Quercetin, a Compound of the Total Flavonoids of Periploca forrestii Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α by Chen S, Xue W, Wu Z, Lu D, Zheng L, Zhou M, Li Y, Wang Y, Liu T

“…This study investigates the specific compounds of TFPF responsible for TNF-α inhibition and delineates their mechanism of action.Methods: L929 cells and luciferase-based assays were used to assess anti-TNF-α activity. …”
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Social Support, Quality of Life, and Financial Toxicity Among Patients with Hepatocellular Carcinoma by Liu S, Xie Y, Li T, Huang Y, Xu D, Cai L, Fu Y, Chen J, Zhang Y, Huang J, Hu Z

“…Shuyue Liu,1– 3,* Yawen Xie,1– 3,* Tiantian Li,1– 3,* Yanxia Huang,1– 3 Danting Xu,1– 3 Linli Cai,1– 3 Yizhen Fu,1– 3 Jinbin Chen,1– 3 Yaojun Zhang,1– 3 Jia Huang,4 Zili Hu1– 3 1Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 4Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jia Huang, Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86 13828442672, Email hjia@mail.sysu.edu.cn Zili Hu, Department of Liver Surgery, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86-20-87343115, Email huzl1@sysucc.org.cnBackground & Aims: Despite the significant hepatocellular carcinoma (HCC) patient population, gaps exist in understanding their survivorship journey.Methods: Patients diagnosed with HCC at all stages were recruited at Sun Yat-sen University Cancer Center from August 1, 2023, to December 30, 2023. …”
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Leonurine Attenuates CCl4-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway by Wang P, Bai J, Ye M, Huang Z, Chen J, Sun L, Zhong X, Zheng Y, Ma T, Fu W, Du Y

“…This study aims to investigate the effect of Leo on liver fibrosis and clarify the mechanisms at play.Methods: We employed a mouse model of liver fibrosis induced by carbon tetrachloride (CCl4) and utilized LX-2 cells to investigate the mechanisms through which Leo exerts its effects.Results: Mice administered CCl4 displayed an elevated hepatic index, considerable necrosis as revealed by H&E staining, and significantly heightened serum markers of liver injury (ALT and AST). …”
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Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study by Chen X, Wu X, Peng W, Liu L, Liu X, Wan X, Xu H, Zheng Y, Zhao H, Mao Y, Lu X, Sang X, Chang X, Zhou K, Pan J, Guan M, Hu D, Tan H, Zhang Y, Du S

“…This study evaluates the efficacy of different adjuvant treatments on disease-free survival (DFS) and overall survival (OS) in HCC patients with MVI following curative resection.Methods: A retrospective cohort of 409 HCC patients with MVI who underwent curative resection from three clinical centers between 2017 and 2024 was analyzed. …”
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Providing a Robust Dynamic Pricing Model and Comparing It with Static Pricing in Multi-level Supply Chains Using a Game Theory Approach by Sara Mehrjoo, Hanan Amoozad Mahdirji, Jalil Heidary Dahoei, Seyyed Hossein Razavi Haji Agha, Mahnaz Hosseinzadeh

“…In addition, many sources, including Chen et al, 2018, have indicated that dynamic pricing is being used in many innovative businesses, that 60% of market development managers around the world are familiar with dynamic pricing methods, and that 35% of CEOs and business managers plan to base all their pricing models on dynamic pricing methods in the next three years. …”
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Lithuania's Poles and Russians: two different perspectives by Virginijus Savukynas

“…By taking to analyze the problem of national minorities from the standpoint of cultural anthropology, the author undertakes to provide for equally fruitful and actual hypotheses. In this article he does not aim to generalize or question the validity of the conducted researches. …”
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Phytotea “ATINE” enhances the immunomodulatory effect of adaptogenic factors of the Truskavets’ Spa in patients after radical treatment of oncological pathology by Igor Bombushkar, Mykhaylo Korda, Anatoliy Gozhenko, Ivan Savytskyi, Oleksandr Chebanenko, Nataliya Badiuk, Walery Zukow, Anatoliy Anchev, Viktor Duzhar, Dariya Popovych, Igor Popovych

“…The state of cellular, humoral and phagocytic links of immunity was assessed using routine methods, and two equal groups were formed on this basis. …”
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On using dynamical seasonal forecasts to develop management-driven wildland fire outlooks in Alaska by Cecilia Borries-Strigle, Uma S. Bhatt, Peter A. Bieniek, Mitchell Burgard, Eric Stevens, Heidi Strader, Richard L. Thoman, Alison York, Robert H. Ziel

“…May forecasts typically have equal or greater skill than March forecasts, with the greatest increases in skill seen during the wind subseason. …”
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Data-sharing and trustworthiness of trials evaluating cervical ripening in induction of labour: a meta-epidemiological study of randomised controlled trialsResearch in context by Malitha Patabendige, Daniel Lorber Rolnik, Wanlin Li, Ben Willem Mol, Wentao Li

“…It is still unclear whether there are substantial differences in trial characteristics, trustworthiness, effect sizes, and the certainty of evidence between RCTs that share data and those that do not. Methods: In this meta-epidemiological study of RCTs comparing different methods of induction of labour, we included nine IPD meta-analyses. …”
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Optimal 2D Placement of Virtual Objects in Physical Space for Augmented Reality Applications by M. V. Alpatova, Yu. V. Rudyak

“…The work aims at creating and implementing such a 2D algorithm for placing objects in physical space, which takes into account the above limitations.Materials and Methods. Using a set of numerical methods, the authors applied the previously created 1D algorithm for the placement of objects. …”
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Non-Invasive Diagnosis and Monitoring of Diabetic Nephropathy: Assessment of Renal Function and Fibrosis by Diffusion Kurtosis Imaging by Yuan JL, Hu LA, Wang XY, Shi ZY, Chen T, Huang XZ, Wu Y, Cai QJ, Yang ZX, Chen XY, Yuan L, Zhang Y

“…Jian-Lei Yuan,1,2,* Li-Ao Hu,1,2,* Xin-Yu Wang,2,3,* Zhao-Yu Shi,1,2 Ting Chen,1,2 Xin-Zhong Huang,1,2 Yu Wu,1,2 Qiu-Jie Cai,1,2 Zi-Xu Yang,1,2 Xin-Yi Chen,4 Li Yuan,1,2 Yuan Zhang1,2 1Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, 226001, People’s Republic of China; 2Medical School of Nantong University, Nantong, 226001, People’s Republic of China; 3Department of Medical Imaging, Affiliated Hospital of Nantong University, Nantong, 226001, People’s Republic of China; 4Nanjing Medical University School of Basic Medical Sciences, Nanjing, 211166, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuan Zhang, Email zhangy.nt.nd@ntu.edu.cn Li Yuan, Email yuanlint@163.comBackground: This monocentric, cross-sectional study explored the use of diffusion kurtosis imaging (DKI) as a non-invasive means to diagnose and monitor diabetic nephropathy (DN).Methods: Patients with diabetes mellitus (DM, n = 11), mild DN (N = 14), and severe DN (n = 29) were recruited. …”
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Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens Implantation by Zaldivar R, Zaldivar R, Cummings AB, Cummings BK, Mertens EL, Ang RE, Zarate Piscopo LI, Quintero G, Cerviño A

“…Doctors currently use different methods to estimate the best lens size, but these are not always perfect.This study tested a new artificial intelligence (AI) tool that predicts how much space (or “vault”) will be left between the implanted lens and the eye’s natural structures after surgery. …”
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Application value of nucleic acid MALDI-TOF MS in mycobacterial species identification and drug resistance detection in Mycobacterium tuberculosis by Xiaofang Liu, Honghong Niu, Donglin Guo, Huixia Gao, Lihong Wu, Jingyang Liu, Chunfeng Bai, Yuxi Li, Peilong Wang, Zhengfeng Zhou, Yuling Wang, Jianqin Liang, Wenping Gong

“…The ability to discern MTB from NTM is equally vital, as they demand distinct therapeutic approaches. …”
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Erector spinae plane block versus caudal epidural block in pediatric surgery: a systematic review and meta-analysis of randomized clinical trials by Barbara Bombassaro Masiero, Deivyd Cavalcante, Fatemeh Akbarpoor, Capela António Dicazeco Pascoal, Lubna Al-Sharif, Fellipe Feijó Halfeld, Lucas Cael Azevedo Ramos Bendaham, Patricia Viana, Jesslyn N. Haryianto, Maria Luiza de Souza Rasia, Mariana Copetti de Almeida Cunha, Ana Djulia Tesche, Júlia Caletti Roth de Oliveira, Rafael Arsky Lombardi

“…Therefore, we performed this systematic review with meta-analysis to compare both techniques. Methods: We searched PubMed, Embase and Cochrane Central for Randomized Controlled Trials (RCTs) comparing ESPB versus CEB in pediatric patients undergoing abdominal and sub-abdominal surgeries. …”
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Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD by Ahmad Moolla, Toryn Poolman, Nantia Othonos, Jiawen Dong, Kieran Smith, Thomas Cornfield, Sarah White, David W. Ray, Sofia Mouchti, Ferenc E. Mózes, Helena Thomaides-Brears, Stefan Neubauer, Jeremy F. Cobbold, Leanne Hodson, Jeremy W. Tomlinson

“…Impact and implications: Weight loss, through either lifestyle intervention or pharmacotherapy with GLP-1RA has an equally beneficial impact on the liver, and both strategies should be considered in the management of people with MASLD. …”
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Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts by Kristen D. Brantley, Michael E. Jones, Rulla M. Tamimi, Bernard A. Rosner, Peter Kraft, Hazel B. Nichols, Katie M. O’Brien, Hans-Olov Adami, Amaia Aizpurua, Amy Berrington de González, William J. Blot, Tonje Braaten, Yu Chen, Jessica Clague DeHart, Laure Dossus, Sjoerd Elias, Renée T. Fortner, Montserrat Garcia-Closas, Inger T. Gram, Niclas Håkansson, Susan E. Hankinson, Cari M. Kitahara, Woon-Puay Koh, Martha S. Linet, Robert J. MacInnis, Giovanna Masala, Lene Mellemkjær, Roger L. Milne, David C. Muller, Hannah Lui Park, Kathryn J. Ruddy, Sven Sandin, Xiao-Ou Shu, Sandar Tin Tin, Thérèse Truong, Celine M. Vachon, Lars J. Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter Willett, Alicja Wolk, Jian-Min Yuan, Wei Zheng, Dale P. Sandler, Minouk J. Schoemaker, Anthony J. Swerdlow, A. Heather Eliassen

“…Abstract Background Incidence of premenopausal breast cancer (BC) has risen in recent years, though most existing BC prediction models are not generalizable to young women due to underrepresentation of this age group in model development. Methods Using questionnaire-based data from 19 prospective studies harmonized within the Premenopausal Breast Cancer Collaborative Group (PBCCG), representing 783,830 women, we developed a premenopausal BC risk prediction model. …”
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Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within... by Deborah D Stocken, Charles H Knowles, Jared Torkington, David Jayne, Julie Hepburn, Laura Knight, Neil Corrigan, Julie Cornish, Katie Gordon, Ashley Douglas, Kate Wilson, Megan Dale, Julie Croft, Christina Lloydwin, Alexandra Harriet Coxon-Meggy, Judith White, Alun Meggy, Aaron Quyn, Emily Farrow, Kheng-Seong Ng, Hannah Mather, Huey Yi Chong, Betty Tan, Ralph Powell, Andrea Warwick

“…Participants entering the RCT will be randomised between OCM, TAI or SNM, all with equal allocation ratios.Cohort and RCT participants will be followed up for a 24-month period, completing a series of questionnaires measuring LARS symptoms and QoL, as well as clinical review for those in the RCT. …”
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Gender Influence on Bimekizumab Response in Patients with Psoriasis: Results of a Real-World Multicenter Retrospective Study—IL PSO (Italian Landscape PSOriasis) by Helena Gioacchini, Agnese Rossi, Maria Esposito, Emanuele Vagnozzi, Maria Concetta Fargnoli, Paolo Gisondi, Francesco Bellinato, Chiara Assorgi, Pina Brianti, Santo Raffaele Mercuri, Martina Burlando, Emanuele Cozzani, Giovanna Brunasso, Stefano Caccavale, Anna Balato, Giacomo Caldarola, Clara De Simone, Elena Campione, Alessandro Giunta, Francesco Tonon, Marina Venturini, Carlo Giovanni Carrera, Angelo Valerio Marzano, Andrea Carugno, Paolo Sena, Antonio Costanzo, Alessandra Narcisi, Francesco Cusano, Paolo Dapavo, Pietro Quaglino, Annunziata Dattola, Antonio Giovanni Richetta, Francesca Gaiani, Piergiorgio Malagoli, Matteo Megna, Luca Potestio, Edoardo Mortato, Francesco Loconsole, Francesca Romano, Andrea Faragalli, Rosaria Gesuita, Tommaso Bianchelli, Federico Diotallevi, Diego Orsini, Anna Campanati

“…Notably, no studies have specifically investigated bimekizumab, a humanized, full-length IgG1 monoclonal antibody that acts as a dual inhibitor of interleukin (IL)-17A and IL-17F. Methods This was a cross-sectional, observational, retrospective, multicenter analysis. …”
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Inspiring Social Capital Through Community Green Space: Pathways and Implications by Lin YE, Shi HE, Yinghao LI, Zhaohui YAN, Lei HUANG

“…The second stage carefully examines existing research to identify common research methods, areas of agreement among scholars, and ongoing debates in the field. …”
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Impact of Low Hand Grip Strength on Quality of Life, Utilization of Healthcare, and Mental Health in Individuals with Airflow Limitation by Kim SH, Zo S, Kong SA, Cho JH, Do JG, Shin SH, Park HY

“…However, data on the impact of sarcopenia on quality of life, utilization of healthcare, and mental health in individuals with AFL are limited.Patients and methods: We used data from the 2014– 2019 Korea National Health and Nutrition Examination Survey (KNHANES), and participants with AFL were included. …”
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