Phase II study of venetoclax added to bendamustine and obinutuzumab in patients with high-risk follicular lymphoma as front-line therapy: PrE0403 by Craig A. Portell, Opeyemi A. Jegede, Nina Wagner-Johnston, Grzegorz S. Nowakowski, Christopher Fletcher, Jonathon B. Cohen, Andrew M. Evens, Lori J. Rosenstein, Jeffrey W. Craig, Nishitha Reddy, Brad S. Kahl

“…A total of 56 subjects were planned to be accrued with a goal of having 51 subjects eligible to improve the historical 50% CR rate to 65% with an 85% power and 15% type I error rate. Immunohistochemistry (IHC) expression of 3 antiapoptotic proteins (BCL-xL, MCL-1, and BCL-2) was performed and correlated with clinical outcomes. …”
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Dentoalveolar process remodelling in the anterior mandible after Class III camouflage treatment with lower premolar extractions by Dirk Wiechmann, Robert Leven, Per Rank, Yann Janssens, Jonas Q. Schmid

“…Methods This retrospective study included 25 patients in retention (f/m 12,13) who had previously been treated with lower premolar extractions for Class III camouflage with a completely customized lingual appliance (Wits at T0 -6.7, ± 2.5 mm). …”
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Neuraminidase Inhibitors: Development and Validation of a Procedure for <i>In Vitro</i> Determination of the Inhibitory Effect by N. M. Faustova, S. S. Petlitskaya, I. N. Ampilogova, M. V. Karlina, M. N. Makarova, V. G. Makarov

“…Neuraminidase inhibitors are a class of antivirals used to  treat  influenza  infections. Screening assays for potential neuraminidase inhibitors would benefit from  the development of in vitro procedures that do not require handling viruses. …”
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Cerebral Embolic Protection Devices in Transcatheter Aortic Valve Implantation: Meta‐Analysis With Trial Sequential Analysis by Nav Warraich, Michel Pompeu Sá, Xander Jacquemyn, Toshiki Kuno, Derek Serna‐Gallegos, Ibrahim Sultan

“…Trial sequential analysis was conducted to generate adjusted significance boundaries, futility boundaries, and the required information size considering a type I error of 5% and a power of 90%. Seven trials were included with a total of 4031 patients, of whom 2171 were treated with a device and 1860 were not. …”
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Excellent outcomes with adjuvant toremifene or tamoxifen in early stage breast cancer by Jaime D. Lewis, Anees B. Chagpar, Elizabeth A. Shaughnessy, Jacob Nurko, Kelly McMasters, Michael J. Edwards

“…On the basis of intenttotreat, 5-year actuarial DFS was not significantly different between tamoxifen and toremifene (91.2 % (standard error of the mean (SE) 1.2 %) vs 91.2 % (SE 1.1 %), respectively). …”
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Supervised machine learning statistical models for visual outcome prediction in macular hole surgery: a single-surgeon, standardized surgery study by Kanika Godani, Vishma Prabhu, Priyanka Gandhi, Ayushi Choudhary, Shubham Darade, Rupal Kathare, Prathiba Hande, Ramesh Venkatesh

“…Methods This retrospective study included 158 eyes (151 patients) with full-thickness MHs treated between 2017 and 2023 by the same surgeon and using the same intraoperative surgical technique. …”
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The relationship between proteinuria and coronary risk: a systematic review and meta-analysis. by Vlado Perkovic, Christine Verdon, Toshiharu Ninomiya, Federica Barzi, Alan Cass, Anushka Patel, Meg Jardine, Martin Gallagher, Fiona Turnbull, John Chalmers, Jonathan Craig, Rachel Huxley

“…This lack of clarity has led to great uncertainty as to how proteinuria should be treated in the assessment and management of cardiovascular risk. …”
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Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA by Tobias Solli Iveland, Lars Hagen, Mirta Mittelstedt Leal de Sousa, Nina Beate Liabakk, Per Arne Aas, Animesh Sharma, Bodil Kavli, Geir Slupphaug

“…HDAC inhibition apparently exacerbates cytotoxicity of these agents by inhibiting error-free repair of misincorporated ribonucleotides in DNA. …”
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Evaluating the impact of machine learning models on adult major depressive disorder using conventional treatment strategies: a systematic review approach by Nishant Yadav, Anamika Gulati, Varun Gulati, Prashant Yadav

“…Abstract Background Major Depressive Disorder (MDD) is a leading cause of global disability often treated through a trial-and-error approach, yet treatment response to antidepressants remains highly variable, with remission rates below 50% after initial treatment. …”
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Medial Portal Placement for ACL Femoral Tunnel Drilling With an Over-the-Top Guide: Concepts and Technique by Travis Baes MD, Michael Gaudiani MD, Vasilios Moutzouros MD

“…Surgeons must mitigate risks of failure by limiting technical errors. Femoral tunnel malposition has been cited as the most common technical error associated with ACL reconstruction. …”
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Pengenalan Ekspresi Wajah Menggunakan DCT dan LDA untuk Aplikasi Pemutar Musik (MOODSIC) by I Gede Pasek Suta Wijaya, Asno Azzawagaam Firdaus, Aditya Perwira Joan Dwitama, Mustiari Mustiari

“…MOODSIC also give good performance with the accuracy of expression recognition about 91.51% or recognition error of 9,49% for real-time testing. …”
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Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy by Nicholas Richards, Douglas Christensen, Joshua Hillyard, Michelle Kline, Sara Johnson, Henrik Odéen, Allison Payne

“…When muscle acoustic absorption value in the simulations was adjusted to approximately 54% of the measured attenuation, the average root-mean-squared error between simulated and experimental spatial-average temperature profiles was 0.046 ± 0.019 °C/W. …”
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Dynamic electro‐clinical features in Guanidinoacetate N‐methyltransferase deficiency: A familial case series by Mariapaola Schifino, Emanuele Bartolini, Stefano Pagano, Camilla Meossi, Rosa Pasquariello, Roberta Battini

“…Abstract Guanidinoacetate N‐methyltransferase deficiency is an inborn error of creatine metabolism, responsible for the absent conversion of guanidinoacetic acid into creatine, resulting in cerebral creatine deficit. …”
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COVID-19 pandemic, oil prices and Saudi stock market: empirical evidence from ARDL modeling and Bayer–Hanck cointegration approach by Jamel Boukhatem, Ali M. Alhazmi

“…Finally, the findings should be treated with some cautions because of the limited sample size and the tests’ statistical inference. …”
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A novel machine learning-based approach to determine the reduction factor for punching shear strength capacity of voided concrete slabs by Alireza Mahmoudian, Mussa Mahmoudi, Mohammad Yekrangnia, Nima Tajik, Mostafa Mohammadzadeh Taleshi

“…The efficacy of the approach is showcased using the Random Forest Regressor model, finely tuned through a Grid Search technique, with performance evaluated using the R-squared coefficient and Root Mean Squared Error metrics. If the aforementioned distance is less than 0.3d, a factor of 0.55 should be applied. …”
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Riboflavin Transporter Deficiency Type 2: Expanding the Phenotype of the Lebanese Founder Mutation p.Gly306Arg in the <i>SLC52A2</i> Gene by Jean-Marc T. Jreissati, Leonard Lawandos, Julien T. Jreissati, Pascale E. Karam

“…<b>Background</b>: Riboflavin transporter deficiency type 2 is an ultra-rare, yet treatable, inborn error of metabolism. This autosomal recessive disorder is caused by pathogenic mutations in the <i>SLC52A2</i> gene leading to progressive ataxia, polyneuropathy, and hearing and visual impairment. …”
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Computer‐Aided High Tibial Osteotomy—A Comparative Study of Commonly Used 3D Printing Technology and Navigation Application by Elvis Chun‐Sing Chui, Kyle Ka‐Kwan Mak, Randy Hin‐Ting Ng, Ericsson Chun‐Hai Fung, Mei‐Shuen Chan, Kai Yue, Lawrence Chun‐Man Lau, Clifford Long‐Fung Chan, Edmond Wing‐Fung Yau, Wei Zhao, Xiuyun Su, Jin Zhang, Jianglong Xu, Hongxun Sang, Guoxian Pei, Louis Wing‐Hoi Cheung, Sheung‐Wai Law, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung

“…ABSTRACT Background High tibial osteotomy (HTO) is a surgical procedure for treating certain knee conditions. Proper execution of HTO can preserve joint function and delay or avoid the need for total knee replacement. …”
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Immune biomarker differences and changes comparing HCV mono-infected, HIV/HCV co-infected, and HCV spontaneously cleared patients. by Lauren E Kushner, Aaron M Wendelboe, Laura C Lazzeroni, Aarthi Chary, Mark A Winters, Anu Osinusi, Shyam Kottilil, Michael A Polis, Mark Holodniy

“…A Bonferroni correction, adjusting for tests of 50 biomarkers, was used to reduce Type I error.<h4>Results</h4>Compared to HCV patients at BL, HIV/HCV patients had 22 significantly higher and 4 significantly lower biomarker levels, following correction for multiple testing. …”
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A review of UK publicly funded non-inferiority trials: is the design more inferior than it should be? by Nikki Totton, Steven Julious, Stephen Walters, Elizabeth Coates

“…Additionally, despite suggestions that it can increase the type 1 error in NI trials, the use of the intention-to-treat alone is the most common analysis population. …”
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Prognostic Utility of F‐Waves in Paraplegic Dogs With Absent Pain Perception Secondary to Intervertebral Disc Extrusion by Go Togawa, Melissa J. Lewis, Stephen R. Were, R. Timothy Bentley, Stephanie A. Thomovsky

“…Objective Evaluate the prognostic utility of F‐waves in DPN dogs secondary to TL‐IVDE treated surgically. Animals Thirty client‐owned, acutely paraplegic DPN dogs secondary to TL‐IVDE were managed surgically. …”
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