Decreased serum and local GPX4 and SLC7A11 expression correlates with disease severity in non-traumatic osteonecrosis of the femoral head by Qing-He Ye, Peng Zhang, Yong-Heng Zhao, Wen-Xiu Zhu, Hong-Xun Zhu, Biao-Fang Wei

“…Objective The objective of this study was to explore the levels of two crucial proteins associated with ferroptosis, namely Glutathione peroxidase 4 (GPX4) and Solute Carrier Family 7 Member 11 (SLC7A11), in both serum and femoral head samples, and to correlate their expression levels with the clinical severity of NT-ONFH. Methods The study included 136 NT-ONFH patients and an equal number of healthy controls. …”
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Clinical Outcomes of Hepatic Arterial Infusion Chemotherapy Plus Lenvatinib and Tislelizumab for Treating Hepatocellular Carcinoma and Type IV Portal Vein Tumor Thrombus by Li X, Cao K, Fu Z, Chen X, Zhong J, Liu L, Ding N, Zhang X, Qu Z, Zhu L, Zhai J

“…Xiaowei Li,* Kunkun Cao,* Zhigang Fu,* Xiaoxia Chen, Jiaming Zhong, Li Liu, Ning Ding, Xiaoli Zhang, Zengqiang Qu, Lijun Zhu, Jian Zhai Department II of Interventional Radiology, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, 200438, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Zhai; Lijun Zhu, Department II of Interventional Radiology, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, 200438, People’s Republic of China, Email jianzhai1979@126.com; lijun_zhush@163.comPurpose: To assess the activity and toxicity of hepatic arterial infusion chemotherapy (HAIC)+tislelizumab+lenvatinib (HAIC+tisle+len) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) type IV (Vp4 hCC) in a real-world context.Methods: Fifty-five patients, with Vp4 hCC receiving HAIC+tisle+len therapy from April 2021 to December 2022, were analyzed retrospectively. …”
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Developing and Externally Validating a Simple Index Based on the Nonlinear Relationship of Fecal Calprotectin and Long-Term Outcomes in Ulcerative Colitis by Zheng J, Zheng D, Fan Z, Li L, Chen R, Zhang S

“…We aimed to explore the nonlinear association between FC levels and long-term therapeutic outcomes in patients with ulcerative colitis and establish a clinically applicable FC index.Methods: We included patients treated with vedolizumab or adalimumab from the VARSITY (n=661) and GEMINI 1 (n=620) studies as discovery and validation cohorts, respectively. …”
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Parameters of the UNIQUAC model for describing the vapor-liquid phase equilibrium of D₂-T₂, D₂-DT, DT-T₂ hydrogen isotope mixtures by T. G. Korotkova

“…Determination of the parameters of the binary energy interaction of the (UNIversal QUAsiChemical) UNIQUAC model on the basis of mathematical processing of experimental literature data on the phase equilibrium of hydrogen isotopic mixtures D2-T2, D2-DT, DT-T2 to calculate the activity coefficients of the components D2, DT, and T2.Methods. The method of successive approximations was used in junction with the “from stage to stage” method, which consists in calculating a single evaporation process on a theoretical plate.Results. …”
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Risk Factors for Postpartum Hemorrhage Following Vaginal Deliveries in China: A Case-Control Study of Second Births After IUD Removal by Shen L, Xu Y, Li B, Long Y

“…A case-control design was employed, comprising 524 women with PPH (blood loss ≥ 500 mL) 24h after giving birth and an equal number of controls (blood loss < 500 mL) matched on a 1:1 ratio. …”
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Enablers and Barriers to Medication Self-Management in Patients With Type 2 Diabetes: A Qualitative Study Using the COM-B Model by Li H, Li Y, Wang J, Zhang Y, Ben S

“…Sampling was done using purposive sampling method and data collection was done using semi-structured interviews. …”
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Adipose-Derived Stem Cells for Cartilage Tissue Engineering: A Bibliometric Analysis of Trends and Themes by Zhang J, Wu K, Zhou L, Zheng S

“…This study aims to systematically evaluate research trends, collaboration patterns, and emerging themes in ADSC-based cartilage TE through a bibliometric analysis, providing actionable insights to address knowledge gaps and advance the field.Patients and Methods: A systematic search was conducted on the Web of Science Core Collection (WoSCC) database to identify publications related to ADSCs and cartilage TE. …”
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Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: INSIG1 by Zhou X, Ning J, Cai R, Liu J, Yang H, Bai Y

“…Consequently, the identification of novel targets and therapeutic agents remains a pressing priority in the field of psoriasis research.Methods: We collected single-cell RNA sequencing (scRNA-seq) datasets and inferred T cell differentiation trajectories through pseudotime analysis. …”
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Effect of Succinate Crystalloid Solution on Hemostasis in Children with Severe Community-acquired Pneumonia by Vladimir V. Lazarev, Pavel E. Anchutin, Manuel M. Megeryan, Mikhail V. Bykov, Dmitry A. Smirnov, Tatiana A. Pchelicnceva, Nikolay S. Frolov, Khurzada M. Makhachilaeva, Boris I. Golubev, Elena A. Spiridonova

“…To improve outcomes in children with severe community-acquired pneumonia (CAP) by including succinate-containing crystalloid solution (SCCS) in the treatment plan.Materials and methods. The study included 100 patients diagnosed with CAP. …”
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Effectiveness and Economic Evaluation of Chiropractic Care for the Treatment of Low Back Pain: A Systematic Review of Pragmatic Studies. by Marc-André Blanchette, Mette Jensen Stochkendahl, Roxane Borges Da Silva, Jill Boruff, Pamela Harrison, André Bussières

“…<h4>Conclusion</h4>Moderate evidence suggests that chiropractic care for LBP appears to be equally effective as physical therapy. Limited evidence suggests the same conclusion when chiropractic care is compared to exercise therapy and medical care although no firm conclusion can be reached at this time. …”
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Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment by Guo T, Zhao Y, Liang S, Wang J, Liu H, Zhou Y, Xu H, Chen Z

“…Tingting Guo,1,2,&ast; Yanying Zhao,2,3,&ast; Shengnan Liang,2,3 Jie Wang,2 Hengwei Liu,2 Yufan Zhou,2 Heping Xu,3– 5 Zhongping Chen1– 3,6 1Aier Eye Hospital, Jinan University, Guangzhou, People’s Republic of China; 2Changsha Aier Eye Hospital, Changsha, People’s Republic of China; 3Aier Academy of Ophthalmology, Central South University, Changsha, People’s Republic of China; 4Aier Institute of Optometry and Vision Science, Aier Eye Hospital Group, Changsha, People’s Republic of China; 5The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, UK; 6School of Stomatology and Ophthalmology, Xianning Medical College, Xianning, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhongping Chen; Heping Xu, Email chenzhongping@csu.edu.cn; heping.xu@qub.ac.ukPurpose: To assess dynamic changes of complement protein in aqueous humor (AH) and plasma of retinal vein occlusion (RVO) patients during ranibizumab treatment, and to explore the differential expression of complement proteins in branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO).Patients and Methods: This prospective, consecutive case series study collected AH and plasma samples from 27 RVO patients at baseline, 1 and 2 months after ranibizumab treatment, including 19 BRVO and 8 CRVO patients. …”
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Desenvolvimento de uma régua para medidas de área foliar do algodoeiro Development of a ruler for measurements of leaf area of the cotton plant by José Fideles Filho, Napoleão E. de M. Beltrão, Antonildo S. Pereira

“…The analysis of regression between the leaf area measured in samples of leaves and the estimated areas showed a good adjustment with coefficient of determination equal to 0.95. Comparing the means of both the methods, it was verified that the mean leaf area of the four cultivars of cotton, measured with the proposed ruler, did not differ statistically from the mean area measured with the planimeter. …”
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Determination of antioxidant and phytochemical properties of premix extract of brown macroalgae Padinaaustralis, Sargassum licifolium and Stoechospermum marginatum from Chabahar co... by Paria Akbary

“…The normality of the data was checked using the Kolmogorov-Smirnov test and the equality of variances was checked using the Levene test. …”
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Comparative Efficacy of Esketamine vs Sufentanil with Propofol for Sedation in EUS: A Randomized, Controlled Study by Liu C, Wang Y, Yin Y, Wang P, Ji X, Sun J, Zhao S, Jia Y, Liu S, Zhou Z

“…Cuicui Liu,1,&ast; Yanting Wang,1,&ast; Yanwei Yin,2 Pei Wang,1 Xiangyu Ji,1 Jian Sun,1 Shuo Zhao,1 Yanfang Jia,1 Shanling Liu,1 Zangong Zhou1 1Daytime Anesthesiology Department, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People’s Republic of China; 2Pain Department, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zangong Zhou, Daytime Anesthesiology Department, the Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Shinan District, Qingdao, Shandong Province, 266000, People’s Republic of China, Tel +86 532-82912511, Email zhouzangong@qdu.edu.cnPurpose: This randomized, controlled trial aimed to assess the sedative effects of esketamine and sufentanil combined with propofol during EUS.Patients and Methods: Three hundred and forty patients undergone EUS were randomly divided into two groups to receive esketamine 0.25 mg/kg combined with propofol (esketamine group) or sufentanil 0.1 μg/kg combined with propofol (sufentanil group). …”
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Efficacy of neck-mounted lazy holder for smartphones on cervical pain and function in patients with non-specific neck pain by Omnia Mohamed Mohamed Abdel Moneim, Ragia Mohamed Kamel, Mohamed Ibrahim Abdelhay

“…The study aimed to explore clinical benefits of addressing daily postural habits by integrating an ergonomic accessory called neck-mounted smartphone holder. Methods The study included 40 patients aged 18–45 years diagnosed with NSNP who used a smartphone at least 6 h a day, recruited from the outpatient clinics of faculty of physical therapy at Benha University and they were randomly allocated to two equal groups. …”
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Correlation Between Gastroesophageal Reflux Disease and Small Intestinal Bacterial Overgrowth: Analysis of Intestinal Microbiome and Metabolic Characteristics by Wang ZT, Tan WT, Huang JL, Zhang PF, Li Q, Wang MM, Meng MM, Su H, Guo CM, Liu H

“…We also explore changes in gut microbiota and metabolism in patients with both conditions.Methods: This study included patients from the Department of Gastroenterology, Beijing Shijitan Hospital, between February 2021 and November 2023. …”
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Biomarkers for Early Predicting In-Hospital Mortality in Severe Fever with Thrombocytopenia Syndrome and Differentiating It from Hemorrhagic Fever with Renal Syndrome by Chen C, Zheng Y, Li X, Shen B, Bi X

“…This study used routine laboratory parameters, epidemiology and clinical manifestations to develop a model for the early diagnosis of SFTS and identify fatal risk factors, ultimately reducing mortality of SFTS.Patients and Methods: This retrospective cohort study included 141 SFTS and 141 HFRS patients. …”
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Effectiveness of level two anomaly ultrasound scan for detection of congenital anomalies - an observational retrospective study by Alka S Gupta, Geeta S Kulkarni, Suraj D Bhame

“…Objectives: This study was done to find the effectiveness of level two anomaly scan in detection of congenital anomalies and also to find the maternal and neonatal factors associated with congenital anomalies. Methods: Pregnant women with gestational age of more than or equal to 18 weeks were included in the study. …”
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Mathematical model of on-demand route formation for public transport based on individual passenger requests in low-density population area by Svetlana S. Titova, Andrey V. Ostroukh

“…Various route optimization algorithms were investigated, and the most suitable method was selected for solving the stated problem. …”
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Exploration of the Application Rules and Clinical Significance of Acupoints in Acupuncture Treatment of Migraine Based on Data Mining by He Y, Wang X, Liu M, Li L, Han T, Wu Y, Li X

“…Yujun He,&amp;ast; Xiaoyi Wang,&amp;ast; Minhui Liu,&amp;ast; Lu Li, Tingfen Han, Yachao Wu, Xiaojun Li Department of Traditional Chinese Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xiaojun Li, Department of Traditional Chinese Medicine, Taizhou Hospital of Zhejiang Province, 150 Ximen Street, Linhai City, Taizhou, Zhejiang, 317000, People’s Republic of China, Email lixj@enzemed.comBackground: Abundant clinical investigations have attested to the efficacy of acupuncture in treating migraines. …”
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