Adherence to Medical Treatment in Elderly Patients with Coronary Artery Disease in the Settings of Primary Outpatient Care by S. K. Zyryanov, S. B. Fitilev, A. V. Vozzhaev, I. I. Shkrebneva, N. N. Shindryaeva, D. A. Klyuev, L. N. Stepanyan, A. M. Lutsenko, A. T. Tsai, A. A. Danilova

“…To study medication adherence in elderly patients with coronary artery disease (CAD) in primary care practice.Material and methods. The study conducted in out-patient clinic of Moscow city. 293 elderly (≥65 years) patients with established CAD included. …”
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Diagnostic and Predictive Values of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis: A Multi-Center Prospective Clinical Study by Wang K, Zhang Y, Sang L, Hu Y, Su L, Xie S, Xiao K, Xu J, Wang J, Xie F, Zhu G, Fu S, Xie L

“…Kaifei Wang,1,* Youchen Zhang,2,* Lei Sang,3,* Ye Hu,1,* Longxiang Su,4 Sheling Xie,1 Kun Xiao,1 Jianqiao Xu,1 Jiang Wang,1 Fei Xie,1 Guangfa Zhu,5 Shihui Fu,6– 8 Lixin Xie1 1College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pediatrics, Hainan Hospital of Chinese PLA General Hospital, Sanya, People’s Republic of China; 3Information Department, Hainan Hospital of Chinese PLA General Hospital, Sanya, People’s Republic of China; 4Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 5Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, People’s Republic of China; 6Department of Cardiology, Hainan Hospital of Chinese PLA General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, People’s Republic of China; 7Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China; 8The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shihui Fu, Department of Cardiology, Hainan Hospital of Chinese PLA General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, People’s Republic of China, Email xiaoxiao0915@126.com Lixin Xie, College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, People’s Republic of China, Email xielx301@126.comObjective: To determine diagnostic values of serum and urine soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in sepsis including septic shock and their predictive values for clinical prognosis and sepsis-associated acute kidney injury (AKI).Methods: A multi-center prospective research method was used to enroll patients with sepsis.Results: A total of 586 cases were studied, including 238 patients with sepsis and 348 healthy individuals. …”
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Survival of retinoblastoma patients: a cohort study by two Russian medical centers by S. V. Saakyan, O. A. Ivanova, S. S. Tadevosyan, A. Yu. Tsygankov, L. V. Olkhova, T. L. Ushakova, V. G. Polyakov

“…Yet timely enucleation in cases of absolute indications remains the method of choice in saving the life of a child.…”
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Distinct Airway Microbiome and Metabolite Profiles in Eosinophilic and Neutrophilic Asthma by Liu S, Lin Z, Zhou J, Yang X, You L, Yang Q, Li T, Hu Z, Zhan X, Jiang Y, Sun B

“…While allergen triggers are well-known, the role of the airway microbiome and metabolites in asthma exacerbations remains poorly understood.Methods: We recruited 64 participants (24 EA, 20 NEA, 20 healthy controls [HC]) for the discovery cohort, with validation in an external cohort (10 EA, 8 NEA, 8 HC). …”
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Comparing cervical cerclage, pessary and vaginal progesterone for prevention of preterm birth in women with a short cervix (SuPPoRT): A multicentre randomised controlled trial. by Natasha L Hezelgrave, Natalie Suff, Paul Seed, Vicky Robinson, Jenny Carter, Helena Watson, Alexandra Ridout, Anna L David, Susana Pereira, Fatemeh Hoveyda, Joanna Girling, Latha Vinayakarao, Rachel M Tribe, Andrew H Shennan, SuPPoRT Collaborating Team

“…<h4>Conclusions</h4>In this study, we found that for women who develop a short cervix, cerclage, pessary, and vaginal progesterone were equally efficacious at preventing PTB, as judged with a 20% equivalence margin. …”
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Rapid Initiation of Antiretroviral Therapy Suppresses T Cell Pathological Proliferation and Improves Immune Recovery in People Living with HIV by Ji J, Guo C, Li Z, Cai M, Wang R, Chen X, Zhang Y, Wu H, Zhang T, Zhang Y

“…The objective of this research is to examine how rapid ART affects T-cell pathological proliferation, immune recovery, and systemic inflammation in PWH.Patients and Methods: In this cross-sectional study (conducted at Beijing Youan Hospital, Capital Medical University, China, from April 1 to September 18, 2022), we recruited 39 PWH, including 23 in the rapid ART group (within 30 days) and 16 in the non-rapid ART group (after 180 days). …”
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Immunological Efficacy and Safety of a New Pneumococcal Polysaccharide Conjugated Thirteen-Valent Vaccine in the Immunization of Adults and Children (Results of Clinical Studies in... by I. V. Feldblium, M. H. Alyeva, A. V. Bikmieva, V. V. Romanenko, O. A. Rychkova, A. N. Galustyan

“…A clinical study in adults showed no statistically significant difference between the study groups according to the results of primary (the proportion of volunteers whose concentration of serotype-specific IgG to each of the 13 pneumococcal serotypes is equal to or exceeds the level of 0.35 mcg/ml (p &gt; 0.039) before vaccination and 4 weeks after vaccination) and secondary criteria for evaluating effectiveness. …”
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Electroacupuncture Prevent and Treat Perioperative Cognitive Impairment in Elderly Patients Undergoing Hip Surgery: A Protocol for a Randomized Controlled Trial by Fang Q, Xie J, Zheng S, Hou Y, Wu M, Chen Y, Yang Y, Wang G, Li J

“…However, the mechanism of electroacupuncture treatment for PND is comparatively unexplored.Methods/Design: This is a single-center clinical, prospective randomized controlled clinical trial protocol. 180 patients will be randomly divided into the treatment group and the control group in a ratio of 1:1. …”
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Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation by Lei B, Su Y, Chen R, Chen Z, Liu B, Chen Y, Zhou M, Wang X, Ma Q

“…To predict its therapeutic targets via network pharmacology and verify the therapeutic effect and the mechanism of BB against influenza virus in vitro and in vivo.Material and Methods: The potential active and underlying mechanism of BB in the treatment of influenza virus was predicted through network pharmacological strategies and Molecular Docking. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…Leveraging the radiosensitizing ability of Deruxtecan (DXd) and the internal radiation therapy of 131I for tumors, we aimed to develop the first radio-antibody-drug conjugates (RADCs) for the treatment of gastric cancer.Methods: The CLDN18.2-specific antibody HLX58 was conjugated with the payload DXd through a cleavable maleimide glycynglycyn-phenylalanyn-glycyn (GGFG) peptide linker. …”
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Impact of Pre-Interventional Observational Management Duration on Outcomes of Embolization for Splenic Injuries: Experience from Two Centers by Nguyen VT, Le TD, Pham HD, Tran QL

“…Van Thang Nguyen,1,2,&amp;ast; Thanh Dung Le,3,4,&amp;ast; Hong Duc Pham,1,5,&amp;ast; Quang Loc Tran3,4,&amp;ast; 1Radiology Department, Hanoi Medical University, Hanoi, Vietnam; 2Radiology Department, Hai Duong Medical Technical University, Hai Duong, Vietnam; 3Radiology Department, VNU University of Medicine and Pharmacy, Hanoi, Vietnam; 4Radiology Department, Viet Duc University Hospital, Hanoi, Vietnam; 5Radiology Department, Saint Paul Hospital, Hanoi, Vietnam&amp;ast;These authors contributed equally to this workCorrespondence: Van Thang Nguyen, Department of Radiology, Hai Duong Medical Technical University, Hai Duong, Vietnam, Email nguyenvanthang@hmtu.edu.vnObjective: To evaluate the clinical and technical success of splenic artery embolization (SAE) in the management of splenic trauma and factors affecting treatment outcomes.Materials and Methods: A retrospective and prospective study was conducted at two centers from December 2019 to December 2023, including 400 patients with splenic trauma (grade III–V according to the American Association for the Surgery of Trauma (AAST) - 2018 classification) and the Abbreviated Injury Scale (AIS) 2005 change from the AIS-1998. …”
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Spleen Volume Dynamics and Survival Outcomes in HCC Patients Undergoing Immune Checkpoint Inhibitors: A Retrospective Analysis by Fu X, Jiang S, Li Y, Guo Y, Gong B, Lou J, Li Y, Wang S, Sun Y, Ren Y, Chen Q, Yang L

“…This study investigated the prognostic impact of spleen volume (SV) on the survival in hepatocellular carcinoma (HCC) patients receiving immune checkpoint inhibitors (ICIs).Patients and Methods: This retrospective study included 224 HCC patients treated with ICIs, categorized into Higher and Lower SV groups by median SV and further into SV increased and Non-SV increased groups based on changes in SV at 3 months after ICIs. …”
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Narrow-Margin Treatment with Modified Mohs Microsurgery for Extramammary Paget&amp;rsquo;s Disease: A Retrospective Clinical Analysis by Yang J, Yan J, Luo H, Li L, Jiang L, Chen X, Wu L, Chai J, Xue H, Gan L, Liu Y, Chen J, Fei W, Bai Y, Zhu Q, Chen Z, Guo L, Chen Y

“…Jing Yang,1,&amp;ast; Jianna Yan,1,&amp;ast; Hao Luo,1 Liang Li,1 Long Jiang,1 Xuewen Chen,1 Ling Wu,1 Jingxiu Chai,1 Huan Xue,1 Leimeng Gan,1 Yeqiang Liu,2 Jia Chen,3 Wu Fei,2 Yun Bai,4 Quangang Zhu,5 Zhongjian Chen,5 Lehang Guo,6 Yuchong Chen1 1Department of Surgery, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 2Department of Pathology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 3Department of Rheumatology and Immunology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 4Department of Central Laboratory, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 5Department of Pharmacy, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 6Department of Ultrasonography, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yuchong Chen, Department of Dermatologic Surgery Division, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China, Email 973309637@qq.comBackground: To investigate the clinical efficacy of narrow-margin modified Mohs microsurgery (mMMS) in the treatment of extramammary Paget’s disease (EMPD).Methods: A retrospective cohort review was conducted on 52 patients with EMPD who were treated at the Skin Disease Hospital of Tongji University in Shanghai between 2017 and 2023. …”
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Real-World Efficacy and Safety of Anti-PD-1 Antibody Plus Apatinib and Temozolomide for Advanced Acral Melanoma by Zhang J, Tian H, Mao L, Li C, Wei X, Gu J, Wang X, Zhou L, Lian B, Tang B, Yan X, Li S, Cui C, Chi Z, Sheng X, Guo J, Si L

“…The aim of this retrospective study was to evaluate the efficacy and safety of the triplet regimen for advanced AM in the real-world setting.Methods: The data of patients with advanced AM who received anti-PD-1 antibody plus apatinib and temozolomide at Peking University Cancer Hospital and Institute between September 2019 and December 2023 were analyzed. …”
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Predictive Potential of CRTP5 and SII for Coronary Artery Severity and Myocardial Fibrosis in Patients with NSTE-ACS: An Exploratory Biomarker Study by Ji J, Qiao M, Ding Y, Wei X, Wan D, Wu L, Liu H

“…Jinrui Ji,1,2,&amp;ast; Mu Qiao,3,4,&amp;ast; Ya’nan Ding,1,2,&amp;ast; Xiaoyun Wei,1,2,&amp;ast; Dongyu Wan,1,2,&amp;ast; Lei Wu,1,2,&amp;ast; Hengliang Liu1,2,&amp;ast; 1Clinical Medical Department, Faculty of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 2Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 3Department of Cardiology, Seventh People’s Hospital of Zhengzhou, Zhengzhou, 450000, People’s Republic of China; 4Department of Cardiology, Zhengzhou Cardiovascular Institute, Zhengzhou, 450000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Hengliang Liu, Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China, Email hnzzjjr@163.comPurpose: Findings from this research aim to enhance clinical assessments of coronary artery disease severity and myocardial fibrosis (MF).Methods: A total of 523 eligible non-ST-segment elevation acute coronary syndromes (NSTE-ACS) patients were included. …”
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Effectiveness of isoniazid preventive treatment among patients on antiretroviral treatment in Southeast Nigeria: A retrospective cohort study by Chukwuma David Umeokonkwo, Bello Segun, Patrick Nguku, Muhammad Shakir Balogun, Peter Nsubuga, Lilian Bulage, Adanna Anthonia Umeokonkwo, Olufunmilayo Ibitola Fawole

“…The log-rank ratio was used to compare the equality of the survival function. Results: Six hundred and sixty-one patients were recruited for the study with a mean age of 38.5±9.6 years. …”
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PHASE 2 MULTICENTER RANDOMIZED CLINICAL TRIAL: NEOADJUVANT CHEMORADIOTHERAPY FOLLOWED BY D2 GASTRECTOMY AND ADJUVANT CHEMOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED GASTRIC CANCER by V. Yu. Skoropad, S. G. Afanasyev, S. V. Gamayunov, N. K. Silanteva, T. A. Agababyan, P. V. Sokolov, S. A. Ivanov, A. D. Kaprin

“…Additional objectives of the study were to assess the accuracy of preoperative staging of gastric cancer; tumor regression grade of the primary tumor and regional lymph node metastases according to CT findings; treatment outcomes according to the criteria of frequency and time to recurrence/metastasis; 1-, 2 -, and 3-year survival rates. Material and methods. The study included 70 patients with equal distribution between the treatment groups. …”
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AuNRs-PPAR&amp;gamma;mAb Induce Targeted Adipocyte Apoptosis Through Photothermal Effects for Effective Localized Fat Reduction by Hu Y, Xiao K, Chen Z, Ou S, Sima C, Wang H, Zhang J, Zhang Z, Li X

“…This targeted approach offers a promising method for non-surgical, localized fat reduction. …”
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IN VITRO STUDY OF SUPERFICIAL ENAMEL LAYER OF PERMANENT TEETH DURING STAGE OF SECONDARY MINERALIZATION by G.M. Grigorenko, L.A. Khomenko, G.V. Sorochenko, L.M. Kapitanchuk

“…The remaining 10 samples were randomly divided into two equal groups (6 months and 12 months) and placed into two boxes that were filled with artificial saliva (T. …”
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Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling by Lv P, Zhang Y, Zhao Z, Wu W, Zhou Y, Liu Z, Wang H, Jiang X, Li S, Yan P, Huang X, Xiang W, Fu P

“…This study aimed to explore the effects and mechanisms of GaMSCs-derived exosomal miRNA-191-5p on the PMT of glioblastoma.Methods and Results: Conditioned medium from three independently established GaMSCs lines (GaMSCs-CM) significantly enhanced the tumorigenicity of glioma cells. …”
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