Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model by Wei PS, Chou PY, Hsu HY, Chen M, Chen YJ, Tsai TH, Wen BY, Sheu MT, Chuang KH, Lin HL

“…Program of Translational Medicine, Taipei Medical University, Taipei, Taiwan*These authors contributed equally to this workCorrespondence: Kuo-Hsiang Chuang; Hong-Liang Lin, Email khchuang@tmu.edu.tw; hlglin@kmu.edu.twPurpose: CD3-based Bispecific T-cell engagers (BiTEs) are effective for solid tumors due to their tumor specificity and tissue penetration, but they face challenges like short half-lives and narrow therapeutic windows. …”
Get full text

Clinical Characteristics and Mechanism Discussion of Peripheral Nerve Injury in 2 Cases of Severe Viral Meningoencephalitis by Guo X, Zheng M, Wei Z, Song J, Wang X, Shen Z, Guo X, Zhang N, Xing Y, Zhang Y, Zhang W, Du R, Qiu B, Tian S, Wang Z

“…This study analyze the prognosis, clinical characteristics, and outcomes of patients with PN secondary to CNS infections to aid early diagnosis and improve prognosis.Methods: Clinical data from two patients admitted to our Neurology Department with PN secondary to severe viral meningoencephalitis were collected, summarized, and analyzed. …”
Get full text

Determining the probability of spondyloarthritis in patients with uveitis by A. A. Godzenko, I. Yu. Razumova, S. I. Glukhova

“…SpA was diagnosed in 51/160 pts with unilateral uveitis and was not diagnosed in 109/160 (OR=2.028; 95% CI: 0.913–4.501; p=0.082); out of 48 pts with bilateral uveitis was 9 with SpA and 39 without SpA (OR=0.493; 95% CI: 0.222–1.095; p=0.082); among 149 pts with isolated AU – 55 with SpA and 94 without SpA (OR=6.319; 95% CI: 2.384–16.749; p=0.001); of 59 pts with panuveitis – 5 with SpA and 54 without SpA (OR=0.158; 95% CI: 0.060–0.419; p=0.001); among 159 HLA-B27-positive – 56 with SpA and 103 without SpA (OR=6.117; 95% CI: 2.091–17.888; p=0.001); the onset of uveitis at the age of ≤30 years was in 44/107 pts with SpA and in 63/107 – without SpA (OR=3.710; 95% CI: 1.921–7.168; p=0.001); SpA was confirmed in 39/79 male pts and was not confirmed in 40 (OR=5.014; 95% CI: 2.637–9.535; p=0.001).A formula to determine the probability of SpA in pts with uveitis was obtained by the method of multifactorial discriminant analysis: 1.972 × Х1 + 1.476 × Х2 + 1.418 × Х3 + 1.270 × Х4 + 0.668 × Х5 + 0.162 × Х6, where X1 – male; X2 – the onset of uveitis at the age of ≤30 years; X3 – HLA-B27; X4 – isolated anterior uveitis; X5 – unilateral uveitis; X6 – acute recurrent uveitis.If the amount is greater than 4.552, the probability of SpA is estimated as high, if the amount is less than or equal to 4.552, it is low.Conclusion. …”
Get full text

Comparative Effectiveness and Safety of Molecular Targeted Therapy Plus PD-(L)1 with or without TACE in Unresectable Hepatocellular Carcinoma: A Retrospective Study by Liu J, Wang Y, Cui L, Nie Y, Li C, Tan W, Li Y, Bai Y, Wan T, Hu B, Liu Z, Hu M, Wang M, Duan F

“…Jiangtao Liu,1,* Yan Wang,2,* Li Cui,2 Yan Nie,1 Chao Li,1 Wenle Tan,2 Ye Li,1 Yanhua Bai,1 Tao Wan,3 Bingyang Hu,3 Zhe Liu,3 Minggen Hu,3 Maoqiang Wang,2 Feng Duan2 1Department of Gastroenterology, Hainan Hospital of Chinese People’s Liberation Army (PLA) General Hospital, Sanya, Hainan, 572000, People’s Republic of China; 2Department of Interventional Radiology, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, 100853, People’s Republic of China; 3Faculty of Hepato-Biliary-Pancreatic Surgery, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Duan, Email duanfeng@vip.sina.comObjective: This study aims to compare the effectiveness and safety of TACE combined with molecular targeted therapy (MTT) plus Programmed death-ligand 1 (PD-(L)1) antibodies versus MTT plus PD-(L)1 antibodies for HCC patients.Methods: Data from HCC patients who received either MTT plus PD-(L)1 (systemic therapy group) or TACE combined with MTT plus PD-(L)1 (combination therapy group) were retrospectively analyzed. …”
Get full text

Unravelling the Information Contained in the Single Items of the COPD Assessment Test for Different Outcomes and Smoking Status in Patients with COPD: Results from COSYCONET by Alter P, Kahnert K, Trudzinski FC, Bals R, Watz H, Speicher T, Söhler S, Rabe KF, Wouters EFM, Vogelmeier CF, Jörres RA

“…The CAT total score was associated with mortality (p< 0.05) only in nonsmokers, while for exacerbation frequency/severity, it was of about equal importance in smokers and nonsmokers. Regarding KCO, the total score was indicative (p< 0.05) only in nonsmokers. …”
Get full text

Risk and Prognostic Factors for Bloodstream Infections Due to Clonally Transmitted Acinetobacter baumannii ST2 with armA, blaOXA-23, and blaOXA-66: A Retrospective Study by Ji J, Chen W, Jiang P, Zheng J, Shen H, Liu C, Zhang Y, Liao X, Yang Z, Cao X, Wu C

“…The risk and prognostic factors for BSIs caused by clonally transmitted A. baumannii ST2, carrying armA, blaOXA-23 and blaOXA-66, remain unclear.Methods: We retrospectively analyzed 97 hospitalized patients with A. baumannii BSI (January 2019–May 2022). …”
Get full text

ASSESSMENT OF THE OCCLUSAL RELATIONS NATURE AT THE STAGES OF ORTHOPEDIC REHABILITATION OF PERSONS WITH PERIODONTAL TISSUE DISEASES COMPLICATED BY DENTITION DEFECTS by О.V. Bida, О.V. Bida

“…The aim of the study is to improve the effectiveness of orthopedic treatment of periodontal diseases complicated by defects of the dentition with the control of occlusal relationships with a computerized T-Scan III system. Materials and methods. We have examined 87 persons aged between 30 and 69 years with generalized periodontitis of I – III severity, complicated by partial loss of teeth of different sizes and topography, and a control group of the same age in 10 patients with intact dentition and physiological forms of occlusion without clinically diagnosed periodontal diseases. …”
Get full text

Socioeconomic inequalities in patient-reported outcome measures among total hip and knee arthroplasty patients: a comprehensive analysis of instruments and domains by Joshua M. Bonsel, Max Reijman, Erin M. Macri, Jan A. N. Verhaar, Liza N. van Steenbergen, Gouke J. Bonsel

“…A SES-indicator based on neighborhood income, unemployment rate, and education level was divided into quintiles, which are equal groups representing 20% of the Dutch population, and was ranked from least to most deprived. …”
Get full text

Efficacy and Safety of Biologics Targeting Type 2 Inflammation in COPD: A Systematic Review and Network Meta-Analysis by Li S, Yi B, Wang H, Xu X, Yu L

“…Shujie Li,1,&amp;ast; Baiyi Yi,1,&amp;ast; Huan Wang,2 Xianghuai Xu,1 Li Yu1 1Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 2Clinical Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xianghuai Xu, Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, People’s Republic of China, Email 05849@tongji.edu.cn Li Yu, Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, People’s Republic of China, Email 96778@tongji.edu.cnPurpose: This study aims to comparatively evaluate the efficacy and safety profiles of biologic agents targeting type 2 inflammation in COPD.Methods: As of September 1, 2024, we identified and screened eight clinical studies evaluating biologic agents targeting type 2 inflammation for COPD treatment from multiple databases. …”
Get full text

Transcutaneous Electrical Acupoint Stimulation (TEAS) Facilitates Postoperative Recovery in Day Lung Cancer Surgery: A Randomized Controlled Trial by Wu S, Lou J, Zou H, Wang W, Zhang Y, Xu Y, Hou X, Wu J

“…This study evaluated whether Transcutaneous Electrical Acupoint Stimulation (TEAS) reduces postoperative pain and analgesic use in lung cancer surgery.Methods: In this randomized, sham-controlled trial at a tertiary hospital in Shanghai, 100 patients (18– 70 years old, ASA I–II) who underwent day lung cancer surgery (video-assisted thoracoscopic pulmonary wedge resection) were enrolled. …”
Get full text

Aneurysm Wall Enhancement and Systemic Inflammation Jointly Contribute to Cognitive Dysfunction in Untreated Unruptured Intracranial Aneurysm Patients by Wu XB, Luo B, Guo X, Liu CC, Liu YA, Ye JS, Fan SY, Li QJ, Wang SW

“…We assessed cognitive function and its association with inflammatory markers in UIA patients.Methods: The study included 120 consecutive patients with UIAs diagnosed between September 2018 and December 2023 and a control group of 27 healthy adults at our institution. …”
Get full text

The effects of esketamine on postoperative delirium in older patients with fragile brain function during the non-acute phase following lung cancer surgery: a randomized controlled... by Honglin Fu, Jingna Hu, Xuewei Zhang, Kaiyun Xie, Lihong Hu

“…Control group received an equal volume of normal saline during both induction and maintenance of anesthesia. …”
Get full text

Simulating the risk of heat stress on grain maize production under arid and semi-arid conditions by Khosro Azizi, Sajjad Rahimi-Moghaddam

“…Furthermore, the risk window for maize flowering in each region was equal to the first day of the year with a temperature of over 36 °C until the last day of the year with a temperature above 36 °C. …”
Get full text

Photothermal Antibacterial Effect of Gold Nanostars Coating on Titanium Implant and Its Osteogenic Performance by Li L, Wu J, Liu L, Zhang P, Zhang Y, Zhou Z, Gao X, Sun S

“…The research aimed to enhance osseointegration through surface modification while leveraging GNS’s photothermal effect for on-demand antibacterial activity, offering a dual-functional strategy to improve implant performance.Methods: GNSs were synthesized and anchored onto titanium surfaces through surface modification via silanization. …”
Get full text

Evaluation of Luteolin Nanosuspensions on Pharmacokinetics of Atorvastatin: Drug-Drug Interactions Using Rat Models by Liang Y, Sun B, Yang M, Meng X, Wang M, Yang L, AI-Hamyari B, Zhang Y, Shen Y, Meng S

“…This study aims to explore the pharmacokinetic (PK) drug-drug interactions (DDIs) of LUT toward ATV and the influencing mechanisms involving CYP450s and OATPs, and using the physiologically based pharmacokinetic (PBPK) models extrapolated to humans to optimize the DDIs dosage regimens for subsequent research.Methods: Luteolin nanosuspensions lyophilized powder (LUT-NS-LP) were prepared for improving LUT’s solubility and bioavailability, the effects of both LUT on the ATV CYP450s enzyme kinetics and LUT-NS-LP/LUT on the PK behavior of ATV in rats were further studied by UPLC. …”
Get full text

Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease by Liu X, Zhang Y, Wang Y, Xu Y, Xia W, Liu R, Xu S

“…The CIBERSORT algorithm and Wilcoxon test method were used to analyze the differences in immune cells between the CAD and normal samples. …”
Get full text

Association Between Sleep and Vertigo Severity in Benign Paroxysmal Positional Vertigo: Mediating Role of Psychological Factors by Xing J, Xu X, Shan H, Wu J, Liu P, Shi W, Ren P, Liu J, Huang Y, Mi B

“…Juanli Xing,1,&amp;ast; Xinyu Xu,2– 4,&amp;ast; Hongying Shan,2 Jiaqian Wu,4 Peiyu Liu,5 Wenyan Shi,4 Peihua Ren,2 JinLing Liu,4 Yuge Huang,2 Baibing Mi2 1Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China; 3Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 4Department of Health Science Center, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 5Department of Health Science Center, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Baibing Mi, Department of Epidemiology and Biostatistics Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China, Email xjtu.mi@xjtu.edu.cnObjective: To investigate the relationship between sleep quality and vertigo severity among patients with benign paroxysmal positional vertigo (BPPV) and to elucidate the mediating effects of anxiety and depression on this association.Methods: We analyzed baseline data from an ongoing cohort study of 1056 BPPV patients in Northwest China. …”
Get full text

Effects of Xenon on Neuroinflammatory Markers: a Prospective Pilot Study by A. I. Shpichko, R. A. Cherpakov, A. K. Shabanov, A. K. Evseev, I. V. Goroncharovskaya, O. A. Grebenchikov

“…Patients were randomized into 2 equal groups. In Group I (Comparison, n=15) in addition to the standard treatment for TBI, each patient included in the study underwent 7 sessions of inhalation of an air mixture with an oxygen content of at least 30 vol.% for 30 minutes. …”
Get full text

Efficacy of a 6-month supported online programme (Feeling Safer) for the treatment of persecutory delusions: protocol for a randomised controlled trial by Richard Emsley, Verity Westgate, Daniel Freeman, Thomas Kabir, José Leal, Anthony Morrison, Kate Chapman, Robert Dudley, Laina Rosebrock, Felicity Waite, Louise Isham, Jason Freeman, Stephanie Common, Alex Kenny, Ariane Beckley, Natalie Rouse, Megan McGovern

“…We will also test whether Feeling Safer works equally across gender, age, ethnicity and cognitive functioning (moderation) and whether Feeling Safer works via the targeted psychological processes (mediation).Methods and analysis The study design is a multicentre, single-blind (outcome assessor), parallel, four-arm randomised controlled trial; 484 patients with persistent persecutory delusions will be randomised to one of the four conditions (1:1:1:1): Feeling Safer (added to treatment as usual (TAU)) supported by peer-support workers, or Feeling Safer (added to TAU) supported by graduate mental health workers including assistant psychologists, or Feeling Safer (added to TAU) supported by CBT therapists or TAU. …”
Get full text

FDG PET/CT AND PSMA PET/CT IN MUSCULOSKELETAL SOFT TISSUE SARCOMAS by Ellen Nogueira Lima, Thaisa Ramos Freire, Mayara Branco E. Silva, Natalia Tobar Toledo Prudente Silva, Thiago Alves, Allan Santos, Mariana Lima, José Carvalheira, Mauricio Etchebehere, Elba Etchebehere

“…The detectability of DLNs was equal in both studies (7 patients). Conclusion: Our preliminary findings indicate that PSMA PET/CT is a potential diagnostic tool for staging sarcomas patients. …”
Get full text