The prospect of novel orphan therapeutic protocol for TSC2/PKD1 contiguous gene syndrome: a case report by Bogdan D. Agavriloaei, Radu C. Costache, Ramona G. Babici, Stela Racoviță, Gianina Dodi, Adrian C. Covic, Irina L. Mititiuc

“…By integrating detailed clinical assessment with genetic testing, the diagnosis was clarified, and targeted therapies can be selected to address the dual impact of ADPKD and TSC; however, further studies are needed to evaluate the efficacy and safety of this approach. …”
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Cerebral Amyloid Angiopathy Is Associated With Higher R2 Relaxation Rate: An MRI and Pathology Study by Md Tahmid Yasar, Arnold M. Evia, Mahir Tazwar, Sue E. Leurgans, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis

“…This study tested the hypothesis that CAA is associated with R2, extracted the spatial pattern of CAA‐related R2 abnormalities, and evaluated R2 at different CAA severity levels in a large number of community‐based older adults. …”
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Thermal Analysis of Whole Bacterial Cells Exposed to Potassium Permanganate Using Differential Scanning Calorimetry: a Biphasic Dose-Dependent Response to Stress by Marina K. Abuladze, Victor M. Sokhadze, Emma N. Namchevadze, E. Kiziria, Leila V. Tabatadze, Lia V. Lejava, Sh. Gogichaishvili, Nugzar B. Bakradze

“…This study presents the DSC method for evaluating and monitoring the effects of exposure to potential human and environmental toxicants.…”
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Spatial-temporal baseline study of nutrients and trace elements characterization of a large tropical transition system in West Africa by Celso Paulo, João A. Carreiras, Susanne Tanner, Carmen Van-Dúnem dos Santos, Vanessa F. Fonseca, Bernardo Duarte

“…The Bay's physicochemical features, nutrients, and trace element contamination were evaluated to assess the system's anthropogenic pressure. …”
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Chromosomal and plasmid DNA mediated antibiotic resistance among Staphylococcus aureus obtained from mastitic milk of cattle in Jaipur, Rajasthan by SHIV KUMAR BASOTIA, SANDEEP KUMAR SHARMA, JYOTI, BINCY JOSEPH, VIKAS GALAV, NIRMAL KUMAR JEPH

“… The present investigation was aimed to isolate and identify the Staphylococcus aureus isolates from mastitic milk sample of cattle along with studies of phenotypic and genotypic antibiotic resistance pattern. Among 100 mastitic milk samples of cattle, total 20 (20.0%) isolates were identified and confirmed as S. aureus. …”
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Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult by Helena Luís, Carolina Barros, Mariana Gomes, José Luís Andrade, Nancy Faria

“…Blood count and biochemistry were performed with liver cytolysis pattern. Chest teleradiography showed diffuse interstitial infiltrate. …”
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l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis by Yiding Zhang, Lin Xie, Masayuki Fujinaga, Yusuke Kurihara, Masanao Ogawa, Katsushi Kumata, Wakana Mori, Tomomi Kokufuta, Nobuki Nengaki, Hidekatsu Wakizaka, Rui Luo, Feng Wang, Kuan Hu, Ming-Rong Zhang

“…Here, we developed a positron emission tomography (PET) imaging platform using l-[5-11C]glutamine ([11C]Gln) and evaluated its efficacy in NASH mice undergoing metabolic therapy with bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES), a glutaminase 1 (GLS1) inhibitor that intervenes in the first and rate-limiting step of glutaminolysis. …”
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Long-term outcomes of patients with refractory cytopenia of childhood under observation only by Beatrice Drexler, Stephan Schwarz-Furlan, Irith Baumann, Martina Rudelius, Peter Nöllke, Dirk Lebrecht, Senthilkumar Ramamoorthy, Natalia Rotari, Axel Karow, Shinsuke Hirabayashi, Fabian Beier, Yvonne Lisa Behrens, Gudrun Göhring, Reinhard Kalb, Marcin W. Wlodarski, Brigitte Strahm, Miriam Erlacher, Charlotte M. Niemeyer, Ayami Yoshimi

“…We evaluated the long-term outcome of patients with RCC without evidence of a genetic predisposition who had a normal karyotype and had not received HSCT or immunosuppressive therapy within 2 years from diagnosis. …”
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Effect of Nd:YAG Low Level Laser Therapy on Human Gingival Fibroblasts by Andreas S. Gkogkos, Ioannis K. Karoussis, Ioannis D. Prevezanos, Kleopatra E. Marcopoulou, Kyriaki Kyriakidou, Ioannis A. Vrotsos

“…Aim. To evaluate the effect of Low Level Laser Therapy (LLLT) on human gingival fibroblasts in terms of proliferation and growth factors’ secretion (EGF, bFGF, and VEGF). …”
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THE PRESCRIBING TRENDS OF ACE-INHIBITORS AFTER MYOCARDIAL INFARCTION IN TERTIARY CARE HOSPITALS OF HAZARA REGION by Fiaz Alam, Ghazala Batool, Sidra Noureen, Muhammad Saad Khan, Mahnoor, Jamil ur Rehman, Iqra Zaman

“…Objective: In three sizable tertiary care hospitals in the Hazara region, the study's objective was to evaluate the usage of ACE-inhibitors in patients who had experienced MI. …”
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Efficacy of VG26 and K1 acupuncture points in cardiopulmonary resuscitation of neonatal puppies born by cesarean section by Maria Lucia G. Lourenço, Fabíola C. Knupp, Keylla Helena N. P. Pereira, Keylla Helena N. P. Pereira, Kárita M. Fuchs, Gleice M. Xavier, Júlia C. Mendonça, Miriam Harumi Tsunemi, Fabiana F. Souza, Jean G. F. Joaquim

“…The aim of this study was to evaluate the effects of acupuncture points VG26 and K1 on the reversal of apnea and the elevation of heart and respiratory rates in neonatal dogs after birth. …”
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Plasma levels of the neuron damage markers brain-derived tau and glial fibrillary acidic protein in Lyme neuroborreliosis: A longitudinal study by Mathilde Ørbæk, Fernando Gonzalez-Ortiz, Rosa M.M. Gynthersen, Åse Bengaard Andersen, Kubra Tan, Ulf Andreasson, Kaj Blennow, Helene Mens, Henrik Zetterberg, Anne-Mette Lebech

“…Changes in biomarker concentrations were analyzed using linear mixed models with an unstructured covariance pattern, with follow-up included as a categorical fixed effect. …”
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Comparative analysis of different hydrological models in flood forecasting for the upper Juma River basin by Ting Li, Shilong Hao, Fuxin Chai, Kuang Li, Haoqiang Tong

“…The Xin’anjiang model demonstrated superior performance, achieving an average Nash-Sutcliffe Efficiency (NSE) approximately 0.21 higher than the other models across the evaluated events. When flood discharge is high and exhibits a single-peak pattern, the simulation performance of all runoff models improves. …”
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Germinated Spores of the Probiotic Bacterium <i>Bacillus coagulans</i> JBI-YZ6.3 Support Dynamic Changes in Intestinal Epithelial Communication and Resilience to Mechanical Woundin... by Sage V. McGarry, Earvin A. F. Grinage, Krista Sanchez, Dina Cruickshank, Liang Anderson, Gitte S. Jensen

“…The spore-forming probiotic <i>Bacillus coagulans</i> JBI-YZ6.3 interacts with the gut epithelium via its secreted metabolites as well as its cell walls, engaging pattern-recognition receptors on the epithelium. We evaluated its effects on human T84 gut epithelial cells using in vitro co-cultures, comparing metabolically active germinated spores to the isolated metabolite fraction and cell wall fraction under unstressed versus inflamed conditions. …”
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The Utility of Notched P‐Wave on the Occurrence of Ventricular Fibrillation in Patients With Brugada Syndrome by Keisuke Yonezu, Tetsuji Shinohara, Masaki Takahashi, Taisuke Harada, Kazuki Mitarai, Masayuki Takano, Kei Hirota, Ichitaro Abe, Hidekazu Kondo, Akira Fukui, Hidefumi Akioka, Yasushi Teshima, Naohiko Takahashi

“…Depending on the model, symptomatic BrS, early repolarization pattern, and fragmented QRS were also independently associated with VF. …”
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Death Receptor 3 (TNFRSF25) Increases Mineral Apposition by Osteoblasts and Region Specific New Bone Formation in the Axial Skeleton of Male DBA/1 Mice by Fraser L. Collins, Jessica O. Williams, Anja C. Bloom, Michael D. Stone, Ernest Choy, Eddie C. Y. Wang, Anwen S. Williams

“…They potentially begin to explain the atypical pattern of new bone formation observed in the axial skeleton of grouped, aging DBA/1 mice.…”
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Adherence to the EAT-Lancet Diet is Not Associated With Weight Status in a Latin American Urban Multicentric Study by Rulamán Vargas-Quesada, Rafael Monge-Rojas, Juan José Romero-Zúñiga, Carolina Araya-Bastias, Irina Kovalskys, Marianella Herrera-Cuenca, Lilia Yadira Cortés, Martha Cecilia Yépez García, Reyna Liria-Domínguez, Attilio Rigotti, Mauro Fisberg, Georgina Gómez

“…Adherence to the EAT-Lancet diet was evaluated using the Planetary Health Diet Index (PHDI). …”
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One-pot hydrothermal synthesize and characterization of Au/Gd bimetallic nanostructure as potential contrast agents in CT and MR imaging by Rashed Ahmadyani, Hamed Ahmadyani, Milad Moradi, Sajad Moradi, Mohsen Shahlaei, Saleh Salehi Zahabi, Faranak Aghaz, Kave Moloudi, Negin Farhadian

“…The physicochemical properties of bimetal nanostructures were evaluated, their safety and ability to enhance contrast in both CT and MR imaging were also examined. …”
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Analysis of comb morphology in Sichuan Mountaineous Black-bone chickens and its correlation with growth performance by Kunlong Qi, Juan He, Felix Kwame Amevor, Zheliang Liu, Chencan Zhai, Yingjie Wang, Liuting Wu, Gang Shu, Xiaoling Zhao

“…In female chickens, a similar pattern was observed in the large-comb group, but the differences were not statistically significant. …”
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Development of Ferrero Nutrition Criteria: category-specific, progressive guidelines for product innovation by Federico Canzoneri, Mélanie Charron, Adam Drewnowski, Emanuela Alzari, Marta Biolatti, Emanuela Cavalli, Marco Franci, Stefania Giri, Fritz Maingrette, Maria Malgorzata Maj, Ileana Manera, Ginevra Rosso, Vittoria Russo, Gloria Veneziani, Sebastiano Collino, Enrico Pavesi

“…Often category-specific, such standards are used to guide product innovation and new product development.ObjectiveTo develop Ferrero Nutrition Criteria (FNC), a new set of progressive nutrition standards for internal use to evaluate product portfolio and to guide product formulation and development.MethodsThe FNC was developed with reference to a publicly available database, the Food and Nutrient Database for Dietary Studies (FNDDS 2017-18) and the corresponding Food Pattern Equivalents Database (FPED), both maintained by the US Department of Agriculture. …”
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