Toward Characterizing Dark Matter Subhalo Perturbations in Stellar Streams with Graph Neural Networks by Peter Xiangyuan Ma, Keir K. Rogers, Ting S. Li, Renée Hložek, Jeremy J. Webb, Ruth Huang, Julian Meunier

“…The phase space of stellar streams is proposed to detect dark substructure in the Milky Way through the perturbations created by passing subhalos—and thus is a powerful test of the cold dark matter paradigm and its alternatives. …”
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Spectral Hardening Reveals Afterglow Emergence in Long-duration Fast X-Ray Transients: A Case Study of GRB 250404A/EP250404a by Yi-Han Iris Yin, Yuan Fang, Bin-Bin Zhang, Chen Deng, Jun Yang, Run-Chao Chen, Yuan Liu, Yehao Cheng, Dong Xu, Xiaofeng Wang, Rongfeng Shen, Rui-Zhi Li, Jirong Mao, Wen-Xiong Li, Alberto Javier Castro-Tirado, Weihua Lei, Shao-Yu Fu, Yuan-Pei Yang, Shuai-Qing Jiang, Jie An, Chun Chen, Zhong-Nan Dong, Guowang Du, Ali Esamdin, Zhou Fan, Haicheng Feng, Lu Feng, Emilio Fernández-García, Xing Gao, Maria Gritsevich, Wei-Jian Guo, Jingwei Hu, You-Dong Hu, Yanlong Hua, Abdusamatjan Iskandar, Junjie Jin, Niu Li, Xia Li, Ziwei Li, Jia-Qi Lin, Dezi Liu, Jinzhong Liu, Qichun Liu, Xiaowei Liu, Xing Liu, Daniele B. Malesani, Ignacio Pérez-García, Hui Sun, Xue-Feng Wu, Yun-Ao Xiao, Ding-Rong Xiong, Shengyu Yan, Beibei Zhang, Jinghua Zhang, Haichang Zhu, Zipei Zhu, Hu Zou, Weimin Yuan, Bing Zhang

“…In this Letter, we present a detailed analysis of GRB 250404A/EP250404a, a bright, fast X-ray transient detected simultaneously by EP and the Fermi Gamma-ray Burst Monitor in X-rays and gamma rays. …”
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Severe Acute Respiratory Syndrome Coronavirus 2 Variant Infection Dynamics and Pathogenesis in Transgenic K18-h<i>ACE2</i> and Inbred Immunocompetent C57BL/6J Mice by Hongwei Liu, Brianna M. Ramirez, Talia S. Wong, Christopher M. Weiss, Kevin C. K. Lloyd, Qizhi Gong, Lark L. Coffey

“…SARS-CoV-2 nucleoprotein was detected, and interstitial pneumonia of varying severity was observed in K18 mice infected with all variants. …”
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Earth observations reveal impacts of climate variability on maize cropping systems in sub-Saharan Africa by Adomas Liepa, Michael Thiel, Hannes Taubenböck, Doris Klein, Ingolf Steffan-Dewenter, Marcell K. Peters, Sarah Schönbrodt-Stitt, Insa Otte, Tobias Landmann, Zeyaur R. Khan, Michael Ochieng Obondo, Frank Chidawanyika, Emily A. Martin, Tobias Ullmann

“…Field data from 58 sites in southwestern Kenya provided training for this analysis, revealing detectable inter-class differences. …”
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Genomics and integrative clinical data machine learning scoring model to ascertain likely Lynch syndrome patients by Ramadhani Chambuso, Takudzwa Nyasha Musarurwa, Alessandro Pietro Aldera, Armin Deffur, Hayli Geffen, Douglas Perkins, Raj Ramesar

“…Annovar, Intervar, Variant Effect Predictor (VEP), and OncoKB software tools were used to functionally annotate and interpret somatic variants detected. The OncoKB precision oncology knowledge base was used to provide information on the effects of the identified variants. …”
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A Histopathological Study of Mean Eosinophil Count in Adult Gastrointestinal Pathologies: A Cross-sectional Study by Ashwini Annappa Moger, Padma Priya Kasukurti, Sulata M Kamath, SR Mangala Gowri, Karthik Yadavalli

“…While eosinophils are usually detected in varying numbers in most mucosal biopsies of the GIT, present findings significantly contribute to defining the limits of eosinophil association in different conditions that can feature significant eosinophilia. …”
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Multidisciplinary, Clinical Assessment of Accelerated Deep-Learning MRI Protocols at 1.5 T and 3 T After Intracranial Tumor Surgery and Their Influence on Residual Tumor Perception by Christer Ruff, Till-Karsten Hauser, Constantin Roder, Daniel Feucht, Paula Bombach, Leonie Zerweck, Deborah Staber, Frank Paulsen, Ulrike Ernemann, Georg Gohla

“…<b>Methods</b>: This study uses a multidisciplinary approach involving a neuroradiologist, neurosurgeon, neuro-oncologist, and radiotherapist to evaluate qualitative aspects using a 5-point Likert scale, the preferred reconstruction variant and potential residual tumor of DLR and conventional reconstruction (CR) of FLAIR, T1-weighted non-contrast and contrast-enhanced (T1), and coronal T2-weighted (T2) sequences for 1.5 and 3 T MRI. Quantitative analysis included the image quality metrics Structural Similarity Index (SSIM), Multi-Scale SSIM (MS-SSIM), Feature Similarity Index (FSIM), Noise Quality Metric (NQM), signal-to-noise ratio (SNR), and Peak SNR (PSNR) with CR as a reference. …”
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Endothelial cell iron overload and ferroptosis mediate thrombosis and inflammation through the miR-32-5p/neurofibromin 2 pathway by Ying Deng, Xueguang Lin, Jun Wei, Bo Chen, Huafang Yan, Bo Wang, Jialong Li, Yuqun Zhao, Bo Yu, Jingdong Tang, Shuai Jiang

“…Abstract Thromboangiitis obliterans (TAO) is characterized by progressive inflammatory vasculopathy featuring thrombotic occlusion. Aberrant thrombosis induces endothelial damage through pathological clotting, while iron may act as a pro-oxidant cofactor. …”
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Integration of agronomic information, vegetation indices (VIs), and meteorological data for phenological monitoring and yield estimation of rice (Oryza sativa L.) by Jorge A. Fernandez-Jibaja, Nilton Atalaya-Marin, Yeltsin A. Álvarez-Robledo, Victor H. Taboada-Mitma, Juancarlos Cruz-Luis, Daniel Tineo, Malluri Goñas, Darwin Gómez-Fernández

“…The temporal dynamics of the VIs consistently increased from the seedling to inflorescence emergence stage, followed by a decrease during flowering and ripening, which aligns with known physiological transitions in rice, however, significant differences in the NDVI index were detected during ripening (p > 0.05). For yield estimation, feature selection was performed using principal component analysis (PCA) and the least absolute shrinkage and selection operator (LASSO) to increase model efficiency and interpretability. …”
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6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols by Stef Bannink, Kateryna O. Bila, Joosje van Weperen, Nina A.M. Ligthart, Maria J. Ferraz, Rolf G. Boot, Daan van der Vliet, Daphne.E.C. Boer, Herman S. Overkleeft, Marta Artola, Johannes M.F.G. Aerts

“…Plants contain glycosyl phytosterols (campesterol, β-sitosterol, and sigmasterol) that may also be acylated at C-6. LC-MS/MS analysis revealed that 6-O-acylated and regular glycosylcholesterol (HexChol) tend to be increased in spleens of patients with GD. …”
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Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis by Yaqiong Tian, Xuan Zhou, Mi Tian, Lijun Ren, Ruyi Zou, Hanyi Jiang, Miaomiao Xie, Mei Huang, Jingjing Ding, Yin Liu, Jingyu Chen, Min Cao, Hourong Cai

“…COX regression and LASSO algorithm were used to screen featured characteristics. Then nomogram models were constructed, ROC curve, calibration curve and decision curve analysis(DCA) were conducted to evaluate the performance of model. …”
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Accumulation of long-chain unsaturated fatty acids in the airway inflammatory microenvironment drives eosinophil etosis and corticosteroid resistance by Yurong Bai, Pengda Fang, Shasha Li, Zhenhao Xiao, Wenyi Chen, Wenlong Li, Xinyue Wang, Jingyuan Chen, Yue Li, Junhai Chen, Weiqiang Huang, Xin Luo, Shigeharu Ueki, Deyu Fang, Qintai Yang, Yana Zhang

“…Abstract Background Eosinophilic inflammation is a feature of chronic rhinosinusitis with nasal polyps (CRSwNP). …”
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Improving image reconstruction to quantify dynamic whole-body PET/CT: Q.Clear versus OSEM by Sam Springer, Jeremy Basset-Sagarminaga, Tineke van de Weijer, Vera B. Schrauwen-Hinderling, Walter H. Backes, Roel Wierts

“…Abstract Background The introduction of PET systems featuring increased count rate sensitivity has resulted in the development of dynamic whole-body PET acquisition protocols to assess 18F-FDG uptake rate ( $${K}_{i}$$ K i ) using 18F-FDG PET/CT. …”
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…In total, there were 357 participants defined as adherent and are included in the protocol analysis (174 bisoprolol, 183 placebo). The results of per-protocol analysis were not substantially different from the results from the ITT analysis. …”
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Photosynthetic pigments and phenolic potential of Rhodiola rosea L. from plant communities of different ecology and geography by Sergeeva Irina Yu., Zaushintsena Alexandra V., Bryukhachev Evgeniy N.

“…The photosynthetic pigments were detected using the spectrophotometric method. The obtained data underwent a statistical analysis based on Statistica 6.0 software. …”
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Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway by Yan Luo, Feng Zhou, Xiaojing Wang, Runwei Yang, Yi Li, Xiaochun Wu, Bin Ye

“…Chondrocyte apoptosis is the most common pathological feature of OA. Interleukin-1β (IL-1β), a major inflammatory cytokine that promotes cartilage degradation in OA, often stimulates primary human chondrocytes in vitro to establish an in vitro OA model. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…The EAG base case applies the EAG RCT network meta-analysis estimate of −0.29% HbA1c for HCL relative to CSII + CGM. …”
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Impact of short-term aircraft noise on cardiovascular disease risk in the area surrounding London Heathrow airport: the RISTANCO epidemiological study by Xiangpu Gong, Nicole Itzkowitz, Calvin Jephcote, Kathryn Adams, Glory O Atilola, John Gulliver, Marta Blangiardo, Anna Hansell

“…We did not proceed to conduct health analyses using these criteria because the small sample size may have been insufficient to detect effects. The approach we explored for health analysis was empirical and based on noise variability as seen in the whole dataset. …”
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Aquaporins modulate the cold response of Haemaphysalis longicornis via changes in gene and protein expression of fatty acids by Han Wang, Ruwei Bai, Tingwei Pei, Jianglei Meng, Chuks F. Nwanade, Yuchao Zhang, Xiujie Liang, Yunsheng Tang, Jingze Liu, Zhijun Yu

“…Quantitative real-time PCR (qPCR) was used to detect different expressions of H. longicornis genes under different cold treatment conditions. …”
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Lingual foramina on cone beam computed tomography: A retrospective radiographic study by Om Nemichand Baghele, Vishnudas Dwarkadas Bhandari, Pratiksha Shivajirao Late, Bhushan Rajendra Bangar, Gauri Mahesh Ugale, Raghavendra Metri

“…All participants had at least 1 lingual foramen (LF). Total 172 LF were detected on 100 CBCT scans, including 154 (89.5 %) medial LF (MLF) and 18 lateral LF (LLF) (10.4 %). …”
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