Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and extern... by Ankur Gupta-Wright, Elizabeth L Corbett, Douglas Wilson, Joep J van Oosterhout, Keertan Dheda, Helena Huerga, Jonny Peter, Maryline Bonnet, Melanie Alufandika-Moyo, Daniel Grint, Stephen D Lawn, Katherine Fielding

“…A simplified score (any 3 or more of the predictors) performed equally well. The main limitations of the scores were their imperfect accuracy, the need for access to urine LAM testing, modest study size, and not measuring all potential predictors of mortality (e.g., tuberculosis drug resistance).…”
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Optimized layout and excavation sequence of deep chambers by Shenghua YIN, Yongyuan KOU, Yun ZHOU, Zepeng YAN, Dexin ZENG

“…The study also examined the influence of different chamber layout methods on stability and provided layout guidelines for primary chamber prioritization, parallel arrangements, and intersecting layouts. …”
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The Role of the Tourists in the Karst Dissolution of the Secondary Shapes inside Caves (Case Study: Hamedan Alisadr Cave) by Amjad Maleki, Mohammad Hosayn Ghobadi, Payman Karimi Soltani

“…After removing the samples from the glass chambers and determining exact physical properties, the solving and corrosion rates were obtained separately for natural and human influential factors based on weight method. 3- Result and Discussion The findings reveal that the amount of the dissolution and lamination of the secondary shapes inside the Ali Sadr Cave is 0.078 G/cm3 annually that 0.060 G/cm3 of this amount equals to 77% of the total annual dissolution of the tourists portion. …”
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Interleukin-1β in circulating mononuclear cells predicts steatotic liver disease improvement after weight loss in subjects with obesity and prediabetes or type 2 diabetes by Paola Giustina Simeone, Sarah Costantino, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Armando Tartaro, Alessandro Mengozzi, Francesco Cosentino, Francesco Cipollone, Agostino Consoli, Francesco Paneni, Francesca Santilli

“…Methods Thirty-two obese subjects with prediabetes (n = 16) or newly diagnosed T2D (n = 16), were randomized to the glucagon-like peptide receptor agonist (GLP1-RA) liraglutide or lifestyle counselling until achieving a comparable weight loss. …”
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Chronic Inflammation Index-Based Tumor Subsite Classification Correlated with Chemotherapy Benefit and Survival Outcomes in Stage II-III Colorectal Cancer by Lu Y, Ye QY, Mei O, Li YN, Peng Y, Ying HQ, Cheng XX

“…Ying Lu,1,* Qiu-Ying Ye,1– 3,* Ou Mei,4,* Ya-Nan Li,1 Yue Peng,1 Hou-Qun Ying,1,3,5 Xue-Xin Cheng1 1Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2Department of Medical Technology, Jiangxi Medical College, Shangrao, 334000, People’s Republic of China; 3Department of Laboratory Medicine, Central Hospital of Shangrao City, Shangrao, 334000, People’s Republic of China; 4Department of Orthopedics, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People’s Republic of China; 5Shangrao Medical Center, The Second Affiliated Hospital of Nanchang University, Shangrao, 334000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xue-Xin Cheng, Department of Clinical Laboratory, Immunity and Inflammation Key Laboratory of Jiangxi Province, The Second Affiliated Hospital of Nanchang University, No. 1 of Minde Road, Nanchang, 330006, People’s Republic of China, Tel/Fax +86 0791-86297662, Email cxxncu@163.com Hou-Qun Ying, Department of Clinical Laboratory, Immunity and Inflammation Key Laboratory of Jiangxi Province, The Second Affiliated Hospital of Nanchang University, No. 1 of Minde Road, Nanchang, 330006, People’s Republic of China, Tel/Fax +86 0791-86297662, Email yinghouqun2013@163.comPurpose: This study aimed to develop and validate an integrated inflammatory prognostic index and to investigate associations between primary tumor location, chronic inflammatory status, adjuvant chemotherapy response, and survival outcomes in stage II–III colorectal cancer (CRC).Patients and Methods: A total of 1413 stage II–III CRC patients who underwent radical resection were enrolled and divided into discovery and validation cohorts. …”
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The Persistent Threat of Chronic Inflammation on the Mortality Among Cervical Cancer Survivors: A Mendelian Randomization and Machine Learning Analysis Using UK Biobank and Chinese... by Wang J, Chen Z, Guan M, Ma Z, Peng L, Chen J, Fiori PL, Carru C, Capobianco G, Coradduzza D, Zhou L

“…We aimed to comprehensively evaluate the genetic association between inflammation and cervical cancer, and construct an accurate prognosis model based on circulating inflammatory parameters and indexes with machine learning (ML) algorithms.Patients and Methods: We tested the genome-wide association of circulating inflammatory molecules (CIMs) (91 circulating inflammatory cytokines and 10 inflammatory cells) and summary data retrieved from the UK biobank (cases = 1659 and controls =381,902) with two-sample Mendelian randomization (MR) and colocalization analyses. …”
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Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis by Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xinliang Ma, Yajing Wang

“…Intramyocardial injection of an equal number of diabetic plasma sEV in nondiabetic hearts significantly increased cardiac apoptosis and exacerbated MI/R-induced cardiac dysfunction. …”
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IL-22 Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Epithelial Cell Apoptosis Associated with STAT3 Signalling by Zhu C, Chen J, Yan Z, Wang F, Sun Z, Liu Z, Li Y, Chen X, Bao Z, Li Q, Chen Z

“…This study aimed to investigate the therapeutic efficacy of IL-22 in sepsis and explore the regulatory mechanisms involved.Methods: A mouse caecal ligation and puncture (CLP) model of sepsis was established, and the effect of IL-22 was investigated as indicated. …”
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RAR-Based Prognostic Model for Predicting Overall Survival in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Multicenter Study by Tan M, Liu Y, Dai W, Chen Y, Cai D, Chen B, Wang J, You R, Li D, Huang H

“…This study aimed to develop and validate a novel prognostic nomogram integrating the red blood cell distribution width-to-albumin ratio for predicting patients’ overall survival.Patients and Methods: A retrospective cohort of 1403 patients was divided into training, internal validation, and external validation cohorts. …”
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Hypoglycemic and antihyperglycemic effects of Abelmoschus esculentus and Alchornea cordifolia in normal and alloxan-induced diabetic rats by Barnabé Lucien Nkono Ya Nkono, Adjia Hamadjida, Damolai Gounkagou, Fidèle Ntchapda, Sélestin Sokeng Dongmo, Pierre Kamtchouing

“…Rats with a blood glucose level greater than or equal to 200 mg/dL were selected, divided into groups and were daily administered orally with either aqueous extracts of A. esculentus at 30 mg kg−1 (AEAE30) or A. cordifolia at 400 mg kg−1 (AEAC400) for 14 consecutive days. …”
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The Perceptions of Husbands Regarding Early Marriage in Community Settings in Bengkulu, Indonesia: A Case-Control Study by Jipri Suyanto, Steyo Adiningsih, Rina Isnawati, Anna Lystia Poetranto, Nona Rahmaida Puetri, Muhammad Ibrahim Desem, Lisa Andriani Lienggonegoro, Suriyani Tan, Diki Bima Prasetio, Sri Susanty

“…Engaging men in gender equality discussions and offering educational and career opportunities can help reduce the incidence of early marriage and foster healthier relationships. …”
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A New Risk Prediction Tool for Bleeding and Adverse Cardiovascular Events in Patients with Pre-Existing Coronary Stents Undergoing Gastrointestinal Cancer Surgery by Xu ZY, Hao XY, Zhang Z, Zhang J, Gao L, Li T, Wang XX

“…Therefore, this study will establish a prediction tool that can predict both bleeding events and major adverse cardiovascular events (MACEs).Methods: Multicenter clinical data from 3127 gastrointestinal cancer surgery patients with a history of coronary stent implantation were utilized to establish and validate our prediction tool. …”
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Changes in Serum PDGF-C and TGF-β1 Levels After PCI in Premature Coronary Artery Disease: Combined Predictive Value for MACCE by Liu H, Tan S, Zhao J, Lin X

“…Haide Liu,1,* Shanglang Tan,1,* Jiaxin Zhao,2 Xuejuan Lin3 1Department of Cardiology, Guigang City People’s Hospital, Guigang, Guangxi, 537100, People’s Republic of China; 2Department of Ultrasound, Guigang City People’s Hospital, Guigang, Guangxi, 537100, People’s Republic of China; 3Department of Surgery, Guigang Maternal and Child Health Care Hospital, Guigang, Guangxi, 537100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shanglang Tan, Guigang City People’s Hospital, No. 1 Zhongshan Middle Road, Gangbei District, Guigang, Guangxi, 537100, People’s Republic of China, Email tanshanglang@21cn.com Haide Liu, Guigang City People’s Hospital, No. 1 Zhongshan Middle Road, Gangbei District, Guigang, Guangxi, 537100, People’s Republic of China, Email gcgo40@sina.comObjective: This study evaluates dynamic changes in platelet derived growth factor C (PDGF-C) and transforming growth factor β 1 (TGF-β 1) levels after percutaneous coronary intervention (PCI) in patients with premature coronary artery disease (PCAD) and their combined predictive value for major adverse cardiac and cerebrovascular events (MACCE).Methods: A total of 100 PCAD patients admitted to the hospital from July 2021 to July 2023 who had completed 2 years of follow-up were retrospectively selected as the research objects. …”
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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

“…Thus, this study aimed to develop a rhein-loaded self-nano emulsifying drug delivery system (RL-SNEDDS) to improve solubility and bioavailability.Methods: The RL-SNEDDS was prepared by aqueous titration method with eucalyptus oil (oil phase), tween 80 (surfactant), and PEG 400 (co-surfactant) and optimization was performed by 32 factorial design. …”
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Oleanolic Acid@SPIONs Alleviates Lipid-Oxidative Stress Injury of Zebrafish Blood Vessels via Regulating the Expression of JNK and MAPK Signaling Pathways in Vascular Endothelial C... by Gao H, Liu T, Liu J, Yang L, Liu L, Cui Z, Du X, Gu Y, Huang P

“…Oleanolic acid (OA), an active component of the traditional Chinese medicine Ligustrum lucidum, has been proven to have significant anti-inflammatory and lipid-lowering potential.Methods: The fli1a::EGFP+ zebrafish fed with oxidized low-density lipoprotein (oxLDL) diet were used as Atherosclerosis model. …”
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Effectiveness and Safety of Shenxiong Huanglian Detoxification Granule Combined with Donepezil for the Treatment of Alzheimer’s Disease: Study Protocol for a Multicenter, Pra... by Lin J, Liu X, Lin X, Liu N, Pei H, Zhao Y, Yu G, Wang W, Chen C, Hou T, Li X, Lin X, Li H

“…A total of 386 eligible individuals with mild to moderate Alzheimer’s disease will receive random assignment and equal access to the test or control group. The effectiveness and safety of Shenxiong Huanglian Detoxification Granule in combination with donepezil will be observed. …”
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Anti-leukemia effect of B7 gene-modified leukemia cell-derived exosomes by ZHANG Difan, WANG Minghui, ZHAO Jie, WAN Jiangbo, HUANG Fang, HAO Siguo

“…Objective·To investigate the immunotherapeutic effects of exosomes derived from leukemia cells with high expression of B7 molecules (co-stimulatory molecules CD80 and CD86) in tumor-bearing mice.Methods·L1210 leukemia cells were transfected with lentiviral vectors containing the CD80 and CD86 genes, and thereby the leukemia cells with high expression of CD80 and CD86 molecules were obtained. …”
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A Peptide Encoded by lncRNA HOXB-AS3 Promotes Cigarette Smoke-Induced Inflammation in Bronchial Epithelial Cells via EZH2-Mediated H3K27me3 Modification by Lin M, Zhou X, Yang Y, Xie P, Li Q, He C, Lin Q, Wei X, Ding Y

“…This study aimed to investigate the role of a peptide encoded by lncRNA HOXB-AS3 in cigarette smoke extract (CSE)-induced inflammation and in 16HBE cells.Methods: Open reading frames (ORF) Find software was utilized to predict the encoding potential of HOXB-AS3. …”
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Effect of Hardiness Training on Self-Esteem and Adjustment of Addicted Male by Mohammad Javad Aghajani

“…Method: This research is a pre-post test and control group. …”
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Diagnostic Performance of Clinical Metagenomic Next-Generation Sequencing for Suspected Central Nervous System Infections in a Municipal Hospital: A Retrospective Study in China by Wang H, Zhao J, Wang X, Li M, Hu T, Xu H, Dong M, He W, Che Z

“…However, there are few related studies investigating in a municipal hospital.Patients and Methods: A total of 52 suspected CNSi patients were retrospectively recruited in Xinxiang central hospital between July 2019 and April 2023. …”
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