Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection by Andrea A. Berry, Thomas L. Richie, L. W. Preston Church, Matthew B. Laurens, Colleen Boyce, Natasha KC, Sudhaunshu Joshi, Abra Rachida Koudjra, Lauryn Butler, Mei-Chun Chen, Yonas Abebe, Tooba Murshedkar, Eric R. James, Peter F. Billingsley, B. Kim Lee Sim, Stephen L. Hoffman, Kirsten E. Lyke

“…Solicited local and systemic adverse events recorded for 2 and 7 days after immunizations, respectively, occurred with equal frequency and severity in the 23 vaccinees and 7 controls receiving two immunizations, as did unsolicited adverse events recorded for 28 days and laboratory abnormalities 1 and 5 weeks after V2. …”
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Correlation of Novel Inflammation Index with Postoperative Acute Kidney Injury in Patients with Joint Arthroplasty: A Retrospective Cohort Study by Yan YT, Liu R, Liu J, Zhang WJ, Wang S, Tang TY, Lei YQ, Zhu XY, Liu KX, Zheng QJ, Liu HM

“…This study investigated the association between novel inflammation indices and postoperative AKI.Methods: This retrospective cohort study included 1434 patients who underwent hip or knee arthroplasty, with 1225 patients comprising the complete case analysis dataset. …”
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Real-World Assessment of the Association Between PCSK9i Adherence and LDL Reduction and Variability in a Chinese Clinical Practice by Ye X, Zhang S, Zhong X, Li M, Liu M, Zhuang X, Liao X

“…Xiaomin Ye,1,2,* Shaozhao Zhang,1,2,* Xiangbin Zhong,1,2 Miaohong Li,1,2 Menghui Liu,1,2 Xiaodong Zhuang,1,2 Xinxue Liao1,2 1Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinxue Liao, Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, People’s Republic of China, Tel +86-13903063724, Fax +86-020-28823388, Email liaoxinx@mail.sysu.edu.cn Xiaodong Zhuang, Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, People’s Republic of China, Tel +86-13760755035, Email zhuangxd3@mail.sysu.edu.cnBackground: Real-world evidence about adherence to proprotein convertase subtilisin/kexin type-9 inhibition (PCSK9i) is needed in Chinese population.Objective: We aimed to evaluate the adherence patterns using anti-PCSK9 monoclonal antibody in Chinese clinical practice and explored the association between adherence to PCSK9i and low-density lipoprotein cholesterol (LDL-C) reduction ratio and variability.Methods: A total of 5373 patients initiating PCSK9i in the First Affiliated Hospital of Sun Yat-sen University were included as sub-analysis of the RED-CARPET registry. …”
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Socio-economic inequalities in minimum dietary diversity among Ethiopian children aged 6–23 months: a decomposition analysis by Nigusu Worku, Amare Mesfin Workie, Lamrot Yohannes, Mihret Getnet, Mihret Getnet, Wubshet Debebe Negash, Wubshet Debebe Negash, Adina Yeshambel Belay, Lakew Asmare, Hiwot Tadesse Alemu, Demiss Mulatu Geberu, Melak Jejaw, Kaleb Assegid Demissie, Misganaw Guadie Tiruneh, Asebe Hagos

“…Wealth and educational status show positive CIX values for inequality, as exhibited by the concentration curve under the equality line. The CIX with household and maternal education status were (CIX: 0.1034, p < 0.0029) and (CIX: 0.1057, p < 0.0002), respectively. …”
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Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass by Alejandra Ramírez-Venegas, Francisco Montiel-Lopez, Robinson E. Robles-Hernández, Bartolome R. Celli, Raúl H. Sansores, Maricruz Cassou-Martínez, José L. Pérez Lara-Albisua, Claudia González-González, María E. Mayar-Maya, Aloisa P. Hernández-Morales, Rafael J. Hernández-Zenteno, Ramcés Falfán-Valencia, Ireri Thirión-Romero, Oliver Pérez-Bautista, Rogelio Pérez-Padilla

“…Conclusions Among patients with COPD-B and COPD-C with a history of exacerbation, FF/VI was equally effective as UMEC/VI in preventing exacerbations and improving dyspnoea and HRQL.…”
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Pragmatic, multicentre, factorial, randomised controlled trial of sepsis electronic prompting for timely intervention and care (SEPTIC trial): a protocol by Daniel Brodie, Manish Sharma, Matthew J Cummings, Hassan Mohamed, William N Southern, Edward J Schenck, Benjamin L Ranard, David Y Zhang, Jeremy R Beitler, Min Qian, Jo R Applebaum, Jason S Adelman, Shing M Lee, Richard Trepp, Hanson Hsu, Jean Scofi, Sarah C Rossetti, Natalie H Yip, Baruch S Fertel

“…The SEPTIC trials are pragmatic, multicentre, blinded, randomised controlled trials, with equal allocation to compare four SIRS-based sepsis screening alert groups: no alerts (control), nurse alerts only, prescribing clinician alerts only, or nurse and prescribing clinician alerts. …”
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Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective... by Itske Fraterman, Lucia Sacchi, Henk Mallo, Valentina Tibollo, Savannah Lucia Catherina Glaser, Stephanie Medlock, Ronald Cornet, Matteo Gabetta, Vitali Hisko, Vadzim Khadakou, Ella Barkan, Laura Del Campo, David Glasspool, Alexandra Kogan, Giordano Lanzola, Roy Leizer, Manuel Ottaviano, Mor Peleg, Konrad Śniatała, Aneta Lisowska, Szymon Wilk, Enea Parimbelli, Silvana Quaglini, Mimma Rizzo, Laura Deborah Locati, Annelies Boekhout, Lonneke V van de Poll-Franse, Sofie Wilgenhof

“…Baseline HRQoL was on average 10 points higher in the intervention group compared with controls, although equally matched on baseline and clinical characteristics. …”
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Imaging and Clinical Outcomes Six Months After Middle Meningeal Artery Embolization with Squid for Chronic Subdural Hematoma: A Prospective Study by Ángela H. Schmolling, Carlos Pérez-García, Isabel Bérmudez, Alfonso López-Frías, Eduardo Fandiño, Carmen Trejo, Santiago Rosati, Daniel Padrón, Lara Guardado, José Carlos Méndez, Juan Arrazola, Manuel Moreu

“…Procedures were performed under general anesthesia in 72.3% of patients, with radial and femoral access used equally frequently, and 32.7% underwent bilateral embolization. …”
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Neutrophil elastase inhibitor (Sivelestat) in the treatment of acute respiratory distress syndrome induced by COVID-19: a multicenter retrospective cohort study by Yuting Li, Jianjun Zhao, Jiahui Wei, Yanhong Zhang, Haitao Zhang, Ying Li, Ting Liao, Yang Hu, Bo Yuan, Xinmei Zhang, Wanyan Liu, Changgang Liu, Qingsong Cui, Shunzi Wu, Hongmei Jiang, Wenge Liu, Weiheng Liu, Hongguang Xu, Gang Li, Yuyan Cai, Liting Chen, Bingwei Chen, Dong Zhang

“…The differences in continuous outcomes were assessed with the Wilcoxon signed-rank test. Kaplan–Meier method was used to show the 28-day survival curves in the matched cohorts. …”
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Efficacy of Rikkunshito on Chemotherapy-Induced Nausea and Vomiting in Patients With Uterine Corpus or Cervical Cancer Treated With Cisplatin-Based Regimen-Placebo-controlled, Doub... by Yosuke Konno MD, Shunsuke Ohnishi MD, Shinichiro Minobe PhD, Eiji Nomura PhD, Takayuki Nagasawa PhD, Etsuko Fujimoto MD, Tatsuru Ohara PhD, Shin Nishio MD, Hisamori Kato PhD, Yoshihito Yokoyama PhD, Etsuko Miyagi PhD, Hideki Tokunaga PhD, Koji Nishino MD, Akira Kikuchi PhD, Yoshio Yoshida PhD, Takashi Iwata PhD, Daito Noguchi MD, Wataru Kudaka PhD, Shunsuke Oyamada PhD, Keisuke Ariyoshi PhD, Kota Kihara PhD, Hidemichi Watari MD

“…Patients were randomized with a 1:1 equal allocation ratio to the rikkunshito group or placebo groups and given oral administration on days 1 to 5 with standard antiemetics (granisetron, aprepitant, and dexamethasone). …”
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The Prognostic Value of Platelet Kinetics Assessment in Pediatric Chronic Idiopathic Thrombocytopenic Purpura by Nebojsa Igrutinovic, Jelena Pantovic, Bojana Markovic, Marija Medovic, Milica Cekerevac, Vladimir Markovic, Strahinja Odalovic, Sanja Knezevic, Ana Vujic, Isidora Mihajlovic, Nevena Stojadinovic, Dragan Knezevic, Nina Urakovic, Ivana Andrejevic, Gordana J. Ristic, Vladimir Slavkovic, Kristina Andric, Rasa Medovic

“…The remaining 10%, which represented the most severe cases, required all available therapies, had equally mixed and liver sequestration, and splenectomy showed no effect. …”
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Using Human-Centered Design to Bridge Zero-Dose Vaccine Gap: A Case Study of Ilala District in Tanzania by Simon Martin Nzilibili, Hellen Maziku, Awet Araya, Ruthbetha Kateule, Millenium Anthony Malamla, Suna Salum, Furaha Kyesi, Lotalis Gadau, Tumaini Menson Haonga, Florian Tinuga, Rashid Mfaume, Zaitun Hamza, Georgina Joachim, Alice Geofrey Mwiru, Alex Benson, Oscar Kapela, Ona Machangu, Norman Jonas, Ntuli Kapologwe

“…As a result, 67,145 houses, equal to 104%, were reached, surpassing the initial target of 64,800 houses, and 131,088 families, equal to 83% of the targeted 156,995 households, were sensitized through a home-to-home campaign approach. …”
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Improvement in long-term survival with mesenchymal stem cell transplantation in systemic sclerosis patients: a propensity score-matched cohort study by Wenyi Yuan, Mian Liu, Dapeng Yang, Yirui Shi, Zhikang Wang, Xuan Cao, Jun Liang, Linyu Geng, Huayong Zhang, Xuebing Feng, Ziyi Jin, Dandan Wang, Lingyun Sun

“…While several studies have investigated the therapeutic potential of mesenchymal stem cell transplantation (MSCT), the clarity of its long-term outcomes for SSc patients is still lacking. Methods Data on MSCT were extracted from the medical records of inpatients at Nanjing Drum Tower Hospital between January 2013 and December 2022. …”
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Proportional representation and incidence rate of repeat visits in ethnic minorities compared to native Dutch people under the age of 25 years in the Netherlands by Y.J. Evers, A. Verhaegh, A. Ibrahim, C. Peters, N.H.T.M. Dukers-Muijrers, R. Reijs, C.J.P.A. Hoebe

“…In this study, we aimed to determine the proportional representation of first- and second generation EMs under 25 years at Dutch Sexual Health Centers (SHCs) compared to native Dutch citizens. Methods: In this retrospective cohort study, coded health records data of 270,927 persons in the age group of 15 till 24 years visiting SHCs between 2016 and 2021 were included. …”
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Effect of traditional Chinese medicine combined with conventional Western medicine for patients with severe/very severe chronic obstructive pulmonary disease: a multi-center, rando... by Jiansheng Li, Yang Xie, Minghang Wang, Suyun Li, Xuefeng Yu, Nianzhi Zhang, Zhengang Zhu, Wei Zhang, Jihong Feng, Zikai Sun, Lin Lin, Zhijia Sun, Hailong Zhang, Xueqing Yu

“…This study aimed to evaluate the clinical efficacy of comprehensive therapy based on TCM patterns for patients with stable, severe to very severe COPD. Methods A multicenter, randomised, double-blind, placebo-controlled trial was conducted. …”
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Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study by Marcio Steinbruch, Carlos Nunes, Romualdo Gama, Renato Kaufman, Gustavo Gama, Mendel Suchmacher Neto, Rafael Nigri, Natasha Cytrynbaum, Lisa Brauer Oliveira, Isabelle Bertaina, François Verrière, Mauro Geller

“…The difference between groups was -2.1 mm with an upper limit of one-sided 90% confidence interval equal to 1.0 mm for a noninferiority margin set at 20 mm (noninferiority demonstrated). …”
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Diagnostic work-up of lipomatous tumors: a decision-making analysis among European sarcoma centers by Ali Naimi, Paul Martin Putora, Christian Rothermundt, Antonia Digklia, Jose Manuel Asencio, Sylvie Bonvalot, Florian Bösch, Anant Desai, Amer James Durrani, Haim Gutman, Daphne Hompes, Jens Jakob, Wolfram Trudo Knoefel, Elisabetta Pennacchioli, Piotr Rutkowski, Winan J. van Houdt, Barbara L. van Leeuwen, Stephan Waelti, Tim Steffen Fischer, Stefan Markart, Simon Wildermuth, Tobias Johannes Dietrich

“…In these settings, CNB and follow-up were almost equally recommended. For lipomatous tumors smaller than 3 cm, without growth or symptoms, no localization in the trunk, and homogeneous imaging features, a consensus rate of 71% was achieved for follow-up. …”
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Ensemble Computational Intelligent for Insomnia Sleep Stage Detection via the Sleep ECG Signal by Pragati Tripathi, M. A. Ansari, Tapan Kumar Gandhi, Rajat Mehrotra, Md Belal Bin Heyat, Faijan Akhtar, Chiagoziem C. Ukwuoma, Abdullah Y. Muaad, Yasser M. Kadah, Mugahed A. Al-Antari, Jian Ping Li

“…For the sleep stage-based classification scenario, the detection evaluation results are recorded equally with 96.0% for ceiling level accuracy, sensitivity, and specificity. …”
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Heterogeneous treatment effects of stress ulcer prophylaxis among ICU patients at risk for gastrointestinal bleeding by Yongpeng Xie, Yao Yan, Qixiang Hong, Hui Zheng, Lijuan Cao, Xiaoming Li, Songqiao Liu, Hui Chen

“…Understanding HTE is crucial for tailoring SUP to individual treatment. Methods This cohort study included patients admitted to intensive care unit (ICU) with at least one risk factor for clinically important gastrointestinal bleeding (GIB). …”
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Safety and efficacy of amnion-derived mesenchymal stem cells (AM01) in patients with steroid-refractory acute graft-versus-host disease after allogeneic haematopoietic stem cell tr... by Hiroki Nishikawa, Shunsuke Ohnishi, Hiroshi Hayashi, Rika Okamoto, Kenichi Yamahara, Toshiyuki Isoe, Norihiro Sato, Akiko Hamada, Toshihiro Soma, Masaya Okada, Satoshi Yoshihara, Kyoko Yoshihara, Kazuhiro Ikegame, Hiroya Tamaki, Katsuji Kaida, Takayuki Inoue, Yuko Ohsugi, Hiroaki Iijima, Daigo Hashimoto, Takanori Teshima, Hiroyasu Ogawa, Yoshihiro Fujimori

“…Our non-clinical studies confirmed that human amnion-derived MSCs had immunomodulatory activity equal to or higher than that of human bone marrow MSCs. …”
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