Chlorogenic Acid-Cucurbit[n]uril Nanocomplex Delivery System: Synthesis and Evaluations for Potential Applications in Osteoporosis Medication by Jiang Y, Qi H, Wang M, Chen K, Chen C, Xie H

“…The nanocomplex drug delivery system is intended to overcome the unsatisfactory biocompatibility and bioavailability of CGA and realizing its potential role in long-term osteoporosis (OP) medication.Methods: The nanocomplex was synthesized by the reflux stirring method. …”
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Impact of Relaxation and Music Intervention on Psychological and Gastrointestinal Health in Military Recruits: A Prospective Study by Liu J, Liu T, Lu H, Zhao X, Ma S, Song F, Qiao N, Cheng W, Qi X

“…This prospective before-after study aimed to explore whether progressive muscular relaxation training combined with music intervention, which is potentially beneficial for psychological conditions, can improve gastrointestinal symptoms.Methods: A total of 623 recruits’ effective questionnaires before and after intervention were collected. …”
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Unveiling the Temporal Dynamics and Molecular Regulation Profiles of Neutrophil Extracellular Traps Following Spinal Cord Injury by Li J, Chang C, Li Y, Cui S, Bai J, Zhang C, Wang X, Li K, Jian F

“…This study aimed to explore the temporal dynamics and key regulatory genes of NET formation in SCI to identify therapeutic targets.Methods: We integrated two transcriptomic datasets from the GEO database to identify differentially expressed NETs-related genes (NRGs) in SCI. …”
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Prognostic Value of Spontaneous Potential in Left Atrial Posterior Wall Isolation and Radiofrequency Ablation for Non-Paroxysmal Atrial Fibrillation by Chen ZY, Zhong YH, Gong KZ, Chen XH, Xu Z, Zhang FL

“…Zhi-Yang Chen,1,2,* Yu-Hong Zhong,1,3,* Ke-Zeng Gong,1 Xue-Hai Chen,1 Zhe Xu,1 Fei-Long Zhang1 1Department of Cardiology, Fujian Medical University Union Hospital; Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease; Fujian Clinical Medical Research Center for Heart and Macrovascular Disease, Fuzhou, 350001, People’s Republic of China; 2Department of Cardiology, Zhangzhou Yuanshan Hospital, Zhangzhou, 363100, People’s Republic of China; 3Department of Cardiology, Huian County Hospital, Quanzhou, 362100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei-Long Zhang, Department of Cardiology, Fujian Medical University Union Hospital; Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease; Fujian Clinical Medical Research Center for Heart and Macrovascular Disease, No. 29 Xinquan Road, Gulou District, Fuzhou, 350001, People’s Republic of China, Tel +86 10 8888888, Fax +86 10 6666666, Email cardizhang@163.comObjective: This study aimed to examine the long-term effects of left atrial posterior wall spontaneous potential (SP) in patients with non-paroxysmal atrial fibrillation (AF) who underwent pulmonary vein isolation (PVI) combined with left atrial posterior wall isolation (PVI+BOX) ablation.Methods: Clinical data were retrospectively collected from 140 patients with symptomatic non-paroxysmal atrial fibrillation (NPAF) who underwent first-time radiofrequency ablation between 2022 and 2023. …”
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Endometriosis Severity and Risk of Preeclampsia: A Combined Mendelian Randomization and Observational Study by Zu Y, Xie Y, Zhang H, Chen L, Yan S, Wang Z, Fang Z, Lin S, Yan J

“…This study aimed to further explore the potential association between endometriosis and PE/eclampsia through Mendelian randomization (MR) and confirm these findings in a retrospective cohort study.Methods: A two-sample MR study was performed using genetic variants associated with endometriosis from the Finnish database, with outcome data for PE and eclampsia from the UK Biobank. …”
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Correlations Between TyG-Related Indices and Bone Health: A Cross-Sectional Study of Osteoporosis in a Rural Chinese Population by Jia F, Lu Y, Wen H, Tu J, Ning X, Wang J, Li P

“…This study aimed to explore the association between TyG indices and OP in a low-income rural Chinese population.Methods: This cross-sectional study was conducted in rural Tianjin, China, in 2020. …”
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Compare the Effects of 0 mg/kg, 0.1 mg/kg, 0.3 mg/kg and 0.5 mg/kg Esketamine on Emergence Agitation After Tonsillectomy and Adenoidectomy in Children: A Randomized Control Trial by Jiang P, Liu W, Peng Q, Feng Y, Wang D, Luo K, Huang S

“…This study investigated the effects of pre-anesthesia sedation of esketamine at 0mg/kg (Control group), 0.1mg/kg, 0.3mg/kg and 0.5mg/kg on EA in children.Methods: 164 children aged 3– 10 years, with American Society of Anesthesiologists (ASA) class I–II were included. …”
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Clinical Value of Complement C3a, C5a, and sC5b-9 in Evaluating the Severity of Patients with Severe Fever with Thrombocytopenia Syndrome by Chen T, Liu Y, Liu Y, Hu N, Dai Y, Zhu C, Han Y, Jin K, Li J

“…This article aims to evaluate the validity of complement C3a, C5a, and sC5b-9 in predicting the severity and clinical outcomes in SFTS.Patients and Methods: Patients diagnosed with SFTS at the First Affiliated Hospital with Nanjing Medical University from March to November 2021 were enrolled in this retrospective analysis. …”
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Exploring the Mechanism of Qinzhuliangxue Mixture for Treating Skin Lesions in Atopic Dermatitis: Insights from Network Pharmacology and Experimental Validation by Qiao Y, Yin H, Zhang H, He Q, Li Y, Sun L, Wang J, Li X, Koh WX, Pottakorn A, Chu Z, Xiang Y

“…The hospital preparation-Qinzhuliangxue mixture (QZLX) has shown potential in alleviating skin lesions in AD patients; however, its underlying mechanisms remain largely unexplored.Methods: QZLX’s key compounds and their targets in AD skin lesions were screened by network pharmacology, and gene enrichment analysis was performed. …”
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Comparative Effectiveness of Different Frequencies of Spinal Cord Stimulation for the Treatment of Patients with Failed Back Surgery Syndrome: Systematic Review and Network Meta-An... by Qin YY, Zhang CP, Tang SS, Wu JP, Zhu LX, Li YH, Xu F

“…This first network meta-analysis (NMA) compared the effectiveness and superiority of different SCS frequencies for FBSS.Material and Methods: Adhering to PRISMA guidelines, we searched PubMed, Web of Science, Embase, and CENTRAL for RCTs. …”
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Prevalence, Risk Factors, and Clinical Outcomes with Advanced HIV Disease Among People with Newly Diagnosed HIV During the “Treat-All” Era: A Retrospective Coho... by Jin J, Pan S, Chen J, Yin J, Ba H, Hou H, Zhang Y, Ma K

“…This study investigated the prevalence, characteristics, risk factors, and clinical outcomes of advanced HIV disease (AHD) in newly diagnosed HIV-positive individuals in China during the “treat-all” period.Patients and methods: We performed a retrospective cohort study on newly diagnosed adult ART-naive people with HIV (PWH) in Xi’an from 2016 to 2022. …”
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The Interaction Between Family Functioning and the PCDH9 rs9540720 Polymorphism on Major Depressive Disorder in Chinese Freshmen by Qin Y, Hu S, Niu S, Zhang W, Sun H, Xu R, Li H, Mu F, Liu N, Wang J, Sun H, Zhang Y, Liu Y

“…This study examined the effects of the interaction between PCDH9 and family functioning on MDD in first-year university students.Methods: A cohort of 6985 first-year university students in China was established in 2018 and was followed for one year. …”
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Association of the Triglyceride-Glucose Index and Obesity Indicators with Multiple Chronic Diseases: A Longitudinal Cohort Study Based on CHARLS by Lan Y, Qi G, Li B, Sooranna SR, Chen D, Rao W, Lin Y, Pang Y

“…Yincai Lan,1,* Guangzi Qi,1,* Boya Li,1 Suren Rao Sooranna,2 Dongshun Chen,3 Wenlian Rao,3 Yinxia Lin,1 Yaqin Pang4– 7 1School of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 2Life science and clinical research center, Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China and Department of metabolism, digestion and reproduction, Imperial College London, Chelsea & Westminster Hospital, London, SW10 9NH, UK; 3School of Basic Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 4School of Medical Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 5Key Laboratory of Environmental and Population Health Research, Ecological Aluminum Industrial Base of Guangxi Universities, Baise, Guangxi, 533000, People’s Republic of China; 6Key Laboratory for Environmental Pollution and Health Risk Assessment, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 7Modern Industrial College of Biomedicine and Great Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yinxia Lin; Yaqin Pang, Email lin1837731@163.com; pangyaqin@126.comObjective: To explore the relationship between triglyceride glucose (TyG) and the obesity combined indexes and the occurrence of multiple chronic diseases (MCD), which will help to provide a basis for the prevention and treatment of this condition.Methods: 3037 participants in the China Health and Retirement Longitudinal Study, which was conducted from 2011 to 2015 were selected for this study. …”
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Atherogenic and Inflammatory Markers in Recent Small Subcortical Infarcts: Associations with Location, Morphology, and Short-Term Recurrence by Huang C, Geng J, Fan J, Tian B, Wang K, Zhang Y, Zhou X, Zhu X, Sun Z

“…This study aimed to investigate the associations between the atherogenic index of plasma (AIP), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) with the occurrence and recurrence of RSSIs.Methods: Three hundred forty-two patients with RSSIs who met the eligibility criteria were included in the cross-sectional analysis. …”
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Early infantile epileptic encephalopathy type 16: the new clinical and genetic variant of TBC1D24 gene mutation by A. A. Kholin, I. D. Fedonyuk, O. P. Dovelman, N. N. Zavadenko, T. V. Kozhanova, E. A. Kholina, G. Sh. Khondkarian, E. S. Il`ina

“…Objective: to analyse the clinical and neurophysiological data from a case of early infantile epileptic encephalopathy type 16 in a child with homozygous mutation in TBC1D24 gene.Material and methods. Female child M. aged 1 year and 2 months, with identified mutations in TBC1D24 gene was examined. …”
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Investigating the Role and Underlying Mechanisms of 18β-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-γ/NF-κB... by Zhu A, Qiu Q, Xu Z, Zhang Q, Sun F, Liu Y, Chen Z, Zhang Y, Yao J

“…Aijing Zhu,1,* Qingqing Qiu,1,* Zhengguang Xu,1,* Qilian Zhang,2 Fang Sun,1,3 Yanzhan Liu,1 Zeang Chen,1 Yanan Zhang,4 Jing Yao1,3 1School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China; 2People’s Hospital Affiliated to Shandong First Medical University, Jinan, 271100, People’s Republic of China; 3Jining Key Laboratory of Pharmacology, Jining Medical University, Jining, 272067, People’s Republic of China; 4Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Yao, Jining Medical University, School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China, Tel +86 537-3616269, Email yjing_87@163.com Yanan Zhang, Affiliated Hospital of Jining Medical University, Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China, Tel +86 15153705143, Email yanan1202@163.comBackground: 18β-glycyrrhetinic acid (18β-GA), a triterpenoid saponin naturally occurring in Glycyrrhizae uralensis, has potent anti-inflammatory and antioxidant properties, but the therapeutic efficacy and precise mechanism of 18β-GA in ulcerative colitis (UC) remain unclear.Methods: To determine the therapeutic potential of 18β-GA, we constructed a dextran sodium sulfate (DSS)-induced UC model on a cohort of thirty-two female BALB/c mice and used mouse peritoneal macrophages to establish a co-culture system for in vitro experiments. …”
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Surgical Management of Anterior Urethral Stricture: A 23-year Single-Center Study by Guo Y, Ma N, Zhang J, Chen S, Liu P, Yang Z, Li Y

“…We conducted a 23-year single-center retrospective study to evaluate the long-term surgical outcomes of anterior urethral strictures with different clinical characteristics and to study factors that contribute to stricture recurrence.Methods: A retrospective study was conducted on 145 male patients diagnosed with anterior urethral stricture, who underwent meatotomy, anastomotic urethroplasty (AU), penile skin flap urethroplasty (PFU), single-stage buccal mucosa grafting (SSU), or multistage buccal mucosa grafting (MSU) between April 2000 and August 2023. …”
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Extracting Cognitive Impairment Assessment Information From Unstructured Notes in Electronic Health Records Using Natural Language Processing Tools: Validation with Clinical Assess... by Wang KY, Mahesri M, Novoa-Laurentiev J, Bessette LG, York C, Zakoul H, Lee SB, Ngan K, Zhou L, Kim DH, Lin KJ

“…Kuan-Yuan Wang,1– 3,* Mufaddal Mahesri,4,* John Novoa-Laurentiev,4 Lily G Bessette,4 Cassandra York,4 Heidi Zakoul,4 Su Been Lee,4 Kerry Ngan,4 Li Zhou,4,5,* Dae Hyun Kim,2,3,5,* Kueiyu Joshua Lin4– 6,* 1National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; 3Beth Israel Deaconess Medical Center, Boston, MA, USA; 4Brigham and Women’s Hospital, Boston, MA, USA; 5Harvard Medical School, Boston, MA, USA; 6Massachusetts General Hospital, Boston, MA, USA*These authors contributed equally to this workCorrespondence: Kueiyu Joshua Lin, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 1620 Tremont St. …”
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Association Between Central Sleep Apnea and Left Atrial Enlargement in Snoring Patients with Preserved Ejection Fraction by Sun X, Wang Y, Wu C, Gao Y

“…However, the relationship between CSA and left atrial size in individuals with preserved EF remains underexplored.Objective: This study aims to examine the relationship between left atrial size and CSA in snoring patients with preserved EF.Methods: An observational study was conducted involving 341 consecutive snoring patients from a cardiology department who underwent overnight polysomnography (PSG) and echocardiography. …”
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A Comparison of in-vitro Pharmacokinetics and Pharmacodynamics of Branded and Its Locally Produced Cefuroxime Sodium Against Staphylococcus and Escherichia Escherichia coli by Du M, Sun T, Wang X, Chi X, Xiao Y

“…Mengjiao Du,1,2,* Tingting Sun,1,2,* Xueting Wang,3,4 Xiaohui Chi,5 Yonghong Xiao2– 4 1Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, People’s Republic of China; 2Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, People’s Republic of China; 3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 4Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou, Zhejiang, People’s Republic of China; 5Department of Medical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaohui Chi, Department of Medical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, People’s Republic of China, Email 15684003984@163.com Yonghong Xiao, Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, People’s Republic of China, Email xiao-yonghong@163.comPurpose: To compare the in-vitro antibacterial effects of branded and its locally produced cefuroxime sodium against Staphylococcus ATCC29213, clinical strains of methicillin-sensitive Staphylococcus aureus (MSSA) 164342 and methicillin-sensitive coagulase-negative staphylococci (MSCNS) 117933, and Escherichia coli ATCC25922, and to provide a reference for their clinical use.Methods: An in-vitro antibacterial susceptibility test, time-kill curve and pharmacokinetics and pharmacodynamics (PK/PD) modeling was used in the comparison.Results: The minimum inhibitory concentrations (MIC) of the two types of cefuroxime sodium were identical against four bacterial strains; both types of cefuroxime sodium had MICs of 0.5 μg/mL, 8 μg/mL, 0.5 μg/mL, and 0.25 μg/mL against ATCC 29213, ATCC 25922, M164342 and MSCNS117933, respectively. …”
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