Vertebral Osteoporosis in Systemic Lupus Erythematosus: A Possible Involvement of Inflammation-Related Osteoblast Ferroptosis by Lao Z, Chen X, Chen X, Zhang H, Zhang Z, Bian Y, Zhou C, Tian K, Jin H, Fu F, Wu C, Gan K, Ruan H

“…This study utilized the MRL/lpr mouse model, which effectively replicates human SLE manifestations, to investigate the impact of SLE on vertebral bone homeostasis.Methods: Female MRL/lpr mice were employed to investigate SLE-induced bone loss. …”
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Copper-Based Metal-Organic Framework Nanoplatform for miRNA Delivery: Synergistic Antitumor Therapy by Tu M, Deng X, Lai B, Liu J, Tao Y, Xu S, Li X, Niu X, Li Z, Huang J, Li J, Mao S, Ouyang X, Cao J

“…However, antioxidant mechanisms in tumor cells greatly reduce CDT efficacy.Methods: We propose using MOF-199 nanoparticles (NPs) with tumor microenvironment responsiveness as a carrier for miR-4521 to construct miR-4521@MOF-199 for cancer treatment. …”
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Safety Profile of Intravenous Ferulic Acid Nanoparticles: Acute Toxicity and Neurological Effects in Sprague-Dawley Rats by Huang H, Xuan Y, Ma ZC

“…This study aimed to develop and evaluate FA-loaded lipid nanoparticles (FA-LNPs) as a safe and efficient drug delivery system.Methods: FA-LNPs were prepared via an optimized active loading method. …”
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Analgesic Efficacy of Thoracoscopic Direct-View Versus Ultrasound-Guided Thoracic Paravertebral Block in Multi-Port Video-Assisted Thoracoscopic Lung Surgery: A Randomized Controll... by Tong Y, Wu J, Wu X, Mo Y, Wang F

“…Yao Tong,1,* Jimin Wu,2,* Xuhui Wu,3 Yunchang Mo,1 Faxing Wang2,4 1Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Anesthesiology, Lishui People’s Hospital, Lishui Hospital of Wenzhou Medical University, Lishui, People’s Republic of China; 3Department of Thoracic Surgery, Lishui People’s Hospital, Lishui Hospital of Wenzhou Medical University, Lishui, People’s Republic of China; 4Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Faxing Wang, Department of Anesthesiology, Lishui People’s Hospital, Lishui Hospital of Wenzhou Medical University, No. 15, Dazhong Street, Lishui, Zhejiang Province, 323000, People’s Republic of China, Email wfx2023@wmu.edu.cn Yunchang Mo, Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang Street, Ouhai District, Wenzhou, Zhejiang, 325000, People’s Republic of China, Email myc1104@wmu.edu.cnPurpose: This study compares the analgesic effects of the Thoracoscopic Direct-view Thoracic Paravertebral Nerve Block (DTPVB) with those of the Ultrasound-guided Thoracic Paravertebral Nerve Block (UTPVB), providing a clinical reference.Patients and Methods: Sixty-eight patients undergoing three-port video-assisted thoracic surgery (VATS) with general anesthesia were randomly assigned to either the DTPVB group (Group D, n = 34) or the UTPVB group (Group U, n = 34). …”
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Dynamics of uric acid concentration against the background of early dapagliflozin use in patients with acute decompensation of heart failure by Laura H. Sarieva, Anastasiya E. Poskakalova, Svetlana N. Nasonova, Igor V. Zhirov, Sergey N. Tereshchenko

“…In patients with ADHF and reduced LVEF, a uric acid level equal to or greater than 667.9 μmol/L during hospitalisation predicted a high risk of death during the 6-month follow-up period. …”
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Efficacy and Safety of Low-Dose Lenvatinib and Toripalimab in Patients With Recurrent Platinum-Resistant Ovarian Cancer: Study Protocol of a Multicenter, Open-Label, Single-Arm, Ph... by Su H, Shang X, Liu H, Wang Y, Yu Y, Xu Y, Jiang K, Feng F

“…This study is designed to further validate the efficacy and safety of the combination therapy of low-dose lenvatinib and PD-1 inhibitor toripalimab in patients with recurrent PROC.Study Design and Methods: The study is designed as a multicenter, open-label, single-arm, prospective phase II study. …”
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MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress by Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W

“…However, the role of membrane-associated protein 17 (MAP17) in NASH remains unclear, which prompted this study to explore its relationship with immune infiltration and its regulatory mechanisms.Methods: We employed weighted correlation network analysis (WGCNA) to construct a gene co-expression network aimed at identifying key genes associated with NASH progression. …”
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Treatment With Schistosoma Japonicum Peptide SJMHE1 and SJMHE1-Loaded Hydrogel for the Mitigation of Psoriasis by Liu X, Wang S, Jiang Y, Luo X, Yang Y, Huo L, Ye J, Zhou Y, Yang Z, Du F, Dong L, Mao C, Wang X

“…This study evaluates the effects of the peptide SJMHE1 from Schistosoma japonicum (S. japonicum) on the inflammatory response in imiquimod (IMQ)-induced psoriasis mice and LPS-stimulated keratinocytes, as well as the efficacy of SJMHE1-loaded hydrogel on psoriasis in mice.Methods: SJMHE1 was administered to mice with IMQ-induced psoriasis via topical administration or subcutaneous injection, and effects were evaluated by detecting the skin inflammation of mice. …”
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The Median Effective Dose of Ciprofol Combined with Sufentanil for Inhibiting Responses to Gastroscope Insertion in Obese Patients: A Prospective, Single-Center Study by Xue Z, Liu X, Qian W, Yang N, Pan Y, Zhou Y, Jiang W, Li F, Qian B

“…All patients received 0.1 μg/kg of sufentanil, and the ciprofol dose was determined by the modified Dixon sequential method with an initial dose of 0.4 mg/kg and a dose gradient of 0.01 mg/kg. …”
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A systematic review of evidence on the intersection of gender, sociocultural determinants of health, and antimicrobial resistance in a changing climate by Ms Ambika Lall, Dr. Vrinda Nampoothiri, Dr. Abdul Baasit Isaacs, Dr. Hope Mackline, Dr. Anastasia Koch, Dr. Deepshikha Batheja, Dr. Esmita Charani

“…Conclusion: For a renewed and strengthened gender equality and health equity focus, evidence is critically needed on the intersection of AMR, gender, and climate.…”
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More Physical Exercise is Beneficial to Glycemic Control in Late Pregnancy Among Women with Gestational Diabetes Mellitus: Findings Based on Trajectory Model in a Prospective Cohor... by Zhang X, Ding Y, Duan Z, Cai R, Gao X, Zhang R, Wang R

“…This study aimed to explore this association using a group-based trajectory model (GBTM) among women with GDM.Patients and Methods: We constructed two types of models (A and B) by applying GBTM analysis based on a series of abnormal plasma glucose (PG) prevalence values calculated at each prenatal checkup in the GDM cohort. …”
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The Sensitive Genes for Cervical Cancer: Two-Sample Mendelian Randomization with Experimental Validation by Zhang R, Chai S, Chen Q, Lai J, Cai C

“…This study seeks to identify novel therapeutic targets to address this urgent clinical need.Methods: Our team identified differentially expressed genes (DEGs) in cervical cancer using gene expression omnibus (GEO) datasets. …”
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Cytokine Signatures as Biomarkers of Clinical Remission in Rheumatoid Arthritis by Su W, Xiao Y, Chen X, Wu Y, Wu B, Yang Q, Peng B, Tang J, Yang Y

“…This study aimed to investigate the potential of intricate cytokine networks for predicting the clinical remission of RA.Methods: In total, 164 patients with RA and 69 healthy individuals were included in this study. …”
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La Medicina Tradicional y Natural en el tratamiento de la estomatitis subprótesis by Ivonne Guerrero Ricardo, Yosvany Ramón Armas Pupo, Digna Norma Arévalo Rodríguez, Madelín Machado Coayo

“…Objective: to describe the application of the traditional natural medicine in the treatment of the subprosthesis stomatitis. Methods: a deep review about last year from January 2012 to September 2012 was done. …”
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Effect of Entecavir, Tenofovir Disoproxil Fumarate, and Tenofovir Alafenamideantiviral Therapy on Renal Function in Chronic Hepatitis B Patients: A Real-World Retrospective Study by Li Y, Li YW, Gao Y

“…This study aimed to assess the renal safety profile in NUC-experienced CHB patients who received ETV, TDF or TAF therapy.Methods: This retrospective observational cohort study investigated factors related to renal function in 154 patients with NUC-experienced CHB who received ETV, TDF, and TAF therapy for 48 weeks. …”
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Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling by Cai C, Wang M, Yang D, Jing C, Li Y, Xu H, Liu F, Zhao D

“…Changjiu Cai,1,* Manying Wang,2,* Dan Yang,2 Chenxu Jing,2 Yingna Li,3 Hanying Xu,4 Fangbing Liu,5 Daqing Zhao5 1Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 2Research Center of Traditional Chinese Medicine, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 3College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 4Department of Encephalopathy, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 5Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fangbing Liu, Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China, Email liufb@ccucm.edu.cn Daqing Zhao, Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China, Email zhaodaqing1963@163.comPurpose: To determine whether Gui-Pi-Tang (GPT) has protective effects on skeletal muscle and cardiac muscle in aged mice.Methods: This study used C57BL6/J mice to establish an in vivo natural aging model, while D-galactose (D-gal)-injured C2C12 and H9c2 cells were employed to create in vitro aging cell models. …”
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Multimodal Imaging of Brain Metastasis-Derived Extracellular Vesicles Using Superparamagnetic Iron Oxide Nanoparticle Labeling by Feginn Berle B, Juliussen S, Castilho Á, Solel E, Sdik Saed H, Vanderpoorten O, Lunavat TR, Thorsen F, Rigg E

“…However, tracking their distribution and interactions in vivo remains challenging.Objective: To develop and validate a method for labeling BM-derived EVs using superparamagnetic iron oxide nanoparticles (SPIONs) that enables their visualization and tracking through magnetic resonance imaging (MRI).Methods: Three SPION variants with different coatings and sizes were evaluated using two patient-derived BM cell lines. …”
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Screening and Verification COPD-OSA Overlap Syndrome Core Genes Using Bioinformatics by Qiang S, Wan R, Wu J, Wang C, Cui X, Zhang Y

“…To address this, we explored potential OS mechanisms using bioinformatics.Methods: OSA and COPD gene expression datasets were obtained from the Gene Expression Omnibus (GEO) database. …”
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CLEC3B as a Prognostic and Immunological Biomarker in Pan-Cancer: Multi-Omics Profiling and Validation in Pancreatic Cancer and Exosomes by Nan K, Zhang L, Peng Y, Huang J, Yin S, Zou Y, He K, Zhang M

“…In this study, we explored the potential roles of CLEC3B as a tumor suppressor and in immune function across multiple cancer types.Methods: We visualized outcomes derived from Gene Expression Omnibus (GEO) and diverse online databases. …”
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One‐stage spatial mark–resight analysis reveals an increasing grizzly bear population with declining density near roads by Jesse Whittington, Mark Hebblewhite, Connor Meyer, Barb Johnston, Anne Forshner, Bryan J. Macbeth, Anthony L. Einfeldt, Seth G. Cherry

“…Both methods had >95% credible interval coverage and minimal bias. …”
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