Research on Slope Stability Based on Bayesian Gaussian Mixture Model and Random Reduction Method by Jingrong He, Tao Deng, Shouxing Peng, Xing Pang, Daochun Wan, Shaojun Zhang, Xiaoqiang Zhang

“…To compute the safety factor, the concept of a “reference slope” is introduced. This reference slope represents the state at which the slope reaches limit equilibrium under strength reduction. …”
Get full text

Personalized Treatment Response in Progressive MS: Can the Patient's Profile Influence the Outcome? by Francesca Bovis, Ludwig Kappos, Sophie Arnould, Goeril Karlsson, Maria Pia Sormani

“…Identifying factors that predict individual treatment response is crucial for optimizing patient care, and this study aimed to demonstrate the feasibility (proof of concept) of applying a statistical method to predict individual treatment response in MS trials. …”
Get full text

A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein by Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balázs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt

“…We provide in vitro and in vivo proof‐of‐concept data demonstrating that the low molecular weight tool compound inhibits CRP‐driven exacerbation of local inflammatory responses, while potentially preserving pathogen‐defense functions of CRP. …”
Get full text

Exploratory development of human–machine interaction strategies for post-stroke upper-limb rehabilitation by Kang Xia, Xue-Dong Chang, Chong-Shuai Liu, Yu-Hang Yan, Han Sun, Yi-Min Wang, Xin-Wei Wang

“…Utilizing motion capture technology, the glenohumeral joint (GH) centers of both human and exoskeleton exhibit well-matched motion curves, suggesting a comfortable dynamic wear experience. …”
Get full text

An spike-accum® bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity by Jean Pierre Bikorimana, Nathanael A. Caveney, Nehme EL-Hachem, Gabrielle A. Mandl, John A. Capobianco, Daniela Stanga, Jamilah Abusarah, Mark A. Hancock, Roudy Farah, Marina P. Gonçalves, Darryl Falzarano, Mingmin Liao, Glenn Hamonic, Qiang Liu, Simon Beaudoin, Sebastien Talbot, Moutih Rafei

“…Altogether, this proof-of-concept study not only demonstrates once again the versatility of the Accum® technology in vaccine engineering, but it provides an enabling technology for the rapid development of value-added, protein-based vaccines for future pandemics.…”
Get full text

Exploring bladder cancer through urinary microbiota: innovative “urinetypes” classification and establishment of a diagnostic model by Zhaoyang Sheng, Jing Liu, Maoyu Wang, Xiang Chen, Jinshan Xu, Chen Zhang, Yang Xu, Hui Zhang, Jinpeng Zhu, Nan Qin, ShuXiong Zeng, Zhijun Zheng, ZhenSheng Zhang

“…The introduction of the innovative concept of “Urinetypes” and the identification of high-risk subtypes associated with BCa offer the potential for improved diagnostic and therapeutic strategies. …”
Get full text

Granger causality connectivity analysis of persistent atrial fibrillation dynamics reveals posterior wall mechanistic insights by Joseph Barker, MRes, Arunashis Sau, PhD, Nikesh Bajaj, PhD, Alex Jenkins, MPhys, Alex Sharp, MRCP, Xili Shi, PhD, Xinyang Li, PhD, Nabeela Karim, PhD, Balvinder Handa, PhD, Richard Chambers, MSc, Timothy Betts, PhD, Nicholas S. Peters, MD, FHRS, Tom Wong, MD, Fu Siong Ng, PhD, FHRS

“…Objective: This study aimed to apply GC to intracardiac electrograms to uncover patient-specific AF dynamics and describe a proof-of-concept approach to targeted PWI after PVI. Methods: A prospective cohort study was undertaken at Royal Brompton Hospital. …”
Get full text

Schaftoside from Plumula nelumbinis mitigates “Shanghuo” by inhibiting low‐grade inflammation, diminishing oxidative stress, and enhancing energy metabolism by Zhiqiang Li, Weijie Wu, Ruiling Liu, Huizhi Chen, Lishu Wang, Ben Niu, Honglei Mu, Haiyan Gao, Hangjun Chen

“…In modern medicine, it is associated with various factors, including dietary irritants, stress, gut microbiota imbalances, and immunological issues. The concept of Yin–Yang balance is pivotal in the theory of traditional Chinese medicine. …”
Get full text

Research on Stacking Distribution of Steel Plates Input Based on Improved Multi-objective Particle Swarm Optimization by ZHONG Chuanjie, CHENG Wenming, DU Run, GAO Xuchao, ZHANG Lin

“…A multi-objective particle swarm optimization algorithm (PCDMOPSO) based on species clustering degree was designed to solve this model using the concept of Pareto dominance and the classical particle swarm optimization algorithm. …”
Get full text

Unveiling the third dimension of glass by Faidra Oikonomopoulou

“…Based on the aforementioned challenges, a new concept for glass structures out of dry-assembled interlocking cast glass components is developed that tackles the integral limitations of the adhesively-bonded system. …”
Get full text

Unveiling alcohol bias and impaired inhibitory control in young binge drinkers: insights from the alcohol hayling task by Carina Carbia, Natália Almeida-Antunes, Margarida Vasconcelos, Eduardo López-Caneda

“…These findings suggest that young binge drinkers exhibit a semantic accessibility bias towards alcohol-related concepts and difficulties inhibiting alcohol-related content. …”
Get full text

Research and Application of Ga-Based Liquid Metals in Catalysis by Yu Zhang, Ying Xin, Qingshan Zhao

“…Furthermore, Ga-based liquid metal catalysts also exhibit distinct advantages in catalytic reactions within battery systems and mechano-driven catalysis, offering innovative concepts and technical pathways for developing novel catalytic systems. …”
Get full text

Andean Epistemology Ch’ixi, and Neutrosophic Logic by Florentin Smarandache, Maikel Y. Leyva Vázquez

“…However, current models like GPT-4 exhibit critical limitations: biases toward overestimating truth values (T) and artificially clustering indeterminacy (I ≈ 0.7), flattening nuanced concepts such as yanantin and ch’ixi. …”
Get full text

Stakeholder Perspectives on EU Regulatory Frameworks: Navigating Critical Raw Materials, Battery Innovation, and Recycling Challenges [version 2; peer review: 2 approved] by Willem Arie Vonk, Anish Patil

Get full text

An exploratory study on midwives' perceptions of the availability of preconception care in health facilities in the Kpandai District of Northern Ghana. by Richard Kwaku Bawah, Gilbert Abotisem Abiiro, Gifty Apiung Aninanya, Barnabas Sackeyuah

“…<h4>Background</h4>Preconception care is a critical component of reproductive health that significantly influences the well-being of individuals and couples prior to conception. Midwives play a critical role in addressing potential health problems prior to pregnancy, with the priority of optimizing positive pregnancy outcomes. …”
Get full text

Defective verbs in Portuguese: a morphomic approach by O’Neill Paul

“…Within such a broader conception of meaning, morphomes have essentially the same predictive value as ‘meaning-driven’ patterns. …”
Get full text

Innovation-driven growth: the power of technological capability in regional development by Yixin Dai, Yuanhong Hu, Manzoor Ahmad, Yunting Mou

“…Traditional theories predominantly concentrate on macro-level concepts, often overlooking the relationship between technological capability and regional economic growth, which has seldom been empirically examined. …”
Get full text

Genre Features of Professional Screenplays in Russia in 1910s: Theory and Practice by A. G. Plotnikova

“…The article explores the genre dominants of Silver Age screenplays. Theoretical concepts of film dramaturgy are applied to the texts of A. …”
Get full text

Cultural Code in Scientific and Journalistic Dimensions by O. A. Dimitrieva

“….); the value aspect of culture (the cultural component) highlights actions denoted by verbs like preserve, protect, transmit, among others, as well as abstract concepts such as values, knowledge, understanding, and mastery. …”
Get full text

EXPLORING CREATIVE THINKING SKILL by Hilaria Yesieka Ayu Wulandari, Rooselyna Ekawati, Ali Shodikin

“…Furthermore, the creative thinking skills displayed by the subject contribute to their comprehensive understanding of mathematical concepts and foster deeper engagement with the subject. …”
Get full text