ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1 by Yin L, Mao L, Yin R, Lv C, Shi X, Yue C, Chen Y, Lu C, Wu Z, Xu K, Cao W

“…However, the function of RAAS has not been verified in Clear-cell renal cell carcinoma (ccRCC).Methods: ACE expression in ccRCC tissues was determined using RT-PCR, Western blot, and immunohistochemistry staining. …”
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IL7-IL7R Interaction Mediates Fibroblast-Driven Macrophage-to-Osteoclast Differentiation in Periodontitis by Huang P, Gao L, Guan J, Li Y, Jia Y, Zeng Z, Chen Y, Wang L, Li W, Wang Y, Yang B

“…Pengjie Huang,1,* Li Gao,1,* Jiezhong Guan,1 Yijiao Li,1 Yibing Jia,1 Zixiang Zeng,1 Yurun Chen,1 Linge Wang,2 Weichang Li,1 Yan Wang,1 Bo Yang1 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, People’s Republic of China; 2South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Wang, Email wangyan9@mail.sysu.edu.cn Bo Yang, Email yangb86@mail.sysu.edu.cnAim: To identify osteoclastogenic macrophage subsets and their regulatory mechanisms in periodontitis.Methods: We integrated single-cell RNA sequencing datasets from human and murine periodontitis to construct a comprehensive macrophage and monocyte atlas. …”
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Identification and Validation of Key Genes Related to Lipophagy in Osteoporosis by Hu YX, Zuo ML, Wu Y, Yang Y, Shi XB, Zhang Q, Wu J, Xie RQ, Bi Y, Lin B, Mo C

“…This study aimed to determine the key genes linked to lipophagy in osteoporosis (OP) and provided a reference for the treatment of OP.Methods: The study analyzed OP-related datasets (GSE56815, GSE62402) and lipophagy-related genes (LRGs). …”
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Analysis of the distribution and persistence of organophosphorus pesticides malathion and diazinon in herbal plants by A. M. Savvateev, O. V. Fateenkova, A. V. Braun, V. L. Beloborodov, I. V. Gravel

“…All of the plants were divided into three equal groups. Young plant shoots were processed twice with "Aliot" products containing 570 g/l of malathion and "Terradox" containing 40 g/kg of diazinon. …”
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Multi-Response Au-Nanohybrid Composite Triggered NIR-Light for Effective Anti-Tumor Therapy in Animal Model by Kong LZ, Zhou D, Mo G, Shu M, Yu W, Cheng H, Li K

“…While targeted nanomedicines are highly regarded for their potential, they are not spared from issues of colloidal instability and uncontrolled drug release.Methods: The hybrid system (Au@SiO2-HA-DOX) was designed to enhance colloidal stability and facilitate controlled drug delivery by coating gold nanorods with silica shells and hyaluronic acid (HA) for tumor targeting. …”
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Identification of Macrophage-Related Biomarkers for Abdominal Aortic Aneurysm Through Combined Single-Cell Sequencing and Machine Learning by Yao G, Hu X, Song D, Yao J, Chen D, Luan T, Zhao Y

“…In this study, we elucidated the mechanism whereby macrophages promote AAA development and identified associated biomarkers, with the goal of developing new targeted therapies and improving patient outcomes.Patients and Methods: Differential expression analysis, weighted gene co-expression network analysis, and single-cell analysis were used to identify macrophage-related genes in an AAA dataset. …”
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Effectiveness of an Individualized Diabetes Health Education Program Using Real-Time Continuous Glucose Monitoring in Improving Blood Glucose: A Pilot Interventional Study on Subje... by Ma Y, Deng S, Xie W, Weng M, Jia Y

“…This study evaluated whether an individualized diabetes health education program using RT-CGM could improve glycemic control compared to general dietary guidance in prediabetic individuals.Methods: In this randomized controlled trial conducted at Guangdong Provincial People’s Hospital (initiated September 2022), we enrolled 41 adults (> 18 years) with prediabetes, randomly assigning them to either: (1) RT-CGM group (n=20) receiving meal adjustments based on continuous glucose data and energy balance, or (2) control group (n=21) receiving adjustments based solely on energy balance. …”
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Development and Validation of a Risk Predictive Model for Adverse Postoperative Health Status of Elderly Patients Undergoing Major Abdominal Surgery Using Lasso-Logistic Regression by Wang Y, Yang Y, Li W, Wang Y, Zhang J, Wan J, Meng X, Ji F

“…The aim of this study was to identify risk factors that can predict the health status of patients aged 80 and over after major abdominal surgery and to establish a nomogram model.Methods: We conducted a retrospective study of elderly patients (aged 80+) who underwent major abdominal surgery at the First Affiliated Hospital of Soochow University from January 2017 to June 2023. …”
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The Neutrophil Percentage-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Maintenance Hemodialysis Patients by Shi C, Wang J, Liu W, Mo Y, Huang Y, Wei X, Huo D, Huang A

“…This study aimed to investigate the association between NPAR and all-cause mortality in MHD patients.Methods: Patients undergoing maintenance hemodialysis in the blood purification department of The First Affiliated Hospital of Guangxi Medical University from January 2021 to June 2021 were prospectively studied. …”
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Coix Seed Oil Alleviates DSS-Induced Ulcerative Colitis via Intestinal Barrier Repair and Ferroptosis Regulation by Zeng YX, Li NR, Deng BY, Gu YF, Lu SF, Liu Y

“…Here, the effects and mechanisms of CSO on ulcerative colitis (UC) in vivo are systematically investigated.Methods: Firstly, the UC mice was replicated by 3% DSS, and assessed the efficacy of CSO by observing the fecal occult blood, colon length, DAI score and pathological histomorphological changes of colon tissues. …”
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Diagnostic Value of Glycosylated Extracellular Vesicle microRNAs in Gastric Cancer by Wang S, Ma C, Ren Z, Zhang Y, Hao K, Liu C, Xu L, He S, Zhang J

“…This study aimed to develop a novel diagnostic model based on miRNAs from glycosylated extracellular vesicles and evaluate its effectiveness in diagnosing gastric cancer.Methods: GlyExo-capture technology was used to isolate glycosylated extracellular vesicles from serum samples. …”
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PM2.5 Induces Cell-Specific Transcriptomic Alterations in the Lungs of Juvenile Mice by Gui B, Li Y, Li K, Wang J, Fan W, Li L, Wu Q, Chen H

“…However, its cell-type-specific effects on the lungs and the underlying molecular mechanisms remain poorly defined.Methods: This study established a juvenile mouse model of PM2.5 airway exposure to assess transcriptional alterations in lung cells via single-cell RNA sequencing (scRNA-seq). …”
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Hemiarthroplasties via Posterior Trochanter Osteotomy for Treating Femoral Neck Fractures in Post-Cerebrovascular Disease by Jia YA, Qiao LN, Liu ZB, Xue L, Bi WM, Chen MF, Kang K, Wang F

“…Ying-Ao Jia,1,* Li-Na Qiao,2,* Zhi-Bin Liu,1 Liang Xue,1 Wei-Ming Bi,1 Meng-Fei Chen,1 Kai Kang,1 Fei Wang1 1Department of Orthopaedics, Affiliated Hospital of Yan’an University, Yan’an, 716000, People’s Republic of China; 2Department of Pathology, Affiliated Hospital of Yan’an University, Yan’an, 716000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Wang, Department of Orthopaedics, Affiliated Hospital of Yan’an University, Yan’an, Shaanxi, 716000, People’s Republic of China, Tel +86 18691133000, Email ww_ff@sina.comObjective: The study investigated to examine the clinical outcomes of hemiarthroplasties using posterior femoral trochanter osteotomy for the treatment of femoral neck fractures in patients at the sequelae stage of cerebrovascular disease.Methods: A retrospective analysis was conducted on the data of 53 patients who had been admitted to the Department of Orthopedics at Yan’an University Affiliated Hospital between May 2020 and May 2023. …”
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A cash transfer plus gender transformative economic empowerment intervention seeking to improve the wellbeing of caregivers of children and adolescents living with HIV in South Afr... by Darshini Govindasamy, Nwabisa Shai, Nelly Mwandacha, Stanley Carries, Nokwanda Sithole, Kalysha Closson, Arvin Bhana, Lovemore Sigwadhi, Laura Washington, Andrew Gibbs, Angela Kaida

“…Methods Caregivers of CALHIV will be recruited from public sector HIV clinics within the eThekwini Municipality, KwaZulu-Natal, South Africa. …”
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Exploring The Role of TOP2A in the Intersection of Pathogenic Mechanisms Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis Based on Bioinformatics by Shi S, Hong X, Zhang Y, Chen S, Huang X, Zheng G, Hu B, Lu M, Li W, Zhong Y, Sun G, Ouyang Y

“…Our study aims at exploring the genetic-level pathogenic mechanism of these two diseases.Methods: We carried out bioinformatics analysis on the GSE55235 and GSE213001 datasets. …”
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Patient and public involvement and engagement with underserved communities in dementia research: Reporting on a partnership to co‐design a website for postdiagnostic dementia suppo... by Claudio Di Lorito, Sarah Griffiths, Marie Poole, Chandrika Kaviraj, Martin Robertson, Neil Cutler, Jane Wilcock

“…These seven members of the public undertook the role of partners in the study. They all equally contributed to the study design, recruitment of participants, development and revision of topic guides for the interviews and development of the website. …”
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Long-term results of lymphedema treatment with Combined lymph node transfer and collagen scaffolds: An Observational Study by Dimitrios Dionyssiou, Antonios Tsimponis, Eleni Georgiadou, Konstantina Mamaligka, Efterpi Demiri

“…Our observational study aimed to examine the hypothesis that nanofibrillar collagen scaffolds (NCS) combined with VLNT can provide guided lymphagiogenesis creating long-lasting lymphatic pathways. Methods: Twenty-four patients (21 female, 3 male) underwent a lymphatic microsurgery for upper (n = 11) or lower (n = 13) limb secondary lymphedema and completed at least 18 months follow-up were selected and equally divided in 2 groups; Group-A underwent VLNT, Group-B underwent combined VLNT and NCS procedure. …”
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Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation by Dong Q, Wu J, Zhang H, Chen X, Xu X, Chen J, Shi C, Luo L, Zhang D

“…This study explores the complex immunometabolic landscape of RA to identify potential therapeutic targets.Patients and Methods: We integrated genome-wide association study (GWAS) data involving 1,400 plasma metabolites, 731 immune cell traits, and RA outcomes from over 58,000 participants. …”
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Effectiveness of Finnish SISU training in enhancing prehospital personnels’ work performance: A randomised controlled pilot study by Hanna Vihonen, Janne Karvonen, Harri Gustafsberg, Juha-Matti Huhta, Heidi Kangasniemi, Timo Jama, Sanna Hoppu

“…The sample comprised 16 paramedics, divided equally between the intervention and control groups. …”
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Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload by Hou XX, Wang S, Ma XX, Wen Y, Li ZJ, Liu XY, Zhang X, Zhang Y, Qin XY

“…The aim of the study was to design and synthesize novel hybrid molecules to improve HT’s biological efficiency.Materials and Methods: A pharmacophore connection strategy was used to design and synthesize novel hybrid molecules by combining HT or its analogues with adamantane (ADM). …”
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