Etlingera Elatior Inflorescence Extract Mitigates Acute Gastric Ulcers by Suppressing the Expression of Inducible Nitric Oxide Synthase in Ethanol-Induced Wistar Rats by Prayoga DK, Aulifa DL, Budiman A, Levita J, Jiranusornkul S

“…However, such a study on the downregulation of the iNOS expression is lacking.Purpose: To confirm the gastro-protective and anti-ulcer effects of the E. elatior inflorescence (EEIE) extract via downregulation of iNOS expression in ethanol-induced gastric ulcer rats.Methods: The fresh inflorescence petals were collected from West Java, Indonesia, and were extracted using 70% ethanol. …”
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Long-Term Outcomes of a Health Information System-Based Feedback Intervention Study of Antimicrobial Prescriptions in Primary Care Institutions: Follow-Up of a Randomized Cross-Ove... by Yan Y, Yang J, Lu Y, Cui Z, Chang Y

“…Yuxing Yan,1,* Junli Yang,1,* Yun Lu,2 Zhezhe Cui,3 Yue Chang1,4 1School of Medicine and Health Management, Guizhou Medical University, Guiyang, Guizhou Province, People’s Republic of China; 2School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou Province, People’s Republic of China; 3Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, Guangxi Province, People’s Republic of China; 4Center of Medicine Economics and Management Research, Guizhou Medical University, Guiyang, Guizhou Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yue Chang, School of Medicine and Health Management, Guizhou Medical University, 6 Ankang Avenue, GUI ‘An New District, Guiyang, Guizhou Province, People’s Republic of China, Tel/Fax +86-0851-88308118, Email 4567401@qq.com Zhezhe Cui, Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, 18 Jinzhou Road, Nanning, Guangxi Province, People’s Republic of China, Tel/Fax +86-0771-2518785, Email czz6997@163.comPurpose: To evaluate the long-term impacts of the feedback intervention on controlling inappropriate use of antimicrobial prescriptions in primary care institutions in China, as a continuation of the previous feedback intervention trial.Methods: After the intervention ended, we conducted a 12-month follow-up study. …”
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Time-Varying Effects of Glucocorticoid Treatment in Critically III Patients with Severe Fever with Thrombocytopenia Syndrome: An Inverse Probability of Treatment Weighting Analysis by Xia P, Liu Y, Wang J, Li H, Zhai Y, Wang B, Tong H, Ge W, Jiang C

“…Peng Xia,1,2,* Yun Liu,3,* Jun Wang,3,* Haopeng Li,4 Yu Zhai,3 Baoyan Wang,5 Hanwen Tong,3 Weihong Ge,1,5 Chenxiao Jiang1,5 1Department of Pharmacy, Nanjing Drum Tower Hospital, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 3Department of Emergency Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, People’s Republic of China; 4Department of Emergency Medicine, Nanjing Drum Tower Hospital, School of Clinical Medicine, Xuzhou Medical University, Nanjing, Jiangsu, People’s Republic of China; 5Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chenxiao Jiang, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Zhongshan Road No. 321, Nanjing, Jiangsu, People’s Republic of China, Email sharejcx@163.com Weihong Ge, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Zhongshan Road No. 321, Nanjing, Jiangsu, People’s Republic of China, Email glg6221230@163.comPurpose: To evaluate the efficacy of glucocorticoid treatment in critically ill patients with severe fever with thrombocytopenia syndrome (SFTS) and to assess whether glucocorticoid use increases the risk of fungal infections.Patients and Methods: A retrospective cohort study was conducted involving confirmed SFTS patients from a tertiary hospital. …”
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Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

“…Here, we screened nucleic acid aptamers against the widespread HuNoV GII.4 and emerging HuNoV GII.17.Methods: After ten rounds of sieving for HuNoV GII.4 and GII.17 virus-like particles (VLPs), eight ssDNA aptamers were generated and characterized for each genotype.Results: Four of the eight aptamers generated for GII.4 VLP had dissociation constants (Kd) less than 100 nM, and all aptamers for GII.17 VLP had Kd less than 10 nM. …”
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Explainable Prediction of Long-Term Glycated Hemoglobin Response Change in Finnish Patients with Type 2 Diabetes Following Drug Initiation Using Evidence-Based Machine Learning App... by Chandra G, Lavikainen P, Siirtola P, Tamminen S, Ihalapathirana A, Laatikainen T, Martikainen J, Röning J

“…It also aimed to identify the predictors associated with these changes.Patients and Methods: Electronic health records (EHR) from 10,139 type 2 diabetes patients in North Karelia, Finland, were used to train models integrating randomized controlled trial (RCT)-derived HbA1c change values as predictors, creating offset models that integrate RCT insights with real-world data. …”
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Short-Term Effectiveness of Ustekinumab in Crohn’s Disease: Results from a Real-World Retrospective Multicenter Study in China by Zhu X, Fang X, Wang Q, Li M, Zhang K, Xie L, Niu X, Wang S

“…Our study is a real-world retrospective multicenter study aimed at exploring the effectiveness of ustekinumab in CD patients and comparing the effectiveness of first line and second line treatments.Methods: Laboratory indicators, CD activity index (CDAI) and simple endoscopic score for CD (SES-CD) scores of patients at the 8th, 16th and 24th weeks of treatment were collected, and the clinical remission rate, clinical response rate, endoscopic remission rate and endoscopic response rate were calculated, and the patients were divided into first line group and second line group for comparison.Results: A total of 102 patients were treated with ustekinumab, and 56 patients with a clinical data integrity rate greater than 70% were ultimately included. …”
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Efficacy of Cooling Blankets for Early Temperature Management in Heat Stroke Patients: A Multicenter Retrospective Cohort Study by Chen L, Jin D, Gong Z, Lu L, Zhao J, Xu S, Yang X, Zhang Y, Feng X

“…This study aimed to assess the cooling effect of the cooling blanket within the first 24 hours after emergency department admission in patients with heat stroke.Methods: Retrospective data were collected from six hospitals. …”
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ALBI Grade Analyses of TACE Combined with Anti-Angiogenesis Therapies Plus PD-1 Inhibitors versus Anti-Angiogenesis Therapies Plus PD-1 Inhibitors in Advanced HCC by Hong X, Hu D, Zhou WJ, Wang XD, Huang LH, Huang TA, Guan YW, Qian J, Ding WB

“…Xin Hong,1,* Di Hu,2,* Wen-Jie Zhou,3,* Xiu-De Wang,4 Li-Hua Huang,5 Tian-An Huang,1 Yi-Wei Guan,1 Jingyu Qian,6 Wen-Bin Ding1 1Department of Interventional Radiology, Affiliated Hospital 2 of Nantong University, Nantong, People’s Republic of China; 2Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 3Department of Interventional Radiology, Northern Jiangsu People’s Hospital, Clinical Medical College of Yangzhou University, Yangzhou, People’s Republic of China; 4Department of Interventional Radiology, Nantong Second People’s Hospital, Nantong, People’s Republic of China; 5Department of Interventional Radiology, Nantong Haimen District People’s Hospital, Nantong, People’s Republic of China; 6Department of Interventional Radiology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wen-Bin Ding, Department of Interventional Radiology, Affiliated Hospital 2 of Nantong University, Nantong, 226001, People’s Republic of China, Tel/Fax +86 15951302169, Email 15951302169@163.com Jingyu Qian, Department of Interventional Radiology, the First Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, People’s Republic of China, Tel/Fax +86 13004081388, Email jyqian1388@163.comObjective: To evaluate the baseline albumin-bilirubin (ALBI) grade’s role in advanced hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE) plus anti-angiogenesis therapies and PD-1 inhibitors (TACE+TP) versus anti-angiogenesis therapies and PD-1 inhibitors (TP).Methods: This multicenter retrospective study enrolled advanced HCC undergoing TACE+TP or TP from January 2019 to June 2023 at three hospitals in China. …”
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Histopathological Changes of Liver Observed in Paediatric Patients Presenting with Choledochal Cyst: A Cross-sectional Study in a Tertiary Care Hospital, Kolkata, India by Swagata Mistry, Ruplekha Mitra Mustaphi, Saugata Kumar Bhattacharya, Seema Mondal

“…The data indicated that there were an equal number of patients (50%) with histologically proven liver cirrhosis in the <1 year and 1-6 years age group. …”
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Mechanistic Insights Into Ganoderma Lucidum for Diabetes Treatment via Network Pharmacology and Validation by Guo S, Yang L, Zhou J, Luo W, Nie B, Zhong X, Liu D, Kang X

“…This study was aimed to explore the active ingredients and mechanism of G. lucidum in the treatment of diabetes.Materials and Methods: Relevant compounds and targets of Ganoderma were collected from the TCMSP database, BATMAN-TCM database, relevant literature and PubChem. …”
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Effective Dose of Oliceridine Fumarate Co-Administered with Remimazolam in Suppressing Gastroscope Insertion Responses for Adults by Yang W, Zhou R, Zhou X, Chen X, Zhou D, Zhang X

“…Weilin Yang,1,&amp;ast; Rui Zhou,2,&amp;ast; Xinyu Zhou,1 Xuemeng Chen,1 Dan Zhou,1 Xianjie Zhang1 1Department of Anesthesiology, Deyang People’s Hospital, Deyang, 618000, People’s Republic of China; 2Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain‑Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Dan Zhou, Department of Anesthesiology, Deyang People’s Hospital, NO. 173, Section 1 of North Taishan Road, Jingyang District, Deyang, Sichuan Province, 618000, People’s Republic of China, Email zd13069617@163.com Xianjie Zhang, Department of Anesthesiology, Deyang People’s Hospital, NO. 173, Section 1 of North Taishan Road, Jingyang District, Deyang, Sichuan Province, 618000, People’s Republic of China, Email zhangxianjie791002@163.comObjective: To determine the 50% effective dose (ED50) and 95% effective dose (ED95) of oliceridine in suppressing gastroscope insertion responses during painless gastroscopy when combined with 0.3 mg/kg remimazolam.Methods: This prospective study enrolled 52 patients scheduled for elective painless gastroscopy. …”
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Digitising the on-call medical team's patient list system: a QIP by Fahad-Bin Zahid

“…Feedback was collected after each cycle to address challenges and refine functionality, including: • Removal of unnecessary columns • Removal of the ‘low-priority’ category (eg, falls, social issues), because such patients were delayed for extended periods, raising clinical safety concerns; • Improved navigation by fixing headers and introducing alternate row colouring to support dyslexic users1–3; • Enhanced visibility for same-day emergency care department (SDEC) and patients who were post-take; • Created a video guide for staff and clarified the log-in process; • Created a secure folder for archived spreadsheets to improve data storage; • Developed an automatic timestamp for when details were entered.Efficiency gains: • Reduced handover times by 13.5 min (on average) per handover; • 73% of registrars reported improved workflow efficiency; • Features, such as live updates and centralised tracking, minimised information loss and streamlined referral management.Environmental impact: • Eliminated 100% of official paper-based referral list, aligning with NHS sustainability goalsUser satisfaction: • 91% of registrars preferred the electronic system. • 73% rated the system 8–10 for usabilityEquality impact: • The project had no adverse effects on any protected characteristic groups. …”
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DETERMINATION OF SOME PHYSICAL AND CHEMICAL PROPERTIES OF PECTIN SUBSTANCES FROM THE SOLVENT CAKE OF TAGETES PATULA L. INFLORESCENCES by N. M. Chervonnaya, I. I. Kharchenko, S. L. Adzhiakhmetova, L. P. Mykots, O. A. Andreeva, E. T. Oganesyan

“…In the result of the studies using viscometer method, we have determined a molar weight of PS equal to 45272 g/mol. …”
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Paroxysmal Sympathetic Hyperactivity, Volume Status, and Neurological Prognosis in Acute Brain Injury: A Prospective Cohort Analysis by Chen R, Cai X, Gui X, Lin G, Du W

“…Rongping Chen,1,&amp;ast; Xin Cai,2,&amp;ast; Xiying Gui,2 Guoying Lin,2 Wei Du3 1Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department of Critical Care Medicine, Tibet Autonomous Region People’s Hospital, Lhasa, People’s Republic of China; 3Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Wei Du, Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing, People’s Republic of China, Tel +13691018276, Email pink_dallas@126.comObjective: In this study, we enrolled patients with acute brain injury (ABI) to examine the relationship between paroxysmal sympathetic hyperactivity (PSH) and volume status, right heart function, and pulmonary edema, and their impact on prognosis.Methods: Thirty patients with ABI were prospectively enrolled. …”
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Research of subpopulation CD3+ CD4- CD8- double-negative T lymphocytes in kidney transplant recipients by S. V. Zybleva, S. L. Zyblev

“…The graft dysfunction was defined as creatinine values equal to or greater than 300 μmol/L and the need for dialysis in the first week after surgery. …”
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IMAGES OF THE ELEMENTS IN N.A. LVOV`S WORLD ARTISTIC PICTURE by Elena N. Borowska

“…The purpose stipulates the usage of methods of both contextual (in the context of the scientific and aesthetic trends of the era) and immanent (addressed to the individual creative principles and features of Lvov’s worldview) analysis of the author’s poetic texts. …”
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The Danish Lymphoid Cancer Research (DALY-CARE) Data Resource: The Basis for Developing Data-Driven Hematology by Brieghel C, Werling M, Frederiksen CM, Parviz M, Lacoppidan T, Faitova T, Teglgaard RS, Vainer N, da Cunha-Bang C, Rotbain EC, Agius R, Niemann CU

“…However, access to large, shared datasets is largely missing and limits mAI research.Aim: Creating a large-scale data repository for patients with LC to develop data-driven hematology.Methods: We gathered electronic health data and created open-source processing pipelines to create a comprehensive data resource for Danish LC Research (DALY-CARE) approved for epidemiological, molecular, and data-driven research.Results: We included all Danish adults registered with LC diagnoses since 2002 (n=65,774) and combined 10 nationwide registers, electronic health records (EHR), and laboratory data on a high-powered cloud-computer to develop a secure research environment. …”
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Oxycodone vs the Combination of Fentanyl and Remifentanil for General Anesthesia in Laparoscopic Uterine Myomas Surgery: A Prospective, Randomized, Controlled Study by Xu X, Zhang H, Li J, Zhou L, Zhu S, Bao F

“…Xiaowei Xu,1,&amp;ast; Honggang Zhang,1,&amp;ast; Jun Li,2,&amp;ast; Li Zhou,1,3 Shengmei Zhu,1 Fangping Bao1 1Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310003, People’s Republic of China; 2Department of Anesthesiology, Shulan (Hangzhou) Hospital, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang Province, 310022, People’s Republic of China; 3Department of Pain Medicine, Ningbo No.6 Hospital, Ningbo, Zhejiang Province, 315040, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Fangping Bao Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Qingchun Road 79, Hangzhou, Zhejiang Province, 310003, People’s Republic of China, Tel +8613958105226, Email baofp@zju.edu.cn Shengmei Zhu, Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Qingchun Road 79, Hangzhou, Zhejiang Province, 310003, People’s Republic of China, Tel +8613857169801, Email smzhu20088@zju.edu.cnPurpose: This study evaluated whether oxycodone alone could substitute for fentanyl combined with remifentanil for general anesthesia in laparoscopic uterine myoma surgery.Patients and Methods: 90 adult female patients were randomized into three groups: oxycodone 0.35 mg/kg (Group A), oxycodone 0.30 mg/kg (Group B), or fentanyl 5 μg/kg (Group C) for induction. …”
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The Resilience of Attitude Toward Vaccination: Web-Based Randomized Controlled Trial on the Processing of Misinformation by Benoît Béchard, Julie A Gramaccia, Dominique Gagnon, Elhadji Anassour Laouan-Sidi, Ève Dubé, Mathieu Ouimet, Delphine de Hemptinne, Sébastien Tremblay

“…The final sample comprised 525 participants distributed about equally across the 4 news article versions. Chi-square analyses revealed a statistically significant association between general attitude toward vaccination and the perceived tentativeness of the information about COVID-19 vaccines included in the news article (χ21=37.8, P<.001). …”
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Interleukin &minus;39 Expression in Pleural Effusion and Its Diagnostic Value for Tuberculous Pleurisy by Song X, Zhang Q, Cen T, Fan W, Chen W, Guo L, Du Y, Lv C, Tang P, Dong Z, Li M, Ding Q

“…Xuxiang Song,1,2,&ast; Qipan Zhang,3,&ast; Tiantian Cen,1,3,&ast; Wei Fan,1,2 Weili Chen,1,2 Lun Guo,4 Yingying Du,1,2 Chengna Lv,2 Pan Tang,2 Zhaoxing Dong,5 Mingcai Li,6 Qunli Ding2 1Health Science Center, Ningbo University, Ningbo, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, People’s Republic of China; 3Department of Infectious Diseases, The First Affiliated Hospital of Ningbo University, Ningbo, People’s Republic of China; 4Department of Respiratory Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, People’s Republic of China; 5Department of Respiratory and Critical Care Medicine, Ningbo Second Hospital, Ningbo, People’s Republic of China; 6School of Basic Medical Sciences and Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Mingcai Li, Email limingcai@nbu.edu.cn Qunli Ding, Email dingqunli@nbu.edu.cnObjective: This study aimed to assess Interleukin-39 (IL-39) levels in various types of pleural effusion (PE), explore IL-39’s diagnostic value in tuberculous pleurisy, analyze its correlation with other PE and tuberculosis indicators, and confirm the involvement of IL-39 in tuberculosis infection and the resulting inflammatory response.Methods: This study enrolled 113 patients with PE caused by different etiologies: 20 with transudative effusion, 39 with malignant pleural effusion (MPE), 15 with uncomplicated parapneumonic effusion (UPPE), and 39 with tuberculous pleural effusion (TPE). …”
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