The Efficacy of Sodium Bicarbonate Ringer’s Solution and Lactate Ringer’s Solution in Patients Undergoing Long-Term Abdominal Open Surgery: A Multicenter Prospe... by Zhou S, Zhao K, Liu C, Luo H, Shi J, Liu C, Li X, Gao F, Wu X, Shen Q, Yuan W, Chai X, Wei X

“…The aim is to investigate the effects of sodium bicarbonate Ringer’s solution on lactate metabolism, acid-base balance, and clinical outcomes in patients undergoing extended-duration open abdominal surgery, with the objective of refining fluid replacement strategies for this patient population.Patients and Methods: A multicenter randomized controlled trial was conducted involving 112 patients undergoing open abdominal surgery. …”
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Determination of Composition and Amount of Different Feeds to Produce Animal Products to Use in Agricultural Policy Studies in Iran by Seyed Majid Alimagham, Afshin Soltani, Behrouz Dastar, Taghi Ghoorchi

“…Extended Abstract Background: The value of water, energy, and food resources is such that access to and proper use of these resources are pillars of security, success, and equality worldwide. Today, governments are struggling to find solutions to a complex set of problems that, if left unresolved, could lead to the collapse of human civilization. …”
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Relationship Between Social Support, Symptom Burden, Dyspnea, Perceived Stress, Perceived Stigma, Coping Styles, and Psychological Distress in Patients with Stable COPD: A Structur... by Tian X, Yi L, Liu X, Zuo F, Shang H, Zhang J, Ren Y

“…This study aimed to explore how social support, symptom burden, dyspnea, perceived stress, perceived stigma, and coping styles impact psychological distress in stable COPD using a structural equation model (SEM).Methods: A convenience sample of 386 stable COPD patients was recruited from three tertiary hospitals in Chongqing, China. …”
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Probiotic Bifico Ameliorates Depression- and Anxiety-Like Behaviors Induced by Estrogen Deficiency via NLRP3 Inflammasome Inhibition by Yu X, Yu X, Yang Y, Cheng W, Shi M, Chen L, Zhang X, Xu Y

“…This study aims to investigate the effects of the probiotic Bifico on neuroinflammation and behaviors in ovariectomized (OVX) rats.Methods: After OVX rats were treated with Bifico for 6 weeks, depression- and anxiety-like behaviors were evaluated using the sucrose preference test, forced swimming test, open field test and elevated plus maze. …”
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Adverse Event Management in Patients with Platinum-Resistant Ovarian Cancer Treated with Niraparib and Anlotinib: Updates from the Phase II, Multi-Center ANNIE Study by Deng T, Yan L, Li J, Liu G, Yin A, Feng Y, Zheng M, Zhang C, Huang H, Huang Q, Lin A, Jiang J, Kong B, Liu J

“…We report updated overall survival (OS) and safety data and the management of key treatment-emergent adverse event (TEAE) from the ANNIE study.Methods: In the multi-center, single-arm, Phase 2 ANNIE study, enrolled patients received oral niraparib 200 mg or 300 mg (baseline bodyweight-directed) once daily and anlotinib 10 mg (12 mg before protocol amendment) once daily on days 1– 14 of each 21-day cycle. …”
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EFFICACY OF CARDIOVERTER-DEFIBRILLATORS IN PREVENTION OF SUDDEN DEATH AND OVERALL MORTALITY DECREASE IN PATIENTS WITH THE SYNDROME OF DILATION CARDIOMYOPATHY: DIFFERENTIAL APPROA... by O. V. Blagova, A. V. Nedostup, E. V. Zaklyazminskaya

“…To evaluate the exact efficacy of the implantable cardioverter-defibrillators (ICD) and combination devices (CRT-D), and to evaluate their influence on the rate of sudden death and overall mortality in patients with the dilation cardiomyopathy syndrome (DCMP), and to clarify the selection criteria for implantation.Material and methods. Totally, 220 DCMP patients investigated: 66 (30%) of them (mean age 48,5±12,8 y. o., 47 males) underwent implantation of ICD (n=37) and CRT-D (n=29), 154 (70%) patients were in comparison group (mean age 47,1±12,4 y. o., 104 males). …”
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DYNAMICS OF BIOCHEMICAL MARKERS OF HUMORAL IMMUNITY AND METABOLISM IN MANDIBULAR BONE TISSUE UNDER INFLUENCE ON REPARATIVE OSTEOGENESIS by A.A. Boiko, O.A. Nakonechna

“…On the 28th day, a decrease in the activity of ALP (by 43.12%) was observed in the oral fluid of rats of group IV compared to day 3 and was equal to the control. On the third day, there was an increase in the activity of AP in the oral fluid of all rats. …”
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Assessment of Preserved Ratio Impaired Spirometry (PRISm) Based on Different Definitions in the Early COPD Cohort by Dai C, Tang G, Yang H, Wu F, Deng Z, Zheng Y, Zhao N, Lu L, Wan Q, Wang Z, Peng J, Wu X, Zhou K, Cai G, Xiao S, Wen X, Yang C, Chen S, Yu S, Sun R, Zhou Y, Ran P

“…However, definitions for PRISm vary across studies, and researches comparing these definitions are limited.Objective: We aim to assess the agreement, the clinical features, and the prevalence of PRISm defined by restrictive spirometric pattern (RSP) method [that is forced vital capacity (FVC) method] versus forced expiratory volume in the first second (FEV1) method and by fixed values versus the lower limit of normal (LLN).Methods: All 1862 participants from the ECOPD study underwent questionnaire investigation, spirometry, biphasic CT, and impulse oscillometry. …”
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Integrated Multi-Omics Profiling Identifies PDZ-Binding Kinase (PBK) as a Novel Prognostic Biomarker in Hepatocellular Carcinoma by Zhang J, Xu Y, Ni X, Mao Z, Xiao H, Chen M, Lin Y, Pan J, Zhang B, Zhang L, Zheng X, Song G, Ge N

“…PBK, a cancer/testis antigen (CTA), was identified as a pivotal hub gene influencing prognosis, tumor mutation burden (TMB), and immune microenvironment remodeling.Methods: PBK was prioritized using weighted gene co-expression network analysis (WGCNA) and differential expression screening in the TCGA-LIHC cohort, intersected with curated CTAs. …”
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THE VOICES OF THE WAR (“EPITAPHS OF THE WAR” BY R. KIPLING) by Tetiana M. Potnitseva

“…To reveal the specificity of that poetic work, the comparative and historical-literary methods are applied. The original form of the epitaphs is presented as an epigram which allows one to hear either a voice of a perished soldier or of someone who is reading the epitaph. …”
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Integrated Early CRP Kinetics and Plasma EBV DNA Clearance as Prognostic Biomarkers in De Novo Metastatic Nasopharyngeal Carcinoma Treated with First-Line Chemoimmunotherapy by Fang M, Hu Y, Wang T, Su Y, Lu T, Zhang H, Li J, Xie C, Gong X

“…Min Fang,1,2,* Yujun Hu,3,4,* Tiejun Wang,5,* Yong Su,2,6 Tianzhu Lu,2,6 Hao Zhang,7 Jingao Li,2,6 Chuanmiao Xie,3,4,* Xiaochang Gong2,6,* 1Department of Oncology, Gaoxin Branch of The First Affiliated Hospital of Nanchang University, Nanchang, 330000, People’s Republic of China; 2NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Nanchang, 330029, People’s Republic of China; 3Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China; 4State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China; 5Breast cancer center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 6Department of Radiation Oncology, Jiangxi Clinical Research Center for Cancer, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Nanchang, 330029, People’s Republic of China; 7Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaochang Gong, NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Nanchang, People’s Republic of China, Email gxcanddw@163.com Chuanmiao Xie, Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China, Email xiechm@sysucc.org.cnPurpose: This study investigates the predictive value of early C-reactive protein (CRP) kinetics in patients with de novo metastatic nasopharyngeal carcinoma (dmNPC) receiving first-line chemotherapy combined with anti-PD-1 mAbs (first-line chemoimmunotherapy).Patients and Methods: Patients were categorized into three groups based on early CRP kinetics within one and three months after the start of immunotherapy: (1) CRP flare-responders, with CRP levels rising to more than double the baseline within one month and subsequently falling below baseline within three months; (2) CRP non-flare-responders, with CRP levels decreasing by more than 30% within three months without initial flare; (3) CRP non-responders, with no significant CRP changes. …”
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17(R)-RvD1 Ameliorates Liver Injury in Hyperuricemia Through Inhibiting Pyroptosis via NF-κB Signaling Pathway by Zhao L, Zhang Y, Qiao Y, Jia L, Luo S

“…This study aims to investigate the effects of 17(R)-RvD1 on hyperuricemia-induced hepatic injury.Methods: Potassium oxonate and hypoxanthine were used to establish a hyperuricemic mouse model and investigate the effects of 17(R)-RvD1 on hyperuricemia and concomitant liver injury. …”
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The sensitive Amnesia Light and Brief Assessment (ALBA) is a valid 3-min test of 4 tasks indicative of mild cognitive deficits by A. Bartos, S. Diondet

“…The ALBA was performed in 590 persons older than 50 years, including 60 individuals who completed a neuropsychological battery, equally divided into patients with MCD (Montreal Cognitive Assessment [MoCA] score of 21 ± 3 points) and matched cognitively normal (CN) individuals (MoCA of 27 ± 2). …”
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Microbial Patterns in Newly Diagnosed Inflammatory Bowel Disease Revealed by Presence and Transcriptional Activity - Relationship to Diagnosis and Outcome by Vatn SS, Hansen SH, Tannæs TM, Brackmann S, Olbjørn C, Bergemalm D, Keita ÅV, Gomollon F, Detlie TE, Kalla R, Satsangi J, Jahnsen J, Vatn MH, Halfvarson J, Hov JR, Ricanek P, Moen AEF

“…Simen Svendsen Vatn,1– 3,* Simen Hyll Hansen,1,4,* Tone Møller Tannæs,5 Stephan Brackmann,1,2 Christine Olbjørn,1,6 Daniel Bergemalm,7 Åsa V Keita,8 Fernando Gomollon,9 Trond Espen Detlie,1,2 Rahul Kalla,10 Jack Satsangi,10,11 Jørgen Jahnsen,1,2 Morten Harald Vatn,1 Jonas Halfvarson,7 Johannes Roksund Hov,1,4,12 Petr Ricanek,2,13 Aina EF Moen1,5,14 On behalf of the IBD-Character Consortium1Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 2Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; 3Innlandet Hospital Trust, Gjøvik, Norway; 4Norwegian PSC Research Center and Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway; 5Section for Clinical Molecular Biology (Epigen), Akershus University Hospital, Lørenskog, Norway; 6Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway; 7Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 8Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; 9Digestive Diseases Unit, IIS Aragón, Zaragoza, Spain; 10Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK; 11Translational Gastroenterology Unit, Medical Sciences/ Experimental Medicine Division, University of Oxford, Oxford, UK; 12Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; 13Department of Gastroenterology, lovisenberg Diaconal Hospital, Oslo, Norway; 14Department of Virology, Norwegian Institute of Public Health, Oslo, Norway*These authors contributed equally to this workCorrespondence: Simen Svendsen Vatn, Innlandet Hospital Trust, Gjøvik, Norway, Tel +47 94277594, Email bikkjas@hotmail.comBackground: As part of the IBD Character initiative, we examined an inception cohort and investigated mucosal microbiota composition and transcriptional activity in relation to clinical outcomes.Methods: A cohort of 237 individuals were included from five countries: Crohn’s disease (CD, n = 72), ulcerative colitis (UC, n = 57), symptomatic non-IBD controls (SC, n = 78) and healthy controls (HC, n = 30). …”
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Functional Outcome of Percutaneous K-wiring vs Closed Reduction and Plaster Casting in Treatment of Unstable Distal Radius Fractures: A Comparative Study by R Sahaya Jose, M Syed Moosa, N Kattu Bava

“…In the cast immobilization group, an equal proportion (40%) had grade I and grade II, 12% had grade III, and 8% had grade IV outcomes. …”
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Development and Validation of the Resident Healthcare-Seeking Culture Scale (RHCS) Among Chinese Demographics in the Community Setting by Xu H, Feng J, Qiu L, Yan S, Li L, Tian Q, He Y, Lu Z

“…Hongbin Xu,1,* Jie Feng,1,2,* Lei Qiu,3 Shijiao Yan,3,4 Liqing Li,5 Qingfeng Tian,6 Yan He,6 Zuxun Lu1 1School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2College of Public Health, Chongqing Medical University, Chongqing, People’s Republic of China; 3School of Public Health, Hainan Medical University, Haikou, Hainan, People’s Republic of China; 4Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University, Haikou, Hainan, People’s Republic of China; 5Department of Management Science and Engineering, School of Economics and Management, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, People’s Republic of China; 6College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zuxun Lu, Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 hangkong Road, Wuhan, 430030, People’s Republic of China, Tel/Fax +86 027 83693756, Email zuxunlu@yahoo.comObjective: This study aimed to develop a measurement scale with good reliability and validity to assess the reasonableness of resident healthcare-seeking culture.Methods: This investigation utilized a cross-sectional research design, employing a multi-stage random sampling technique to select adult inhabitants aged eighteen and above who possess fundamental literacy abilities. …”
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Effectiveness of Pharmacist-Led Training Regarding Medication for Type 2 Diabetes, Based on Patient and Physician Medication-Related Issues Identified in China by Yang ZH, Cheng CJ, Chen GM, Huang J, Zhou H, Jiang J, Ye Z, Weng YF, Tan HH

“…Zhong Hui Yang,1,* Chang Juan Cheng,1 Guo Mei Chen,1 Ji Huang,1,* Hai Zhou,2 Jie Jiang,3 Zhen Ye,4 Yu Fang Weng,5 Hai Hong Tan1 1Department of Pharmacy, Taicang First People’s Hospital, Soochow University, Taicang, Jiangsu, People’s Republic of China; 2Health Service Center of Chengxiang Town, Taicang, Jiangsu, People’s Republic of China; 3Taicang Port District People’s Hospital, Taicang, Jiangsu, People’s Republic of China; 4Huangjing People’s Hospital of Taicang City, Taicang, Jiangsu, People’s Republic of China; 5Taicang Shuangfeng People’s Hospital, Taicang, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chang Juan Cheng, Department of Pharmacy, Taicang First People’s Hospital, Soochow University, No. 58, Changsheng South Road, Taicang City, Jiangsu Province, People’s Republic of China, Tel +86 13915495574, Email 532782210@qq.com Guo Mei Chen, Department of Pharmacy, Taicang First People’s Hospital, Soochow University, No. 58, Changsheng South Road, Taicang City, Jiangsu Province, People’s Republic of China, Tel +86 13776297087, Email 23451210@qq.comAim: To determine the effect of pharmacist-led specialized medication training on rational drug prescription by family physicians, and to characterize the drug-related issues and glycemic control of patients.Methods: We performed a study led by clinical pharmacists. …”
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Incidence and Risk Factors of Tuberculosis-Associated Chronic Obstructive Pulmonary Disease by Joo DH, Kim MC, Sin S, Kang HR, Song JH, Kim HJ, Song MJ, Kwon BS, Kim YW, Lee YJ, Park JS, Lee JH, Lee YJ

“…We evaluated the incidence of tuberculosis-associated COPD and compare the characteristics of patients with and without COPD.Patients and Methods: This multicenter, retrospective cohort study included 351 patients treated with anti-tuberculosis drugs for more than 6 months in four hospitals in Korea, followed for 11 years (132 months). …”
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A Prospective, Crossover, Randomized, Double-Blind Clinical Study Comparing the Effectiveness and Ocular Comfort of 0.1% Hyaluronic Acid and 0.3% Hyaluronic Acid in Patients With D... by Kim SJ, Yoo WS, Kwon LH, Kim RB, Yoon HJ, Yoon KC

“…Korea) to treat dry eye disease (DED).Methods: This study was designed as a prospective, crossover, randomized, and double-blind study. …”
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Effectiveness and Safety of Tildrakizumab in Elderly and Frail Elderly Psoriatic Patients Up to 2 years by Mastorino L, Dapavo P, Burlando M, Gisondi P, Maronese CA, Ruggiero A, Galluzzo M, Pisani MC, Sacchelli L, Caldarola G, Avallone G, Marzano AV, Megna M, Campione E, Loconsole F, Bardazzi F, De Simone C, Quaglino P, Ribero S

“…To date, there is no study in the literature examining possible differences between frail and non-frail elderly with psoriasis being treated with tildrakizumab.Patients and Methods: The present multicentre retrospective study evaluated the effectiveness, drug survival and safety up to 2 years of treatment with tildrakizumab in the elderly (≥ 65 years) comparing frail and non-frail patients. …”
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