Split otoferlins reunited by Jeffrey R Holt, Gwenaelle SG Geleoc

“…Abstract Gene therapy for genetic hearing loss is a nascent field with just a handful of studies published to date that demonstrate proof‐of‐concept recovery of auditory function (reviewed in Ahmed et al, 2017; Lustig & Akil, 2018). One challenge that faces the inner ear field, as well as the broader gene therapy field, is the need to deliver large gene sequences despite the limited genetic capacity (~4.5 kB) of delivery vehicles such as adeno‐associated viral vectors (AAV). …”
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Getting time and building trust: unveiling the systemic, relational, and personal factors influencing clinical pharmacy service implementation in South Africa, a qualitative study by Lucille Crafford, Rashmi A Kusurkar, Elmien Bronkhorst, Andries Gous, Anouk Wouters

“…Thematic analysis employed an inductive approach, following an initial preliminary analysis of open and selective coding to develop a coding framework. Results Clinical pharmacists (n = 16) reported various challenges impacting service implementation and motivation. …”
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The role of conformity in mask-wearing during COVID-19. by Anna Woodcock, P Wesley Schultz

“…We focused on mask-wearing behavior during fall 2020, and coded livestream public webcam footage of 1,200 individuals across seven cities. …”
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O racismo escondido sob o manto da Lei / The Racism hidden under cover of law by Gustavo Távora Rodrigues

“…<p><strong>RESUMO</strong></p> <p>A ineficiência do combate à conduta racial no Brasil resulta da impropriedade da legislação ordinária posta, mesmo em face de expresso Mandado de Criminalização da Constituição Federal. …”
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Barriers and challenges: a descriptive qualitative study of job satisfaction among direct care workers who provide long-term care services in Shandong Province, China by Qiang Sun, Jia Yin, Jing Gao

“…To enhance the stability of the care workforce, there is an urgent need for an in-depth analysis of the barriers and challenges that affect job satisfaction from the perspective of DCWs.Objectives This study uses the Herzberg’s two-factor theory to explore the barriers and challenges that affect job satisfaction among DCWs in LTC services from their perspective.Design A descriptive qualitative study design involving face-to-face semistructured interviews. Thematic framework analysis was used to generate qualitative codes and identify themes.Participants The study included 31 DCWs from an LTC service institution.Setting This study was conducted in Shandong Province, China. …”
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Compassion in Mexico and the United States: Unpacking Cultural Differences by Naomi Hernandez, Liam Llerena, Evita Morales, Jack Tillman, David Ruiz Mendez, Birgit Koopmann-Holm

“…Participants from Mexico and the United States engaged in a reverse correlation task, selecting stimuli that most closely resembled a compassionate face. The selected images were aggregated and coded for the extent of sadness and happiness depicted. …”
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Evaluating Factors Affecting Knowledge Sharing Among Health Care Professionals in the Medical Imaging Departments of 2 Cancer Centers: Concurrent Mixed Methods Study by Maryam Almashmoum, James Cunningham, John Ainsworth

“…A total of 59% (17/29) of health care professionals from The Christie shared their knowledge using emails and face-to-face communication as their main tools on a daily basis, and 57% (32/56) of health care professionals from the KCCC used face-to-face communication for knowledge sharing. …”
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Where did the footnote go? How the change of mode in sight translation affects meaning-making by Randi Havnen

“…This change is most evident at the interpersonal level in face-to-face encounters. These new insights should inform interpreters' sight translation practice and training, as well as future research.…”
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Adeno-associated viral vectors for modeling Parkinson’s disease in non-human primates by Julia Chocarro, José L. Lanciego

“…Although still facing several limitations, these models have managed to mimic the known neuropathological hallmarks of Parkinson’s disease with unprecedented accuracy, delineating a more optimistic scenario for the near future.…”
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Female Itinerant Migrants' Experiences Receiving Maternal Care in Healthcare Facilities; Application of the Three‐Delay Model by Joshua Sumankuuro, Fauzia Yussif, Maximillian Kolbe Domapielle

“…To develop themes around the “third delay,” we used deductive coding. Both manual and computer coding were applied. …”
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Integrating Palliative Care and Heart Failure: the PalliatHeartSynthesis realist synthesis by Tracey McConnell, Carolyn Blair, Geoff Wong, Claire Duddy, Clare Howie, Loreena Hill, Joanne Reid

“…Data extraction Initial coding of the documents used both inductive (codes emerging through data analysis) and deductive methods (codes determined prior to analysis through initial programme theory and stakeholder discussions). …”
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Exploring the Willingness of Young and Middle-Aged CHD Patients to Participate in Home-Based Cardiac Rehabilitation: A Qualitative Study by Liu T, Yang S, Rong S, Liu M, Wang X, Ji Y

“…This study used the theory of planned behavior (TPB) as the theoretical framework to carry out data collection and analysis. Face-to-face, semi-structured interviews were used to collect the data. …”
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Patient Perspectives on Health Care Utilization at Two Free Clinics – A Qualitative Study by Patrick Fagan, Danny Guillen Perez, Roberta Baer, John Petrilli

“…Data were collected through face-to-face, open-ended interviews at two free clinics in an urban Florida community. …”
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Exploring experiences regarding contraception practices among married men in a rural area of West Bengal: A qualitative study by Anil Karmakar, Jayita Pal, Rakhi Saha, Sankalpa Satapathy, Manoj Ghosh

“…Methods: A community-based cross-sectional qualitative study was conducted among married men (n=10), aged 18 to 50 years by in-depth face-to-face interviews using a predesigned interview guide. …”
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Integrated Psychosocial Care in Intensive Care (IPS-Pilot): Protocol for the Systematic, Multimethod Development of a Complex Intervention (Phase A) by Sophie Felicitas Nickel, Simone Korger, Wencke Schindler, Heike Heytens, Gironimo Krieg, Karl-Philipp Drewitz, Katrin Schürmann, Leon Schössow, Julianna Gehrig, Marius Binneböse, Christian Hirning, Klaus Hönig, Rolf Konstantin Niessen, Julia Kirschbaum, Laurence Erdur, Sophie Peter, Florian Junne, Matthias Rose, Christian Apfelbacher, Harald Gündel

“…These methods included (1) a scoping umbrella review conducted by 2 researchers, who independently screened and selected reviews and meta-analyses in the field of needs and demands in the ICU setting, following the Levac framework; (2) web-based and face-to-face interviews and focus group discussions, which were coded independently by 2 researchers and analyzed using qualitative content analysis; the identified categories and codes were then quantified by (3) an online survey conducted with former ICU patients, their relatives, HCPs working in ICUs, and members of the general population. …”
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Research on the factors influencing the identity of Chinese doctor of education candidates by Liangliang Hu, Jiawei Chen, Mengxue Li, Shasha Zhang, Wenlan Zhang, Zhaoyang Liu

“…Abstract Doctor of Education (Ed.D) candidates are facing an identity crisis, and enhancing their identity has become an urgent issue. …”
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Is Spirituality a Source of Support or Conflict for Infertility? A Qualitative Study by Sevda Karakaş, Rukiye Höbek Akarsu, Özden Tandoğan, Özlem Şahan

“…Twenty participants participated in the face-to-face, in-depth interview technique used to gather the research data. …”
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Multi-Omic Approaches in Cancer-Related Micropeptide Identification by Katarina Vrbnjak, Raj Nayan Sewduth

“…In this review, we survey the current landscape of known micropeptides with a role in cancer progression or treatment, discuss their potential as anticancer agents, and describe the methodological challenges facing the proteome field of research.…”
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Evaluation of state administration performance in improving access to education in rural areas of Indonesia by Daniel T Todapa

“…Indonesia faces significant challenges in providing equitable access to education, particularly in rural areas. …”
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Improved grey wolf optimization algorithm based service function chain mapping algorithm by Yue ZHANG, Junnan ZHANG, Xiaochun WU, Chen HONG, Jingjing ZHOU

“…With the rise of new Internet applications such as the industrial Internet, the Internet of vehicles, and the metaverse, the network’s requirements for low latency, reliability, security, and certainty are facing severe challenges.In the process of virtual network deployment, when using network function virtualization technology, there were problems such as low service function chain mapping efficiency and high deployment resource overhead.The node activation cost and instantiation cost was jointly considered, an integer linear programming model with the optimization goal of minimizing the average deployment network cost was established, and an improved grey wolf optimization service function chain mapping (IMGWO-SFCM) algorithm was proposed.Three strategies: mapping scheme search based on acyclic KSP algorithm, mapping scheme coding and improvement based on reverse learning and nonlinear convergence were added to the standard grey wolf optimization algorithm to form this algorithm.The global search and local search capabilities were well balanced and the service function chain mapping scheme was quickly determined by IMGWO-SFCM.Compared with the comparison algorithm, IMGWO-SFCM reduces the average deployment network cost by 11.86% while ensuring a higher service function chain request acceptance rate.…”
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