DS-Modified Paeoniflorin pH-Responsive Lipid–Polymer Hybrid Nanoparticles for Targeted Macrophage Polarization in a Rat Model of Rheumatoid Arthritis by Zhang J, Yang J, Yu Z, Bai H, Wang Y, Wang R

“…Simultaneously, dextran sulfate serves as a ligand to actively target Scavenger receptor class A type I overexpressed on activated macrophages in RA synovium, achieving dual-targeted delivery via environmental responsiveness and ligand-receptor interaction.Methods: We developed dextran sulfate-modified Pae–PPNPs–DS, which exhibits dual capabilities of active macrophage targeting and pH-triggered drug release, to deliver paeoniflorin to macrophages and improve drug delivery at the joint inflammation site. …”
Get full text

Evaluating Digital Rehabilitation Outcomes in Chronic Musculoskeletal Conditions Across Non-Obesity, Obesity, and Severe Obesity by Pereira AP, Janela D, Areias AC, Molinos M, Tong X, Bento V, Yanamadala V, Cohen SP, Correia FD, Costa F

“…The rising prevalence of obesity calls for scalable solutions to address MSK conditions in this population, given their complex clinical profile and barriers to accessing care.Purpose: To evaluate the engagement and clinical outcomes of a fully remote digital care program in patients with MSK conditions, focusing on those with and without comorbid obesity.Patients and Methods: A post-hoc analysis of a prospective, longitudinal, single-arm observational home-based study conducted between August, 2023, and August, 2024. …”
Get full text

Safety and efficacy of low-dose esketamine weakly opioidized anesthesia in elderly patients with lumbar spinal stenosis undergoing surgery: a prospective, double-blind randomized c... by Ni-Na Hou, Meng-Yun Zhang, Yu-Wei Zhang, Hong-Jing Wu, Hong Luo, Heng Yang

“…We aimed to evaluate the intraoperative safety and efficacy of weak opioidized anesthesia with low-dose esketamine in the treatment of elderly patients with lumbar spinal stenosis undergoing total laminectomy with complete decompression and interbody implant fusion. Methods In total, 90 elderly patients were randomized into three groups: the esketamine HS group (0.2 mg/kg induction, 0.25 mg/(kg·h) infusion), the esketamine LS group (0.2 mg/kg induction, 0.125 mg/(kg·h) infusion), and the control group (group C receiving an equal volume of saline). …”
Get full text

Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress by Guan H, Huang L, Liu Y, Zhu E, Chen L, Li W, Wu H, Zhang X, Qin R, Zheng J, Mo Y, Zhong M, Xu B, Dai X, Wei Q, Chen Y, Wang Q, Zheng Z, Ma K, Tang C

“…In this study, we aimed to explore the effector mechanisms of PS immune-complex during lupus development.Patients and Methods: Serological profiles of immune-complexes in SLE patients were analyzed. …”
Get full text

Studying Spatiotemporal Changeability of Oak Forests in Zagros in Response to Rainfall Variation by Zahra Alirezai, Amir Gandomkar, Morteza khodagholi, Alireza Abbasi

“…Borhan et al., 2015). 2-Materials and Methods In this study, two categories of data were used. …”
Get full text

Social Media Behavior Guidelines for Healthcare Professionals: An American Society of Pain and Neuroscience NEURON Project by Giuffrida A, Saia-Owenby C, Andriano C, Beall D, Bailey-Classen A, Buchanan P, Budwany R, Desai MJ, Comer A, Dudas A, Tieppo Francio V, Grace W, Gill B, Grunch B, Goldblum A, Garcia RA, Lee DW, Lavender C, Lawandy M, Mandell L, Mata R, Rabii M, Patel K, Patel RG, Patel AA, Sayed D, Singh G, Strand N, Tate J, Schatman ME, Deer T

“…As part of the broader initiatives on Spine and Nerve practice, the executive board of ASPN has decided it would be beneficial to include comprehensive guidance for healthcare providers when engaging on social media.Methods: A panel of experts was chosen based on expertise, publications, diversity, and their social media presence. …”
Get full text

A caffeine and theacrine combination improves cognitive performance in tactical personnel under physically fatiguing conditions by Blaine S. Lints, Adam T. Harrison, Sten O. Stray-Gundersen, Gianna F. Mastrofini, Riccardo F. Romersi, Noah K. Nakagawa, Mackenzie B. Yoder, Chimaobim E. Martin-Diala, Alexa J. Chandler, R. Davis Moore, Shawn M. Arent

“…Thus, combining lower-dose caffeine and theacrine may improve cognitive-behavioral performance before and after fatiguing exercise to an equal or greater degree than higher doses of caffeine alone. …”
Get full text

The effectiveness of psychosocial interventions for reducing problematic substance use, mental ill health, and housing instability in people experiencing homelessness in high incom... by Chris O'Leary, Esther Coren, Sandor Gellen, Anton Roberts, Harry Armitage

“…Objectives To summarise the existing evidence of whether psychosocial interventions work in reducing problematic substance use, mental ill health, and housing instability for adults experiencing homelessness in high income countries. Search Methods We used searches undertaken for the Homelessness Effectiveness Evidence and Gap Map (EGM) 5th edition. …”
Get full text

Comparison of Clinical Outcomes between the Fourth Day and the Fifth Day Embryo Transfer in IVF/ICSI Cycles: A Retrospective Cohort Study before and after PSM by Yasong Geng, Fangfang Dai, Meiyang Du, Linlin Tao, Haoyang Dai, Bo Zheng, Shusong Wang

“…The propensity score matching (PSM) was performed with a ratio of 1:1, ensuring equal representation of treated and control groups in the analysis. …”
Get full text

Serum LCAT as a Gender-Neutral Biomarker for Early Osteoporosis: A Multicenter Cohort Validation Study by Wen Y, Cheng S, Gou L, Zhou W, Li Y, Wang R, Wu J, Dai X, Gao M, Wang L, Xue B, Wang Y

“…Yali Wen,1,* Shoujun Cheng,2,* Liming Gou,3,* Weihong Zhou,4,* Yishan Li,5 Ruoxuan Wang,6 Ji Wu,7 Xuening Dai,8 Ming Gao,9 Lei Wang,10 Bin Xue,3,11,12 Yinhe Wang1,13 1Department of Orthopedics, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 2Department of Clinical Laboratory, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 3Department of Translational Medicine Research Center, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 4Department of Health Management Centre, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 5Department of Translation Studies, Army Engineering University of PLA, Nanjing, People’s Republic of China; 6Department of Clinical Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 7Department of Orthopedics, Sir Run Run Hospital, Nanjing, Jiangsu, People’s Republic of China; 8Department of Geriatrics, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 9Department of Endocrinology, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 10Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 11Department of Jiangsu Key Laboratory of Early Development and Chronic Diseases Prevention in Children, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 12Department of General Surgery, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of China; 13Department of Orthopedics, Clinical College, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yinhe Wang, Department of Orthopedics, Nanjing Drum Tower Hospital, Nanjing University of Chinese Medicine, Nanjing, 210000, People’s Republic of China, Email milkyway199@hotmail.com Bin Xue, Translational Medicine Research Center, Children’s Hospital of Nanjing Medical University, Nanjing, 210008, People’s Republic of China, Email xuebin@njmu.edu.cnPurpose: This study aims to identify a novel biomarker for the early detection and prevention of osteoporosis.Methods: A cross-sectional study (n=138, from 497 screened) was conducted at Nanjing Drum Tower Hospital (Sep 2023-Jun 2024). …”
Get full text

Efficacy and safety of doravirine/lamivudine/tenofovir disoproxil fumarate in HIV treatment: a real-world single-center study in China by Aixin Li, Letian Liu, Hongwei Zhang, Xi Wang, Zaicun Li, An Liu, Lili Dai, Jingji Zhang, Yue Gao, Jiangzhu Ye, Jianwei Li, Lijun Sun, Lijun Sun

“…This study presents real-world results of a retrospective analysis of patients who initiated DOR/3TC/TDF at a Chinese HIV center.MethodsThis retrospective analysis was carried out on patients who received DOR/3TC/TDF (initial or switch) at the outpatient clinic of the Infection Center in Beijing Youan Hospital in China. …”
Get full text

Immune Microenvironment Characterization and Machine Learning-Guided Identification of Diagnostic Biomarkers for Ulcerative Colitis by Zheng Q, Wang L, Zhang Y, Peng J, Hou J, Wang H, Ma Y, Tang P, Li Y, Li H, Chen Y, Li J, Chen Y

“…Current treatments often show limited efficacy, highlighting the need for novel diagnostic and therapeutic approaches.Methods: RNA-Seq data from 495 UC patients and 320 controls (training dataset) and 389 UC patients and 209 controls (testing dataset) were analyzed. …”
Get full text

Optimizing Treatment for Hospitalized Patients with COPD: A Study on the Impact of a LINE App-Based Multidisciplinary Team Approach Targeting Pharmacological Treatment, Lifestyle C... by Huang HY, Chen CL, Lin YL, Chen SC, Lee LC, Dai HM, Chiang CY, Chang YF, Lu H, Lee MR, Yang CC, Su CH, Chiang YZ, Yang MC, Shyu RY, Lan CC

“…This study explored the effectiveness of LINE-based MDT interventions in hospitalized patients with COPD.Methods: This retrospective analysis included patients with COPD admitted for exacerbations and compared their outcomes before and after the implementation of LINE-based MDT care. …”
Get full text

Adverse childhood experiences and subsequent experiences of intimate partner violence in adulthood: a gender perspective by Zheng Tian, Nan Zhang, Yimiao Li, Yibo Wu, Lan Wang

“…Abstract Aims Investigate the prevalence of adverse childhood experience (ACE) and intimate partner violence (IPV) using a large representative Chinese sample, explore the association mechanism between ACE and adult exposure to IPV and to examine gender differences. Methods A total of 21,154 participants were included in this study. …”
Get full text

Analysis of the Rights and Obligations of Stakeholders in China’s National Park Concession System by Le ZHONG, Zhicong ZHAO

“…Following the principle of equality of stakeholders’ rights and obligations, this research aims to provide a comprehensive theoretical and practical framework to guide ongoing research and the systematic construction of China’s national park concession system.MethodsThis research is designed to investigate the overarching and universal challenges associated with the establishment of the national park concession system in China. …”
Get full text

Comprehensive Analysis of Differences in N6-Methyladenosine RNA Methylation Groups in CVB3-Induced Viral Myocarditis and Identification of the Anti-Apoptotic Role of RBM15B by Hu Y, Lin J, Yi L, Cheng S, You G, Chang H, Liu H, Yang Z, Chen S

“…In this study, we investigated alterations in global RNA m6A methylation levels during CVB3 infection using both in vitro and in vivo models, and further examined the regulatory role of the m6A methyltransferase RBM15B in vitro.Methods: First, the total quantity of m6A was quantified in Balb/c mice and HL-1 cells with CVB3 infection via m6A dot blot analysis. …”
Get full text

Overtime Histological Changes in the Lungs after Intoxication with Baclofen Alone or in Combination with Ethanol (Experimental Study) by O. L. Romanova, M. L. Blagonravov, P. G. Dzhuvalyakov, V. I. Torshin, A. V. Ershov, E. Kh. Barinov

“…The aim of the study was to evaluate the overtime histological changes in the lungs after intoxication with baclofen alone or in combination with ethanol.Materials and methods. The experiment was carried out on 35 male Wistar rats weighing 290-350 g and aged 20 weeks. …”
Get full text

ASSESSMENT OF ADHERENCE TO TREATMENT AND FACTORS AFFECTING IT IN PATIENTS WITH STABLE ISCHEMIC HEART DISEASE DURING THERAPY WITH NICORANDIL by S. Yu. Martsevich, Yu. V. Lukina, N. P. Kutishenko, A. V. Akimova, V. P. Voronina, O. V. Lerman, O. V. Gaisenok, T. A. Gomova, A. V. Ezhov, A. D. Kuimov, R. A. Libis, G. V. Matyushin, T. N. Mitroshina, G. I. Nechaeva, I. I. Reznik, V. V. Skibitsky, L. A. Sokolova, A. I. Chesnikova, N. V. Dobrynina, S. S. Yakushin

“…To study the adherence to treatment and the factors that affect it in patients with stable coronary heart disease during the treatment with nicorandil. Material and methods. The use of nicorandil in addition to standard antianginal therapy was recommended to patients (n=590) in a prospective, observational, multicenter NIKEA study. …”
Get full text

Prognostic Significance of Elevated Platelet Count (>200 x 10^9 per L) in BCLC Stages B and C of Hepatocellular Carcinoma: A Retrospective Multicenter Analysis by Munker S, Rodriguez I, Bernhart K, Ben Khaled N, Findik M, Siegmund LK, Ye L, Reiter FP, Roessler D, Nasseh D, Balcar L, Pomej K, Scheiner B, Weiss C, Pinter M, Seidensticker M, Mayerle J, Philipp AB, De Toni EN

“…However, recent evidence suggests that elevated platelet count may also predict worse outcomes in advanced stages, suggesting a stage-dependent prognostic impact.Aim: This study evaluated the prognostic role of platelet counts across BCLC stages, adjusted for portal hypertension, to improve individualized patient management.Methods: In this retrospective, multicenter study, platelet count of 1112 patients with HCC in different tumor stages was analyzed. …”
Get full text

SEPLINE: Socioeconomic Position in Epidemiological Research—A National Guideline on Danish Registry Data by Hjorth CF, Kjærulff TM, Thomsen MK, Cronin-Fenton D, Dalton SO, Olsen MH

“…Workshop II (fall 2024) addressed analytical methods, including causal inference challenges and income/wealth assessment methods. …”
Get full text