Natural SEL1L variants rescue a model of NGLY1 deficiency and modify ERAD function and proteasome sensitivity. by Travis K Tu'ifua, Clement Y Chow

“…We found that the SEL1LS780P and SEL1LΔ806-809 variants improve resistance to ER stress, with enhanced ERAD function as a likely contributing mechanism. This effect depends on NGLY1 activity, further implicating NGLY1 in general ERAD function. …”
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Functional Characterization of Deubiquitinase UBP Family and Proteomic Analysis of Aaubp14-Mediated Pathogenicity Mechanism in <i>Alternaria alternata</i> by Jiejing Tang, Hang Zhou, Chen Jiao, Hongye Li

“…<i>Alternaria citri</i> toxin (ACT) is the primary virulence factor, but the regulatory mechanisms governing ACT synthesis remain unclear. …”
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Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice by Yejin Park, Subin Moon, Harry Jung, Songyi Park, Ju Won Kim, Dan-Gyeong Song, Yong-Ho In, Sang Won Han, Sang Won Han, Jong-Hee Sohn, Jong-Hee Sohn, Chan Hee Lee, Chan Hee Lee

“…Cerebrovascular perfusion, blood–brain barrier (BBB) integrity, microgliosis, and amyloid-beta 42 (Aβ42) accumulation were examined. Cognitive functions were assessed using the Morris water maze, Y-maze, and novel object recognition tests. …”
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Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation: Protocol for a Randomized, Placebo-Controlled Functional Near-Infrared Spectroscopy Trial by Hyeonsang Shin, Woohyun Seong, Yeonju Woo, Joo-Hee Kim, Kwang-Rak Park, Dong Hyuk Lee

“…Each group will undergo cognitive function tests, functional near-infrared spectroscopy imaging before and after acupuncture stimulation, and an assessment of CR. …”
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EXPERIMENTAL EVALUATION OF LONG-TERM ADVERSE SIDE EFFECTS OF CYTOSTATIC DRUGS ON FEMALE REPRODUCTIVE FUNCTION AND PHARMACOLOGICAL WAYS TO REDUCE THEM by T. G. Borovskaya, V. E. Goldberg, M. E. Poluektova, A. V. Vychuzhanina, Yu. A. Shchemerovа, V. A. Grigoreva, A. A. Ligacheva, E. A. Bokhan

“…The purpose of the study was a comparative experimental assessment of long-term toxic effects of cytostatic drugs (epirubicin, etoposide, platidiam, carboplatin, paclitaxel) on the female reproductive function and search for pharmacological ways to reduce them.Material and Methods. …”
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Adaptation and psychometric evaluation of the Chinese version of the hip disability and osteoarthritis outcome Score–Physical function Short-form (HOOS-PS) by Mengyuan He, Benjing Song, Hongbao Hu, Dongfa Liao, Lin Cui, Li Yin, Lin Wu, Amuyida, Shihong Li, Yingchao Tang, Jianxiang Long, Qingyun Xie, Wei Wang

“…Abstract Background Chronic hip joint disease has a high prevalence in China, and the primary scale currently used to assess functional recovery after total hip arthroplasty (THA) is the Hip disability and Osteoarthritis Outcome Score - Physical Function Short-form (HOOS-PS). …”
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The significant impact of meconium ileus on clinical outcomes among Brazilian individuals with cystic fibrosis—a retrospective analysis of a patient registryResearch in context by Luiz Vicente Ribeiro F. da Silva-Filho, Gianluca Belchior, Angela Tavares Paes, Nicole Costa Soriano Freire, Cintia Steinhaus, Matias Epifanio, Adriana S.C. Knabben, Adriana Goya, Alberto A. Vergara, Albin E. Augustin, Ana Cristina C.F. Fonseca, Antonio F. Ribeiro, Bruna Ziegler, Bruno P. Pessoa, Carlos A. Riedi, Claudia Castro-e-Silva, Claudia M. Gonçalves, Cleyde M.A. Nakaie, Constantino G.B. Cartaxo, Daniela S.P. Borgli, Daniela G. Meneses, Daniele M.T. Ferrao, Dayse V. Oliveira, Debora C. Chong-e-Silva, Denise M.C. Haidar, Edna L.S. Souza, Eduardo Piacentini-Filho, Elenara F.A. Procianoy, Elizabet V. Guimarães, Elizabeth P.S. Silva, Evalto M. Araujo-Filho, Fabiola V. Adde, Fernanda B.S. Malini, Flavia F. Fernandes, Francyelly W. Yamamoto, Gilberto B. Fischer, Glaunir M. Foletto, Izabela Sad, Jocemara Gurmini, Katharina V.N. Moura, Katia I. Oliveira, Lais R. Mota, Leonardo A. Pinto, Liana S. Coelho, Lilian C.F. Andries, Lorenna J.A. Prado, Luciana F. Velloso-Monte, Lusmaia D.C. Costa, Mara R.F. Figueiredo, Marcela D. De-Sillos, Marcelo B. Fuccio, Marcelo T. Rodrigues, Maria A.C.A. Sousa, Maria Angelica Santana, Maria E.S.A. Moreira, Maria F.B.H. Perez, Maria I.M. Fernandes, Mariane G.M. Canan, Marina M. Gonçalves, Marina P. Nishi, Marta C. Duarte, Murilo C.A. Britto, Neiva Damaceno, Patricia G.M. Bezerra, Paulo C. Kussek, Paulo T.R. Dalcin, Paulo J.C. Marostica, Raphael F.J. Oliveira, Roberta C.N.C. Melotti, Rosangela V. Garcia, Samia Rached, Silvia O.T. Tanaka, Sonia E.L. Valente, Sonia M. Chiba, Suzana F.O. Melo, Tania W. Folescu, Tiago N. Veras, Valeria C. Martins, Vera M. Dantas, Virginia A.F. Castro

“…Demographic data, genotype, lung function, nutritional data, microbiological data and survival data were compared between groups. …”
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The Cognitive Correlates of Obsessive-Compulsive Disorder: The Predictive Role of Looming Maladaptive Style, Executive Function, Thought-Action Fusion and Metacognition by Maryam Koosheshi, Rahim Yousefi, Ladan Vaghef

“…The participants completed the Threat Magnification Maladaptive Style Questionnaire, the Barkley Deficits in Executive Functioning Scale, the Metacognition Assessment Questionnaire (30 items), the Thought-Action Fusion Questionnaire, and the Yale-Brown Obsessive-Compulsive Scale. …”
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La enseñanza del español a hablantes de herencia en inmersión parcial y total: factores eficaces del aprendizaje en aulas heterogéneas / The teaching of Spanish to heritage speaker... by María Pilar López-García

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Interactive Learning Tool for System of Linear Equations: Bridging the Gap Between Novice and Expert Through MATLAB-Based Solutions by Reem A. Alnanih, Lamiaa A. Elrefaei

“…Additionally, a user satisfaction questionnaire assessed subjective factors across four categories: look and feel, interaction, feedback, and functionality. …”
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Validation of the Farsi version of the video-game addiction scale for children: its associations with social media addiction, internet addiction and executive functions by Nima Rabiei, Saeid Sadeghi, Nahal Ranaei, Nikzad Ghanbari

“…The VASC showed significant correlation with the Bergen Social Media Addiction Scale (BSMAS) and the Internet Addiction Test (IAT), indicating its convergent validity. The VASC was negatively correlated with executive function, as measured by the Behavior Rating Inventory of Executive Function (BRIEF). …”
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Effect and Mechanism of Action of Pushing Method on Rats with Skeletal Muscle Overuse Injury based on Wnt/β-catenin Signaling Pathway by DUAN Miaomiao, HUANG Bo, RUAN Lei, MU Pangpang, CHEN Yiming, PENG Liang

“…The intervention was performed in the right hind limb gastrocnemius muscle for 24 h after the modeling, and in the intervention group for 3 d after the modeling was completed.) The balance beam test was used to assess the motor function of the rats after skeletal muscle injury at 24 h after the end of modeling and 24 h after the end of the intervention, respectively; hematoxylin-eosin staining (HE) method was used to observe the pathological changes of the gastrocnemius muscle; EM-1400 transmission electron microscope was used to observe the ultrastructure of the skeletal muscle fibers; and fluorescence PCR was used to detect the myogenic regulatory factor myogenic differentiation antigen (Myogenic differentiation antigen (MyoD), myogenin (MyoG) and paired box 7 (Pax7) mRNA transcript levels were detected by fluorescence quantitative PCR; MyoD, MyoG, Pax7, Wnt3a, Axin2 and β-catenin protein expression levels were detected by Western blot. …”
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Optimized and Additively Manufactured Face Mills for Enhanced Cutting Performance by Ozgur Poyraz, Daniel Tomlinson, Anthony Molyneux, Marie E. Baxter, Evren Yasa, James Hughes

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Explanatory Model of Self-Efficacy for Cervical Cancer Screening by Angela-Cristina Yanez Corrales, Maria-Teresa Urrutia, Oslando Padilla

“…Results: The factors that explain high levels of SE are low levels of education and knowledge of the risk factors of CC, better beliefs about the barriers to and benefits of a Papanicolaou (Pap) test, participation in breast cancer screening, and highly functional family Apgar. …”
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Exploring perceived barriers and facilitators to using mobile phone technology for delivering HPV test results in malawi: a qualitative study with HPV-Screened women, healthcare pr... by John C. Chapola, Lameck Chinula, Wezzie Dunda, Agatha Bula, Bettie Kasonkanji, Jennifer H. Tang

“…The study findings revealed several critical factors influencing the implementation of HPV result delivery via mobile phone. …”
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Effects of high-intensity interval training on executive functions and IGF-1 levels in sedentary young women: a randomized controlled trial by Manuel Jesús Jimenez-Roldán, Borja Sañudo Corrales, Luis Carrasco Páez

“…Salivary IGF-1 concentrations were measured using enzyme-linked immunosorbent assay (ELISA). Executive functions were evaluated with the Stroop Test, Wisconsin Card Sorting Test, and Digit Span Test. …”
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Artificial intelligence as a transforming factor in motility disorders–automatic detection of motility patterns in high-resolution anorectal manometry by Miguel Mascarenhas, Francisco Mendes, Joana Mota, Tiago Ribeiro, Pedro Cardoso, Miguel Martins, Maria João Almeida, João Rala Cordeiro, João Ferreira, Guilherme Macedo, Cecilio Santander

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Viscoelastic Point-of-Care Testing (ClotPro^®) to Guide Intravenous Thrombolysis in Acute Ischemic Stroke Patients on DOACs: Replacing History with Hemostasis in a Proof-... by Jessica Seetge, Balázs Cséke, Zsófia Nozomi Karádi, Edit Bosnyák, Eszter Johanna Jozifek, László Szapáry

“…However, reliable medication histories are often unavailable, and conventional coagulation tests inadequately detect DOAC activity. This study evaluated whether viscoelastic point-of-care testing (ClotPro^®) could identify the absence of anticoagulant effect in AIS patients on DOACs, thus enabling IVT administration and potentially improving clinical outcomes. …”
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Calycosin suppresses the activating effect of granulocyte-macrophage-colony-stimulating factor-producing T helper cells on macrophages in experimental atherosclerosis by Xiaofang Xiong, Wei Huang, Xuexue Yang, Xun Wang, Beibei Wu, Dongsheng Li

“…This study was designed to test the calycosin-induced impact on the pro-atherosclerotic function of ThGM cells in a mouse atherosclerosis model.MethodsApolipoprotein E knockout (ApoE−/−) mice were fed a high-fat diet and calycosin. …”
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Correlation of Dance Functional Status with Lower Limb Flexibility, Power and Dynamic Balance in Recreational Ballet Dancers – A Cross-Sectional Study by Priyanka Kumbhar, Neetu Mahapatra

“…The accumulation of repetitive injuries often hampers their ability to attain the highest levels of achievement in their careers, underscoring the necessity to identify and comprehend contributing factors. The aim is to fnd a correlation between the Dance Functional Outcome Survey (DFOS) and critical factors like lower limb flexibility, power, and dynamic balance among recreational ballet dancers. …”
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