Exploring the Mechanism of 2ʹ-Hydroxychalcone Improving Copper Sulfate-Induced Inflammation in Zebrafish Through Network Pharmacology by Shen Y, Yao YD, Li H, Zhang Q, Wang CL, Hu L, Hu YC, Chen MH

“…Simultaneously, research endeavors were made to delve into how functional changes of target affect the inflammation and exercise capacity of Danio rerio young fish.Methods: Upon mating breeding, mature transgenic zebrafish and type AB zebrafish expressing red fluorescent macrophages T g (mpeg1:m Cherry) were cultured for 72 h and exposed to 12.5, 6.25, 3.14 and 0uM 2ʹ-Hydroxychalcone, respectively, for three hours of pretreatment, which were subsequently incubated in CuSO4 at 20uM concentration for 12 h. …”
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From East to West: Regional Disparities in Depressive and Anxious Symptoms Among Chinese Adolescents by Yang R, Yang XJ, Wan JL, Wang LL, Deng H, Chen JX, Zhou SJ

“…Rui Yang,1,* Xing-Jie Yang,2,* Jin-Ling Wan,3 Lei-Lei Wang,2 Hu Deng,2 Jing-Xu Chen,2 Shuang-Jiang Zhou2 1Beijing Anding Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, People’s Republic of China; 3Zhangjiakou Shalingzi Hospital, Zhangjiakou Mental Health Center, Zhangjiakou, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing-Xu Chen, Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, 100096, People’s Republic of China, Tel +86-10-83024442, Email chenjx1110@163.com Shuang-Jiang Zhou, Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, 100096, People’s Republic of China, Tel +86-10-83024135, Email zhoushuangjiang@126.comBackground: To explore the prevalence and determinants of depressive and anxious symptoms among adolescents in China, focusing on regional disparities, cognitive function, psychological resilience, and family functioning.Methods: A total of 39854 adolescents, aged 12– 18 years, participated in this survey. …”
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Correlation Of Fut2 And Fut3 Gene Polymorphisms With Inflammatory Bowel Disease In Guangxi Zhuang Population by Lv X, Huang Z, Li S, Xu X, Chen D, Han L, He Y, Huang S, Wu H, Qi Y, Wei L, Chen M, Zhan L, Lv X

“…Xiaodan Lv,1,* Zhou Huang,2,* Shiquan Li,3 Xiaofang Xu,3 Deyi Chen,3 Lichun Han,3 Yu He,1 Shan Huang,1 Huiling Wu,1 Yunwei Qi,1 Liqiang Wei,1 Min Chen,1 Lingling Zhan,1 Xiaoping Lv3 1Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Emergency Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 3Departments of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoping Lv, Departments of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, No. 6 of Shuangyong Street, Qingxiu District, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China, Email lxxp58@hotmail.comObjective: This study aimed to investigate the association between the polymorphisms of the FUT2 gene (rs1047781, rs601338) and the FUT3 gene (rs3745635, rs28362459) with susceptibility to inflammatory bowel disease (IBD) in the Zhuang population of Guangxi.Methods: Intestinal mucosal tissues were collected from 113 Zhuang patients (41 with Crohn’s disease [CD] and 72 with ulcerative colitis [UC]) and 120 han patients (42 with CD and 78 with UC), all of whom were unrelated and diagnosed with IBD, as well as from 106 Zhuang and 119 han unrelated healthy controls, from January 2021 to December 2023. …”
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sJAM-C as a Potential Biomarker for Coronary Artery Stenosis: Insights from a Clinical Study in Coronary Heart Disease Patients by Wang D, Mao L, Li K, Wang L, Wang Y, Yang L

“…This study aimed to analyze the effect of sJAM-C on coronary artery stenosis and to verify whether sJAM-C could be a biomarker for coronary artery stenosis.Patients and Methods: The participants registered at the Beijing Luhe Hospital, Capital Medical University in the cross-sectional study. …”
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Pharmacokinetic Changes and Influencing Factors of Polymyxin B in Different ECMO Modes by Xu M, Chen N, Yu YW, Pan XY, Li T

“…This study aimed to clarify the changes in PK parameters and identify factors influencing PMB levels in patients receiving venovenous or venoarterial ECMO.Patients and Methods: A prospective PK study was performed in 11 patients receiving ECMO with resistant bacteria. …”
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Association Between Dietary Patterns and All-Cause Mortality in Individuals with Hypertension and Osteoporosis: A Retrospective Cohort Study by Guan J, Ding L, Wang Y, Zhu Z, Pan M, Du L, Yin N

“…Jianhua Guan,* Liang Ding,* Yifei Wang,* Zhongsheng Zhu,* Mingmang Pan, Li Du, Nuo Yin Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus (Shanghai Fengxian District Central Hospital), Shanghai, 201599, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nuo Yin, Department of Orthopedics, South Hospital of the Sixth People’s Hospital Affiliated to Shanghai University of Medicine & Health Sciences (Shanghai Fengxian District Central Hospital), No. 6600 South Fenggong Road Fengxian District, Shanghai, 201599, People’s Republic of China, Tel +86 18916174997, Email nuoyindoc_SUMHS@outlook.comObjective: To explore the association of dietary patterns with all-cause mortality in individuals with hypertension and osteoporosis.Methods: Data on individuals aged ≥ 20 years who completed bone mineral density tests were retrieved from the National Health and Nutrition Examination Survey database. …”
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Assessment of the Impact of Dexmedetomidine on Myocardial Injury in TAVI Patients: A Retrospective Cohort Study Utilizing PSM-DID by Song Y, Zhang J, Xu H, Gui C, Cheng H, Chen Y, Wang S

“…But its effectiveness during TAVI remains unclear.Objective: To assess the impact of DEX on myocardial injury in patients undergoing TAVI under general anesthesia.Methods: A retrospective cohort study of 159 patients (after exclusions) who underwent TAVI from January 2022 to August 2024. …”
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Cancer Recurrence Fear and Return to Work in Breast Cancer Survivors:The Mediating Effects of Health Literacy by Zhu X, Lei J, Chen R, Chen Z, Xiong Z, Yang L, Jiang M, Zhang H

“…By employing structural equation modeling, we examine the mediating effect of health literacy on the interplay between cancer recurrence fear and the ability to return to work.Patients and Methods: We conducted a survey involving 190 breast cancer survivors, utilizing a general information questionnaire, the Concern About Recurrence Scale, and the Health Literacy Management Scale.Results: Our findings indicate that only 54.2% of the participants successfully returned to work. …”
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Heat-Stable Carbetocin in the Management of Postpartum Haemorrhage in Low- and Middle-Income Countries: A Comprehensive Review of Clinical Evidence, Cost-Effectiveness, Implementat... by Adnani QES, Adepoju VA, Jamil S

“…Low- and middle-income countries disproportionately bear this burden, often due to compromised cold chains for oxytocin and insufficient staff training.Methods: This review synthesized thirty publications on heat stable carbetocin (HSC) published from January 2018–March 2025. …”
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Association Between Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Insulin Resistance in Mongolian Adults by Narkhajid G, Oyuntugs B, Yagaantsetseg A, Bolormaa E, Anuurad E, Enkhmaa B, Berglund L, Bayasgalan T

“…This study aimed to investigate its association with HOMA-IR adjusting for waist circumference among Mongolian adults.Materials and Methods: This cross-sectional study, conducted at the Mongolian National University of Medical Sciences Hospital, included 365 participants over 35 who participated in health check-up examinations (mean age 46.8 ± 8.8 years, 37.0% male). …”
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Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study by Xiao S, Ou J, Qiu W, Ye C, Li N, Chen S, Lai Y, Deng Z, Wu F, Shen Y

“…We explored the all-cause mortality risk of individuals with PRISm in a large sample of the general population.Methods: We used data from the National Health and Nutrition Examination Survey III and 2007– 2012. …”
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Measuring the effects of community polygyny on intimate partner violence: a multilevel modeling using nationally representative cross-sectional data by Zacharie Tsala Dimbuene, Bright Opoku Ahinkorah, Dickson Abanimi Amugsi

“…This study showed that community polygyny, since communities might differ on the acceptance levels towards polygyny, is equally important to understand how polygyny could affect the prevalence of intimate partner violence in Central Africa. …”
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Diagnostic Value of ADC in Distinguishing Endometrial Cancer from Atypical Endometrial Hyperplasia and Within Molecular Subtypes by Xu S, Abdifatah Mohamed R, Xu J, Yao Y, Gu Y, Tang W, Jia X

“…Shengjie Xu,1,* Ridwan Abdifatah Mohamed,1,* Juan Xu,1,2 Yao Yao,3 Yun Gu,4 Wenwei Tang,3 Xuemei Jia1,2 1Department of Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China; 2Nanjing Medical Key Laboratory of Female Fertility Preservation and Restoration, Nanjing, 210004, People’s Republic of China; 3Department of Radiology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China; 4Department of Pathology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenwei Tang, Department of Radiology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China, Email tww3077@163.com Xuemei Jia, Department of Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, No. 123 Mochou Road, Nanjing, 210004, People’s Republic of China, Email xmjia@njmu.edu.cnPurpose: The study aimed to evaluate the effectiveness of using specific indicators, particularly the apparent diffusion coefficient (ADC), alone or in combination to differentiate endometrial cancer (EC) from atypical endometrial hyperplasia (AEH) and to explore non-invasive biomarkers for the molecular classification of EC.Methods: A retrospective analysis was conducted on 300 EC and 126 AEH cases who had undergone preoperative magnetic resonance imaging, complete blood count, coagulation profile testing, and tumor biomarkers assessment. …”
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Stented Biological Prosthesis Versus Mitral Allograft in Surgical Treatment of Tricuspid Valve Infective Endocarditis by Mikhail Nuzhdin, Yury Malinovsky, Maksim Galchenko, Roman Komarov, Aleksey Fokin, Nikita Nadtochiy

“…Early safety, clinical efficacy, and time-to-event survival were compared between the two equal B and MA groups. …”
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The short-term effects of different cold spell definitions on asthma outpatient visits in Lanzhou, China by Jianjun Wu, Xizhuoma Zha, Xuelin Ren, Boxi Feng, Ying Zhang, Linghong Wang, Xingmin Wei, Yahui Xie, Jia Zhang, Jie Lu

“…This study aimed to identify the optimal definition of cold spells in Lanzhou, China, and examine their association with outpatient asthma visits, identifying potentially vulnerable populations. Methods This study collected daily asthma outpatient records, along with meteorological and air pollutant data, from January 1, 2017, to December 31, 2020, in Lanzhou, Gansu Province. …”
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Tumor Necrotic Factor-Alpha (−308A/G, rs1800629) and Interleukin-13 (R130Q, rs20541) Gene Polymorphisms as Predictors of Severe Asthma in Pilot Cohort of Kuwaiti Populati... by Al-Ahmad M, Ali A, Maher A, Haider MZ

“…Mona Al-Ahmad,1,2,* Asmaa Ali,2– 4,* Ahmed Maher,2 Mohammad Z Haider5 1Department of Microbiology, College of Medicine, Kuwait University, Kuwait City, Kuwait; 2Department of Allergy, Al-Rashed Allergy Center, Ministry of Health, Kuwait City, Kuwait; 3Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, People’s Republic of China; 4Department of Pulmonary Medicine, Abbassia Chest Hospital, Ministry of Health, Cairo, Egypt; 5Department of Pediatrics, College of Medicine, Kuwait University, Kuwait City, Kuwait*These authors contributed equally to this workCorrespondence: Mona Al-Ahmad, Department of Microbiology, College of Medicine, Kuwait University, P.O. …”
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Semaglutide Alleviates Ovarian Oxidative Stress and Autophagy via the PI3K/AKT/mTOR Pathway in Mice with Polycystic Ovary Syndrome by Guo S, Li X, Liu M, Feng M, Wang X, Xue H, Zhang L

“…Here, we aim to assess the effects of semaglutide (a weekly preparation of GLP-1RAs) on PCOS in vivo.Methods: C57BL/6J female mice aged 3 weeks were subcutaneously injected with dehydroepiandrosterone and fed high-fat diet for 3 weeks to establish PCOS model. …”
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Comprehensive Pan-Cancer Analysis Identifies IGFL1 as an Oncogenic Biomarker and Immunotherapeutic Target with Experimental Validation in Bladder Cancer by Liang Z, An Y, He J, Zhu Z, Jiang K, Chen K, Sun F

“…This study aimed to investigate IGFL1 expression and its prognostic and immunological significance across cancers, with experimental validation in bladder cancer (BLCA).Methods: Data from TCGA, GTEx, and TIMER2.0 were analyzed to assess IGFL1 expression across cancers and its associations with prognosis, immune subtypes, immune infiltration, and tumor-related genomic features. …”
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Construction and Validation of a Hospital Mortality Risk Model for Advanced Elderly Patients with Heart Failure Based on Machine Learning by Shang S, Wei M, Lv H, Liang X, Lu Y, Tang B

“…Shuai Shang,1,2,* Meng Wei,1,2,* Huasheng Lv,1,2,* Xiaoyan Liang,1,2 Yanmei Lu,1,2 Baopeng Tang1,2 1Department of Cardiac Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China; 2Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Baopeng Tang, Department of Cardiac Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinshi Zone, Urumqi, People’s Republic of China, Email tangbaopeng1111@163.com Yanmei Lu, Department of Cardiac Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinshi Zone, Urumqi, People’s Republic of China, Email gracy@189.cnPurpose: This study aimed to develop and validate a model based on machine learning algorithms to predict the risk of in-hospital death among advanced elderly patients with Heart Failure (HF).Methods: A total of 4580 advanced elderly patients who were admitted to the hospital and diagnosed with HF from May 2012 to September 2023 were included in this study, among whom 552 cases (12.5%) died. …”
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Mapping Connection and Direction Among Symptoms of Sleep Disturbance and Perceived Stress in Firefighters: Embracing the Network Analysis Perspective by Liu B, Zou M, Liu L, Wu Z, Jin Y, Feng Y, Jia Q, Li M, Ren L, Yang Q

“…Hence, this study aimed to elucidate the relationship between sleep disturbances and perceived stress in firefighters through network analysis approaches.Methods: A total of 786 Chinese firefighters were included in this study. …”
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