Activity-based recovery training with spinal cord epidural stimulation improves standing performance in cervical spinal cord injury by Claudia A. Angeli, Enrico Rejc, Beatrice Ugiliweneza, Maxwell Boakye, Gail F. Forrest, Katelyn Brockman, Justin Vogt, Brittany Logsdon, Katie Fields, Susan J. Harkema

“…The lower-limb standing activation pattern changes were consistent with the greater standing independence observed by all groups. …”
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Functional Outcome of Bimalleolar Ankle Fractures – A Prospective Study by R. Sahaya Jose, Shaheen Hameed, N. Kattu Bava, M. Syed Moosa

“…This study was conducted to evaluate the functional outcome of bimalleolar ankle fractures treated with various surgical modalities. …”
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Design of a Micro-Plant Factory Using a Validated CFD Model by Xinxin Chen, Tengyuan Hou, Shulin Liu, Yongxiu Guo, Jianping Hu, Gaoming Xu, Guoxin Ma, Wei Liu

“…The uniformity of the cultivation environment in a micro-plant factory plays a critical role in ensuring the consistent growth of seedlings, and an optimal airflow pattern is the key to maintaining environmental uniformity. …”
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Activation of the Reelin/GSK-3β/p-Tau Signaling Pathway in the Hippocampus of Patients with Temporal Lobe Epilepsy by Lin J, Lin X, Fu YJ, Li X, Li X, Wang Y, Zhao L, Yu S, Piao YS

“…Immunohistochemistry and the histelide assay, a novel technique quantifying antigens in paraffin section, were used to confirm the distribution of protein within Reelin/GSK-3β/p-Tau signaling pathway and validate the expression of GSK-3β and AT8 (hyperphosphorylated tau) in this study.Results: Immunohistochemical staining for AT8 revealed punctate and filamentous positive expression in the CA1, CA2 and CA3 regions of the hippocampus with TLE under the ependyma, distributed in a band-like pattern. By contrast, the control group did not exhibit any immunopositivity. …”
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Prevalence of problematic khat use and its associated factors among high school students in Legambo woreda, Ethiopia by Bihonegn ligaba, Minale Tareke, Almaz Mamaru, BirhanuAssefa Fentahun

“…Objectives The aim of the study was to evaluate the prevalence of PKU and to identify factors that contribute to this issue among high school students. …”
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Dynamic serum lactate dehydrogenase monitoring during the acute phase and association with in-hospital all-cause mortality risk in large vessel occlusion acute ischemic stroke pati... by Weiwei Gao, Lijuan Cai, Xingyu Chen, Renjing Zhu

“…Progressively adjusted multivariable logistic regression models evaluated associations between LDH and IHM. Restricted cubic spline (RCS) regression explored potential non-linear relationships, while subgroup analyses and interaction testing assessed the consistency and robustness of associations. …”
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Non-linear associations and threshold effects of BRI, CI, and WHtR with grip strength in U. S. adults aged ≥20 years: a cross-sectional study by Sijia Yang, Kun Liao, Lu Zhou, Shengbo Zhang, Jianchao Wu

“…WHtR demonstrated a similar pattern, with a threshold set at 0.51: β = 62.46 (48.36–76.55) below and β = 6.47 (2.85–10.08) above. …”
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Deucravacitinib, an oral, selective, allosteric, tyrosine kinase 2 inhibitor, in patients with active SLE: efficacy on patient-reported outcomes in a phase II randomised trial by Laurent Arnaud, Marta Mosca, Anca Askanase, Vibeke Strand, Subhashis Banerjee, Shalabh Singhal, Coburn Hobar, Samantha Pomponi, Brandon Becker, Jiyoon Choi

“…Missing data were imputed using control-based pattern imputation.Results At week 48, greater mean improvement in pain and fatigue scores from day 1 were reported across all deucravacitinib dose groups compared with placebo. …”
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Association between intake of various sugar subtypes and common mental disorders: A large prospective study by Lina Qin, Boyue Zhao, Meijuan Kang, Tingting Mao, Weixuan Da, Yue Che, Hanchi Wang, Yijia Li, Jin Feng, Yifan Gou, Li Liu, Huan Liu, Bolun Cheng, Yumeng Jia, Yan Wen, Feng Zhang

“…This study aimed to systematically evaluate the associations between ten subtypes of sugar and three mental disorders: depression, anxiety, and self-harm. …”
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Development of Dihydroquercetin-based Oral tablets and Evalution of the General Toxic Effect by S. A. Abdulrazzak, A. N. Vorobyev, N. I. Sinitsyna, I. V. Sharutin, O. V. Menshova, E. V. Elizarova, Yu. V. Ivanov, A. S. Karamyan, R. A. Abramovich, O. G. Potanina, K. M. Sakanyan

“…The lethal dose for a single administration was determined, and the toxic effects of repeated repeated administration of the drug dihydroquercentin in the dosage form of an oral tablet were evaluated. The local irritant effect of the drug during oral administration was evaluated in laboratory animals. …”
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Key events in the process of sex determination and differentiation in early chicken embryos by Xiaoqian Lv, Changhua Sun, Xin Liu, Guanzheng Liu, Wei Gong, Hongwu Qian, Zeyu Li, Jun Wu, Xilin Zhu, Jiuzhou Song, Yingjie Niu, Hongyan Sun, Wei Han, Guo hong Chen, Kai Jin, Bichun Li, Qisheng Zuo

“…Sex-related gene expression, hormone levels, and gonad morphology were evaluated to determine treatment effects. Results Key findings revealed that sex differences emerged as early as the blastocyst stage, intensified with embryonic development and were marked by a surge in sexually dimorphic gene expression. …”
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Efficacy of switching from originator adalimumab to biosimilar adalimumab-AACF in patients with axial spondyloarthritis: a 12-month observational study by Fanny Alcira Reyes Neira, Barbara Bayeh, Karina Rossi Bonfiglioli, Nadia Emi Aikawa, Ana Paula Luppino Assad, Renata Miossi, Fernando Henrique Carlos de Souza, Carlos Emilio Insfrán, Henrique Ayres Mayrink Giardini, Emily Figueiredo Vieira Neves Yuki, Eloisa Bonfa, Carla Gonçalves Schahin Saad, Ana Cristina de Medeiros-Ribeiro, Julio Cesar Bertacini de Moraes, Andrea Yukie Shimabuco

“…Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP remained stable when comparing T0 to T6 [1.56 (± 0.88) vs. 1.50 (± 0.82), P = 0.73] and T12 [1.56 (± 0.88) vs. 1.26 (± 0.86), P = 0.13]. A similar pattern was observed for ASDAS-erythrocyte sedimentation rate (ESR; P > 0.05) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI; P > 0.05). …”
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Short light/dark cycles favour photosynthetic efficiency and growth in grapevines by Mariana Gómez Tournier, Laurent Torregrosa, Jana Kändler, Angélique Christophe, Romain Boulord, Anna Medici, Anne Pellegrino

“…We evaluated photosynthetic efficiency, leaf growth, biomass production and partitioning, and resource use efficiency (water and light). …”
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Distribution and extended triage of high-risk human papillomavirus genotyping based on vaginal self-sampling by Ling Li, Yun Zhao, Rong Liu, Chen Yao, Zhijun Zhang, Yingying Hu, Ruifang Wu, Ruifang An, Hui Du, Xinfeng Qu, Lihui Wei, Bei Lin, Mingzhu Li, Chao Zhao, Jingran Li, Zhixin Lin, Jihong Deng, Songling Zhang

“…The age-specific prevalence curve of HR-HPV followed a U-shaped pattern from 30 to 59 years, with a lower prevalence observed in women aged 40–44 years (12.35%), which subsequently changed with age. …”
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Systemic immune inflammation index and systemic inflammation response index predict frailty progression in older patients undergoing elective orthopedic surgery by Guanghan Gao, Zitian Zheng, Fei Wang, Yaonan Zhang, Lei Shi, Lin Wang, Hongyu Wang, Qingyun Xue

“…The linear trend between SII–SIRI pattern/SII/SIRI levels and frailty progression was statistically significant. …”
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Clinical Utility of Induced Sputum and Bronchoalveolar Lavage Cultures in Diagnosing Nontuberculous Mycobacterial Pulmonary Disease by Maria Angela Licata, Paola Mencarini, Annelisa Mastrobattista, Serena Maria Carli, Carlotta Cerva, Silvia Mosti, Raffaella Libertone, Alberto Zolezzi, Pietro Vittozzi, Carla Nisii, Antonio Mazzarelli, Angela Cannas, Assunta Navarra, Stefania Ianniello, Rocco Trisolini, Delia Goletti, Fabrizio Palmieri, Gina Gualano

“…In this retrospective study, we evaluated the results of microbiological tests performed on respiratory samples of 132 patients affected by NTM-PD. …”
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Disuse-Induced Muscle Loss and Rehabilitation: The National Aeronautics and Space Administration Bed Rest Study by Jessica M. Scott, PhD, Meghan Downs, PhD, Roxanne Buxton, MS, Elizabeth Goetchius, MS, Brent Crowell, MS, Robert Ploutz-Snyder, PhD, Kyle J. Hackney, PhD, Jeffrey Ryder, PhD, Kirk English, PhD, Lori L. Ploutz-Snyder, PhD

“…We sought to characterize bed rest–induced leg muscle atrophy and evaluate the safety and efficacy of an acute rehabilitation program. …”
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White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the Un... by Florencia Altschuler, Verónica Canziani, Matías Fraile-Vázquez, Raul Gonzalez-Gomez, Hernán Hernández, Sandra Baez, Joaquín Migeot, Sol Fittipaldi, Marcelo Adrian Maito, Agustina Legaz, Maria Eugenia Godoy, Sebastián Moguilner, Josephine Cruzat, Carlos Coronel-Oliveros, Enzo Tagliazucchi, Hernando Santamaria Garcia, Pablo Reyes, Diana L. Matallana, José Alberto Avila-Funes, Andrea Slachevsky, María I. Behrens, Nilton Custodio, Juan Felipe Cardona, Luis Ignacio Brusco, Martin A. Bruno, Ana L. Sosa Ortiz, Stefanie D. Pina-Escudero, Leonel T. Takada, Elisa de Paula Franca Resende, Katherine L. Possin, Maira Okada de Oliveira, Kun Hu, Brian Lawlor, Jennifer S. Yokoyama, Bruce Miller, Francisco Lopera, Adolfo Martin Garcia, Vicente Medel, Agustin Ibañez, Cecilia Gonzalez Campo

“…Results In the LA cohort only, higher WMHs load was associated with greater GM atrophy across all groups (HCs, AD, bvFTD), with a specific neurodegenerative pattern involving orbitofrontal, cingulate, and temporal areas. …”
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The role of METTL14 in the progression of chronic myeloid leukemia by Jing Zhang, Zhi-Hua Liao, Yan-Mei Xu, Shu-Qi Li, Fang-Min Zhong, Ling Zhang, Fang-Yi Yao, Qin Bai, Li-Hua Yao, Bo Huang, Jing Liu, Xiao-Zhong Wang

“…Consequently, this modification results in shifting Bcl-xS to Bcl-xL and inactivating the BCL-2/BAX/Caspase-3 pathway.Conclusion METTL14-driven m6A modification regulates the splicing pattern of Bcl-x, and may facilitate the progression of CML. …”
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Hypertension control during the COVID-19 pandemic: results of the MMM2021 in Russia by O. P. Rotar, A. M. Erina, M. A. Boiarinova, E. V. Moguchaia, E. P. Kolesova, K. M. Tolkunova, A. R. Gorshevaya, K. A. Kovalenko, E. A. Smirnova, Ya. A. Belenikina, I. V. Bikushova, M. A. Kercheva, A. V. Svarovskaya, M. M. Petrova, D. S. Kaskaeva, P. A. Shcherbina, S. Yu. Nikulina, A. A. Chernova, A. V. Levshin, A. O. Shabelsky, E. I. Zheleznyak, E. A. Kartashova, Yu. A. Sharapova, T. M. Chernykh, M. V. Derevyanchenko, V. V. Fedotov, N. Yu. Shaposhnikova, E. R. Makeeva, O. V. Ulitina, M. V. Menzorov, E. M. Dolya, A. A. Tanicheva, A. O. Konradi, E. V. Shlyakhto

“…Repetitive quarantines and social restrictions during the coronavirus disease 2019 (COVID-19) pandemic have negatively affected the population health in general, and the control of hypertension (HTN) in particular.Aim. To evaluate the control of HTN in the Russian population during the COVID-19 period based on the results of screening for HTN May Measurement Month 2021 (MMM2021).Material and methods. …”
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