CD226+ B cells in primary Sjögren’s syndrome: a key player in clinical manifestations and disease pathogenesis by Ping Zhao, Ping Zhao, Saizhe Song, Song Zhang, Cheng Peng, Wei Cheng, Xin Chang, Xin Chang, Changhao Xie, Zhongli Hu, Cuiping Liu

“…Multicolor immunofluorescence staining was applied to detect the co-expression of B cells and CD226 in the salivary gland of pSS patients.Microarray analysis was conducted to analyze the transcriptomic profiles of sorted CD226+ CD19+ B cells and CD226- CD19+ B cells.ResultsCD226 expression in the peripheral blood of pSS patients was significantly increased on T cells, CD19+ B cells and CD14+ monocytes, but significantly decreased on CD56+ NK cells.We identified a distinct CD226+CD19+ B cell subset that exhibited pathogenic features in pSS. …”
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Clinico-pathological factors and [18F]FDG PET/CT metabolic parameters for prediction of progression-free survival in radioiodine refractory differentiated thyroid carcinoma by Nguyen Thi Phuong, Mai Hong Son, Mai Huy Thong, Le Ngoc Ha

“…Clinico-pathological factors including age > 55, aggressive variant and follicular histological subtype, extra-thyroidal extension of the primary tumor, stage III – IV disease at initial DTC diagnosis, distant metastases detected on [18F]FDG PET/CT, and metabolic parameters of [18F]FDG PET/CT associated with PFS in univariate analysis (p < 0.01). …”
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Assessing the Consistency of Five Remote Sensing-Based Land Cover Products for Monitoring Cropland Changes in China by Fuliang Deng, Xinqin Peng, Jiale Cai, Lanhui Li, Fangzhou Li, Chen Liang, Wei Liu, Ying Yuan, Mei Sun

“…At the prefecture-level city scale, the correlation coefficients between the cropland area changes detected by five cropland products and the NLSCD are low, with GlobeLand30 having the highest coefficient at 0.67. …”
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Use of quantitative CT chest imaging to derive and assess a radiographic phenotype of deployment-related constrictive bronchiolitis by Alexander J. Bell, Maria Masotti, Sundaresh Ram, Gregory Pappas, Robert F. Miller, Ella A. Kazerooni, Charles R. Hatt, MeiLan K. Han, Bradley W. Richmond, Michael J. Falvo, Craig J. Galban, John J. Osterholzer

“…Future studies incorporating QCT may help establish non-invasive strategies to detect DRCB and other forms of chronic lung injury.…”
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Optimizing Endoscopic Respiratory Diagnostics with Cytology: An Update on Touch Imprints with a Comparative Literature Review by Hatice Elmas, Binnur Önal, Selda Yilmaz, Stefan Steurer, Lutz Welker

“…Under optimal conditions for morphological analysis in a surgical setting, the sensitivity of cytology for detecting malignant tumors was only 6 percentage points lower compared with the clinical endoscopic setting. …”
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Editorial by Teddy Surya Gunawan

“…From deep learning-based anomaly detection and vision transformer analysis for driver fatigue, to latency evaluations of LEO and GEO networks under tropical conditions, these studies reflect the growing importance of digital intelligence and communication resilience. …”
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A Predictive Model for Perinatal Brain Injury Using Machine Learning Based on Early Birth Data by Ga Won Jeon, Yeong Seok Lee, Won-Ho Hahn, Yong Hoon Jun

“…Additionally, SHAP analysis showed that LDH levels had the highest SHAP values. …”
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Prediction of the potential global distribution for Biomphalaria straminea, an intermediate host for Schistosoma mansoni. by Ya Yang, Wanting Cheng, Xiaoying Wu, Shaoyu Huang, Zhuohui Deng, Xin Zeng, Dongjuan Yuan, Yu Yang, Zhongdao Wu, Yue Chen, Yibiao Zhou, Qingwu Jiang

“…We used several approaches to investigate the distribution of B. straminea, including direct comparison of climatic conditions, principal component analysis and niche overlap analyses to detect niche shifts. …”
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Different neutrophil extracellular trap related Ewing sarcoma subtypes exhibit distinct prognosis, and immune microenvironment characteristics by Shihao Li, Yanli Hou, Lina Zhang, Haiyang Zhang, Congcong Wang

“…Abstract Ewing sarcoma (EWS) is a rare bone cancer that is most usually detected in children. Neutrophil extracellular traps (NETs) are closely related to the prognosis of cancer, but the significance of NET-related features in EWS remains uncertain. …”
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Genome Instability-Related miRNAs Predict Survival, Immune Landscape, and Immunotherapy Responses in Gastric Cancer by Yaqiong Liu, Lin Cheng, Wei Huang, Xin Cheng, Weijun Peng, Dazun Shi

“…The GIMiSig showed high accuracy in detecting GC patients. Using GIMiSig to stratify the patients into the high- and low-risk subgroups to predict survival outperformed the use of regular clinical features such as age, gender, or disease stage. …”
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Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection. by Rosario Castro, Luc Jouneau, Hang-Phuong Pham, Olivier Bouchez, Véronique Giudicelli, Marie-Paule Lefranc, Edwige Quillet, Abdenour Benmansour, Frédéric Cazals, Adrien Six, Simon Fillatreau, Oriol Sunyer, Pierre Boudinot

“…In infected animals, we detected complex and highly diverse IgM responses involving all VH subgroups, and dominated by a few large public and private clones. …”
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PROMOTER REGION rs1800629 TNFα POLYMORPHISM AND ITS INFLUENCE ON TUMOR NECROSIS FACTOR ALPHA CONCENTRATION IN BLOOD OF HEALTHY INDIVIDUALS AND PATIENTS WITH ERYSIPELAS by A. S. Emelyanov, A. N. Emelyanova, B. S. Pushkarev, Yu. A. Vitkovsky

“…Gene polymorphism of TNFα rs1800629 was detected by PCR method. Measurement of the concentration of TNFα was performed by immunoassay analysis. …”
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Clinical and etiological characteristics of pneumonia in children with a poor outcome of infectious diseases by E. A. Kozyrev, I. V. Babachenko, V. E. Karev, D. A. Pimenov, E. V. Sharipova, E. D. Orlova, N. S. Tian

“…Purpose: to study the clinical and etiological features of pneumonia in children with a poor outcome of infectious diseases.Materials and methods. …”
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Morphological characteristics and diagnostic criteria of traditional serrated adenoma by A. S. Tertychnyy, N. V. Pachuashvili, P. V. Pavlov, A. P. Kiryukhin, A. A. Fedorenko, N. S. Marenich

“…In 5 cases, foci of highly differentiated adenocarcinoma were detected in the TSAs material.Conclusion. TSAs has characteristic morphological features with a serrated exophytic growth pattern, cytoplasmic eosinophilia and the presence of ectopic crypts. …”
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JAG1 MUTATION SPECTRUM IN CASES WITH ALAGILLE SYNDROME FROM TURKIYE by Ayça Dilruba Aslanger, Behiye Tuğçe Yıldırım, Tuğba Kalaycı, Leyli Şentürk, Şahin Avcı, Umut Altunoğlu, Çağrı Güleç, Volkan Karaman, Güzide Doğan, Zerrin Önal, Özlem Durmaz, Birsen Karaman, Zehra Oya Uyguner

“…Karyotype, fluorescence in situ hybridization (FISH), array comparative genomic hybridization (aCGH), and JAG1 gene sequencing utilizing next-generation and Sanger sequencing methodologies were conducted.Result: The presence of both large deletion and small variants associated with Alagille syndrome was detected in all cases. In karyotype and aCGH analysis of a single case, a gross 20p deletion was identified. …”
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Consequences of parental preconceptional irradiation: Endocrine-metabolic pathology in offspring by S. F. Sosnina, P. O. Okatenko, M. E. Sokolnikov

“…Characteristic features of parental preconceptional exposure were analyzed in relation to thyroid pathology in children. …”
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Role of genotyping in prediction of disseminated intravascular coagulation and multiple organ failure in children with generalized forms of meningococcal infection by S. I. Kapustin, A. A. Vilnits, Zh. Yu. Sidorova, V. N. Chebotkevich, L. P. Papayan, L. A. Alekseeva, N. V. Skripchenko, S. S. Bessmeltsev

“…Allelic variants of genes coding for plasma hemostatic factors (FI-A, FI-B, FXIII-A, PAI-1, ТРА) or pro-inflammatory cytokines (IL-6, IL-1B, TNF-A) were detected by PCR and. subsequent restriction, analysis. …”
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A novel TERT variant associated with a telomere biology disorder and challenges in variant classification by Vahid Pazhakh, Lucy C. Fox, Nicole Den Elzen, Matthew R. Emerson, Scott B. Cohen, Tracy M. Bryan, Kevin Norris, Duncan M. Baird, Tara Cochrane, John Mackintosh, Ashleigh Scott, Piers Blombery

“…A novel TERT variant (K710R) was detected in a patient with classic TBD features showing reduced telomerase activity and processivity. …”
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Leveling up: along-level diffusion tensor imaging in the spinal cord of multiple sclerosis patients by Atlee A. Witt, Atlee A. Witt, Anna J. E. Combes, Anna J. E. Combes, Grace Sweeney, Logan E. Prock, Delaney Houston, Seth Stubblefield, Colin D. McKnight, Kristin P. O’Grady, Kristin P. O’Grady, Kristin P. O’Grady, Seth A. Smith, Seth A. Smith, Seth A. Smith, Kurt G. Schilling, Kurt G. Schilling

“…Notably, while GM atrophy was associated with clinical disability, microstructural changes did not exhibit significant correlations with disability measures.DiscussionThese findings underscore the utility of level-specific analysis in detecting localized pathology and suggest a refined framework for characterizing SC alterations in MS.…”
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STModule: identifying tissue modules to uncover spatial components and characteristics of transcriptomic landscapes by Ran Wang, Yan Qian, Xiaojing Guo, Fangda Song, Zhiqiang Xiong, Shirong Cai, Xiuwu Bian, Man Hon Wong, Qin Cao, Lixin Cheng, Gang Lu, Kwong Sak Leung

“…STModule uncovers diverse expression signals in transcriptomic landscapes such as cancer, intraepithelial neoplasia, immune infiltration, outcome-related molecular features and various cell types, which facilitate downstream analysis and provide insights into tumor microenvironments, disease mechanisms, treatment development, and histological organization of tissues. …”
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