The WHEAT pilot trial—WithHolding Enteral feeds Around packed red cell Transfusion to prevent necrotising enterocolitis in preterm neonates: a multicentre, electronic patient recor... by Neena Modi, Jon Dorling, Chris Gale, Tjeerd Van Staa, Louise Linsell, Ursula Bowler, Ed Juszczak, Mark A Turner, Sena Jawad, Amanda Forster, Andy King, Jenny McLeish, Helen Robberts, Kayleigh Stanbury

“…The use of a simplified opt-out consent model and embedding trial processes within existing electronic patient record (EPR) systems provide opportunities to increase trial efficiency and recruitment.Methods and analysis We will undertake a randomised, controlled, multicentre, unblinded, pilot trial comparing two care pathways: continuing milk feeds (before, during and after red cell transfusions) and withholding milk feeds (for 4 hours before, during and for 4 hours after red cell transfusions), with infants randomly assigned with equal probability. …”
Get full text

Ecosystem Sustainability Assessment Using IUCN (Case Study: Dorook Basin) by Atefeh Teimoori, Seyed Mortza Seyedian, Hamed Rouhani, Reza Ahmadi

“…In contrast to other approaches, the IUCN method of Sustainability Assessment gives equal treatment to people and the ecosystem. …”
Get full text

Age features of myocardial remodeling in men with ischemic chronic heart failure and renal dysfunction by D. A. Lashkul

“…In men with ischemic chronic heart failure, regardless of age eccentric and concentric remodeling of the left ventricle occur equally often, in moderate decrease in renal function in middle age category concentric LV hypertrophy dominates and in elderly men eccentric and concentric hypertrophy are found equally common. …”
Get full text

Comparison of the efficacy of high-flow oxygen insufflations and continuous positive airway pressure during one-lung ventilation undergoing video-assisted thoracoscopic surgery by A. G. Farshatov, E. N. Ershov, A. V. Shchegolev

“…A comparison of Qs/Qt at stage IV revealed statistically significant differences (U 69.0; Z = –5.6; p < 0.001). This parameter was equal to 10.7% (9.5; 15.7) in group 1 and 21.3% (18.4; 23.9) in group 2 correspondingly. …”
Get full text

[Translated article] Risk factors for complications in total hip arthroplasty by L.A. Hoyos-Velasco, J.C. Palacio, W.P. Stangl, C.L. Chacón-Castillo, V. Palacio-Aragón, J.P. Pulgarín

“…The objective of this study is to identify the risk factors associated with local and systemic complications in patients treated with total hip arthroplasty. Methods: Observational, analytical, retrospective cohort study, which included 304 participants treated with total hip replacement. …”
Get full text

Rengalin, a Novel Drug for Treatment of Cough in Children. Intermediate Data on Multicentre, Comparative Randomized Clinical Trial by N. A. Geppe, E. G. Kondyurina, A. N. Galustyan, T. E. Pak, N. B. Baltserovich, O. V. Zhiglinskaya, A. V. Kamaev, S. G. Lazareva, S. L. Laleko, I. M. Melnikova, E. V. Mikhailova, O. A. Perminova, A. U. Sabitov, Yu. M. Spivakovsky

“…The severity of the day-time cough by the area under the curve estimates for 7 days of the treatment in the rengalin group patients was equel to 14.3+5.6 numbers - days and that of the patients of the sinekod® group was equal to 15.9±6.1 numbers - days. The severity of the night-time cough was equal to 4.2+2.7 number - days respectively. …”
Get full text

Factores de riesgo para complicaciones en artroplastia total de cadera by L.A. Hoyos-Velasco, J.C. Palacio, W.P. Stangl, C.L. Chacón-Castillo, V. Palacio-Aragón, J.P. Pulgarín

“…Conclusions: The risk factors for complications in total hip arthroplasty were: hip fracture as the indication for arthroplasty, coronary artery disease, and surgical bleeding equal to or greater than 400 cc.…”
Get full text

Low sensitivity of the fourth‐generation antigen/antibody HIV rapid diagnostic test Determine™ HIV Early Detect for detection of acute HIV infection at the point of care in rural E... by Iza Ciglenecki, Nombuso Ntshalintshali, Esther Mukooza, Skinner Lekelem, Mpumelelo Mavimbela, Sindisiwe Dlamini, Lenhle Dube, Nomvuyo Mabuza, Melat Haile, Tom Ellman, Antonio Flores, Olivia Keiser, Sindy Matse, Roberto de laTour, Alexandra Calmy, Bernhard Kerschberger

“…We nested a diagnostic accuracy study within a larger study of the burden of sexually transmitted infections in rural Eswatini. Methods Adults were enrolled at six routine HIV testing sites (HTS) in the Shiselweni region between June 2022 and April 2023. …”
Get full text

A comparison of applicant and accepted student characteristics to research training programs with implications for recruitment and selection strategy by Young-Hee Cho, Young-Hee Cho, Chi-Ah Chun, Chi-Ah Chun, Hector Ramos, Paul Buonora, Paul Buonora, Paul Buonora, Vasanthy Narayanaswami, Vasanthy Narayanaswami, Kim-Phuong L. Vu, Kim-Phuong L. Vu

“…Its second aim was to investigate whether applicants who were accepted to the programs using a holistic selection process differed in academic discipline, demographics, and psychosocial characteristics from applicants who were not accepted.MethodsInformation on students’ majors, race/ethnicity, and gender was obtained from the university records or applications submitted by students. …”
Get full text

Whole-body and site specific [18F]FDG uptake patterns on PET/CT have limited value in differentiating between polymyalgia rheumatica and other inflammatory diseases: two cohorts of... by Andreas Wiggers Nielsen, Gijs D. van Praagh, Kornelis S. M. van der Geest, Ib Tønder Hansen, Berit Dalsgaard Nielsen, Søren Geill Kjær, Jesper Blegvad-Nissen, Kate Rewers, Christian Møller Sørensen, Elisabeth Brouwer, Ellen-Margrethe Hauge, Lars Christian Gormsen, Riemer H. J. A. Slart, Kresten Krarup Keller

“…Results Patients with PMR were more likely than non-PMR patients to have bilateral [18F]FDG-uptake equal to or above liver compared at the ischial tuberosities (91%/41%), shoulder joints (86%/45%), hip joints (83%/52%), and along the lumbar spinal processes (70%/30%). …”
Get full text

Domestic violence and its determinants among reproductive-age women in Sub-saharan Africa: a multilevel analysis of 2019–2024 demographic and health survey data by Girum Nakie, Gebresilassie Tadesse, Setegn Fentahun, Gidey Rtbey, Fantahun Andualem, Getasew Kibralew, Mulualem Kelebie, Mamaru Melkam, Techilo Tinsae, Mulat Awoke Kassa, Tekletsadik Tekleslassie Alemayehu, Muluken Yigezu, Tigist Kifle Tsegaw, Tesfaye Segon, Yilkal Abebaw Wassie

“…It violates human rights, hinders gender equality, and requires a multifaceted approach. Studies in sub-Saharan Africa (SSA) reveal significant disparities across nations. …”
Get full text

Modifying exercise and physical therapy in medical rehabilitation to promote a physically active lifestyle: Protocol for a multicenter controlled hybrid type 2 effectiveness-implem... by Eva Grüne, Johannes Carl, Wolfgang Geidl, Johanna Popp, David Victor Fiedler, Natalie Boss, Regina Brinkmann, Juliane von dem Bussche, Gabi Eichner, Kathrin Kleinert, Christoph Löhr, Florian Mex, Paul Schwanitz von Keitz, Till Richter, Joachim Schmidt, Rainer Tischendorf, Gorden Sudeck, Klaus Pfeifer

“…The objectives of the STABEKO study are A) to evaluate the implementation of modified exercise and physical therapy and to identify influencing factors for development and implementation, and B) to determine the short- and long-term effectiveness of the modified therapy on PAHCO and physical activity of the persons undergoing rehabilitation. Methods As part of the STABEKO study, we will use cooperative planning as a co-creation approach for planning, developing, and implementing actions to modify exercise and physical therapy by engaging relevant actors from practice, policy, and research in an equal decision-making process. …”
Get full text

The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating... by Navdeep Tangri, Dylan Mackay, Rebecca C Mollard, Matthew Granger, Sharon Bruce, Heather Blewett, Jared Carlberg, Todd Duhamel, Peter Eck, Patrick Faucher, Naomi C Hamm, Ehsan Khafipour, Diana McMillan, Semone Myrie, Amir Ravandi, Meghan Azad, Peter JH Jones

“…The objective of The Manitoba Personalized Lifestyle Research study is to understand how these lifestyle factors interact with each other and with other factors, such as an individual’s genetics and gut microbiome, to influence health.Methods An observational study of adults, with extensive phenotyping by objective health and lifestyle assessments, and retrospective assessment of early life experiences, with retrospective and prospective utilisation of secondary data from administrative health records.Study population A planned non-random convenience sample of 840 Manitobans aged 30–46 recruited from the general population, stratified by sex (equal men and women), body mass index (BMI; 60% of participants with a BMI>25 kg/m2) and geography (25% from rural areas). …”
Get full text

Phase II study of concomitant radiotherapy with atezolizumab in oligometastatic soft tissue sarcomas: STEREOSARC trial protocol by Nicolas Penel, Dominique Vaur, Juliette Thariat, Alexandre Escande, Jennifer le Guevelou, Colin Debaigt, Esma Saada-Bouzid, Julien Viotti, Nazim Khalladi, David Thibouw, Marie Pierre Sunyach, Laurence Moureau-Zabotto, Mohamed Benchalal, Ovidiu Veresezan, Anne Ducassou, Cecile le Pechoux, Maria Jolnerovski, Celine Bazille, Raphael Serre, Christine Lovera

“…In oligometastatic stage, stereotactic body radiation therapy (SBRT) allows reaching high control rates at treated sites (≥80%) and is potentially equally effective to surgery in term of overall survival. …”
Get full text

Obstacles for self-management practices among diabetes patients: A facility-based study from Coastal South India. [version 3; peer review: 2 approved] by Murali Mohan R, Rekha T, Balanarayana Suma, Nithin Kumar, Kausthubh Hegde, Bhaskaran Unnikrishnan, Prasanna Mithra, Ramesh Holla, Aysha Roushida Sahama M, Aadithya M Rao, Patil Nikitha

“…Background The management of diabetes mellitus (DM) extends beyond clinical care, with self-care being equally important to achieve optimal treatment outcomes and prevent complications. …”
Get full text

REMAP Periop: a randomised, embedded, multifactorial adaptive platform trial protocol for perioperative medicine to determine the optimal enhanced recovery pathway components in co... by Brian Williams, Jennifer Holder-Murray, Kathirvel Subramaniam, Kert Viele, Oscar C Marroquin, Scott Berry, Aman Mahajan, Luca La Colla, Charles Luke, Alison R Althans, Stephen A Esper, Joshua Knight, Joseph Derenzo, Ryan Ball, Shawn Beaman, Nicholas Schott, Elizabeth Lorenzi, Lindsay R Berry, Miranda Masters, Katie A Meister, Todd Wilkinson, William Garrard

“…Patients enrolled in the trial will be randomised to arms within both domains, with the possibility of adding additional domains in the future.Methods and analysis In the PONV domain, patients are randomised to optimal versus supraoptimal prophylactic regimens. …”
Get full text

The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss by Jessica Murphy, Jessica Murphy, Jessica Murphy, José A. Morais, José A. Morais, Michael A. Tsoukas, Alexandra B. Cooke, Stella S. Daskalopoulou, Stella S. Daskalopoulou, Stella S. Daskalopoulou, Sylvia Santosa, Sylvia Santosa, Sylvia Santosa

“…Weight loss can modify adipose tissue immune cell composition, but whether these changes differ by obesity onset remains unknown.MethodsWe compared abdominal and femoral subcutaneous adipose tissue (SAT) immune cell percentages between people with CO and AO before and after moderate (~10%) weight loss. …”
Get full text

Low-concentration atropine (0.01%) on quantitative contrast sensitivity function in Chinese children with myopia by Yu-Hao Ye, Yi-Yong Xian, Fang Liu, Zhong-Lin Lyu, Xing-Tao Zhou, Jing Zhao

“…AIM: To investigate the effect of 0.01% low-concentration atropine (LA) on quantitative contrast sensitivity function (qCSF) in children with myopia. METHODS: This paired case-control study included 90 eyes of 58 children who were sex-, age-, and refraction-matched and equally divided into two groups: the 0.01% LA group had undergone 6mo use of daily 0.01% atropine and control group was naïve to LA. …”
Get full text

Effect of butorphanol tartrate combined with dexmedetomidine on postoperative analgesia by Xu Xiaofeng, Zhan Linsen, Lu Huarong, Yu Gongmin, Xia Changxing, Xu Yongqing, Liu Gang, Chai Yuhui, Lan Yunping

“…The patients were divided into two equal groups – research group (RG) and control group (CG), using the random number table method. …”
Get full text

Sleep, physical activity, sedentary behavior, and risk of cataract: a cross-sectional and prospective study from UK Biobank by Yu Peng, Yuzhou Zhang, Ka Wai Kam, Mary Ho, Sunny Au, Xiujuan Zhang, Mandy PH Ng, Patrick Ip, Alvin Young, Chi Pui Pang, Clement C. Tham, Li Jia Chen, Jason C. Yam

“…Replacing 1 h/day of SB time with an equal time spent in total PA and sleep was associated with a 1.7% and 2.7% decreased risk of cataract, respectively. …”
Get full text