Induced Sputum Transcriptomics Profile and Serum C3 are Associated with Asthma Severity by Du F, Wang H, Chen Z, Xiong W, Wang Q, Li B, Li R, Li L, Shen Y, Zhu T

“…Then, this study aimed to explore asthma severity-associated transcriptomics profile and promising biomarkers for asthma severity prediction.Methods: In discovery cohort, induced sputum cells from 3 non-severe and 3 severe asthma patients were collected and analyzed using RNA-seq. …”
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Quercetin, a Compound of the Total Flavonoids of Periploca forrestii Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α by Chen S, Xue W, Wu Z, Lu D, Zheng L, Zhou M, Li Y, Wang Y, Liu T

“…This study investigates the specific compounds of TFPF responsible for TNF-α inhibition and delineates their mechanism of action.Methods: L929 cells and luciferase-based assays were used to assess anti-TNF-α activity. …”
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Social Support, Quality of Life, and Financial Toxicity Among Patients with Hepatocellular Carcinoma by Liu S, Xie Y, Li T, Huang Y, Xu D, Cai L, Fu Y, Chen J, Zhang Y, Huang J, Hu Z

“…Shuyue Liu,1– 3,* Yawen Xie,1– 3,* Tiantian Li,1– 3,* Yanxia Huang,1– 3 Danting Xu,1– 3 Linli Cai,1– 3 Yizhen Fu,1– 3 Jinbin Chen,1– 3 Yaojun Zhang,1– 3 Jia Huang,4 Zili Hu1– 3 1Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 4Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jia Huang, Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86 13828442672, Email hjia@mail.sysu.edu.cn Zili Hu, Department of Liver Surgery, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86-20-87343115, Email huzl1@sysucc.org.cnBackground & Aims: Despite the significant hepatocellular carcinoma (HCC) patient population, gaps exist in understanding their survivorship journey.Methods: Patients diagnosed with HCC at all stages were recruited at Sun Yat-sen University Cancer Center from August 1, 2023, to December 30, 2023. …”
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Leonurine Attenuates CCl4-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway by Wang P, Bai J, Ye M, Huang Z, Chen J, Sun L, Zhong X, Zheng Y, Ma T, Fu W, Du Y

“…This study aims to investigate the effect of Leo on liver fibrosis and clarify the mechanisms at play.Methods: We employed a mouse model of liver fibrosis induced by carbon tetrachloride (CCl4) and utilized LX-2 cells to investigate the mechanisms through which Leo exerts its effects.Results: Mice administered CCl4 displayed an elevated hepatic index, considerable necrosis as revealed by H&E staining, and significantly heightened serum markers of liver injury (ALT and AST). …”
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Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study by Chen X, Wu X, Peng W, Liu L, Liu X, Wan X, Xu H, Zheng Y, Zhao H, Mao Y, Lu X, Sang X, Chang X, Zhou K, Pan J, Guan M, Hu D, Tan H, Zhang Y, Du S

“…This study evaluates the efficacy of different adjuvant treatments on disease-free survival (DFS) and overall survival (OS) in HCC patients with MVI following curative resection.Methods: A retrospective cohort of 409 HCC patients with MVI who underwent curative resection from three clinical centers between 2017 and 2024 was analyzed. …”
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Efficacy and safety of intensive triglyceride-lowering therapy on reducing recurrence of hypertriglyceridemia-associated pancreatitis (REDUCE): protocol for a multicentre, randomis... by Tao Chen, Weiqin Li, Chunping Zhu, Na Liu, Xin Xu, Lihui Deng, Dong Wu, Yao Wu, Jianhua Wan, Xin Huang, Lu Ke, Wenhua He, Hongwei Zhang, Duan Wang, Nong-Hua Lu, Yin Zhu, Ling Ding, Jianing Li, Jianwen Sheng, Nonghua Lu, Huifang Xiong, Liang Xia, Gaifang Liu, Jinyi Sheng, Lingyu Luo, Yupeng Lei, Huajing Ke, Lanting Wang, Shihang Zhang, Zhihua Tang, Youshun Liu, Guan Gui, Yingjie Chen, Yinyu Pan

“…The efficacy and safety of intensive TG-lowering therapy on reducing recurrence of HTG-AP trial aims to determine whether intensive TG-lowering therapy (with a TG goal of <150 mg/dL (equal to 1.7 mmol/L)), compared with usual care (with a TG goal of <500 mg/dL (equal to 5.65 mmol/L)), can reduce recurrence in patients after a first episode of HTG-AP.Methods and analysis This is an investigator-initiated, multicentre, open-label, parallel, superiority, randomised, controlled trial. …”
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Clinical and Economic Outcomes of Intradiscal Injection of Condoliase for a Treatment of Lumbar Disc Herniation with Severe Low Back Pain: A Multicenter Study by Takashi Hirai, Takuya Takahashi, Yohei Takahashi, Kota Watanabe, Tomohiro Banno, Kyohei Sakaki, Yoshiyasu Arai, Yuichi Takano, Yawara Eguchi, Yuki Taniguchi, Satoshi Maki, Yasuchika Aoki, Shunichi Fujii, Kentaro Sakaeda, Yu Matsukura, Tsutomu Akazawa, Akihito Minamide, Hidetoshi Nojiri, Kenichiro Sakai, Satoshi Kato, Koji Tamai, Hidekazu Suzuki, Masayuki Miyagi, Hiroyuki Sato, Toshitaka Yoshii, Hiroshi Yamada, Takashi Kaito, Yutaka Hiraizumi, Masatsune Yamagata, Masaya Nakamura, Akihiro Hirakawa, Naofumi Hosogane, Seiji Ohtori

“…Patients with severe LBP (defined as a preinjection numeric rating scale [NRS] for LBP greater than or equal to that for leg pain) were categorized into the LBP group. …”
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Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis by Jonathan Hourmozdi, MD, MSAI, MA, Nicholas Easton, MSAI, Simon Benigeri, MSAI, James D. Thomas, MD, Akhil Narang, MD, David Ouyang, MD, Grant Duffy, BS, Ross Upton, PhD, Will Hawkes, PhD, Ashley Akerman, PhD, Ike Okwuosa, MD, Adrienne Kline, MD, PhD, Abel N. Kho, MD, Yuan Luo, PhD, Sanjiv J. Shah, MD, Faraz S. Ahmad, MD, MS

“…Bias auditing met fairness criteria for equal opportunity among patients who identified as Black. …”
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Characterizing anticoagulation reversal practices in Colombia: Initial insights from a national registry by Sebastián Seni-Molina, Santiago Posso Marín, Juan Esteban Masmela, María Camila Naranjo-Ramírez, Arturo D. Mora, Juliana María Gutiérrez-Posso, Julio Diez-Sepúlveda, Juan David Victoria-Salcedo, Ana Cristina Montenegro Arenas, Camilo Andrés Rueda Ortiz, Edgar David Gómez Lahitton, Hoover O. León-Giraldo, Juan Esteban Gómez-Mesa

“…Results: The cohort had a mean age of 66.9 years (SD ± 15.3) and a nearly equal sex distribution. Ethnicity was predominantly Mestizo (67.5%), followed by White (17.5%) and Afrodescendant (13.3%). …”
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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…A rat model of pulmonary fibrosis was constructed using bleomycin (5 mg·kg−1) intratracheal instillation, and an equal volume of saline was instilled into the control group. …”
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Conventional and Conformal Radiotherapy with and without Beam Intensity Modulation in Patients with Stage II Hodgkin’s Lymphoma with Supradiaphragmal Lesions by YuN Vinogradova, EI Ivanova, AI Chumachenko, EV Smirnova, GI Andreev, AM Kalesnik, NA Vorob’ev, NV Il’in

“…Overall 5- and 10-year survival (OS) was equal and accounted for 98.0 ± 1.4 %, the disease-free survival (DFS) was also equal between groups and accounted for 85.9 ± 1.3 %. …”
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A Comparative Analysis of Energy Efficiency of Two Sprinkler Irrigation Systems for Wheat Cultivation (Case Study: Dehgolan Plains, Kurdistan) by P. Tahmasbi, F. Dalvand, S.A. Hosseini, B. Karimi, H. Ghadrshnas

“…Moreover, the energy productivity and efficiency of the two systems were almost equal as well as the net energy of irrigation system (1) and irrigation system (2) was 41510.96 and 64156.03 MJ ha-1, respectively. …”
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The Combination of Curcumae Radix and Syzygium Aromaticum Extracts Mitigates Benign Prostatic Hyperplasia through Anti-Proliferative and Anti-Inflammatory Effects by Geum Hwa Lee, Yu Seob Shin, Ji Hyun Kim, Da hee Shim, Hwa Young Lee, Luo Zhao, Mohammad Mamun Ur Rashid, Hwang Eui Cho, Jong Jin Lee, Min Kyoung Kim, Do Sung Kim, Hyun Jun Park, Han Jung Chae

“…The study aimed to investigate the anti-proliferative mechanism of Curcumae Radix (CR) and Syzygium aromaticum (SA) extracts using RWPE-1 cells and testosterone propionate (TP)-induced BPH rats. Materials and Methods: In vitro experiments were performed to assess the synergistic anti-proliferative effects of an equal mixture of CR and SA extracts on TP-treated RWPE-1 cells. …”

HIV-phyloTSI: subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data by Tanya Golubchik, Lucie Abeler-Dörner, Matthew Hall, Chris Wymant, David Bonsall, George Macintyre-Cockett, Laura Thomson, Jared M. Baeten, Connie L. Celum, Ronald M. Galiwango, Barry Kosloff, Mohammed Limbada, Andrew Mujugira, Nelly R. Mugo, Astrid Gall, François Blanquart, Margreet Bakker, Daniela Bezemer, Swee Hoe Ong, Jan Albert, Norbert Bannert, Jacques Fellay, Barbara Gunsenheimer-Bartmeyer, Huldrych F. Günthard, Pia Kivelä, Roger D. Kouyos, Laurence Meyer, Kholoud Porter, Ard van Sighem, Mark van der Valk, Ben Berkhout, Paul Kellam, Marion Cornelissen, Peter Reiss, Helen Ayles, David N. Burns, Sarah Fidler, Mary Kate Grabowski, Richard Hayes, Joshua T. Herbeck, Joseph Kagaayi, Pontiano Kaleebu, Jairam R. Lingappa, Deogratius Ssemwanga, Susan H. Eshleman, Myron S. Cohen, Oliver Ratmann, Oliver Laeyendecker, Christophe Fraser, the HPTN 071 (PopART) Phylogenetics protocol team, the BEEHIVE consortium and the PANGEA consortium

“…Abstract Background Estimating the time since HIV infection (TSI) at population level is essential for tracking changes in the global HIV epidemic. Most methods for determining TSI give a binary classification of infections as recent or non-recent within a window of several months, and cannot assess the cumulative impact of an intervention. …”
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Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respirator... by Mike Clarke, Marc Chikhani, Cliona McDowell, Ranjit Lall, Michael McKelvey, Margaret McFarland, Brenda O'Neill, Cecilia O'Kane, Murali Shyamsundar, Gavin Perkins, Clifford C Taggart, Gordon Sturmey, Barry Williams, John Warburton, Paul Dark, Bronwen Connolly, Ashley Agus, Naomi Dickson, Mark Borthwick, Bronagh Blackwood, Daniel F McAuley, Christina Campbell, Judy Bradley

“…Participants will be equally allocated across four trial arms. All participants will receive usual airway clearance management. …”
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HPV genotyping agreement between paired cervical cytological sample and biopsy across lesion severity and vaccination by Shimin Chen, Qiaoyun Du, Jian Yin, Xiaoqian Xu, Wen Chen, Qinjing Pan, Xun Zhang, Ying Hong, Wenhua Zhang, Bin Liu, Jianfeng Cui, Shangying Hu, Fanghui Zhao

“…Conclusions In conclusion, HPV genotyping by cytological samples and FFPE biopsies performed equally well regardless of lesion severity and vaccination status, directly supporting reliable utility of cytological HPV genotyping for clinical decisions. …”
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From rural practice to scientific evidence: synergistic antiplasmodial and antioxidant properties of combined Ageratum conyzoides and Bidens pilosa extracts by Patrick Valere Tsouh Fokou, Courthney Akwi Mboh, Kenneth Lifoter Navti, Marius Jaurès Tsakem Nangap, Raoul Kemzeu, Canis Parfait Donbou Djiotie, Aubin Youbi Kamche, Hubert Nana Djigang, Arnold Tegen Tah, Mariscal Brice Tchatat Tali, Lauve Rachel Tchokouaha Yamthe, Vincent Ngouana, Fabrice Fekam Boyom

“…Aim: This study evaluates the in vitro and in vivo antiplasmodial, hemolytic, and antioxidant activities of a combined extract of Ageratum conyzoides (A. conyzoides) and Bidens pilosa (B. pilosa), a traditionally used but scientifically unvalidated combination. Methods: Plant leaves were extracted via aqueous decoction and cold maceration, combining equal parts to mimic traditional preparation. …”
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Searching for Axion Dark Matter Gegenschein of the Vela Supernova Remnant with FAST by Wenxiu Yang, Yitian Sun, Yougang Wang, Katelin Schutz, Yichao Li, Calvin Leung, Wenkai Hu, Shuanghao Shu, Kiyoshi Masui, Xuelei Chen

“…If we are embedded in a Milky Way dark matter halo comprised of axions, their stimulated decay would enable us to observe a counterimage (“axion gegenschein”) with a frequency equal to half the axion mass in the opposite direction of a bright radio source. …”
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Evaluation of multidrug-resistant bacteria and their molecular mechanisms found in small animal veterinary practices in Portugal by Joana Moreira da Silva, Joana Moreira da Silva, Juliana Menezes, Juliana Menezes, Juliana Menezes, Laura Fernandes, Laura Fernandes, Cátia Marques, Cátia Marques, Cátia Marques, Sofia Santos Costa, Dorina Timofte, Andreia J. Amaral, Andreia J. Amaral, Andreia J. Amaral, Constança Pomba, Constança Pomba, Constança Pomba

“…The goal of our work was to evaluate the environmental contamination and staff carriage by MDROs in veterinary practices across Portugal.MethodsFourteen SAVPs were enrolled. Environmental samples were collected from critical areas such as operating room, wards and pre-operative area. …”
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Prospective study of continuous rhythm monitoring in patients with early post-infarction systolic dysfunction: clinical impact of arrhythmias detected by an implantable cardiac mon... by Jesus Hernandez-Hernandez, Ana Martin-Garcia, Javier Jimenez-Candil, Pedro L Sanchez, Carlos González-Juanatey, Javier García-Fernández, Alba Cruz-Galban, Olga Duran-Bobin, Javier Garcia-Seara, Teba Gonzalez-Ferrero, Jose Morinigo, Manuel Sanchez-Garcia, Gonzalo Fernandez-Palacios, Jose Seijas-Amigo, Juliana Elices, Javier Portales-Fernandez, Francisco Martin-Herrero, Ana García-Campos, Jose A Perez-Rivera, Marta Alonso-Fernandez-Gatta, Alfonso Macías, Paloma Perez-Espejo

“…Among patients with post-infarction left ventricular dysfunction, modern implantable cardiac monitoring devices (ICM) allow a unique opportunity to determine in real-time the burden of non-sustained ventricular tachycardias and their relationship to the subsequent occurrence of sustained or symptomatic events.Methods and analysis Approximately 200 patients with left ventricular ejection fraction (LVEF) equal to or less than 40% after acute myocardial infarction will be included in the study. …”
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