and single nucleotide gene polymorphisms may partially explain differences in pharmacokinetic profiles among individuals.This review summarized the effects of CYP3 A4/3 A5 and ABC transporter gene polymorphisms on TAC plasma concentrations in patients with primary nephrotic syndrome.It was intended as a theoretical basis for individualized treatment of TAC in this population.…”
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A Case Study of Psoriasis Vulgaris After COVID-19 Vaccination in Saudi Arabia by Hassan Alwafi, Nedaa Alsulaimani, Mohammed E. Almalki, Asma Mohammad Banjar, Reham Abdullah Alamri, Danya Alwafi, Anan S. Jarab, Asaleh El-Qasem, Yosra J. Alhartani, Abdallah Y Naser

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Complex Actions of FKBP12 on RyR1 Ion Channel Activity Consistent with Negative Co-Operativity in FKBP12 Binding to the RyR1 Tetramer by Spencer J. Richardson, Chris G. Thekkedam, Marco G. Casarotto, Nicole A. Beard, Angela F. Dulhunty

“…The association of the 12 KDa FK506 binding protein (FKBP12) with ryanodine receptor type 1 (RyR1) in skeletal muscle is thought to suppress RyR1 channel opening and contribute to healthy muscle function. …”
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