Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases by Lin X, Zhou Y, Lv K, Wu W, Chen C

“…Conventional drug delivery methods—topical, local injection, and systemic administration—face challenges such as low bioavailability (< 5%), rapid clearance, and physiological barriers like the cornea and blood-retinal barrier (BRB). …”
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MANAGEMENT OF MAGNESIUM DEFICIENCY IN PREGNANT WOMEN: PHARMACOEPIDEMIOLOGIC STUDY by D. V. Blinov, U. V. Zimovina, E. M. Dzhobava

“…Objectives: to evaluate Mg deficiency incidence and management in a pregnant population monitored in Russian polyclinics. Materials and Methods: pregnant women (at any trimester) aged over 18 years were included. …”
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Mechanism of Action and Efficacy of Wu-Hua-Yan-Xiao in the Treatment of Pediatric Acute Pharyngitis Based on Network Pharmacology and Experimental Validation by Zhang X, Zhang Z, Xu Y, Luo J, Shen Z, Liang H, Zeng Y, Liu W, Zheng C, Li J

“…Xinyun Zhang,1,* Zengyu Zhang,2,* Yingzi Xu,1 Jiawei Luo,1 Zihao Shen,3 Hao Liang,1,4 Yidi Zeng,1,4 Wanghua Liu,1,4 Caixing Zheng,1 Jinxia Li1,4 1Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 2Research Center for Clinical Medicine, Jinshan Hospital Affiliated to Fudan University, Shanghai, 20000, People’s Republic of China; 3Xiangxing College, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 4Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinxia Li; Caixing Zheng, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China, Email 531249042@qq.com; 947726363@qq.comEthnopharmacological Relevance: Wu-Hua-Yan-Xiao (WHYX) is an innovative volatile oil formulation derived from the traditional Yinqiao-Mabo decoction, developed for the treatment of pediatric acute pharyngitis.Materials and Methods: Network pharmacology was utilized to identify active components and potential therapeutic targets of WHYX in acute pharyngitis. …”
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Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) Before Treatment as the Predictive Indicators for Bone Metastasis in Prostate Cancer Patients by Chen L, Rao H, Chen N, Li R, Chen D, Jiang H

“…The purpose of this study was to investigate the relationship of nutritional status indices (geriatric nutritional risk index (GNRI), neutrophil to albumin ratio (NAR), prognostic nutritional index (PNI)), and comprehensive inflammatory indices (pan-immune inflammation value (PIV), systemic immune inflammation index (SII), and system inflammation response index (SIRI)) and bone metastasis of prostate cancer.Methods: A retrospective analysis was performed on 888 prostate cancer patients treated in Meizhou People’s Hospital from November 2017 to December 2022. …”
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Gut Microbiome Composition Changes During Insomnia Treatment with Lemborexant by Miyata S, Iwamoto K, Ito M, Okada I, Matsuyama N, Fujimoto A, Kogo Y, Nishiwaki H, Ueyama J, Ohno K, Ozaki N

“…Here, we investigated the relationship between the gut microbiota and hypnotic use in insomnia.Participants and Methods: We enrolled 29 adults with insomnia and performed sleep electroencephalography and stool analyses at baseline and after 4 and 12 weeks of open-label lemborexant treatment. …”
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Stomatobaculum longum-Derived Extracellular Vesicles Enhance Oral Squamous Cell Carcinoma Malignancy Through BRCA1/EXO1/TP53BP1 Modulation by Yan L, Wu F, Jiao J, Maimaiti A, Li Y, Shao L, Liang Q, Xiong X, Qin Z

“…This study investigates the role of the oral microbiome, particularly Stomatobaculum longum (S. longum), in OSCC progression and explores the underlying molecular mechanisms involving bacterial extracellular vesicles (EVs).Methods: 16S rRNA sequencing was conducted on tumor and adjacent non-tumor tissues from OSCC patients to identify microbial composition. …”
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Negative Correlation Between Fractional Anisotropy on Diffusion Tensor Imaging and Neck Disability Index in Cervical Spondylotic Radiculopathy After Percutaneous Cervical Nucleopla... by Fan N, Li T, Lu X, Ma X, Yang L, Du P, Zang L, Yuan S

“…Ning Fan,1,* Tusheng Li,1,* Xuanyu Lu,1,* Xinyu Ma,2 Lihui Yang,1 Peng Du,1 Lei Zang,1 Shuo Yuan1 1Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100043, People’s Republic of China; 2Department of Orthopedics, Civil Aviation General Hospital, Beijing, 100123, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Zang, Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China, Email zanglei@ccmu.edu.cn Shuo Yuan, Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China, Email happyshuohappy@163.comPurpose: This study aimed to examine the correlation between diffusion tensor imaging (DTI) parameters (fractional anisotropy, FA; apparent diffusion coefficient, ADC) and clinical outcomes (neck disability index, NDI; visual analog scale, VAS) in cervical spondylotic radiculopathy (CSR) patients following percutaneous cervical nucleoplasty (PCN), respectively.Methods: This is a cross-sectional study. …”
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Refractory Gout and Metabolic Syndrome in a Chinese Cohort: A Propensity Score Matching and Nonlinear Relationship Analysis by Li J, Zhang J, Lu H, Li S, Zhang L, Tan N, Shang S, Li R, Ka Y, Wang S, Liu W

“…This study aimed to explore this association and reveal its potential nonlinear patterns in a Chinese cohort.Methods: This retrospective study included clinical data from 4111 gout patients from a single center in Tianjin, China between 2014 and 20234. …”
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Risk of Depression and Anxiety in Those Who Gave Birth to Children Who Developed Invasive Group B Streptococcal Disease: A Population-Based Cohort Study by Horváth-Puhó E, Chandna J, Paul P, Wilson CA, Sørensen HT, Lawn JE

“…We aimed to examine the risk of depression and anxiety in birthing parents with iGBS-affected infants in a cohort study with prospectively collected data from Danish registries.Materials and Methods: Using Danish healthcare registries from 1997 to 2018, we obtained data on iGBS-affected children and their birthing parents. …”
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Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma by Wang J, Yin X, Li Z, Liang P, Wang Y, Li X, Qiao W, Xiong C, Yu M, Ding X, Wang X

“…This study investigated PANoptosis-related mechanisms underlying HCC progression to identify actionable therapeutic targets and optimize patient-specific treatment outcomes.Patients and Methods: Multi-omics analysis (single-cell/bulk RNA sequencing) combined with machine learning was used to identify the PANoptosis-related prognostic features. …”
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Exosomes Derived from Apelin-Pretreated Mesenchymal Stem Cells Ameliorate Sepsis-Induced Myocardial Dysfunction by Alleviating Cardiomyocyte Pyroptosis via Delivery of miR-34a-5p by Li T, Zhao Y, Cao Z, Shen Y, Chen J, Huang X, Shao Z, Zeng Y, Chen Q, Yan X, Li X, Zhang Y, Hu B

“…This study aimed to determine whether EXOs sourced from Apelin-pretreated MSCs (Apelin-MSC-EXOs) would have potent cardioprotective effects against SMD and elucidate the underlying mechanisms.Methods: MSC-EXOs and Apelin-MSC-EXOs were isolated and identified. …”
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How Health Anxiety is Associated with Perceived Risk of Reinfection Among COVID-19 Infected People After the Epidemic Control Measures Lifted in China: A Multiple Mediating and Mul... by Zhao W, Ding N, Hu H, Tian W, He J, Du M, Zhao C, Zhang G

“…While numerous studies have shown the correlation between them during the COVID-19, research on their underlying mechanism remains limited.Purpose: This study aims to test the relationship and mechanism between health anxiety and perceived risk of reinfection among COVID-19 infected people from different occupational backgrounds.Methods: A cross-sectional study was conducted from December 24th to 28th, 2022, after the epidemic control measures were lifted. …”
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The protective effect of Chlorella vulgaris against diclofenac toxicity in Clarias gariepinus: haemato-immunological parameters and spleen histological features as outcome markers by Ahmed Gabr, Amr M. Mohamed, Amr M. Mohamed, Nasser S. Abou Khalil, Nasser S. Abou Khalil, Alaa El-Din H. Sayed, Alaa El-Din H. Sayed

“…Chlorella vulgaris (C. vulgaris) is rich in active phytochemicals known for their haemato-immunological boosting properties.MethodsOur objective was to investigate the haemato-immunological protective properties of Chlorella in mitigating the toxic effects of DCF. …”
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The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Subcutaneous Administration of a Novel Anti-NGF Monoclonal Antibody (AK115) in Healthy Participants: A Ran... by Zhang J, Fan YX, Huang Y, Guan R, Li R, Long S, Yang M, Yu B, Wang GQ, Chen P, Gong X, Li B, Xia M, He J

“…Juan Zhang,1,2,* Yu-Xin Fan,1,* Yu Huang,1 Runfang Guan,1 Ruixia Li,1 Shuxian Long,1 Mei Yang,1 Binge Yu,3 Guo Qin Wang,3 Peng Chen,3 Xia Gong,3 Baiyong Li,3 Michelle Xia,3 Jianchang He1 1Research Center of Clinical Pharmacology, the First Affiliated Hospital of Yunnan University of Chinese Medicine, Yunnan, People’s Republic of China; 2Research Center for Early Clinical Trials of Drugs (Vaccines), the Affiliated Anning First People’s Hospital, Kunming University of Science and Technology, Kunming, People’s Republic of China; 3Akeso Biopharma, Inc, Zhongshan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianchang He, The First Affiliated Hospital of Yunnan University of Chinese Medicine, 1 huachen Road, Kunming, 650103, People’s Republic of China, Email hejc@yn-cprc.comObjective: This study aimed to investigate the safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of a novel anti-nerve growth factor (NGF) monoclonal antibody (mAb) (AK115) in healthy Chinese participants.Methods: A randomized, double-blind, placebo-controlled, dose-escalation phase I clinical study was conducted as follows: eligible participants were divided into 6 dose groups, among which 0.5 mg group was administrated with AK115 injection and the remaining 5 groups were randomly assigned to AK115 injection or accompanying placebo at a ratio of 3:1. …”
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Prediction of Distant Metastasis of Renal Cell Carcinoma Based on Interpretable Machine Learning: A Multicenter Retrospective Study by Dong J, Duan M, Liu X, Li H, Zhang Y, Zhang T, Fu C, Yu J, Hu W, Peng S

“…Shapley Additive exPlanations (SHAP) method was applied to provide insights into the model’s outcome or prediction.Results: Of 121433 patients involved in the study cohort, 10730 (8.84%) had distant metastasis. …”
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A Cost-Effectiveness Analysis of Mosunetuzumab vs Tisagenlecleucel for Treatment of Third- or Higher-Line (3L+) Relapsed or Refractory (R/R) Follicular Lymphoma (FL) in Italy by Luminari S, Pinto A, Puccini B, D’Arpino A, Omodeo Salè E, Bellone M, Pradelli L, Sabinot A

“…Pascale’, Naples, Italy; 4Hematology, Careggi Hospital and University, Florence, Italy; 5Pharmacy Unit, Santa Maria Della Misericordia Hospital, Perugia, Italy; 6Division of Pharmacy, IEO European Institute of Oncology IRCCS, Milan, Italy; 7Department of Health Economics and Outcome Research, AdRes Health Economics and Outcome Research, Turin, Italy*These authors contributed equally to this workCorrespondence: Marco Bellone, Department of Health Economics and Outcome Research, AdRes Health Economics and Outcome Research, Via Vittorio Alfieri, 17, Turin, 10121, Italy, Tel +39 011 7651239, Email m.bellone@adreshe.comPurpose: To compare the cost-effectiveness of mosunetuzumab with tisagenlecleucel for treating patients with relapsed or refractory follicular lymphoma (R/R FL 3L+) from the perspective of the Italian National Health Service (NHS).Patients and Methods: The analysis employs a weekly cycle partitioned survival model (PSM) with a lifetime horizon. …”
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Metagenomics Analysis of Altered Gut Microbiome in Psoriasis and the Mediation Analysis: A Case-Control Study by Xiao Y, Jing D, Xiao H, Mao M, Kuang Y, Shen M, Lv C, Jian X, Peng C, Chen X

“…However, the mechanisms underlying gut microbiome changes caused by dietary habits in psoriasis remain unclear.Patients and Methods: We performed a case-control study including 64 psoriasis patients and 64 age-, sex-, and body mass index (BMI)-matched controls. …”
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Clinical Characteristics and Seizure Outcomes in Antibody-Positive Autoimmune Limbic Encephalitis by Song H, Xu S, Du BQ, Lai QL, Cai MT, Li H, Hu Y, Ding Y, Ding MP, Zhang YX, Shen CH

“…We aimed to investigate the clinical characteristics and seizure outcomes in a cohort with antibody-positive ALE.Methods: We consecutively recruited patients with antibody-positive ALE and new-onset seizures between July 2014 and February 2024. …”
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Cornus officinalis Protects Against Steroid-Induced Osteonecrosis of the Femoral Head Through Inhibiting Inflammatory Responses and Apoptosis via Network Pharmacology and Experimen... by Wang Y, Fan Y, Li M, Song Z, Wang P, Xie F, Miao Y, Wang Y, Zhang P, Zhan Q

“…This study is to investigate the mechanisms of SZY against SONFH via network pharmacology and experimental validation analysis.Methods: The active components and related targets of SZY and related-SONFH targets were collected from public databases. …”
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cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats by Liu X, Guo H, Sayed MDSM, Lu Y, Yang T, Zhou D, Chen Z, Wang H, Wang C, Xu J

“…Next, we also investigated the alterations of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA) catalytic subunit (PKAca), cAMP response element-binding (CREB), and glutamate transporter 1 (GLT1) levels produced by GEBR-7b in the rats model of depression.Methods: Effects of GEBR-7b on CUS (35 days)-induced depression-like behaviors were examined by measuring immobility time in the forced swimming test (FST). …”
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