Qingda granules mitigate cardiac inflammation in spontaneously hypertensive rats via the MCP-1/CCR2 signaling pathway by Jianfeng CHU, Huai WANG, Tianyi WANG, Meizhong PENG, Xueling ZHOU, Yan LU, Shan LIN, Aling SHEN, Changgeng FU, Jun PENG

“…Objective: This study investigated effects and underlying mechanisms of Qingda granules (QDG) on cardiac inflammation in spontaneously hypertensive rats (SHRs). Methods: Twelve SHRs (17 weeks old) were randomly divided into SHR and SHR + QDG groups, with six rats in each group. …”
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Colorectal cancer risk factors: A multi-center, case-control study in Egypt by Essam A. El-Moselhy, Mohamed M. Abdel-Halim, Alshaimaa M.M. Eid Eid, Ahmed M. Ghazy, Neamat A. Abdelmageed, Amir A. Eldamaty, Sherif A. Sherif, Asmaa A. Attia, Fatma M. Kotb, Abdelhamid A. Abdelhafez, Mohamad M. Abdelnaser, Mohamed H. El Sisi, Ahmed M. Abdelnaby, Moshira A. Ibrahim, Osama O. Khalil, Mohmed Tag El-Din, Esam M. Osman, Abd-Elnaser S. Mohammed, Alyaa H. Abo-Rahma, Ahmed E. Abdrabo, Ayman M. El Guindy, Karima M-S Kholief

“…This study aimed to define characteristics and risk factors (RFs) of CRC in Egypt. Methods: A multi-center, hospital-based, case-control study was conducted. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…In line with realist methods, eight context–mechanism–outcome configurations and an overarching programme theory were used to explain the why and how of preventing and reducing the use of restrictive practices for people with a learning disability. …”
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Comparing the Effectiveness of Self-Compassion and Mindfulness Therapies on Affection Control of Poor Parenting Adolescents by Zahra EffatDoost Sani, Mohammad Reza Zarbakhsh Bahri, Alireza Homayuni

“…Therefore, based on the results, the assumption of variance equality was accepted. In M-Box assumption also, the equality of variance- covariance was not accepted (p>0.001). …”
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Non-Invasive Ventilation Failure in Pediatric ICU: A Machine Learning Driven Prediction by Maria Vittoria Chiaruttini, Giulia Lorenzoni, Marco Daverio, Luca Marchetto, Francesca Izzo, Giovanna Chidini, Enzo Picconi, Claudio Nettuno, Elisa Zanonato, Raffaella Sagredini, Emanuele Rossetti, Maria Cristina Mondardini, Corrado Cecchetti, Pasquale Vitale, Nicola Alaimo, Denise Colosimo, Francesco Sacco, Giulia Genoni, Daniela Perrotta, Camilla Micalizzi, Silvia Moggia, Giosuè Chisari, Immacolata Rulli, Andrea Wolfler, Angela Amigoni, Dario Gregori

“…The RF model demonstrated the highest AUROC and sensitivity equal to 0.83 (0.64, 0.94). Base excess, weight, age, systolic blood pressure, and fraction of inspired oxygen were identified as the most predictive features. …”
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Study on the risk factors for colorectal polyp recurrence: a cross-sectional retrospective cohort study by Fang Li, Fang Li, Mengge Lu, Mengge Lu, Bo Xu, Zheng Xiang, Zheng Xiang, Yuan Zhang, Yuan Zhang, Boran Cao, Xuewei Li, Xuewei Li, Yanan Wu, Yanan Wu, Rongrong Zheng, Rongrong Zheng, Qin Cai, Qin Cai, Jun Shen, Pengfei Xin, Pengfei Xin, Lianbo Xiao, Lianbo Xiao, Yanqin Bian, Yanqin Bian

“…Patients with a risk prediction model value greater than or equal to 0.44 have increased odds to experience postoperative recurrence.…”
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Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration by Gissel Herrera, MD, Yuxuan Cheng, PhD, Yamini Attiku, MD, Farhan E. Hiya, MD, Mengxi Shen, MD, PhD, Jeremy Liu, MD, Jie Lu, PhD, Alessandro Berni, MD, Omer Trivizki, MD, Jianqing Li, MD, Robert C. O’Brien, PhD, Giovanni Gregori, PhD, Ruikang K. Wang, PhD, Philip J. Rosenfeld, MD, PhD

“…Participants: Forty eyes from 35 patients with iAMD. Methods: Patients underwent SD-OCTA and SS-OCTA imaging at the same visit using a 6 × 6 mm OCTA scan pattern. …”
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Post-registration experience of nivolumab in advanced hepatocellular carcinoma: an international study by Dominik Bettinger, Bo Yu, David Szafron, Yinghong Wang, Mahvish Muzaffar, Thomas Marron, Uqba Khan, Yi-Hsiang Huang, David J Pinato, Ahmed Kaseb, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Musharraf Navaid, ChiehJu Lee, Anushi Bulumulle, Sonal Paul, Petros Fessas, Neil Nimkar, Hannah Hildebrand, Tiziana Pressiani, Yehia I Abugabal, Nicola Personeni, Lorenza Rimassa, Celina Ang, Abdul Rafeh Naqash, Francesca Benevento

“…Achievement of an objective response predicted for improved OS (25.4 months vs 13.2 months, p<0.001).Conclusions This study confirms safety and efficacy of nivolumab in advanced HCC across various lines of therapy and degrees of liver dysfunction. Despite equal ORR and toxicity to nivolumab, patients with CP-B functional class have shorter survival than the patients with CP-A.…”
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Intravascular lithotripsy vs. rotational atherectomy on coronary microcirculation: a retrospective multicenter propensity-matched multicenter study by Xi Zhang, Xi Zhang, Xi Zhang, Peijian Wang, Chenguang Li, Tao Zhao, Tao Zhao, Tao Zhao, Jiaji He, Jiaji He, Jiaji He, Bin Liu, Qing Jin, Qing Jin, Qing Jin, Pin Gan, Pin Gan, Pin Gan, Jilei Zhang, Jilei Zhang, Jilei Zhang, Qiang Xue, Qiang Xue, Qiang Xue

“…These findings suggest that IVL may offer advantages in preserving coronary microvascular function across various clinical scenarios when both techniques are equally available and applicable, but further large-scale prospective studies are needed to verify these results.…”
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CREATING THE KULTUK POLYGON FOR EARTHQUAKE PREDICTION: VARIATIONS OF (234U/238U) AND 87SR/86SR IN GROUNDWATER FROM ACTIVE FAULTS AT THE WESTERN SHORE OF LAKE BAIKAL by S. V. Rasskazov, E. P. Chebykin, A. M. Ilyasova, E. N. Vodneva, I. S. Chuvashova, S. A. Bornyakov, A. K. Seminsky, S. V. Snopkov, V. V. Chechel'nitsky, N. A. Gileva

“…In 1970s and 1980s, only quite laborious methods were available for measuring uranium isotopic ratios. …”
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Synthesis and investigation of the physicochemical properties of 2-(5-((theophylline-7'-yl)methyl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)-acetic acid salts by A. S. Gotsulya, O. O. Mikolasyuk, O. I. Panasenko, Ye. G. Knysh

“…After cooling to the reaction mixture with stirring, adds an equal volume of water. The precipitate dissolves, then falles again. …”
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Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD by Ahmad Moolla, Toryn Poolman, Nantia Othonos, Jiawen Dong, Kieran Smith, Thomas Cornfield, Sarah White, David W. Ray, Sofia Mouchti, Ferenc E. Mózes, Helena Thomaides-Brears, Stefan Neubauer, Jeremy F. Cobbold, Leanne Hodson, Jeremy W. Tomlinson

“…Impact and implications: Weight loss, through either lifestyle intervention or pharmacotherapy with GLP-1RA has an equally beneficial impact on the liver, and both strategies should be considered in the management of people with MASLD. …”
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Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk? by Komodo Matta, Vivian Viallon, Anastasia Chrysovalantou Chatziioannou, Nivonirina Robinot, Roland Wedekind, Christina C. Dahm, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Therese Truong, Chloé Marques, Pauline Frenoy, Rudolf Kaaks, Renée Turzanski Fortner, Matthias B. Schulze, Sabrina Sieri, Mario Fordellone, Rosario Tumino, Fulvio Ricceri, Tonje Braaten, Therese Haugdahl Nøst, Maria-Jose Sánchez, Olatz Mokoroa-Carollo, Sandra Colorado-Yohar, Camino Trobajo-Sanmartín, Keren Papier, Rhea Harewood, Kostas Tsilidis, Salvatore Vaccarella, Mattias Johansson, Elisabete Weiderpass, Cyrille Delpierre, Sebastien Lamy, Kristin Benjaminsen Borch, Pekka Keski-Rahkonen, Elio Riboli, Heinz Freisling, Marc Gunter, Pietro Ferrari

“…Metabolomics offers potential to uncover biological mechanisms linking lifestyle and colon cancer. Methods Lifestyle and untargeted metabolomic data were available from a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 1,067 colon cancer cases and 1,067 controls matched on age, sex, study centre, and blood collection time. …”
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Assessment of the thoracic aorta after aortic root replacement and/or ascending aortic surgery using 3D relaxation-enhanced angiography without contrast and triggering by Carsten Gietzen, Jan Paul Janssen, Juliana Tristram, Burak Cagman, Kenan Kaya, Robert Terzis, Roman Gertz, Thorsten Gietzen, Henry Pennig, Alexander C. Bunck, David Maintz, Thorsten Persigehl, Navid Mader, Kilian Weiss, Lenhard Pennig

“…The purpose of this study was to evaluate the performance of REACT after surgery of the aortic root and/or ascending aorta by performing an intraindividual comparison to CE-MRA.Material and methodsThis retrospective single center study included 58 MRI studies of 34 patients [mean age at first examination 45.64 ± 11.13 years, 31 (53.44%) female] after ascending aortic surgery. …”
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The Magnetic Field in Quiescent Star-forming Filament G16.96+0.27 by Qi-Lao Gu, Tie Liu, Zhi-Qiang Shen, Sihan Jiao, Julien Montillaud, Mika Juvela, Xing Lu, Chang Won Lee, Junhao Liu, Pak Shing Li, Xunchuan Liu, Doug Johnstone, Woojin Kwon, Kee-Tae Kim, Ken’ichi Tatematsu, Patricio Sanhueza, Isabelle Ristorcelli, Patrick Koch, Qizhou Zhang, Kate Pattle, Naomi Hirano, Dana Alina, James Di Francesco

“…The magnetic field and turbulence are both weaker than gravity, but magnetic fields and turbulence together are equal to gravity, suggesting that G16.96+0.27 is in a quasi-equilibrium state. …”
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Investigation of the anti-influenza activity of siRNA complexes against the cellular genes <i>FLT4, Nup98</i>, and <i>Nup205 in vitro</i> by E. A. Pashkov, M. O. Korotysheva, A. V. Pak, E. B. Faizuloev, A. V. Sidorov, A. V. Poddubikov, E. P. Bystritskaya, Yu. E. Dronina, V. K. Solntseva, T. A. Zaiceva, E. P. Pashkov, A. S. Bykov, O. A. Svitich, V. V. Zverev

“…Evaluation of changes in the viral activity of influenza A/WSN/33 after complex knockdown of combinations of cellular genes FLT4, Nup98 and Nup205 in human lung cell culture A549. Methods. The work was carried out using the equipment of the Center for Collective Use of the I. …”
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AI-Based Quantification of Enhancing Tumor Volume on Contrast-Enhanced MRI to Predict Pathologic Response and Prognosis in HCC After HAIC Plus Targeted Therapy and Immunotherapy by Zhou Y, Li J, Li Q, Liu L, Huang P, Mao Y, Yang Y, Lv F, Liu Z

“…Yin Zhou,1,&amp;ast; Junjie Li,2,&amp;ast; Qingshu Li,3,&amp;ast; Liu Liu,1 Ping Huang,4 Yun Mao,1 Yaying Yang,3 Furong Lv,1 Ziyu Liu1 1Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Pathology, School of Basic Medicine, Chongqing Medical University, Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Department of Clinical Pathology Laboratory of Pathology Diagnostic Center, Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 4Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ziyu Liu, Master of Medicine, Department of radiology, the first affiliated hospital of Chongqing medical university, No. 1, Youyi Road, Yuzhong District, Chongqing, People’s Republic of China, 400016, Tel +19942338328, Email liuziyu301@163.comPurpose: To explore the diagnostic and prognostic value of AI-quantified MRI tumor volume for assessing pathologic response in unresectable hepatocellular carcinoma (uHCC) after hepatic arterial infusion chemotherapy plus targeted therapy and immunotherapy (HAIC-TI).Materials and Methods: This retrospective study included 35 patients (46 lesions) who underwent HAIC-TI followed by hepatectomy. …”
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H2FPEF and HFA‐PEFF scores for heart failure risk stratification in hypertrophic cardiomyopathy patients by Yi‐Peng Gao, Hong‐Yun Liu, Xiao‐Jun Bi, Jie Sun, Ying Zhu, Wei Zhou, Ya‐Ting Fan, Xue‐Qing Cheng, Pei‐Na Huang, Ya‐Ni Liu, You‐Bin Deng

“…This study aimed to explore the value of the H2FPEF and HFA‐PEFF scores for HF risk stratification in patients with hypertrophic cardiomyopathy (HCM). Methods and results In this cohort study, 1068 HCM patients were included. …”
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Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy against Enterococcus faecalis in root canal disinfection by Rizwan Jouhar, FCPS, Mohamad Syahrizal Halim, M.Rest.Dent, Sayed A. Quadri, MD, Muhammad Adeel Ahmed, PhD, Faheem Shah, PhD

“…Six experimental groups with equal numbers of samples (n = 15) were treated with 5 % NaOCl (groups 1 and 2), MB-based PDT (groups 3 and 4), or MB/rGO-based PDT (groups 5 and 6). …”
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Delivery of miR-26a-5p by Subcutaneous Adipose Tissue-Derived Extracellular Vesicles Alleviates Acute Lung Injury in Mice Through CHUK/NF-&amp;kappa;B Pathway by Xie Y, Ran L, Yue C, Wang C, Chen F, Su Y, Qin Y, Zhang Q, Liu J, Du N, Zhang L, Jiang Y, Liu G

“…This study aimed to elucidate the immunomodulatory roles and underlying mechanisms of adipose tissue-derived EVs in the pathogenesis of ARDS.Methods: Subcutaneous adipose tissue extracellular vesicles (SAT-EVs) were collected from the mice via ultracentrifugation. …”
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