A unique case of late-onset CIPO caused by a missense mutation in the long isoform of FLNA by Ilaria D’Amato, Enrico Ganguzza, Enrico Ganguzza, Guido Basilisco, Alessia Strippoli, Erika Salvi, Elkadia Mehmeti, Federica Chiappori, Grazia Devigili, Maurizio Vecchi, Maurizio Vecchi, Giuseppe Lauria, Giuseppe Lauria, Margherita Marchi

“…Structural modeling of the mutant Filamin A suggested that the p.Gly19Val substitution alters the local protein folding and may interfere with the protein ability to cross-link actin filaments, potentially impairing cytoskeletal dynamics in visceral smooth muscle cells. …”
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Novel, soluble 3-heteroaryl-substituted tanshinone mimics attenuate the inflammatory response in murine macrophages by Elisa Facen, Giulia Assoni, Greta Donati, Dalila Paladino, Agata Carreira, Isabelle Bonomo, Valeria La Pietra, Roberta Lotti, Josef Houser, Luca L. Fava, Pierfausto Seneci, Luciana Marinelli, Daniela Arosio, Alessandro Provenzani

“…To this aim, we previously synthesized a novel class of small molecules named Tanshinone Mimics (TMs) able to interfere with HuR-RNA binding, and that dampen the LPS-induced immune response. …”
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Immune Evasion Mechanism Mediated by ITPRIPL1 and Its Prognostic Implications in Glioma by Zou Xiaoyun, Ye Wenhao, Wu Huan, Yang Yuanyuan, Liu Changqing, Wen Hebao, Ma Caiyun

“…This included evaluating ITPRIPL1 expression levels in glioma, its association with clinicopathological features, prognostic significance, immune landscape, targeted drug sensitivity, and underlying biological functions. …”
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Fostering experiential learning of neurocognitive skills in brain injury tele-rehabilitation: bridging gaps in remote training by integrating scenario-based digital experiences wit... by Fred Loya, Deborah Binder, Nicholas Rodriguez, Bruce Buchanan, Tatjana Novakovic-Agopian, Tatjana Novakovic-Agopian, Anthony J.-W. Chen

“…Moreover, we designed this system specifically to bridge important gaps that interfere with skill learning when individuals are remote from therapists. …”
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Major Aortopulmonary Collateral Arteries and Their Effects on Perioperative Parameters and Mortality of Children with Tetralogy of Fallot: A Case-control Study by Mohammadreza Edraki, Amir Naghshzan, Hamid Amoozgar, Kambiz Keshavarz, Nima Mehdizadegan, Hamid Mohammadi

“…Background: Inadequate pulmonary blood flow in tetralogy of Fallot (TOF) can lead to the development of major aortopulmonary collateral arteries (MAPCA), which interferes with surgical repair. The present study evaluated the features of MAPCAs among patients with TOF and their treatment approaches. …”
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A practical protocol for correlative confocal fluorescence and transmission electron microscopy characterization of extracellular vesicles by Juan M. Martínez-Andrade, Daniel Salgado-Bautista, Kendra Ramirez-Acosta, Ruben Darío Cadena-Nava, Meritxell Riquelme

“…CLEM analysis revealed that vesicle-like structures with membranous features, as observed under TEM, corresponded to the dispersed green fluorescence signal seen with LSCM. …”
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Multiparametric MRI for the improved diagnostic accuracy of Alzheimer's disease and mild cognitive impairment: Research protocol of a case-control study design. by Albert Dayor Piersson, Buhari Ibrahim, Subapriya Suppiah, Mazlyfarina Mohamad, Hasyma Abu Hassan, Nur Farhayu Omar, Mohd Izuan Ibrahim, Ahmad Nazlim Yusoff, Normala Ibrahim, M Iqbal Saripan, Rizah Mazzuin Razali

“…The accuracy of imaging helps to identify the neuropathological features that differentiate AD from its common precursor, mild cognitive impairment (MCI). …”
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Development of ptxD/Phi as a new dominant selection system for genetic manipulation in Cryptococcus neoformans by Muthita Khongthongdam, Tanaporn Phetruen, Sittinan Chanarat

“…This is particularly useful because it does not interfere with the normal growth of the fungus or the features that make it harmful (like its ability to change shape or produce protective coatings). …”
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Clonal hematopoiesis in metastatic urothelial and renal cell carcinoma by Aslı D. Munzur, Jack V. W. Bacon, Francine Fishbein, Cameron Herberts, Gráinne Donnellan, Cecily Q. Bernales, Karan Parekh, Gillian Vandekerkhove, David C. Müller, Yi Jou Ruby Liao, Maria Stephenson, Lucia Nappi, Daniel Khalaf, Corinne Maurice-Dror, Kim N. Chi, Bernhard J. Eigl, Christian Kollmannsberger, Maryam Soleimani, Alexander W. Wyatt

“…However, CH variants frequently affected solid cancer driver genes and were not individually discriminable from ctDNA variants based on cfDNA features including fragment length. In contrast, matched WBC DNA sequencing to ≥25% of cfDNA depth sufficiently resolved CH from ctDNA variants. …”
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Identification of functional near-infrared spectroscopy for older adults with mild cognitive impairment: a systematic review by Bo Yang, Xia Deng, Xianfeng Qu, Yingjie Li, Lei Guo, Nengwei Yu

“…ObjectiveMild cognitive impairment (MCI), a common state of cognitive impairment without significant impairment in daily functioning among older adults, is mainly identified using various neuropsychological tests, clinical interviews, and collateral history with some subjective interferences. This systematic review aimed to investigate the functional near-infrared spectroscopy (fNIRS) features of older adults with MCI compared with those with normal cognitive function to assist in the diagnosis of MCI.MethodsA literature search was conducted in electronic databases, including PubMed, Web of Science, Embase, and Cochrane Library, up to June 15, 2024. …”
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Impact of transphyseal intramedullary nailing on tibial distraction regenerate and subsequent tibial growth in sheep: an experimental study by Natalia A. Kononovich, Sergey S. Leonchuk, Evgeniy S. Gorbach, Elena N. Gorbach, Dmitry A. Popkov

“…The purpose of the work was to study the features of tibial distraction regenerate formation and residual growth of the lengthened segment in lambs under the conditions of external fixation combined with a transphyseal rigid titanium rod. …”

Microbial characteristics of bile in gallstone patients: a comprehensive analysis of 9,939 cases by Xin Zheng, Yunjun Yan, Xin Li, Mimin Liu, Xiaoyue Zhao, Jing He, Xuewei Zhuang, Xuewei Zhuang

“…IntroductionThe exact triggers of gallstone formation remain incompletely understood, but research indicates that microbial infection is a significant factor and can interfere with treatment. There is no consensus on the bile microbial culture profiles in previous studies, and determining the microbial profile could aid in targeted prevention and treatment. …”
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Therapeutic Potential of Dimethyl Fumarate for the Treatment of High-Fat/High-Sucrose Diet-Induced Obesity by Helber da Maia Valenca, Evelyn Caribé Mota, Andressa Caetano da Fonseca Andrade Silva, Alexsandro Tavares Figueiredo-Junior, Fernanda Verdini, Bruna Romana-Souza, Mariana Renovato-Martins, Manuella Lanzetti, Samuel dos Santos Valenca, João Alfredo Moraes

“…Our data demonstrate that DMF and its metabolite MMF interfere with adipogenesis and prevent the key features of diet-induced obesity. …”
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The Effect of Task-Oriented Basketball Training on Motor Skill-Related Fitness in Children with Developmental Coordination Disorder by Faiçal Farhat, Achraf Ammar, Nourhen Mezghani, Mohamed Moncef Kammoun, Khaled Trabelsi, Adnene Gharbi, Lassad Sallemi, Haithem Rebai, Wassim Moalla, Bouwien Smits-Engelsman

“…DCD is classified as a motor learning deficit because it interferes with the ability to learn and automate movement skills. …”
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Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes by Hannah Hipp, Camilla Tondello, Hanna Gmehling, Lena K. Scholz, Antigoni Stavridou, Maike Becker, Anne-Marie Bührer, Edith Hintermann, Sandra M. Dirschl, Till M. Johannsmann, Martin G. Scherm, Hella Kohlhof, Isabelle Serr, Urs Christen, Carolin Daniel

“…We assessed Treg-inducing features of DHODH inhibition in T cells from ongoing murine islet autoimmunity and human T1D in vitro. …”
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Sustainable forest management: success and challenges in Ethiopia by Rusha Begna Wakweya

“…It has been a dominant feature of forest governance in the tropics since the 1980s. …”
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Progress and application of salinomycin-induced cell autophagy in anti-cancer treatment by CHEN Siyuan, HU Ji'an

“…Poor microenvironmental conditions, such as hypoxia, elevated interstitial fluid pressure, glycolysis, low pH and inflammatory cell infiltration, are common features of solid tumors, which are closely related to tumor progression, metastasis and therapy. …”
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Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer’s disease by Hongli Chen, Na Li, Na Liu, Hongyu Zhu, Chunyan Ma, Yutong Ye, Xinyu Shi, Guoshuai Luo, Xiaoxi Dong, Tao Tan, Xunbin Wei, Huijuan Yin

“…Amyloid β-protein (Aβ) is one of the key pathological features of AD, which is cytotoxic and can damage neurons, thereby causing cognitive dysfunction. …”
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Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice by Marin Truchi, Marine Gautier-Isola, Grégoire Savary, Célia Scribe, Arun Lingampally, Hugo Cadis, Alberto Baeri, Virginie Magnone, Cédric Girard-Riboulleau, Marie-Jeanne Arguel, Clémentine de Schutter, Julien Fassy, Nihad Boukrout, Romain Larrue, Nathalie Martin, Roger Rezzonico, Olivier Pluquet, Michael Perrais, Véronique Hofman, Charles-Hugo Marquette, Paul Hofman, Andreas Günther, Nicolas Ricard, Pascal Barbry, Sylvie Leroy, Kevin Lebrigand, Saverio Bellusci, Christelle Cauffiez, Georges Vassaux, Nicolas Pottier, Bernard Mari

“…Finally, we find that aging also alters the transcriptome of PCEC, which displays typical pro-fibrotic and pro-inflammatory features. We propose that age-associated alterations in specific PCEC subpopulations may interfere with the process of lung progenitor differentiation, thus contributing to the persistent fibrotic process typical of human pathology.…”
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Remote work – the new normal needs more research by Annina Ropponen

“…Working from home: mismatch between access and need in relation to work-home interference and fatigue. Scand J Work Environ Health 2021(8):619-27. https://doi.org/10.5271/sjweh.3983 2. …”
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