Exploring the Incidence and Risk Factors of Diabetic Nephropathy in Type 1 Diabetes: Insights from a Retrospective Cohort Study in Northwest China by Du Z, Liu X, Zhang L, Zhao H, Tian L

“…Zouxi Du,1,2,* Xiaoning Liu,3,* Leyuan Zhang,4 Hui Zhao,5,6 Limin Tian1,7 1The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 2Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, Gansu, People’s Republic of China; 3Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 4The First Clinical College, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, People’s Republic of China; 5College of Integrated Traditional Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, People’s Republic of China; 6Department of Nephrology, Gansu Provincial Hospital, Lanzhou, Gansu, People’s Republic of China; 7Department of Endocrinology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Limin Tian, The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China, Email tlm7066@sina.comPurpose: The study aimed to investigate the incidence of diabetic nephropathy (DN) and their relationship with certain risk factors in patients with type 1 diabetes (T1D) across hospitals in Gansu Province, China.Methods: There were 434 T1D patients recruited from Gansu Province, China, in the present retrospective cohort study between January 2016 and December 2024. …”
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Association Between Pain and Frailty in Middle-Aged and Older Patients: The Mediating Roles of Sleep and Mood by Wang HP, Wang T, Ye HT, Dong YY, Zhao SJ, Liu QR, Hu XY, Ji MH, Yang JJ

“…This study aimed to investigate the association between pain and frailty, with a particular focus on the mediating roles of sleep and mood.Patients and Methods: A cross-sectional study was conducted involving 244 middle-aged and older participants in local hospital. …”
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Plasma Aldosterone Elevation in Hypertensive Patients and Association with Urinary Stone Formation: A Large-Scale Population Study from Northwest China by Song S, Li N, Shen D, Hu J, Cai X, Zhu Q, Zhang Y, Ma R, Zhou P, Zhang Z, Jiang W, Hong J

“…Therefore, this study aimed to investigate the relationship between PAC levels and urinary stones, including their subtypes, in patients with hypertension.Methods: This large-scale study included a total of 35161 hypertensive patients. …”
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Nasal mRNA Nanovaccine with Key Activators of Dendritic and MAIT Cells for Effective Against Lung Tumor Metastasis in Mice Model by Li A, Cai X, Li D, Yu Y, Liu C, Shen J, You J, Qiao J, Wang F

“…Intranasal immunization has emerged as a more effective method of inducing local immune responses against cancer cells in the lungs.Methods: An innovative layered double hydroxide- and 5-OP-RU–based mRNA nanovaccine (Mg/Al LDH-5-OP-RU/mRNA) was synthesized via coprecipitation. …”
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Effects of Dexmedetomidine as an Adjuvant in Preoperative Ultrasound-Guided Internal Branch of Superior Laryngeal Nerve Block on Postoperative Sore Throat and Hemodynamics in Patie... by Chen Z, Zhang L, Lu G, Zhang Y, Zhao D, Zhao S, Zhang H, Jin Y, Zhao X, Jin Y

“…In this first randomized controlled trial to date, we aimed to investigate the effects of US-guided iSLNB, with or without perineural dexmedetomidine, on the incidence and severity of POST following DLTs.Methods: A total of 159 patients were randomly assigned to three groups: control, bilateral US-guided iSLNB (2 mL 0.20% ropivacaine + 1 mL saline on each side), and bilateral US-guided iSLNB combined with perineural dexmedetomidine group (2 mL 0.20% ropivacaine + 1 mL 0.5 μg·kg− 1 dexmedetomidine on each side). …”
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Reflecting on the Implementation of United Kingdom (UK) General Practitioner Training Models in China: Highlights From a Train-the-Trainer Pilot Program by Luo F, Chen M, Chen Y, Huang H, Zhan W, Chen L, Xu D, Lv B

“…Faguang Luo,1,* Mengyuan Chen,2,* Yongba Chen,1,* Huayan Huang,2 Wenfeng Zhan,2 Lian Chen,2 Dan Xu,3 Bo Lv1,2 1Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China; 2Department of General Practice, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, People’s Republic of China; 3Department of General Practice Research and International Collaboration, Curtin Medical School/Curtin School of Population Health, Faculty of Health Sciences, Curtin University, Perth, Australia*These authors contributed equally to this workCorrespondence: Bo Lv, Email gdlvbo@163.com Dan Xu, Email daniel.xu@curtin.edu.auPurpose: The rising number of Chinese general practitioners is placing pressure on the Chinese Health Care system to ensure the quality of training for competent general practitioners (GPs) to meet the significantly increased clinical service demand. …”
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Efficacy and Safety of Eravacycline Combination Therapy for Carbapenem-Resistant Acinetobacter baumannii Pneumonia in ICU Patients: A Retrospective Study by Guo Q, Wei Y, Zhao Q, Zhang W, Lv P, Zhou Z, Wang S

“…This study compares eravacycline with tigecycline for CRAB pneumonia in ICU patients.Methods: This retrospective study analyzed 65 ICU patients with CRAB pneumonia treated at Henan Provincial People’s Hospital from September 2023 to March 2024; the clinical efficacy and adverse reactions of eravacycline and tigecycline as target therapies were compared.Results: Both CRAB pneumonia cohorts exhibited more than 50% co-infection rates, predominantly Aspergillus and Klebsiella pneumoniae. …”
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Inflammatory Burden Index: A Superior Prognostic Biomarker of Systemic Inflammation in Patients on Peritoneal Dialysis by Chen J, Tang R, Tian N, Deng J, Ao S, Peng F, Zhan X, Wen Y, Wang X, Feng X, Su N, Tang X, Wu X, Zhou Q, Xu Q

“…The purpose of this study was to evaluate the prognostic value of various systemic inflammation biomarkers and to identify the optimal one in PD patients.Patients and Methods: This longitudinal study involved 3,225 patients undergoing PD across China. …”
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Low-dose Esketamine combined with Propofol in microscopic pediatric strabismus surgery: a randomized controlled study by Yaping Shen, Bo Shi, Yu Mo, Junhe Wu, Zhentao Sun

“…Group C was pre-treated with an equal volume of saline, and propofol 2.5 mg/kg was administered slowly after one minute. …”
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Hypopharyngeal Squamous Cell Carcinoma in Elderly Patients Aged ≥70 Years: Surgery and Postoperative Radiotherapy Improves Outcomes in Selected Patients by Wang R, Hariri AA, Tao H, Wei Y, Lyu Z

“…Ru Wang,1,* Ahmad A Hariri,2,* Hengmin Tao,1 Yumei Wei,1 Zhenghua Lyu3 1Department of Head and Neck Radiotherapy, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Otolaryngology-Head and Neck Surgery, London North West University Healthcare NHS Trust, London, England, UK; 3Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yumei Wei, Email 15553119268@163.com Zhenghua Lyu, Email entlvzhenghua@163.comObjective: To summarize the efficacy of surgery plus postoperative radiotherapy as initial treatment in elderly patients aged ≥ 70 years with advanced hypopharyngeal cancer and to analyze prognostic factors.Methods: Retrospective analysis of 77 elderly patients aged ≥ 70 years with stage III–IV hypopharyngeal squamous cell carcinoma who underwent surgery as initial treatment at Shandong Provincial ENT Hospital between 2006– 2020. …”
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Machine Learning and Experimental Validation Reveal MYH11 as a Novel Prognostic Biomarker and Therapeutic Target in Bladder Cancer by Tan Z, Chen X, Fu S, Huang Y, Li H, Gong C, Lv D, Yang C, Wang J, Ding M, Wang H

“…This study aimed to explore the potential molecular mechanisms of BCa using multi-omics and single-cell analysis.Methods: First, differential analysis of transcriptome data related to BCa from public databases was performed, and a risk model was then developed using 101 different machine learning algorithms to determine prognostic genes, followed by independent prognostic analysis to construct a nomogram. …”
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Chaihu-Shugan-San Ameliorated Osteoporosis of Mice with Depressive Behavior Caused by Chronic Unpredictable Mild Stress via Repressing Neuroinflammation and HPA Activity by He MC, Xia SH, Pan H, Zhou TT, Wang XL, Li JM, Li XM, Zhang Y

“…This study aimed to explore the development of osteoporosis in depressive mice model and investigate the beneficial effects of the classical herbal formula Chaihu-Shugan-San (CHSG) on the brain and bone.Methods: CHSG powder was prepared by spray-drying following extraction with water. …”
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Factors Associated with Nursing Intention of Discharged Patients With Drainage Tubes During Transitional Care: a Case–Control Study by Ding X, Jiao W, Gong X, Sun Y, Sang L, Yu M

“…Xiaoying Ding,* Weijie Jiao,* Xue Gong, Yuanyuan Sun, Lin Sang, Ming Yu Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ming Yu, Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, No. 127 Changle West Road, Xi’an, Shaanxi, 710032, People’s Republic of China, Email yumingfmmu@126.comPurpose: This study aimed to assess the crucial factors that contribute to the self-nursing intention of discharged patients with drainage tubes, with a specific emphasis on percutaneous surgeries.Patients and Methods: A case–control study was conducted in accordance with the EQUATOR-STROBE statement. …”
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NRF2 Deficiency in Bladder Epithelial Cells Owing to Ubiquitination by N6-Methyladenosine-Modified TRIM21 Induces Oxidative Stress and Inflammation to Aggravate IC/BPS by Fan Z, Ge Q, Ni B, Zhang J, Du T, Xu H, Duan Z, Zhang S, Wang C, Xue J, Ling F, Chen Z, Shen B, Wei Z

“…This study aimed to investigate the effects of nuclear factor erythroid 2-related factor 2 (NRF2) on IC/BPS and the potential molecular mechanisms.Methods: Bladder mucosal biopsies from IC/BPS patients were subjected to RT-qPCR and immunoblotting to quantify NRF2 mRNA/protein expression. …”
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AI in Home Care—Evaluation of Large Language Models for Future Training of Informal Caregivers: Observational Comparative Case Study by Clara Pérez-Esteve, Mercedes Guilabert, Valerie Matarredona, Einav Srulovici, Susanna Tella, Reinhard Strametz, José Joaquín Mira

“…When compared to the gold standard, only 10% (2/20) of GPT-4o responses were rated as equally specific, 20% (4/20) included comparable practical advice, and just 5% (1/20) provided a justification as detailed as professional guidance. …”
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The impact of the universities closure on physical activity and academic performance in physical education in university students during the COVID-19 pandemic by Aleksander Yu. Osipov, Tatyana I. Ratmanskaya, Elena A. Zemba, Vladimir Potop, Mikhail D. Kudryavtsev, Roman S. Nagovitsyn

“…All participants (male–n=106 and female–n=103) were divided into approximately equal groups: humanities students (male–MG-1, female–FG-1), medicine students (male–MG-2, female–FG-2), technical students (male–MG-3, female–FG-3). …”
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Predictive Scores for Identifying Chronic Opioid Dependence After General Anesthesia Surgery by Sun M, Chen WM, Lu Z, Lv S, Fu N, Yang Y, Wang Y, Miao M, Wu SY, Zhang J

“…Mingyang Sun,1,2,* Wan-Ming Chen,3,4,* Zhongyuan Lu,1,2 Shuang Lv,1,2 Ningning Fu,1,2 Yitian Yang,1,2 Yangyang Wang,1,2 Mengrong Miao,1,2 Szu-Yuan Wu,5– 11 Jiaqiang Zhang1,2 1Department of Anesthesiology and Perioperative Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China; 2Academy of Medical Sciences of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 3Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei, Taiwan; 4Artificial Intelligence Development Center, Fu Jen Catholic University, Taipei, Taiwan; 5Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan; 6Big Data Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 7Division of Radiation Oncology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 8Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan; 9Cancer Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 10Centers for Regional Anesthesia and Pain Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; 11Department of Management, College of Management, Fo Guang University, Yilan, Taiwan*These authors contributed equally to this workCorrespondence: Szu-Yuan Wu, College of Medical and Health Science, Asia University, Taichung, Taiwan; Director, Big Data Center, Lo-Hsu Medical Foundation, LotungPoh-Ai Hospital, No. 83, Nanchang St., Luodong Township, Yilan County, 265, Taiwan, Email szuyuanwu5399@gmail.com Jiaqiang Zhang, Department of Anesthesiology and Perioperative Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou, Henan, 450003, People’s Republic of China, Email jiaqiang197628@163.comPurpose: To address the prevalence and risk factors of postoperative chronic opioid dependence, focusing on the development of a predictive scoring system to identify high-risk populations.Methods: We analyzed data from the Taiwan Health Insurance Research Database spanning January 2016 to December 2018, encompassing adults undergoing major elective surgeries with general anesthesia. …”
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Activation of TLR4/CCL2 in Intact Neurons Drives Radicular Injury-Induced Global Nerve Trunk Hypersensitivity in Radiculopathy Preclinical Models by Tong SH, Zhou J, Ye F, Ding P, Mei JL, Liao P, Lu YF, Zong Y, Gao CA, Zhang SY, Gao JJ, Liu DL, Huang YG

“…However, the underlying mechanisms remain unclear.Methods: An L5 spinal nerve compression rat model was established. …”
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The effects of normal and interrupted sleep combined with acute caffeine supplementation on some immune system indices and anaerobic power in male athletes by Mohammad hossein Hashemzadeh, Farhad Rahmaninia, Payam Saidie

“…Participants were randomly and equally assigned to 2 groups and 2 sessions: 1) normal sleep, caffeine/placebo (NSP/NSC) and 2) Interrupted sleep, caffeine/placebo (ISP/ISC). …”
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Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis by Gu X, Chen Y, Hu X, Li Y, Zhu R, Li H, Yuan Z, Wang Y

“…Xiangran Gu,1,* Yuan Chen,2,* Xinyue Hu,1,* Yunhui Li,3 Renlong Zhu,2 Hongxu Li,1 Zhengrong Yuan,1 Yajie Wang2,3 1College of Biological Sciences and Technology, Beijing Forestry University, Beijing, People’s Republic of China; 2Department of Clinical Laboratory, Peking University Ditan Teaching Hospital, Beijing, People’s Republic of China; 3Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhengrong Yuan, College of Biological Sciences and Technology, Beijing Forestry University, No. 35 Tsinghua East Road, Haidian District, Beijing, 100083, People’s Republic of China, Email zryuan@bjfu.edu.cn Yajie Wang, Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China, Email wangyajie@ccmu.edu.cnObjective: This study aimed to identify autophagy-related genes (ARGs) with prognostic significance in hepatocellular carcinoma (HCC) using bioinformatics and survival analysis.Materials and Methods: ARGs were sourced from multiple references, including the Human Autophagy Database (HADb), relevant literatures, the Gene Set Enrichment Analysis (GSEA), and a final list was confirmed after eliminating duplicate entries. …”
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