Association Between Advanced Lung Cancer Inflammation Index and Mortality in US Adults with Chronic Obstructive Pulmonary Disease by Su X, Rao H, Zhao C, Zhang X, Li D

“…This study evaluated the association between ALI and all-cause and cause-specific mortality in COPD patients.Patients and Methods: Data from 4616 adults with COPD in the National Health and Nutrition Examination Survey (1999– 2018) were analyzed. …”
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The study of excipients’ influence on Clopidogrel releasing from the rectal suppositories by Ye. А. Redkina, V. V. Gladyshev, B. S. Burlaka, I. A. Pukhalskaya

“…Suppositories were made by the fusion method. Concentration of surfactants in all compositions was 2%, clopidogrel – 0,075 g in one suppository. …”
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Morphometric correlates of the physical development structure of combat athletes in the process of ensuring special work capacity by Oleksandr Pryimakov, Marek Sawczuk, Nataliya Mazurok, Olena Omelchuk

“…The special work capacity of wrestlers was estimated based on the intensity of performing 15 specialized throws of a partner of equal weight in 3 series. Each series of throws was performed 3 times, with a rest interval of 1 minute between the series. …”
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Gegen Qinlian Decoction Ameliorated DSS-Induced Colitis by Attenuating Inflammation, Restoring Intestinal Mucosal Barrier and Modulating Gut Microbiota by Wang Y, Yan R, Ye L, Tang C, Zhou H, Zhao G

“…However, the specific mechanisms by which GQD exerts its effects remain poorly understood, limiting its application in UC treatment.Purpose: In this study, we utilized a dextran sodium sulfate-induced colitis model in mice to evaluate the efficacy of GQD and to elucidate its underlying mechanisms.Methods: Network pharmacology was employed to explore the potential targets and signaling pathways of GQD, which were subsequently validated using Western blot. …”
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Prevalence, characteristics and management of migraine patients with triptan failure in primary care: the EMR France-Mig study by M. Lanteri-Minet, C. Casarotto, O. Bretin, C. Collin, M. Gugenheim, V. Raclot, A. Cases, P. A. Squara, W. Aissani, A. Saighi, H. Lefebvre

“…The aim of the France-Mig study was to quantify the population with triptan failure due to ineligibility or resistance, in the primary care setting, and describe their therapeutic management. Methods The France-Mig study was a retrospective analysis of a cohort of patients suffering from migraine in 2022 identified using data from the IQVIA electronic medical records (EMR). …”
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Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation by Wang Q, Luo X, Su Y, Jin Y, Kuang Q, Li S, Shen W, Zhu Y

“…Tanshinone I (Tan-I) has recently been discovered to have immunomodulatory properties, but its role and mechanisms in treating psoriasis remain unclear.Objective: To evaluate the efficacy of Tan-I in the treatment of psoriasis and to determine the mechanisms involved.Methods: An imiquimod (IMQ)-induced psoriasis-like mouse model was treated topically with Tan-I (7.5 mg/kg/d) or a vehicle. …”
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Clinical Accuracy of the G.LAB MD41A0 Upper Arm Blood Pressure Monitor in Pregnancy and Pre-Eclampsia Using the AAMI/ESH/ISO as Reference Standard by Zhang Y, Shi Z, Liang H, Chen M, Sun Y, Shang F, Wan Y

“…Therefore the study aimed to evaluate the measurement accuracy of the G.LAB MD41A0 oscillometric automatic upper-arm blood pressure monitor in pregnancy and pre-eclampsia women according to the AAMI/ESH/ISO Universal Standard (ISO 81060– 2:2018).Methods: A total of 45 pregnant women were included in the cross-sectional validation study. …”
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Genetic Variants in the Adhesive G Protein-Coupled Receptor ADGRG6 are Associated with Increased Susceptibility to COPD in the Elderly Han Chinese Population of Southern China by Chen F, Zhao J, Mo R, Ding X, Zhang Y, Huang L, Xie T, Ding Y

“…However, the impact of genetic variations in ADGRG6 on chronic obstructive pulmonary disease (COPD) susceptibility has not yet been evaluated.Methods: Considering the high prevalence of COPD among the elderly population in China, this study specifically targets the elderly Han population in Southern China as the study subject. …”
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Untrained perceptual loss for image denoising of line-like structures in MR images. by Elisabeth Pfaehler, Daniel Pflugfelder, Hanno Scharr

“…Therefore, automatic image denoising using deep learning methods is of high interest. In this work, we concentrate on image denoising of MR images containing line-like structures such as roots or vessels. …”
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Combination of DMDD with Nanoparticles Effective Against Diabetic Kidney Disease in vitro by Huang XM, Guo YX, Pang QL, Yan XY, Yan H, Li JY, Tang GL, Jiang HX, Zhang HL

“…This study aimed to formulate DMDD-loaded nanoparticles (DMDD-NPs) using chitosan crosslinked with sodium tripolyphosphate through the ionic crosslinking method and to investigate their effect on diabetic kidney disease (DKD) treatment by inhibiting the development of the epithelial-mesenchymal transition (EMT).Methods: DMDD-NPs were prepared by ionic crosslinking with sodium tripolyphosphate, optimizing six factors that affect nanoparticle characteristics, including particle size and zeta potential. …”
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Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration by Peng H, Hu Q, Zhang X, Huang J, Luo S, Zhang Y, Jiang B, Sun D

“…This study investigated biomarkers connected to DR and oxidative stress and their connection with immune cell infiltration using bioinformatics analysis and found possible therapeutic medications.Methods: The Gene Expression Omnibus (GEO) database was used to obtain the gene expression data for DR. …”
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Investigating Drug-Induced Thyroid Dysfunction Adverse Events Associated With Non-Selective RET Multi-Kinase Inhibitors: A Pharmacovigilance Analysis Utilizing FDA Adverse Event Re... by Meng Z, Song L, Wang S, Duan G

“…Zhuda Meng,1,* Liying Song,2,* Shuang Wang,3,* Guosheng Duan4 1Department of Thyroid Surgery, Changzhi People’s Hospital, Changzhi, People’s Republic of China; 2Department of Thyroid Surgery, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3Department of Gastroenterology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China; 4Radiotherapy Department, Shanxi Provincial Peoples Hospital: Fifth Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhuda Meng, Department of Thyroid Surgery, Changzhi People’s Hospital, Changzhi, 046000, People’s Republic of China, Email jzx23456m@163.comPurpose: This study aims to investigate the potential association between non-selective RET kinase inhibitors and thyroid dysfunction (TD) by conducting a pharmacovigilance analysis using data from the US FDA Adverse Event Reporting System (FAERS).Methods: Data for non-selective RET MKIs were obtained from the FAERS database, spanning the first quarter of 2015 to the fourth quarter of 2023. …”
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Retrograde Approach for Percutaneous Ventricular Septal Defect Closure: Is It Really Better Than Antegrade? by Nataliia S. Yashchuk, Igor O. Ditkivskyy, Alisa P. Soi, Bogdan V. Cherpak, Olha S. Borodinova, Yuliia V. Yermolovych

“…The number of major complications was approximately equal in both groups (p = 0.49). Two patients in Group 1 were referred to surgery due to the new onset of significant aortic or tricuspid insufficiency. …”
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IMPACT OF VITAMIN D DEFICIENCY OR INSUFFICIENCY ON THE SEVERITY OF COVID-19 IN HOSPITALIZED PATIENTS by Olga A. Golubovska, Kyrylo O. Chalyy, Oleksandra V. Bezrodna, Anastasiia A. Holubovska

“…The MR among patients aged 65 years and older with normal vitamin D levels was 30.0% (95% CI 4.8-65.0), but in patients with vitamin D deficiency/insufficiency it was approximately 1.5 times higher and equal to 44.7% (95% CI 29.0-61.1). Conclusions. …”
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Specnuezhenide Alleviates Senile Osteoporosis by Activating TGR5/FXR Signaling in Bone Marrow Mesenchymal Stem Cells and RANKL-Induced Osteoclasts by Deng X, Lin B, Xiao W, Wang F, Xu P, Wang N

“…In this study, the effects of SPN on d-galactose (d-gal)-induced mice, bone marrow mesenchymal stem cells (BMSCs), and nuclear factor-κB ligand-induced osteoclasts were examined.Methods: Micro-computed tomography was used to observe the bone microstructure. …”
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Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway by Huang Z, Li Y, Xie Y, Fu H, Weng Z, Yuan J, Wu L, Lin W, Cao Y, Ding B

“…However, the underlying mechanisms is still unknown.Patients and Methods: In this study, the phytochemical ingredients in WJWE were characterized via UPLC‒MS/MS analysis. …”
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Using Network Pharmacology and in vivo Experiments to Uncover the Mechanisms of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules in Treating Diabetes Mellitus-Induced Ere... by Wang J, Guo Y, Huang J, Yan J, Ma J

“…This study investigates the mechanisms and targets of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules (RAG) in treating DMED using network pharmacology and animal models.Methods: We identified RAG’s active ingredients and potential targets from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. …”
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Human Intestinal Parasitic Infections: Prevalence and Associated Risk Factors among Elementary School Children in Merawi Town, Northwest Ethiopia by Destaw Damtie, Baye Sitotaw, Sissay Menkir, Bizuayehu Kerisew, Kedir Hussien

“…The direct wet mount method was used to diagnose the stool samples. The sociodemographic and behavioral characteristics of the respondents were collected using structured questionnaires. …”
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Genetic Associations Between Specific Sleep-Related Phenotypes and Idiopathic Sudden Sensorineural Hearing Loss: A Mendelian Randomization Analysis by Li M, He J, Liang Y, Zou F, Gou C, Lv J, Zhang X, Li D, Yu Z

“…The inverse variance weighted (IVW) method was utilized, followed by confirming the robustness and reliability using the MR Egger, weighted median, simple mode, and weighted mode. …”
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Rbms3 Upregulation in Mesenchymal Stem Cells Impairs Fracture Healing in Type 2 Diabetes Mellitus by Liu C, Yu Y, Tian L, Liu Y, Zhang D, Yu A

“…Although some research has been conducted to address this, the specific mechanisms remain poorly understood and warrant further exploration.Methods: We downloaded transcriptomic and single-cell RNA sequencing (scRNA-seq) data, performed multiple analyses (differential expression, ssGSEA, co-expression, GO, KEGG, GSEA, and cell clustering identification), and utilized tools (GeneMINIA and Metascape) to investigate alterations in MSCs under diabetic condition. …”
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