Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects by Li H, Wei D, Cao H, Han Y, Li L, Liu Y, Qi J, Wu X, Zhang Z

“…The aim of this study was to determine the protective effects and mechanisms of ginkgetin on postinfarction cardiomyocytes through bioinformatics and experimental validation.Methods: Bioinformatics analysis was performed to predict the underlying biological mechanisms of ginkgetin in the treatment of MI. …”
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Bio-Inspired Nanodelivery Platform: Platelet Membrane-Cloaked Genistein Nanosystem for Targeted Lung Cancer Therapy by Gao R, Lin P, Yang W, Fang Z, Gao C, Cheng B, Fang J, Yu W

“…This innovative approach aims to facilitate targeted drug delivery and solve the problem of biocompatibility of synthetic materials.Methods: First, the liposomes (LPs) loaded with Gen (LPs@Gen) was prepared using the ethanol injection method. …”
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Upregulation of NGF/TrkA-Related Proteins in Dorsal Root Ganglion of Paclitaxel-Induced Peripheral Neuropathy Animal Model by Kim Y, Je MA, Jeong M, Kwon H, Jang A, Kim J, Choi GE

“…The aim of this study was to understand the neurochemical changes induced by NGF/TrkA signaling in PTX-induced neuropathic pain.Methods: The PTX-induced CIPN mouse model was evaluated using nerve conduction velocity (NCV) and behavioral tests. …”
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Association Between Social Capital and Anxiety Among Older Adults in China: A Cross-Sectional Study by Meng L, Li P, Ye L, He Y, Zhong J

“…This study investigated whether there is an interactive effect of social capital and demographic factors on anxiety among Chinese older adults.Methods: A sample of 5115 Chinese older adults (≥ 60 years old) was extracted from cross-sectional survey data in the 2018 Chinese Longitudinal Health and Longevity Study (CLHLS). …”
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Resting-State Functional MRI Reveals Altered Seed-Based Connectivity in Diabetic Osteoporosis Patients by Li J, Liu M, Qin J, An Y, Zheng X, Mohamad NS, Ramli I

“…This study aims to further explore the abnormal functional connectivity between different brain regions based on the team’s previous research.Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were obtained from 14 participants diagnosed with type 2 diabetes mellitus (T2DM) and osteoporosis. …”
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Improving nerve and muscle function: an exploration of targeted nerve function replacement following differential delay periods in a rat model by Chunxiao Tang, Yuanheng Li, Xinxian Fan, Jiamei Guo, Yifeng Lin, Yifan Gao, Lin Yang

“…This study evaluates TNFR efficacy in restoring denervated muscle function across different postoperative intervals in a rat model. Methods Thirty Sprague–Dawley rats (220–250 g) were divided into five equal groups (n = 6 per group): control (no transection), denervated (transection without repair), immediate TNFR after median nerve transection, 2-week delayed TNFR, and 4-week delayed TNFR. …”
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Características físicas de goiabas (Psidium guajava L.) submetidas a tratamento hidrotérmico Physical characteristics of guava (Psidium guajava L.) submitted to hot water treatment... by Stella M. J. Vieira, Sandra M. Couto, Paulo C. Corrêa, Ana E. O. dos Santos, Paulo R. Cecom, Danilo J. P. da Silva

“…The indiscriminate use of chemical products for eradication of plagues and diseases in the cultivation and also in the post harvest period is being substituted successfully by methods that do not cause harm to human beings or to the environment, reasons for which physical treatments (application of heat, cold or ionized radiation) are being intensively investigated. …”
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Sexual violence across gender identities and sexual orientations: a stratified, population-based, cross-sectional study among young people aged 16–29 years in Sweden by Matilda Löfström-Bredell, Eva Åkerman, Renita Sörensdotter, Sara Ström, Henrik Källberg, Marie Klingberg-Allvin

“…Abstract Background Sexual violence is a critical and preventable global threat to public health, sexual and reproductive health and rights, and gender equality. Studies have shown that sexual violence among young people in Sweden is prevalent, with lesbian, gay, and bisexual individuals facing greater exposure than their heterosexual peers do. …”
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Development of methodological approaches to the formation of a risk-based model to minimize the prevalence of adverse reactions in drug application in medical organizations of Mosc... by E. V. Kuznetsova, M. V. Zhuravleva, I. A. Mikhailov, T. I. Kurnosova

“…In the first stage, a statistical method was used (classical multiple regression, linear discriminant analysis, factor analysis, principal component regression, partial least squares regression, estimation of variance accuracy); at the second stage a modeling method was used. …”
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Vancomycin-Loaded Isogenous Membrane Vesicles for Macrophage Activation and Intracellular Methicillin-Resistant Staphylococcus aureus Elimination by Dou J, Shang W, Peng H, Yang Y, Chen J, Rao Y, Tan L, Hu Z, Wang Y, Huang X, Yang Y, Wu J, Hu Q, Xiao C, Rao X

“…Conventional antibiotics exhibit limited efficacy against intracellular MRSA due to poor cellular penetration.Methods: Vancomycin (VAN) was encapsulated into membrane vesicles (ΔagrAMVs) derived from the attenuated S. aureus strain RN4220ΔagrA, generating VAN-loaded nanoparticles (ΔagrAMV-VAN). …”
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Development of an eHealth Intervention Including Self-Management for Reducing Sedentary Time in the Transition to Retirement: Participatory Design Study by Lisa Hultman, Caroline Eklund, Petra von Heideken Wågert, Anne Söderlund, Maria Lindén, Magnus L Elfström

“…Further, the aim was to develop a digital prototype of such an eHealth intervention. MethodsThe study used the participatory design approach to include end users, researchers, and a web designer as equal partners. …”
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Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective... by Dong L, Huang Y, Zhang S, Xu B, Li B, Cao Y

“…The aim of this study was to investigate the risk factors for the development and mortality of patients with carbapenem-resistant P. aeruginosa bloodstream infection (CRPA BSI).Methods: A total of 112 patients with CRPA BSI and 112 patients with carbapenem-sensitive P. aeruginosa (CSPA) BSI were included from a Chinese teaching hospital from January 2017 to December 2023 in this retrospective cohort study. …”
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Combining Hepatic Arterial Interventional Therapies with Lenvatinib and Programmed Cell Death-1 Inhibitors for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Single-... by Shen X, Shao T, Yu J, Zhang Z

“…This study aimed to investigate the efficacy and safety of hepatic arterial interventional therapies (HAIT) combined with lenvatinib and programmed cell death-1 (PD-1) inhibitors for HCC patients with PVTT.Methods: In this retrospective study, HCC patients with PVTT treated with HAIT combined with lenvatinib and PD-1 inhibitors (H-L-P group) or lenvatinib plus PD-1 inhibitors (L-P group) between June 2020 and December 2023 were analyzed. …”
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Lipid-lowering therapy in outpatients of different ages with coronary artery disease by S. K. Zyryanov, S. B. Fitilev, A. V. Vozzhaev, I. I. Shkrebniova, N. N. Landyshev, Ya. G. Voronko, A. M. Lutsenko

“…LLT prescription rates were equally high in all ages — 92,9%, 85,9%, and 81,6% in groups 1, 2, and 3 respectively (p>0,05). …”
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Proposal of a Risk Stratification Model for Recurrence After Excisional Treatment of High-Grade Cervical Intraepithelial Neoplasia (HG-CIN) by Francesco Cantatore, Nadia Agrillo, Alessandro Camussi, Lucrezia Colella, Massimo Origoni

“…This approach assumes that all patients have an equal risk of disease recurrence, regardless of individual characteristics. …”
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Quality by Design Formulation Approach for the Development of Orodispersible Tablets of Dexlansoprazole by Ali AT, Nasir F, Hidayatullah T, Pervez S, Rabqa Zainab S, Gohar S, Ur Rahman A, Khattak MA, Alasmari F, Neau SH, Maryam GE

“…The ODTs were compressed by the most convenient method of compression, that is, direct compression, the formulation contains a combination of citric acid and sodium bicarbonate along with Kyron T-314® (polymer). …”
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Correction of long-standing flexion contracture of digits with surgical release and distraction histogenesis by Anupama Singh, Ankur Bhatnagar

“…Average days of distraction were almost equal in both Z plasty and SSG cover patients. In 50% of patients with Z plasty distraction time was <15 days. …”
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Elementary school compliance with a state recess minimum requirement by racial and geographic factors: a cross-sectional study by Erin K. Howie, Samantha M. Harden, Daheia J. Barr-Anderson, Christopher R. Long

“…The purpose of this study was to determine the current implementation of one state system as a case study to investigate minimum recess requirement and to compare the implementation between school geographic and racial factors. Methods A cross-sectional, observational study of the implementation of one state’s minimum daily recess requirement of 40-minutes recess was conducted during the 2023–2024 academic year. …”
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Extracorporeal Membrane Oxygenation to Support COVID-19 Patients: A Propensity-Matched Cohort Study by Björn Stessel, Maayeen Bin Saad, Lotte Ullrick, Laurien Geebelen, Jeroen Lehaen, Philippe Jr Timmermans, Michiel Van Tornout, Ina Callebaut, Jeroen Vandenbrande, Jasperina Dubois

“…A total of 24 ECMO patients were propensity matched to an equal number of MVA patients. ICU mortality was significantly higher in the ECMO arm (45.8%) compared with the MVA cohort (16.67%) (OR 4.23 (1.11, 16.17); p=0.02). …”
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Efficacy of a Mixed Wavelength Laser for Vaginal Health in Postmenopausal Women: A Randomized Controlled Trial by Salinas Pena J, Tameish S, Guilarte Calzada C, Cavallé Busquets P

“…Universitat Rovira I Virgili, Reus, Spain&ast;These authors contributed equally to this workCorrespondence: Juan Salinas Pena, Hospital Universitari Sant Joan de Reus, Avinguda del Doctor Josep Laporte, 2, Reus, Tarragona, 43204, Spain, Email juanraul.salinas@salutsantjoan.catBackground: Genitourinary syndrome of menopause (GSM) is a chronic and progressive condition. …”
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