Transcending Traditional Treatment: The Therapeutical Potential of Nanovesicles for Transdermal Baclofen Delivery in Repeated Traumatic Brain Injury by Nermin M. Sheta, Amira A. El-Gazar, Ghada M. Ragab, Marwa A. Essa, Khaled M. Abdel-Haleem, Rania Moataz El-Dahmy

“…Besides enhancing the histological findings, the anti-inflammatory effect was clear by decreasing TNF-α and NF-κB p65. …”
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Physicochemical and Biological Modifications in Mesenchymal Stem Cells-Derived Conditioned Media Under Hypoxic Preconditioning: Impact on Oxidative Stress and Nanoparticle Stabilit... by Gülsemin Çiçek, Fatma Öz Bağcı, Mehmet Filizfidan, Selçuk Duman, Tahsin Murad Aktan

“…In conclusion, this study demonstrates that graded hypoxia distinctly modulates oxidative stress and nanoparticle characteristics in MSC-derived CM. These findings provide a basis for optimizing hypoxic preconditioning protocols to improve the quality and therapeutic potential of acellular MSC-based therapies.…”
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Atmospheric Modulation Transfer Function Calculation and Error Evaluation for the Panchromatic Band of the Gaofen-2 Satellite by Zhengqiang Li, Mingjun Liang, Yan Ma, Yang Zheng, Zhaozhou Li, Zhenting Chen

“…The findings reveal that aerosol optical depth (AOD), viewing zenith angle (VZA), and altitude (ALT) are the primary factors influencing the accuracy of GF-2 satellite on-orbit MTF measurements in complex scenarios. …”
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AgNPs biosynthesized from Pseudomonas Z9.3 metabolites as antimicrobial agents against bacterial and fungal pathogens by Svitlana Plokhovska, Svitlana Plokhovska, Elena Fuente-González, Enrique Gutierrez-Albanchez, Francisco Javier Gutierrez-Mañero, Beatriz Ramos-Solano

“…The growing need for sustainable and non-toxic nanoparticle production makes this method significant for various applications.MethodsThe influence of physicochemical parameters, such as temperature, pH, and concentrations of AgNO3, on the synthesis of AgNPs was studied. …”
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Effectiveness of Humidified High Flow Nasal Cannula Versus Continuous Nasal Positive Airway Pressure in Managing Respiratory Failure in Preterm Infants: An Emergency Department Stu... by Duaa Yousof Mahboob, Amber Hassan, Faiza Naheed, Arshad Ali Shah, Maria Fareed Siddiqui

“…Further research is necessary to confirm these findings and explore strategies to optimize outcomes and mitigate adverse effects associated with each modality.…”
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Fine-Tuning Flexographic Ink’s Surface Properties and Providing Anti-Counterfeit Potential via the Addition of TiO₂ and ZnO Nanoparticles by Tamara Tomašegović, Sanja Mahović Poljaček, Ivona Jurišić, Davor Donevski

“…Interfacial tension was low and close to zero for all printed ink layers, and the lowest value was achieved for the ink without added nanoparticles (1.47 mJ/m²). The findings of this research demonstrated that fine-tuning the properties of flexographic inks using nanoparticles can yield several benefits in terms of optimizing the quality of and providing counterfeit protection for specific printed motifs.…”
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Boundary complexity of cortical and subcortical areas predicts deep brain stimulation outcomes in Parkinson’s disease by Devin Schoen, Skyler Deutsch, Juhi Mehta, Sarah Wang, John Kornak, Philip A. Starr, Doris D. Wang, Jill L. Ostrem, Ian O. Bledsoe, Melanie A. Morrison

“…The work also highlights FD as a potentially useful imaging biomarker to enhance DBS candidate selection criteria for optimized treatment planning.…”
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Unveiling tolerance mechanisms in pepper to combined low-temperature and low-light stress: a physiological and transcriptomic approach by Jie Zhang, Hamza Sohail, Xuewen Xu, Yongtai Zhang, Yongji Zhang, Yibo Chen

“…Furthermore, physiological indicators such as chlorophyll fluorescence parameters, chlorophyll content, osmoregulatory substances, and antioxidant enzyme activities decreased under LL stress; however, the reduction was significantly greater in Y2 compared to Y425, further validating the molecular findings from the transcriptome analysis. …”
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Efficacy of Nusinersen Treatment in Type 1, 2, and 3 Spinal Muscular Atrophy: Real-World Data from a Single-Center Study by Anna Lemska, Piotr Ruminski, Jakub Szymarek, Sylwia Studzinska, Maria Mazurkiewicz-Beldzinska

“…This study demonstrates the importance of early and sustained treatment, with most patients showing the continuous improvement or stabilization of motor function. These findings support the use of nusinersen as an effective therapy for SMA; however, further research is needed to understand the long-term outcomes and optimize treatment strategies.…”
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Are tailored primary care services for social inclusion good value for money? A health economics evaluation with Monte-Carlo probabilistic sensitivity analysis comparing tailored s... by Síle Kelly, Anne Dee, Patrick O’Donnell

“…Conclusion This study found that investment in SIPC services, that can meet the needs of a marginalised population, represents good value for money from the perspective of the publicly funded health service. The findings are valuable in supporting stakeholders, policy-makers, and budget holders to make evidence-informed equitable decisions for optimal funding allocation within health and social services.…”
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Thermal Bending Simulation and Experimental Study of 3D Ultra-Thin Glass Components for Smartwatches by Shunchang Hu, Peiyan Sun, Zhen Zhang, Guojun Zhang, Wuyi Ming

“…Using finite element software, the heat transfer between the mold and the glass was modeled, and the temperature distribution and thermal stress under various processing conditions were predicted. The findings of the simulation, when subjected to a numerical analysis, showed that heating rate techniques significantly affect energy consumption. …”
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Fluconazole nanoparticles prepared by antisolvent precipitation technique: Physicochemical, in vitro, ex vivo and in vivo ocular evaluation by Amal El Sayeh F. Abou El Ela, Mohamed Abbas Ibrahim, Yara Alqahtani, Aliyah Almomen, Fadilah Sfouq Aleanizy

“…Moreover, the AUC0-8h from ocular application of FLZ from sodium alginate gel containing nanoparticle formula F3 was 1.4-fold higher than that after its administration in the untreated formula. Based on our findings, the ophthalmic gel formulations containing FLZ nanoparticles enhanced drug corneal permeation and improved the ocular pharmacokinetic parameters.…”
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Modulation of hormonal, metabolic, inflammatory and oxidative stress biomarkers in women with polycystic ovary syndrome following combined (resistant and endurance) training: a ran... by Masoud Nasiri, Amirabbas Monazzami, Solmaz Alavimilani, Zatollah Asemi

“…Exercise training has been known as an effective treatment for this disorder; however, there is small amount of evidence examining the optimal exercise programs. We evaluated the function of combined (COM) training on metabolic, hormonal parameters, and biomarkers of oxidative stress and inflammation in PCOS patients. …”
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Enhanced thermal performance in solar receiver duct with louver-punched V-type winglets: Numerical and experimental study by Maturose Suchatawat, Somchai Sripattanapipat, Pitak Promthaisong, Sompol Skullong, Pongjet Promvonge

“…In the current investigation, the winglet parameters consisted of a single relative winglet height (BR = 0.4), four louver size ratios (RL = e1/b = 0.9, 0.7, 0.5, and 0.3), and five louver-flapped angles (β = 90°, 60°, 45°, 30°, and 0°). …”
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Transforming food systems in Semarang City, Indonesia: A short food supply chain model by Widianarko Budi, Hantoro Inneke, Putri Novita Ika, Nugrahedi Probo Yulianto

“…Specific objectives include assessing SFSC readiness, identifying key commodities and actors, defining success parameters, and proposing an institutional framework. …”
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The effect of thermoelectric craniocerebral cooling device on protecting brain functions in post-cardiac arrest syndrome by Aydın Nadir, Deniz Kara, Ayda Turkoz

“…Body temperature, hemodynamic parameters, biochemical changes, and survival data were meticulously recorded and analyzed. …”
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Seepage Safety of a Rockfill-based Earth Dam Heightening Project by CEN Wei-jun, ZHENG Xiao-yu, DENG Cheng-fa, CAO Yi-fan

“…However, this local leakage at the base of the cutoff wall had minimal impact on the hydraulic head distribution in the dam body and posed no threat to overall seepage safety. [Conclusion] The findings provide a theoretical basis for optimizing seepage control design in rockfill-based earth dam heightening project and offer important guidance for advancing scientific and precise anti-seepage design in old reservoir heightening projects in China.…”
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Comparing the cost-benefit of breast cancer screening programs in rural and urban areas across four economic zones in China: a Markov modeling analysis by Dachuang Zhou, Kejia Zhou, Wenjuan Wang, Hanqiao Shao, Hongliu Zhang, Wenxi Tang

“…Conclusion Our study identified cost-effective breast cancer screening strategies suitable for the rural and urban areas in China’s four major economic zones. These findings highlight the necessity of universal screening and the importance of optimizing strategies based on regional economic development and epidemiological characteristics. …”
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Low-density pedicle screw in adolescent idiopathic scoliosis: a systematic review and meta-analysis of 1,762 patients by Bin Zheng, Qiang Zhou, Xuanwen Liu, Ke Ma, Zhe Qiang

“…The outcomes analyzed included surgical and safety parameters (blood loss, operative time, revision rates, and complications), radiographic outcomes (Cobb angle, correction rate, and thoracic kyphosis), and implant costs. …”
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In silico insights into the molecular mechanisms of Eclipta alba leaf fractions enhancing nonspecific immune mechanisms and resistance to Aeromonas hydrophila in Oreochromis mossam... by D. Christybapita, M. Divya Gnaneswari, Smriti Sharma, R. Dinakaran Michael, Parasuraman Aiya Subramani

“…Disease resistance tests showed that the highest doses of HSF and WSF (400 mg kg−1), when administered as double doses, reduced mortality (p < 0.01) and increased relative percentage survival. These findings suggest that WSF and HSF fractions from E. alba, when administered at an optimal dose of 400 mg kg−1, stimulate the nonspecific immune mechanisms of O. mossambicus, improving resistance to A. hydrophila infection. …”
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