Visual Research of Global Orphan Drug from a Bibliometric Perspective by Wen X, Jin G, Wu C

“…Xiaoya Wen,1,* Guangzhi Jin,2,* Chunxing Wu3 1Department of Pharmacy, The Fourth People’s Hospital of GuiYang, Guiyang, Guizhou Province, 550007, People’s Republic of China; 2Department of Hemodialysis Room, The Second People’s Hospital of Guizhou Province, Guiyang, Guizhou Province, 550001, People’s Republic of China; 3Department of Pharmacy, Binzhou Central Hospital, Binzhou, Shandong Province, 251700, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunxing Wu, Department of Pharmacy, Binzhou Central Hospital, Binzhou, Shandong Province, 251700, People’s Republic of China, Email yurenchunxing@126.comObjective: This study analyzes the current research landscape and trends in orphan drug development, providing insights for future advancements in the field.Methods: Gathering pertinent material from the China National Knowledge Infrastructure (CNKI) and Web of Science databases. …”
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Peritoneal Laser Doppler Flowmetry in Predicting and Diagnosing Tertiary Peritonitis by D. S. Parshin, M. A. Topchiyev

“…To identify early, trigger indicators of peritoneal microcirculation in tertiary peritonitis, obtained by the PLDF method.Material and methods. A retrospective analysis of the results of treatment of 48 patients operated on for secondary diffuse purulent peritonitis in the clinic of general surgery of the Astrakhan State Medical University in the period from 2015 to 2019 was carried out. …”
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Prevention of sufentanil-induced cough during induction of general anesthesia by low-dose esketamine by Xueyue Zhou, Chaoping Guo, Boyu Liu, Yongqing Guan, Shengxiang Wang, Jun Ji

“…This study aimed to investigate the preventive effect of low-dose esketamine on sufentanil-induced cough. Methods This randomised, double-blind, placebo-controlled clinical study was conducted at the Air Force Medical Center between September 2023 and May 2024. …”
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A novel “lateral approach short axis in-plane” technique vs. conventional “short-axis out-of-plane approach” for ultrasound-guided internal jugular vein access: a prospective rando... by Michal Kalina, Patricia Vargová, Adéla Bubeníková, Roman Škulec, Vladimír Černý, David Astapenko

“…Standard descriptive statistical methods were employed for the analysis. Results A total of 200 subjects were equally divided between Group A and Group B. …”
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Histopathological Correlation of Cases with Epithelial Cell Abnormality Detected in Cervicovaginal Smear Screenings of Turkish Women and Their Association with HPV Subtypes by Kılıç HÖ, İlhan Çelik Ö

“…Early detection through Pap (Papanicolaou) smear and HPV (Human Papilloma virus) DNA testing plays a vital role in reducing morbidity and mortality.Objective: This study aims to evaluate the diagnostic concordance between cytological screening methods and definitive histopathological diagnoses, and to identify factors associated with diagnostic discrepancies.Methods: A retrospective analysis was conducted on 643 cases that received both cytological and histopathological diagnoses. …”
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The relationship between serum uric acid level and concentration of proangiogenic endothelial progenitor cells in chronic heart failure patients by A. A. Kremzer

“…the objective of this study: to establish predictive relationship between the content of uric acid in the blood and the level of circulating endothelial progenitor cells in patients with CHF of ischemic origin. Methods: The study population was structured retrospectively in 126 subjects (54 male), aged 48 to 62 years, with mild-to-severe ischemic CHFSUA level was measured by enzymatic methods, NT-pro-BNP level was examined by immunoelectrochemiluminesence method. …”
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Geometric evaluation of the central courtyard and analyzing the structure of architectural spaces in hot and humid local climate by Hamed Hayaty, Fereshteh Khamisi

“…For this reason, courtyards are often square in shape with equal length and width proportions, and a common compressed form. …”
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Host Circulating Immunometabolism-Associated Biomarkers for Early Diagnosis of Active Tuberculosis: Multi-Omics Screening with Experimental Validation by Yang Z, Dong Y, Shang Y, Li H, Ren W, Li S, Pang Y

“…Machine learning methods were used to identify the metabolism-related hub genes. …”
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Optimization of mathematical processing of calibration curves when determining molecular mass of biologicals by SDS-polyacrylamide gel electrophoresis by V. A. Tomilin, N. L. Ivanyutina, E. V. Elbert, R. A. Volkova

“…A third-order polynomial regression equation was used to optimize mathematical processing methods used during calculation of the calibration function. …”
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Professional propaedeutic council in the university by N. N. Malyarchuk, G. M. Krinitzyna, E. V. Pashchenko, V. V. Pivnenko

“…In the course of the research, a complex of theoretical and empirical research methods was employed: analysis, synthesis, moving from abstract to concrete, systematisation, and generalisation.Results and scientific novelty. …”
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Metabolomics Analysis of the Mechanism of Yuquan Capsules in the Treatment of T2DM Rats Using UPLC/MS by Zhang M, Tan Z, Ou M, Li T, Yang X, Chen L, Xiao R, Lu N, Wang X, Wu F

“…The aim of this study was to investigate the potential mechanism and efficacy of YQC in the treatment of T2DM by means of metabolomics.Methods: Thirty-two male SD rats were randomly divided into four groups of control, type 2 diabetic mellitus (T2DM), metformin (Met), and YQC. …”
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Online Broadcasting and Video Recording of Classes as An Effective Tool for Organizing E-Learning by Ramis R. Mukhametshin, Rezeda R. Khadiullina

“…Often, for remote participants in the educational process, an individual educational trajectory of learning is developed and the load on the lecturer increases, who is forced to use different methods and forms of education to ensure equal educational opportunities for all students. …”
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Features of personality trust of Russian and Indonesian students in terms of network activity by N. L. Sungurova, Yu. E. Akimkina, R. Adawiyah

“…A set of methods was used: “Assessment of trust/distrust of a person in other people” (A. …”
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Assessing the impact of the coronavirus pandemic on the mental health status of intensive care unit nurses: a systematic review by Peter Onchuru Mokaya, Nancy Ntinyari, Godfrey Limungi, Evans Kiptulon Kasmai, Hideg-Fehér Gabriella

“…This paper aims to shed light on how COVID-19 affected ICU nurses’ mental health. Methods A literature review of articles published on this topic from January 2020 to December 2024. …”
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Psychological distress in adolescence and later economic and health outcomes in the United States population: A retrospective and modeling study. by Nathaniel Z Counts, Noemi Kreif, Timothy B Creedon, David E Bloom

“…The exposure included a binary variable of clinically significant psychological distress (MHI-5 score of less than or equal to 3) and a categorical variable of symptom severity on the MHI-5. …”
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Evaluating the discriminatory capacity of traditional and novel anthropometric indices in cardiovascular disease risk factors, considering sex differences by Behzad Ensan, Farzam Kamrani, Hanieh Gholamalizadeh, Mohsen Rezaee, Hamed Hashemi Shahri, Habibollah Esmaily, Majid Ghayour-Mobarhan, Mohsen Moohebati, Susan Darroudi

“…Moreover, BMI, WHtR, and BRI showed equal discriminatory power to predict HTN (AUCs: 0.61). …”
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Bidirectional Two-Sample Mendelian Randomization Study Reveals Causal Associations Between Aging and Endometriosis by Chen L, Yan H, Nie J

“…Nonetheless, the causal relationship between aging and endometriosis has yet to be completely understood.Objective: This study aims to determine whether aging had a causal association with the incidence of endometriosis.Methods: We conducted bidirectional MR analyses to evaluate the causal relationship between aging biomarkers, particularly leukocyte telomere length (LTL), and endometriosis risk. …”
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Home and clinical office pressure measurements in assessment of the prevalence and markers of arterial hypertension phenotypes in a cohort study by E. V. Platonova, A. D. Deev, V. M. Gorbunov, S. A. Shalnova

“…To study a combined use of home (HBPM) and office (OBP) blood pressure  measurements in assessment of prevalence and predictors of hypertensive phenotypes  in population of 55 years and older.Material and methods. From prospective cohort of Moscow population, a sample was randomly formed (n=1871, 64% response), representative of parameters of general health, educational level, time of residence in Moscow, and with an equal number of men and women. …”
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Short-Term Spinal Cord Stimulation or Pulsed Radiofrequency for Elderly Patients with Postherpetic Neuralgia: A Prospective Randomized Controlled Trial by Lei Sheng, Zihao Liu, Wang Zhou, Xiaojun Li, Xin Wang, Qingjuan Gong

“…Department of Pain Management, the Second Affiliated Hospital of Guangzhou Medical University. Methods. A total of 70 elderly patients with PHN were equally randomized to the PRF group or stSCS group. …”
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Clinical and economic benefits of using sonidegib in the 1-line therapy of patients with locally advanced basal cell carcinoma by O. I. Ivakhnenko, V. V. Ryazhenov, M. Yu. Frolov, V. A. Rogov

“…One of the key factors in ensuring the availability of modern treatments and choosing the optimal therapy for patients is the clinical and economic characteristics of new medical technologies.The aim: to assess the clinical and economic feasibility of using sonidegib in widespread clinical practice.Materials and methods. General scientific research methods were used as a methodological basis. …”
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